{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P36991","uniProtkbId":"OV17_ONCVO","entryAudit":{"firstPublicDate":"1994-06-01","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1994-06-01","entryVersion":61,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Onchocerca volvulus","taxonId":6282,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Nematoda","Chromadorea","Rhabditida","Spirurina","Spiruromorpha","Filarioidea","Onchocercidae","Onchocerca"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"OV-17 antigen"}},"alternativeNames":[{"fullName":{"value":"Immunodominant hypodermal antigen"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"OV17"}}],"comments":[{"texts":[{"value":"High levels in the hypodermal layer of the adult female"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Present in larvae and in adult parasites"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SXP/RAL-2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"OV-17 antigen","featureId":"PRO_0000021979"},{"type":"Region","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"8253155","citationType":"journal article","authors":["Bradley J.E.","Tuan R.S.","Shepley K.J.","Tree T.I.M.","Maizels R.M.","Helm R.","Gregory W.F.","Unnasch T.R."],"citationCrossReferences":[{"database":"PubMed","id":"8253155"},{"database":"DOI","id":"10.1006/expr.1993.1101"}],"title":"Onchocerca volvulus: characterization of an immunodominant hypodermal antigen present in adult and larval parasites.","publicationDate":"1993","journal":"Exp. Parasitol.","firstPage":"414","lastPage":"424","volume":"77"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"L3 / Rainforest","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U00693","properties":[{"key":"ProteinId","value":"AAA18283.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"A60758","properties":[{"key":"EntryName","value":"A60758"}]},{"database":"AlphaFoldDB","id":"P36991","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P36991","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"OVOC9988.1","properties":[{"key":"ProteinId","value":"OVOC9988.1"},{"key":"GeneId","value":"WBGene00246797"}]},{"database":"HOGENOM","id":"CLU_1621016_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DAQIDQK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PRO","id":"PR:P36991","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000024404","properties":[{"key":"Component","value":"Unassembled WGS sequence"}]},{"database":"InterPro","id":"IPR003677","properties":[{"key":"EntryName","value":"ANIS5_cation-bd"}]},{"database":"InterPro","id":"IPR052823","properties":[{"key":"EntryName","value":"SXP/RAL-2_related"}]},{"database":"PANTHER","id":"PTHR21593:SF36","properties":[{"key":"EntryName","value":"DUF148 DOMAIN-CONTAINING PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21593","properties":[{"key":"EntryName","value":"PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02520","properties":[{"key":"EntryName","value":"ANIS5_cation-bd"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKFVILLTIGLLVVAAIPQRRQQQQQQQQQQQRDEREIPPFLEGAPPSVIDEFYNLLKTDENKTDQQTEADVEAFINRLGGSYKVRFTQFMEEVKKARADYERIHQQAVARFSPAAKDADARMSAIADSPHLTTRQKSQQIQAIMDSLSESVRREIINALSPQE","length":164,"molWeight":18784,"crc64":"5D405CE0DFBDA9CE","md5":"54A5D480406246D9CF8CBC5D2AD389D1"},"extraAttributes":{"countByCommentType":{"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Region":1},"uniParcId":"UPI0000130F41"}}