{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P36943","secondaryAccessions":["P77261","Q2MCC4"],"uniProtkbId":"EAEH_ECOLI","entryAudit":{"firstPublicDate":"1994-06-01","lastAnnotationUpdateDate":"2025-06-18","lastSequenceUpdateDate":"1997-11-01","entryVersion":130,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"5: Uncertain","proteinDescription":{"recommendedName":{"fullName":{"value":"Putative attaching and effacing protein homolog"}},"flag":"Precursor"},"genes":[{"geneName":{"value":"eaeH"},"orderedLocusNames":[{"value":"b0297"},{"value":"JW0291"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the intimin/invasin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Could be the product of a pseudogene"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Putative attaching and effacing protein homolog","featureId":"PRO_0000016468"},{"type":"Sequence conflict","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"in Ref. 4","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"QHA","alternativeSequences":["SMR"]}},{"type":"Sequence conflict","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"in Ref. 4","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"LTQQ","alternativeSequences":["KVLGSLSTLLACQHIHIPYQQKFQP"]}}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-B1UJ6TNQ0SAS1","citationType":"submission","authors":["Chung E.","Allen E.","Araujo R.","Aparicio A.M.","Davis K.","Duncan M.","Federspiel N.","Hyman R.","Kalman S.","Komp C.","Kurdi O.","Lew H.","Lin D.","Namath A.","Oefner P.","Roberts D.","Schramm S.","Davis R.W."],"title":"Sequence of minutes 4-25 of Escherichia coli.","publicationDate":"JAN-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-31NDKQUCRLH3M","citationType":"submission","authors":["Umeda M.","Ohtsubo E."],"publicationDate":"JUL-1992","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-295"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U73857","properties":[{"key":"ProteinId","value":"AAB18025.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAE76082.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"D12594","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A64756","properties":[{"key":"EntryName","value":"A64756"}]},{"database":"AlphaFoldDB","id":"P36943","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P36943","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4259795","properties":[{"key":"Interactions","value":"132"}]},{"database":"FunCoup","id":"P36943","properties":[{"key":"Number of interactors","value":"522"}]},{"database":"IntAct","id":"P36943","properties":[{"key":"Interactions","value":"5"}]},{"database":"KEGG","id":"ecj:JW0291","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_01460","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_24090","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|83333.103.peg.1056","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB2080","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG1388","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_1110106_0_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P36943","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YRITLMA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8320584at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P36943","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.40.160.160","properties":[{"key":"EntryName","value":"Inverse autotransporter, beta-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024519","properties":[{"key":"EntryName","value":"IAT_beta"}]},{"database":"InterPro","id":"IPR038177","properties":[{"key":"EntryName","value":"IAT_beta_sf"}]},{"database":"InterPro","id":"IPR051715","properties":[{"key":"EntryName","value":"Intimin-Invasin_domain"}]},{"database":"InterPro","id":"IPR003535","properties":[{"key":"EntryName","value":"Intimin/invasin_bac"}]},{"database":"PANTHER","id":"PTHR39576:SF2","properties":[{"key":"EntryName","value":"ATTACHING AND EFFACING PROTEIN HOMOLOG-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR39576","properties":[{"key":"EntryName","value":"ATTACHING AND EFFACING PROTEIN HOMOLOG-RELATED-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11924","properties":[{"key":"EntryName","value":"IAT_beta"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01369","properties":[{"key":"EntryName","value":"INTIMIN"}]}],"sequence":{"value":"MSHYKTGHKQPRFRYSVLARCVAWANISVQVLFPLAVTFTPVMAARAQHAVQPRLSMGNTTVTADNNVEKNVASFAANAGTFLSSQPDSDATRNFITGMATAKANQEIQEWLGKYGTARVKLNVDKDFSLKDSSLEMLYPIYDTPTNMLFTQGAIHRTDDRTQSNIGFGWRHFSGNDWMAGVNTFIDHDLSRSHTRIGVGAEYWRDYLKLSANGYIRASGWKKSPDIEDYQERPANGWDIRAEGYLPAWPQLGASLMYEQYYGDEVGLFGKDKRQKDPHAISAEVTYTPVPLTQQ","length":295,"molWeight":33175,"crc64":"93DAD573CCCB2F45","md5":"AE7C6321D406F23EBF292CC82341AA24"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Sequence conflict":2},"uniParcId":"UPI0000129B20"}}