{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P36141","secondaryAccessions":["D6VXB0"],"uniProtkbId":"FMP46_YEAST","entryAudit":{"firstPublicDate":"1994-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1994-06-01","entryVersion":165,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","commonName":"Baker's yeast","taxonId":559292,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Saccharomycetes","Saccharomycetales","Saccharomycetaceae","Saccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Putative redox protein FMP46, mitochondrial"},"ecNumbers":[{"value":"1.-.-.-"}]},"alternativeNames":[{"fullName":{"value":"Found in mitochondrial proteome protein 46"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"FMP46"},"orderedLocusNames":[{"value":"YKR049C"}]}],"comments":[{"texts":[{"value":"Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P36141","intActId":"EBI-26445"},"interactantTwo":{"uniProtKBAccession":"P39940","geneName":"RSP5","intActId":"EBI-16219"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562095"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14576278"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562106"}],"value":"Present with 1240 molecules/cell in log phase SD medium"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the FMP46 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transit peptide","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Mitochondrion","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Putative redox protein FMP46, mitochondrial","featureId":"PRO_0000203215"},{"type":"Active site","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Beta strand","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Beta strand","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Helix","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Turn","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Beta strand","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Helix","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Beta strand","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Helix","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Beta strand","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Helix","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Turn","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Helix","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Helix","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Beta strand","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Beta strand","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]},{"type":"Helix","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WPI"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"8196765","citationType":"journal article","authors":["Dujon B.","Alexandraki D.","Andre B.","Ansorge W.","Baladron V.","Ballesta J.P.G.","Banrevi A.","Bolle P.-A.","Bolotin-Fukuhara M.","Bossier P.","Bou G.","Boyer J.","Buitrago M.J.","Cheret G.","Colleaux L.","Daignan-Fornier B.","del Rey F.","Dion C.","Domdey H.","Duesterhoeft A.","Duesterhus S.","Entian K.-D.","Erfle H.","Esteban P.F.","Feldmann H.","Fernandes L.","Fobo G.M.","Fritz C.","Fukuhara H.","Gabel C.","Gaillon L.","Garcia-Cantalejo J.M.","Garcia-Ramirez J.J.","Gent M.E.","Ghazvini M.","Goffeau A.","Gonzalez A.","Grothues D.","Guerreiro P.","Hegemann J.H.","Hewitt N.","Hilger F.","Hollenberg C.P.","Horaitis O.","Indge K.J.","Jacquier A.","James C.M.","Jauniaux J.-C.","Jimenez A.","Keuchel H.","Kirchrath L.","Kleine K.","Koetter P.","Legrain P.","Liebl S.","Louis E.J.","Maia e Silva A.","Marck C.","Monnier A.-L.","Moestl D.","Mueller S.","Obermaier B.","Oliver S.G.","Pallier C.","Pascolo S.","Pfeiffer F.","Philippsen P.","Planta R.J.","Pohl F.M.","Pohl T.M.","Poehlmann R.","Portetelle D.","Purnelle B.","Puzos V.","Ramezani Rad M.","Rasmussen S.W.","Remacha M.A.","Revuelta J.L.","Richard G.-F.","Rieger M.","Rodrigues-Pousada C.","Rose M.","Rupp T.","Santos M.A.","Schwager C.","Sensen C.","Skala J.","Soares H.","Sor F.","Stegemann J.","Tettelin H.","Thierry A.","Tzermia M.","Urrestarazu L.A.","van Dyck L.","van Vliet-Reedijk J.C.","Valens M.","Vandenbol M.","Vilela C.","Vissers S.","von Wettstein D.","Voss H.","Wiemann S.","Xu G.","Zimmermann J.","Haasemann M.","Becker I.","Mewes H.-W."],"citationCrossReferences":[{"database":"PubMed","id":"8196765"},{"database":"DOI","id":"10.1038/369371a0"}],"title":"Complete DNA sequence of yeast chromosome XI.","publicationDate":"1994","journal":"Nature","firstPage":"371","lastPage":"378","volume":"369"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"24374639","citationType":"journal article","authors":["Engel S.R.","Dietrich F.S.","Fisk D.G.","Binkley G.","Balakrishnan R.","Costanzo M.C.","Dwight S.S.","Hitz B.C.","Karra K.","Nash R.S.","Weng S.","Wong E.D.","Lloyd P.","Skrzypek M.S.","Miyasato S.R.","Simison M.","Cherry J.M."],"citationCrossReferences":[{"database":"PubMed","id":"24374639"},{"database":"DOI","id":"10.1534/g3.113.008995"}],"title":"The reference genome sequence of Saccharomyces cerevisiae: Then and now.","publicationDate":"2014","journal":"G3 (Bethesda)","firstPage":"389","lastPage":"398","volume":"4"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"17322287","citationType":"journal article","authors":["Hu Y.","Rolfs A.","Bhullar B.","Murthy T.V.S.","Zhu C.","Berger M.F.","Camargo A.A.","Kelley F.","McCarron S.","Jepson D.","Richardson A.","Raphael J.","Moreira D.","Taycher E.","Zuo D.","Mohr S.","Kane M.F.","Williamson J.","Simpson A.J.G.","Bulyk M.L.","Harlow E.","Marsischky G.","Kolodner R.D.","LaBaer J."],"citationCrossReferences":[{"database":"PubMed","id":"17322287"},{"database":"DOI","id":"10.1101/gr.6037607"}],"title":"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.","publicationDate":"2007","journal":"Genome Res.","firstPage":"536","lastPage":"543","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14562095","citationType":"journal article","authors":["Huh W.-K.","Falvo J.V.","Gerke L.C.","Carroll A.S.","Howson R.W.","Weissman J.S.","O'Shea E.K."],"citationCrossReferences":[{"database":"PubMed","id":"14562095"},{"database":"DOI","id":"10.1038/nature02026"}],"title":"Global analysis of protein localization in budding yeast.","publicationDate":"2003","journal":"Nature","firstPage":"686","lastPage":"691","volume":"425"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":5,"citation":{"id":"14562106","citationType":"journal article","authors":["Ghaemmaghami S.","Huh W.-K.","Bower K.","Howson R.W.","Belle A.","Dephoure N.","O'Shea E.K.","Weissman J.S."],"citationCrossReferences":[{"database":"PubMed","id":"14562106"},{"database":"DOI","id":"10.1038/nature02046"}],"title":"Global analysis of protein expression in yeast.","publicationDate":"2003","journal":"Nature","firstPage":"737","lastPage":"741","volume":"425"},"referencePositions":["LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":6,"citation":{"id":"14576278","citationType":"journal article","authors":["Sickmann A.","Reinders J.","Wagner Y.","Joppich C.","Zahedi R.P.","Meyer H.E.","Schoenfisch B.","Perschil I.","Chacinska A.","Guiard B.","Rehling P.","Pfanner N.","Meisinger C."],"citationCrossReferences":[{"database":"PubMed","id":"14576278"},{"database":"DOI","id":"10.1073/pnas.2135385100"}],"title":"The proteome of Saccharomyces cerevisiae mitochondria.","publicationDate":"2003","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"13207","lastPage":"13212","volume":"100"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 76625 / YPH499","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"16202234","citationType":"journal article","authors":["Jung J.-W.","Yee A.","Wu B.","Arrowsmith C.H.","Lee W."],"citationCrossReferences":[{"database":"PubMed","id":"16202234"},{"database":"DOI","id":"10.5483/bmbrep.2005.38.5.550"}],"title":"Solution structure of YKR049C, a putative redox protein from Saccharomyces cerevisiae.","publicationDate":"2005","journal":"J. Biochem. Mol. Biol.","firstPage":"550","lastPage":"554","volume":"38"},"referencePositions":["STRUCTURE BY NMR","PUTATIVE FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z28274","properties":[{"key":"ProteinId","value":"CAA82127.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY558316","properties":[{"key":"ProteinId","value":"AAS56642.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK006944","properties":[{"key":"ProteinId","value":"DAA09200.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S38123","properties":[{"key":"EntryName","value":"S38123"}]},{"database":"RefSeq","id":"NP_012975.3","properties":[{"key":"NucleotideSequenceId","value":"NM_001179839.3"}]},{"database":"PDB","id":"1WPI","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-133"}]},{"database":"PDBsum","id":"1WPI","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P36141","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P36141","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P36141","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"34180","properties":[{"key":"Interactions","value":"94"}]},{"database":"FunCoup","id":"P36141","properties":[{"key":"Number of interactors","value":"99"}]},{"database":"IntAct","id":"P36141","properties":[{"key":"Interactions","value":"3"}]},{"database":"MINT","id":"P36141","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"4932.YKR049C","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"4932-YKR049C","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P36141","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"853923","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"YKR049C_mRNA","properties":[{"key":"ProteinId","value":"YKR049C"},{"key":"GeneId","value":"YKR049C"}]},{"database":"GeneID","id":"853923","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"sce:YKR049C","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"SGD:S000001757","properties":[{"key":"Description","value":"-"}]},{"database":"SGD","id":"S000001757","properties":[{"key":"GeneName","value":"FMP46"}]},{"database":"VEuPathDB","id":"FungiDB:YKR049C","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S4SU","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_1939538_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P36141","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LWVDWEK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"4044803at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"YEAST:G3O-32019-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"853923","properties":[{"key":"hits","value":"5 hits in 10 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"P36141","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P36141","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002311","properties":[{"key":"Component","value":"Chromosome XI"}]},{"database":"RNAct","id":"P36141","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"HDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"14562095"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"14576278"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"16823961"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"24769239"}]},{"database":"GO","id":"GO:0016491","properties":[{"key":"GoTerm","value":"F:oxidoreductase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051051","properties":[{"key":"GoTerm","value":"P:negative regulation of transport"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21912684"}]},{"database":"FunFam","id":"3.40.30.10:FF:000409","properties":[{"key":"EntryName","value":"Fmp46p"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.30.10","properties":[{"key":"EntryName","value":"Glutaredoxin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012882","properties":[{"key":"EntryName","value":"Fmp46"}]},{"database":"InterPro","id":"IPR036249","properties":[{"key":"EntryName","value":"Thioredoxin-like_sf"}]},{"database":"PANTHER","id":"PTHR28071","properties":[{"key":"EntryName","value":"REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28071:SF1","properties":[{"key":"EntryName","value":"REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07955","properties":[{"key":"EntryName","value":"DUF1687"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52833","properties":[{"key":"EntryName","value":"Thioredoxin-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSFWKTLQRQPRTISLFTNDIASNIKSQKCLQLLKGDVSHRFDVEIANRFPTWDQLQYMRTSCPQGPVSLQRQIPKLDSVLKYKHTDPTFGMDLQKCVQRGLWNPKEALWVDWENKLVGNEPADIDKYIIQRK","length":133,"molWeight":15650,"crc64":"188F530D3E00FE57","md5":"D4C075F41F4C5923CE7CE686B138FD9F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Transit peptide":1,"Chain":1,"Active site":1,"Beta strand":7,"Helix":7,"Turn":2},"uniParcId":"UPI000013B64E"}}