{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P35658","secondaryAccessions":["A6NFQ0","Q15010","Q3KQZ0","Q5JUP7","Q75R47","Q86XD3"],"uniProtkbId":"NU214_HUMAN","entryAudit":{"firstPublicDate":"1994-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-07-22","entryVersion":233,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Nuclear pore complex protein Nup214"}},"alternativeNames":[{"fullName":{"value":"214 kDa nucleoporin"}},{"fullName":{"value":"Nucleoporin Nup214"}},{"fullName":{"value":"Protein CAN"}}]},"genes":[{"geneName":{"value":"NUP214"},"synonyms":[{"value":"CAIN"},{"value":"CAN"},{"value":"KIAA0023"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31178128"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9049309"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8108440"}],"value":"Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25410864"}],"value":"(Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11777942"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14766228"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19208808"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19219046"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30543681"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9049309"}],"value":"Homodimer. Part of the nuclear pore complex (NPC) (PubMed:9049309). Interacts with NUP88 (PubMed:30543681, PubMed:9049309). Interacts with ZFP36; this interaction increases upon lipopolysaccharide (LPS) stimulation (PubMed:14766228). Interacts with DDX19 (PubMed:19208808, PubMed:19219046). Interacts with XPO1 (PubMed:9049309). Interacts with XPO5 (PubMed:11777942)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19386703"}],"value":"(Microbial infection) Interacts with human herpes virus 1 (HHV-1) protein UL25; this interaction might be essential to the capsid docking onto the host nuclear pore"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25410864"}],"value":"(Microbial infection) Interacts (via N-terminus) with human adenovirus 5 (HAdV-5) protein L3 (hexon); this interaction might be essential for the release of the virus genome to the nucleus"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P35658","intActId":"EBI-1222270"},"interactantTwo":{"uniProtKBAccession":"Q99567","geneName":"NUP88","intActId":"EBI-726178"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35658-1","intActId":"EBI-15757000"},"interactantTwo":{"uniProtKBAccession":"Q9UMR2-1","geneName":"DDX19B","intActId":"EBI-5773937"},"numberOfExperiments":9,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8108440"}],"value":"Cytoplasmic side of the nuclear pore complex"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8108440"}],"value":"Nucleus, nuclear pore complex","id":"SL-0185"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P35658-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P35658-2"],"sequenceIds":["VSP_034896"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P35658-3"],"sequenceIds":["VSP_034897"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["P35658-4"],"sequenceIds":["VSP_034896","VSP_034897"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["P35658-5"],"sequenceIds":["VSP_034896","VSP_034898","VSP_034899"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited"}],"commentType":"DOMAIN"},{"texts":[{"value":"The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B"}],"commentType":"DOMAIN"},{"texts":[{"value":"Probably glycosylated as it reacts with wheat germ agglutinin (WGA)"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1549122"}],"value":"A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1630450"}],"value":"A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Encephalopathy, acute, infection-induced, 9","diseaseAccession":"DI-05581","acronym":"IIAE9","description":"An autosomal recessive disorder characterized by infancy-onset of episodic neurodevelopmental regression in association with infection-induced febrile illness. Clinical features include poor overall growth, seizures, myoclonic jerks, microcephaly, ataxia, and cerebellar atrophy.","diseaseCrossReference":{"database":"MIM","id":"618426"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30758658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31178128"}]},"note":{"texts":[{"value":"Disease susceptibility is associated with variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15361874"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20851865"}],"value":"Chromosomal aberrations involving NUP214 are found in acute lymphoblastic leukemia (PubMed:15361874, PubMed:20851865). Translocation t(9;9)(q34;q34) with ABL1 (PubMed:15361874). Translocation t(5;9)(q35;q34) with SQSTM1 (PubMed:20851865)"}]}},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAD07398.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/29/CAN","ftp":false}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2090,"modifier":"EXACT"}},"description":"Nuclear pore complex protein Nup214","featureId":"PRO_0000204861"},{"type":"Repeat","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Blade 1"},{"type":"Repeat","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Blade 2"},{"type":"Repeat","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"Blade 3"},{"type":"Repeat","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"Blade 4"},{"type":"Repeat","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Blade 5"},{"type":"Repeat","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"Blade 6"},{"type":"Repeat","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"Blade 7"},{"type":"Repeat","location":{"start":{"value":484,"modifier":"EXACT"},"end":{"value":485,"modifier":"EXACT"}},"description":"1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":548,"modifier":"EXACT"},"end":{"value":549,"modifier":"EXACT"}},"description":"2","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1225,"modifier":"EXACT"},"end":{"value":1226,"modifier":"EXACT"}},"description":"3","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1411,"modifier":"EXACT"},"end":{"value":1412,"modifier":"EXACT"}},"description":"4","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1427,"modifier":"EXACT"},"end":{"value":1428,"modifier":"EXACT"}},"description":"5","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1441,"modifier":"EXACT"},"end":{"value":1442,"modifier":"EXACT"}},"description":"6","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1473,"modifier":"EXACT"},"end":{"value":1474,"modifier":"EXACT"}},"description":"7","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1635,"modifier":"EXACT"},"end":{"value":1636,"modifier":"EXACT"}},"description":"8","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1674,"modifier":"EXACT"},"end":{"value":1675,"modifier":"EXACT"}},"description":"9","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1686,"modifier":"EXACT"},"end":{"value":1687,"modifier":"EXACT"}},"description":"10","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1713,"modifier":"EXACT"},"end":{"value":1714,"modifier":"EXACT"}},"description":"11","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1721,"modifier":"EXACT"},"end":{"value":1722,"modifier":"EXACT"}},"description":"12","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1726,"modifier":"EXACT"},"end":{"value":1727,"modifier":"EXACT"}},"description":"13","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1732,"modifier":"EXACT"},"end":{"value":1733,"modifier":"EXACT"}},"description":"14","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1756,"modifier":"EXACT"},"end":{"value":1757,"modifier":"EXACT"}},"description":"15","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1772,"modifier":"EXACT"},"end":{"value":1773,"modifier":"EXACT"}},"description":"16","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1786,"modifier":"EXACT"},"end":{"value":1787,"modifier":"EXACT"}},"description":"17","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1798,"modifier":"EXACT"},"end":{"value":1799,"modifier":"EXACT"}},"description":"18","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1806,"modifier":"EXACT"},"end":{"value":1807,"modifier":"EXACT"}},"description":"19","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1812,"modifier":"EXACT"},"end":{"value":1813,"modifier":"EXACT"}},"description":"20","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1819,"modifier":"EXACT"},"end":{"value":1820,"modifier":"EXACT"}},"description":"21","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1842,"modifier":"EXACT"},"end":{"value":1843,"modifier":"EXACT"}},"description":"22","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1851,"modifier":"EXACT"},"end":{"value":1852,"modifier":"EXACT"}},"description":"23","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1862,"modifier":"EXACT"},"end":{"value":1863,"modifier":"EXACT"}},"description":"24","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1874,"modifier":"EXACT"},"end":{"value":1875,"modifier":"EXACT"}},"description":"25","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1910,"modifier":"EXACT"},"end":{"value":1911,"modifier":"EXACT"}},"description":"26","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1922,"modifier":"EXACT"},"end":{"value":1923,"modifier":"EXACT"}},"description":"27","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1930,"modifier":"EXACT"},"end":{"value":1931,"modifier":"EXACT"}},"description":"28","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1938,"modifier":"EXACT"},"end":{"value":1939,"modifier":"EXACT"}},"description":"29","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1959,"modifier":"EXACT"},"end":{"value":1960,"modifier":"EXACT"}},"description":"30","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1970,"modifier":"EXACT"},"end":{"value":1971,"modifier":"EXACT"}},"description":"31","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1976,"modifier":"EXACT"},"end":{"value":1977,"modifier":"EXACT"}},"description":"32","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1982,"modifier":"EXACT"},"end":{"value":1983,"modifier":"EXACT"}},"description":"33","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1988,"modifier":"EXACT"},"end":{"value":1989,"modifier":"EXACT"}},"description":"34","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1994,"modifier":"EXACT"},"end":{"value":1995,"modifier":"EXACT"}},"description":"35","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":2012,"modifier":"EXACT"},"end":{"value":2013,"modifier":"EXACT"}},"description":"36","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":2024,"modifier":"EXACT"},"end":{"value":2025,"modifier":"EXACT"}},"description":"37","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":2026,"modifier":"EXACT"},"end":{"value":2027,"modifier":"EXACT"}},"description":"38","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":2035,"modifier":"EXACT"},"end":{"value":2036,"modifier":"EXACT"}},"description":"39","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":2046,"modifier":"EXACT"},"end":{"value":2047,"modifier":"EXACT"}},"description":"40","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":2056,"modifier":"EXACT"},"end":{"value":2057,"modifier":"EXACT"}},"description":"41","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":2066,"modifier":"EXACT"},"end":{"value":2067,"modifier":"EXACT"}},"description":"42","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":2075,"modifier":"EXACT"},"end":{"value":2076,"modifier":"EXACT"}},"description":"43","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":2085,"modifier":"EXACT"},"end":{"value":2086,"modifier":"EXACT"}},"description":"44","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"Seven-bladed beta propeller"},{"type":"Region","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":1418,"modifier":"EXACT"}},"description":"44 X 2 AA repeats of F-G","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":460,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":586,"modifier":"EXACT"}},"description":"(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25410864"}]},{"type":"Region","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":2076,"modifier":"EXACT"}},"description":"11 X 5 AA approximate repeats"},{"type":"Region","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":597,"modifier":"EXACT"},"end":{"value":700,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":740,"modifier":"EXACT"},"end":{"value":768,"modifier":"EXACT"}},"description":"Leucine-zipper 1"},{"type":"Region","location":{"start":{"value":861,"modifier":"EXACT"},"end":{"value":882,"modifier":"EXACT"}},"description":"Leucine-zipper 2"},{"type":"Region","location":{"start":{"value":987,"modifier":"EXACT"},"end":{"value":1009,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1128,"modifier":"EXACT"},"end":{"value":1152,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1168,"modifier":"EXACT"},"end":{"value":1213,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1234,"modifier":"EXACT"},"end":{"value":1316,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1337,"modifier":"EXACT"},"end":{"value":1408,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1409,"modifier":"EXACT"},"end":{"value":2084,"modifier":"EXACT"}},"description":"18 X 4 AA approximate repeats"},{"type":"Region","location":{"start":{"value":1427,"modifier":"EXACT"},"end":{"value":2085,"modifier":"EXACT"}},"description":"11 X 3 AA approximate repeats"},{"type":"Region","location":{"start":{"value":1438,"modifier":"EXACT"},"end":{"value":1467,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1479,"modifier":"EXACT"},"end":{"value":1539,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1884,"modifier":"EXACT"},"end":{"value":1903,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":680,"modifier":"EXACT"},"end":{"value":1209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19208808"}]},{"type":"Compositional bias","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":513,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":597,"modifier":"EXACT"},"end":{"value":629,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":637,"modifier":"EXACT"},"end":{"value":658,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":691,"modifier":"EXACT"},"end":{"value":700,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":997,"modifier":"EXACT"},"end":{"value":1007,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1128,"modifier":"EXACT"},"end":{"value":1149,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1168,"modifier":"EXACT"},"end":{"value":1188,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1199,"modifier":"EXACT"},"end":{"value":1213,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1234,"modifier":"EXACT"},"end":{"value":1254,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1273,"modifier":"EXACT"},"end":{"value":1285,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1288,"modifier":"EXACT"},"end":{"value":1299,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1301,"modifier":"EXACT"},"end":{"value":1310,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1347,"modifier":"EXACT"},"end":{"value":1368,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1386,"modifier":"EXACT"},"end":{"value":1408,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1438,"modifier":"EXACT"},"end":{"value":1450,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1479,"modifier":"EXACT"},"end":{"value":1489,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1508,"modifier":"EXACT"},"end":{"value":1527,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":444,"modifier":"EXACT"},"end":{"value":445,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form the NUP214-ABL1 fusion protein","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15361874"}]},{"type":"Site","location":{"start":{"value":812,"modifier":"EXACT"},"end":{"value":813,"modifier":"EXACT"}},"description":"Breakpoint"},{"type":"Site","location":{"start":{"value":1840,"modifier":"EXACT"},"end":{"value":1841,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form the NUP214-ABL1 fusion protein","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15361874"}]},{"type":"Site","location":{"start":{"value":1916,"modifier":"EXACT"},"end":{"value":1917,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form the NUP214-ABL1 fusion protein","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15361874"}]},{"type":"Site","location":{"start":{"value":1967,"modifier":"EXACT"},"end":{"value":1968,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form the NUP214-ABL1 fusion protein","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15361874"}]},{"type":"Site","location":{"start":{"value":1967,"modifier":"EXACT"},"end":{"value":1968,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form the NUP214-SQSTM1 fusion protein","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20851865"}]},{"type":"Site","location":{"start":{"value":2071,"modifier":"EXACT"},"end":{"value":2072,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form the NUP214-ABL1 fusion protein","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15361874"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylglycine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"}]},{"type":"Modified residue","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":416,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":430,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":434,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":437,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":651,"modifier":"EXACT"},"end":{"value":651,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":657,"modifier":"EXACT"},"end":{"value":657,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":670,"modifier":"EXACT"},"end":{"value":670,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":678,"modifier":"EXACT"},"end":{"value":678,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":760,"modifier":"EXACT"},"end":{"value":760,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":940,"modifier":"EXACT"},"end":{"value":940,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":970,"modifier":"EXACT"},"end":{"value":970,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":974,"modifier":"EXACT"},"end":{"value":974,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":989,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":1021,"modifier":"EXACT"},"end":{"value":1021,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1023,"modifier":"EXACT"},"end":{"value":1023,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1045,"modifier":"EXACT"},"end":{"value":1045,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1056,"modifier":"EXACT"},"end":{"value":1056,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1081,"modifier":"EXACT"},"end":{"value":1081,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1134,"modifier":"EXACT"},"end":{"value":1134,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":1150,"modifier":"EXACT"},"end":{"value":1150,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":1156,"modifier":"EXACT"},"end":{"value":1156,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1181,"modifier":"EXACT"},"end":{"value":1181,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"}]},{"type":"Modified residue","location":{"start":{"value":1312,"modifier":"EXACT"},"end":{"value":1312,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":1353,"modifier":"EXACT"},"end":{"value":1353,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1963,"modifier":"EXACT"},"end":{"value":1963,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":1985,"modifier":"EXACT"},"end":{"value":1985,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Cross-link","location":{"start":{"value":1538,"modifier":"EXACT"},"end":{"value":1538,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":590,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"in isoform 2, isoform 4 and isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7584026"}],"featureId":"VSP_034896","alternativeSequence":{"originalSequence":"KFTAAATSTPVS","alternativeSequences":["N"]}},{"type":"Alternative sequence","location":{"start":{"value":648,"modifier":"EXACT"},"end":{"value":648,"modifier":"EXACT"}},"description":"in isoform 3 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_034897","alternativeSequence":{"originalSequence":"S","alternativeSequences":["SA"]}},{"type":"Alternative sequence","location":{"start":{"value":1139,"modifier":"EXACT"},"end":{"value":1148,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7584026"}],"featureId":"VSP_034898","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":2026,"modifier":"EXACT"},"end":{"value":2090,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7584026"}],"featureId":"VSP_034899","alternativeSequence":{"originalSequence":"FGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQGFGGWRS","alternativeSequences":["SLAMSLSPTLKGRLLLMRPKAGGGREQAAPGRKSNESRSLGHLCMERALTSPLKVWEQQQHHILRHARESECPHFRITVPTDFWFWDPE"]}},{"type":"Natural variant","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"in IIAE9; decreased nuclear transport in patient cells; decreased protein levels in patient cells; dbSNP:rs143595616","featureCrossReferences":[{"database":"dbSNP","id":"rs143595616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31178128"}],"featureId":"VAR_082629","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"in IIAE9; uncertain significance; dbSNP:rs1564175808","featureCrossReferences":[{"database":"dbSNP","id":"rs1564175808"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30758658"}],"featureId":"VAR_082630","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"in IIAE9; dbSNP:rs563025075","featureCrossReferences":[{"database":"dbSNP","id":"rs563025075"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31178128"}],"featureId":"VAR_082631","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"in a breast cancer sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_035856","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":574,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"in dbSNP:rs103612","featureCrossReferences":[{"database":"dbSNP","id":"rs103612"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1549122"}],"featureId":"VAR_045691","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":1378,"modifier":"EXACT"},"end":{"value":1378,"modifier":"EXACT"}},"description":"in a breast cancer sample; somatic mutation; dbSNP:rs777822003","featureCrossReferences":[{"database":"dbSNP","id":"rs777822003"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_035857","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":1392,"modifier":"EXACT"},"end":{"value":1392,"modifier":"EXACT"}},"description":"in a breast cancer sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_035858","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":1592,"modifier":"EXACT"},"end":{"value":1592,"modifier":"EXACT"}},"description":"in dbSNP:rs28594669","featureCrossReferences":[{"database":"dbSNP","id":"rs28594669"}],"featureId":"VAR_061533","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"Reduced binding to DDX19B.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19219046"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"Impairs interaction with DDX19B.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19219046"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"in Ref. 1; CAA45535","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"in Ref. 1; CAA45535","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":1091,"modifier":"EXACT"},"end":{"value":1092,"modifier":"EXACT"}},"description":"in Ref. 1; CAA45535","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"AA","alternativeSequences":["QL"]}},{"type":"Sequence conflict","location":{"start":{"value":1872,"modifier":"EXACT"},"end":{"value":1872,"modifier":"EXACT"}},"description":"in Ref. 5; AAH45620","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Beta strand","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Turn","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Turn","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FMO"}]},{"type":"Beta strand","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Turn","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FMO"}]},{"type":"Beta strand","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FMP"}]},{"type":"Beta strand","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Beta strand","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FMO"}]},{"type":"Helix","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OIT"}]},{"type":"Helix","location":{"start":{"value":425,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FMO"}]},{"type":"Helix","location":{"start":{"value":1925,"modifier":"EXACT"},"end":{"value":1929,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5DIS"}]},{"type":"Beta strand","location":{"start":{"value":1937,"modifier":"EXACT"},"end":{"value":1941,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5DIS"}]},{"type":"Turn","location":{"start":{"value":1943,"modifier":"EXACT"},"end":{"value":1945,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5DIS"}]},{"type":"Helix","location":{"start":{"value":1985,"modifier":"EXACT"},"end":{"value":1987,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5DIS"}]},{"type":"Helix","location":{"start":{"value":2016,"modifier":"EXACT"},"end":{"value":2019,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5DIS"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0509","category":"Biological process","name":"mRNA transport"},{"id":"KW-0906","category":"Cellular component","name":"Nuclear pore complex"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0656","category":"Disease","name":"Proto-oncogene"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0811","category":"Biological process","name":"Translocation"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"1549122","citationType":"journal article","authors":["Von Lindern M.","Fornerod M.","Van Baal S.","Jaegle M.","De Wit T.","Buijs A.","Grosveld G."],"citationCrossReferences":[{"database":"PubMed","id":"1549122"},{"database":"DOI","id":"10.1128/mcb.12.4.1687-1697.1992"}],"title":"The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.","publicationDate":"1992","journal":"Mol. Cell. Biol.","firstPage":"1687","lastPage":"1697","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","CHROMOSOMAL TRANSLOCATION WITH DEK","VARIANT SER-574"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-2UR57TO3OCTBR","citationType":"submission","authors":["Nagase T.","Kikuno R.","Ohara O."],"title":"Homo sapiens mRNA for KIAA0023 splice variant 1 protein.","publicationDate":"JAN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"7584026","citationType":"journal article","authors":["Nomura N.","Miyajima N.","Sazuka T.","Tanaka A.","Kawarabayasi Y.","Sato S.","Nagase T.","Seki N.","Ishikawa K.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"7584026"},{"database":"DOI","id":"10.1093/dnares/1.1.27"}],"title":"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.","publicationDate":"1994","journal":"DNA Res.","firstPage":"27","lastPage":"35","volume":"1"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)"]},{"referenceNumber":4,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.S.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.R.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.I.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.M.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)","VARIANT SER-574"],"referenceComments":[{"value":"Placenta","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"1630450","citationType":"journal article","authors":["von Lindern M.","van Baal S.","Wiegant J.","Raap A.","Hagemeijer A.","Grosveld G."],"citationCrossReferences":[{"database":"PubMed","id":"1630450"},{"database":"DOI","id":"10.1128/mcb.12.8.3346-3355.1992"}],"title":"Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.","publicationDate":"1992","journal":"Mol. Cell. Biol.","firstPage":"3346","lastPage":"3355","volume":"12"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH SET"]},{"referenceNumber":7,"citation":{"id":"8108440","citationType":"journal article","authors":["Kraemer D.","Wozniak R.W.","Blobel G.","Radu A."],"citationCrossReferences":[{"database":"PubMed","id":"8108440"},{"database":"DOI","id":"10.1073/pnas.91.4.1519"}],"title":"The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm.","publicationDate":"1994","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1519","lastPage":"1523","volume":"91"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":8,"citation":{"id":"9049309","citationType":"journal article","authors":["Fornerod M.","van Deursen J.M.","van Baal S.","Reynolds A.","Davis D.","Murti K.G.","Fransen J.","Grosveld G."],"citationCrossReferences":[{"database":"PubMed","id":"9049309"},{"database":"DOI","id":"10.1093/emboj/16.4.807"}],"title":"The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88.","publicationDate":"1997","journal":"EMBO J.","firstPage":"807","lastPage":"816","volume":"16"},"referencePositions":["FUNCTION","IDENTIFICATION IN THE NUCLEAR PORE COMPLEX","INTERACTION WITH NUP88 AND XPO1"]},{"referenceNumber":9,"citation":{"id":"11777942","citationType":"journal article","authors":["Brownawell A.M.","Macara I.G."],"citationCrossReferences":[{"database":"PubMed","id":"11777942"},{"database":"DOI","id":"10.1083/jcb.200110082"}],"title":"Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins.","publicationDate":"2002","journal":"J. Cell Biol.","firstPage":"53","lastPage":"64","volume":"156"},"referencePositions":["INTERACTION WITH XPO5"]},{"referenceNumber":10,"citation":{"id":"14766228","citationType":"journal article","authors":["Carman J.A.","Nadler S.G."],"citationCrossReferences":[{"database":"PubMed","id":"14766228"},{"database":"DOI","id":"10.1016/j.bbrc.2004.01.080"}],"title":"Direct association of tristetraprolin with the nucleoporin CAN/Nup214.","publicationDate":"2004","journal":"Biochem. Biophys. Res. Commun.","firstPage":"445","lastPage":"449","volume":"315"},"referencePositions":["INTERACTION WITH ZFP36"]},{"referenceNumber":11,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"16964243","citationType":"journal article","authors":["Beausoleil S.A.","Villen J.","Gerber S.A.","Rush J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"16964243"},{"database":"DOI","id":"10.1038/nbt1240"}],"title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"1285","lastPage":"1292","volume":"24"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430 AND THR-439","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"17924679","citationType":"journal article","authors":["Yu L.R.","Zhu Z.","Chan K.C.","Issaq H.J.","Dimitrov D.S.","Veenstra T.D."],"citationCrossReferences":[{"database":"PubMed","id":"17924679"},{"database":"DOI","id":"10.1021/pr070152u"}],"title":"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.","publicationDate":"2007","journal":"J. Proteome Res.","firstPage":"4150","lastPage":"4162","volume":"6"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-651; SER-940 AND SER-1181","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430; THR-434; THR-437; THR-439; SER-666; SER-970; SER-974; SER-1023 AND SER-1963","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":17,"citation":{"id":"19386703","citationType":"journal article","authors":["Pasdeloup D.","Blondel D.","Isidro A.L.","Rixon F.J."],"citationCrossReferences":[{"database":"PubMed","id":"19386703"},{"database":"DOI","id":"10.1128/jvi.02655-08"}],"title":"Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25.","publicationDate":"2009","journal":"J. Virol.","firstPage":"6610","lastPage":"6623","volume":"83"},"referencePositions":["INTERACTION WITH HHV-1 PROTEIN UL25 (MICROBIAL INFECTION)"]},{"referenceNumber":18,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430 AND SER-989","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-657; THR-670; SER-678; SER-940; SER-1045; SER-1081; THR-1134; THR-1150; THR-1156; THR-1312 AND SER-1985","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":20,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":21,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433; THR-434; THR-437; SER-657; THR-670; SER-678 AND SER-940","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":22,"citation":{"id":"22223895","citationType":"journal article","authors":["Bienvenut W.V.","Sumpton D.","Martinez A.","Lilla S.","Espagne C.","Meinnel T.","Giglione C."],"citationCrossReferences":[{"database":"PubMed","id":"22223895"},{"database":"DOI","id":"10.1074/mcp.m111.015131"}],"title":"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.","publicationDate":"2012","journal":"Mol. Cell. Proteomics","firstPage":"M111.015131","lastPage":"M111.015131","volume":"11"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":23,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; THR-416; SER-421; SER-430; SER-433; THR-434; THR-437; SER-651; SER-657; SER-666; THR-670; SER-678; SER-760; SER-940; THR-1021; SER-1023; SER-1045; SER-1056; SER-1081; THR-1156 AND SER-1353","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430; SER-433 AND SER-678","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":25,"citation":{"id":"25410864","citationType":"journal article","authors":["Cassany A.","Ragues J.","Guan T.","Begu D.","Wodrich H.","Kann M.","Nemerow G.R.","Gerace L."],"citationCrossReferences":[{"database":"PubMed","id":"25410864"},{"database":"DOI","id":"10.1128/jvi.02639-14"}],"title":"Nuclear import of adenovirus DNA involves direct interaction of hexon with an N-terminal domain of the nucleoporin Nup214.","publicationDate":"2015","journal":"J. Virol.","firstPage":"1719","lastPage":"1730","volume":"89"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH HADV-5 PROTEIN L3","REGION"]},{"referenceNumber":26,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-1538","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":27,"citation":{"id":"30543681","citationType":"journal article","authors":["Bonnin E.","Cabochette P.","Filosa A.","Juehlen R.","Komatsuzaki S.","Hezwani M.","Dickmanns A.","Martinelli V.","Vermeersch M.","Supply L.","Martins N.","Pirenne L.","Ravenscroft G.","Lombard M.","Port S.","Spillner C.","Janssens S.","Roets E.","Van Dorpe J.","Lammens M.","Kehlenbach R.H.","Ficner R.","Laing N.G.","Hoffmann K.","Vanhollebeke B.","Fahrenkrog B."],"citationCrossReferences":[{"database":"PubMed","id":"30543681"},{"database":"DOI","id":"10.1371/journal.pgen.1007845"}],"title":"Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.","publicationDate":"2018","journal":"PLoS Genet.","firstPage":"E1007845","lastPage":"E1007845","volume":"14"},"referencePositions":["INTERACTION WITH NUP88"]},{"referenceNumber":28,"citation":{"id":"31178128","citationType":"journal article","authors":["Fichtman B.","Harel T.","Biran N.","Zagairy F.","Applegate C.D.","Salzberg Y.","Gilboa T.","Salah S.","Shaag A.","Simanovsky N.","Ayoubieh H.","Sobreira N.","Punzi G.","Pierri C.L.","Hamosh A.","Elpeleg O.","Harel A.","Edvardson S."],"citationCrossReferences":[{"database":"PubMed","id":"31178128"},{"database":"DOI","id":"10.1016/j.ajhg.2019.05.003"}],"title":"Pathogenic variants in NUP214 cause 'plugged' nuclear pore channels and acute febrile encephalopathy.","publicationDate":"2019","journal":"Am. J. Hum. Genet.","firstPage":"48","lastPage":"64","volume":"105"},"referencePositions":["FUNCTION","INVOLVEMENT IN IIAE9","VARIANTS IIAE9 CYS-38 AND SER-387","CHARACTERIZATION OF VARIANT IIAE9 CYS-38"]},{"referenceNumber":29,"citation":{"id":"17264208","citationType":"journal article","authors":["Napetschnig J.","Blobel G.","Hoelz A."],"citationCrossReferences":[{"database":"PubMed","id":"17264208"},{"database":"DOI","id":"10.1073/pnas.0610828104"}],"title":"Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN.","publicationDate":"2007","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1783","lastPage":"1788","volume":"104"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 1-434","BETA-PROPELLER DOMAIN"]},{"referenceNumber":30,"citation":{"id":"19219046","citationType":"journal article","authors":["von Moeller H.","Basquin C.","Conti E."],"citationCrossReferences":[{"database":"PubMed","id":"19219046"},{"database":"DOI","id":"10.1038/nsmb.1561"}],"title":"The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner.","publicationDate":"2009","journal":"Nat. Struct. Mol. Biol.","firstPage":"247","lastPage":"254","volume":"16"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-405 IN COMPLEX WITH DDX19B","MUTAGENESIS OF VAL-353 AND ASP-359"]},{"referenceNumber":31,"citation":{"id":"19208808","citationType":"journal article","authors":["Napetschnig J.","Kassube S.A.","Debler E.W.","Wong R.W.","Blobel G.","Hoelz A."],"citationCrossReferences":[{"database":"PubMed","id":"19208808"},{"database":"DOI","id":"10.1073/pnas.0813267106"}],"title":"Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"3089","lastPage":"3094","volume":"106"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 1-450 IN COMPLEX WITH DDX19B","COILED-COIL DOMAIN"]},{"referenceNumber":32,"citation":{"id":"15361874","citationType":"journal article","authors":["Graux C.","Cools J.","Melotte C.","Quentmeier H.","Ferrando A.","Levine R.","Vermeesch J.R.","Stul M.","Dutta B.","Boeckx N.","Bosly A.","Heimann P.","Uyttebroeck A.","Mentens N.","Somers R.","MacLeod R.A.","Drexler H.G.","Look A.T.","Gilliland D.G.","Michaux L.","Vandenberghe P.","Wlodarska I.","Marynen P.","Hagemeijer A."],"citationCrossReferences":[{"database":"PubMed","id":"15361874"},{"database":"DOI","id":"10.1038/ng1425"}],"title":"Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"1084","lastPage":"1089","volume":"36"},"referencePositions":["DISEASE","CHROMOSOMAL TRANSLOCATION WITH ABL1"]},{"referenceNumber":33,"citation":{"id":"16959974","citationType":"journal article","authors":["Sjoeblom T.","Jones S.","Wood L.D.","Parsons D.W.","Lin J.","Barber T.D.","Mandelker D.","Leary R.J.","Ptak J.","Silliman N.","Szabo S.","Buckhaults P.","Farrell C.","Meeh P.","Markowitz S.D.","Willis J.","Dawson D.","Willson J.K.V.","Gazdar A.F.","Hartigan J.","Wu L.","Liu C.","Parmigiani G.","Park B.H.","Bachman K.E.","Papadopoulos N.","Vogelstein B.","Kinzler K.W.","Velculescu V.E."],"citationCrossReferences":[{"database":"PubMed","id":"16959974"},{"database":"DOI","id":"10.1126/science.1133427"}],"title":"The consensus coding sequences of human breast and colorectal cancers.","publicationDate":"2006","journal":"Science","firstPage":"268","lastPage":"274","volume":"314"},"referencePositions":["VARIANTS [LARGE SCALE ANALYSIS] ALA-424; LEU-1378 AND VAL-1392"]},{"referenceNumber":34,"citation":{"id":"20851865","citationType":"journal article","authors":["Gorello P.","La Starza R.","Di Giacomo D.","Messina M.","Puzzolo M.C.","Crescenzi B.","Santoro A.","Chiaretti S.","Mecucci C."],"citationCrossReferences":[{"database":"PubMed","id":"20851865"},{"database":"DOI","id":"10.3324/haematol.2010.029769"}],"title":"SQSTM1-NUP214: a new gene fusion in adult T-cell acute lymphoblastic leukemia.","publicationDate":"2010","journal":"Haematologica","firstPage":"2161","lastPage":"2163","volume":"95"},"referencePositions":["DISEASE","CHROMOSOMAL TRANSLOCATION WITH SQSTM1"]},{"referenceNumber":35,"citation":{"id":"30758658","citationType":"journal article","authors":["Shamseldin H.E.","Makhseed N.","Ibrahim N.","Al-Sheddi T.","Alobeid E.","Abdulwahab F.","Alkuraya F.S."],"citationCrossReferences":[{"database":"PubMed","id":"30758658"},{"database":"DOI","id":"10.1007/s00439-019-01979-w"}],"title":"NUP214 deficiency causes severe encephalopathy and microcephaly in humans.","publicationDate":"2019","journal":"Hum. Genet.","firstPage":"221","lastPage":"229","volume":"138"},"referencePositions":["VARIANT IIAE9 GLY-154","INVOLVEMENT IN IIAE9"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X64228","properties":[{"key":"ProteinId","value":"CAA45535.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB159230","properties":[{"key":"ProteinId","value":"BAD07398.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D14689","properties":[{"key":"ProteinId","value":"BAA03515.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL157938","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC045620","properties":[{"key":"ProteinId","value":"AAH45620.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC105998","properties":[{"key":"ProteinId","value":"AAI05999.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS6940.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P35658-1"},{"database":"CCDS","id":"CCDS83429.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P35658-4"},{"database":"PIR","id":"S26058","properties":[{"key":"EntryName","value":"S26058"}]},{"database":"RefSeq","id":"NP_001305253.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318324.2"}],"isoformId":"P35658-4"},{"database":"RefSeq","id":"NP_001305254.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318325.2"}]},{"database":"RefSeq","id":"NP_005076.3","properties":[{"key":"NucleotideSequenceId","value":"NM_005085.4"}],"isoformId":"P35658-1"},{"database":"PDB","id":"2OIT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=1-434"}]},{"database":"PDB","id":"3FHC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1-405"}]},{"database":"PDB","id":"3FMO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.51 A"},{"key":"Chains","value":"A=1-450"}]},{"database":"PDB","id":"3FMP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.19 A"},{"key":"Chains","value":"A/C=1-450"}]},{"database":"PDB","id":"5DIS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"D=1916-2027"}]},{"database":"PDB","id":"7R5J","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"50.00 A"},{"key":"Chains","value":"V0=1-2090"}]},{"database":"PDB","id":"7R5K","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"12.00 A"},{"key":"Chains","value":"V0=1-2090"}]},{"database":"PDBsum","id":"2OIT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3FHC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3FMO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3FMP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5DIS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7R5J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7R5K","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14321","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14322","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"113717","properties":[{"key":"Interactions","value":"231"}]},{"database":"ComplexPortal","id":"CPX-873","properties":[{"key":"EntryName","value":"Nuclear pore complex"}]},{"database":"CORUM","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-38367N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P35658","properties":[{"key":"Number of interactors","value":"3959"}]},{"database":"IntAct","id":"P35658","properties":[{"key":"Interactions","value":"129"}]},{"database":"MINT","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-NUP214","properties":[{"key":"Evidences","value":"10 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000352400","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.I.1.1.3","properties":[{"key":"FamilyName","value":"the nuclear pore complex (npc) family"}]},{"database":"GlyConnect","id":"P35658","properties":[{"key":"glycosylation","value":"1 O-GlcNAc glycan (4 sites)"}]},{"database":"GlyCosmos","id":"P35658","properties":[{"key":"glycosylation","value":"176 sites, 2 glycans"}]},{"database":"GlyGen","id":"P35658","properties":[{"key":"glycosylation","value":"266 sites, 1 N-linked glycan (1 site), 2 O-linked glycans (263 sites)"}]},{"database":"iPTMnet","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"NUP214","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"205831380","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000352400","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"55122","properties":[{"key":"Description","value":"-"}],"isoformId":"P35658-1"},{"database":"ProteomicsDB","id":"55123","properties":[{"key":"Description","value":"-"}],"isoformId":"P35658-2"},{"database":"ProteomicsDB","id":"55124","properties":[{"key":"Description","value":"-"}],"isoformId":"P35658-3"},{"database":"ProteomicsDB","id":"55125","properties":[{"key":"Description","value":"-"}],"isoformId":"P35658-4"},{"database":"ProteomicsDB","id":"55126","properties":[{"key":"Description","value":"-"}],"isoformId":"P35658-5"},{"database":"Pumba","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18059","properties":[{"key":"antibodies","value":"81 antibodies from 20 providers"}]},{"database":"DNASU","id":"8021","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000359428.10","properties":[{"key":"ProteinId","value":"ENSP00000352400.5"},{"key":"GeneId","value":"ENSG00000126883.20"}],"isoformId":"P35658-1"},{"database":"Ensembl","id":"ENST00000411637.6","properties":[{"key":"ProteinId","value":"ENSP00000396576.2"},{"key":"GeneId","value":"ENSG00000126883.20"}],"isoformId":"P35658-4"},{"database":"Ensembl","id":"ENST00000897205.1","properties":[{"key":"ProteinId","value":"ENSP00000567264.1"},{"key":"GeneId","value":"ENSG00000126883.20"}],"isoformId":"P35658-3"},{"database":"Ensembl","id":"ENST00000897208.1","properties":[{"key":"ProteinId","value":"ENSP00000567267.1"},{"key":"GeneId","value":"ENSG00000126883.20"}],"isoformId":"P35658-2"},{"database":"GeneID","id":"8021","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:8021","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000359428.10","properties":[{"key":"ProteinId","value":"ENSP00000352400.5"},{"key":"RefSeqNucleotideId","value":"NM_005085.4"},{"key":"RefSeqProteinId","value":"NP_005076.3"}]},{"database":"UCSC","id":"uc004cag.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P35658-1"},{"database":"AGR","id":"HGNC:8064","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA31851","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"8021","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"8021","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"NUP214","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:8064","properties":[{"key":"GeneName","value":"NUP214"}]},{"database":"HPA","id":"ENSG00000126883","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (testis)"}]},{"database":"MalaCards","id":"NUP214","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"114350","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"618426","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000126883","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"402014","properties":[{"key":"Disease","value":"Acute myeloid leukemia with t(6;9)(p23;q34)"}]},{"database":"Orphanet","id":"99861","properties":[{"key":"Disease","value":"Precursor T-cell acute lymphoblastic leukemia"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000126883","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3630","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000153253","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_001606_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WLSTFQF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"248320at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P35658","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1169408","properties":[{"key":"PathwayName","value":"ISG15 antiviral mechanism"}]},{"database":"Reactome","id":"R-HSA-159227","properties":[{"key":"PathwayName","value":"Transport of the SLBP independent Mature mRNA"}]},{"database":"Reactome","id":"R-HSA-159230","properties":[{"key":"PathwayName","value":"Transport of the SLBP Dependant Mature mRNA"}]},{"database":"Reactome","id":"R-HSA-159231","properties":[{"key":"PathwayName","value":"Transport of Mature mRNA Derived from an Intronless Transcript"}]},{"database":"Reactome","id":"R-HSA-159236","properties":[{"key":"PathwayName","value":"Transport of Mature mRNA derived from an Intron-Containing Transcript"}]},{"database":"Reactome","id":"R-HSA-165054","properties":[{"key":"PathwayName","value":"Rev-mediated nuclear export of HIV RNA"}]},{"database":"Reactome","id":"R-HSA-168271","properties":[{"key":"PathwayName","value":"Transport of Ribonucleoproteins into the Host Nucleus"}]},{"database":"Reactome","id":"R-HSA-168276","properties":[{"key":"PathwayName","value":"NS1 Mediated Effects on Host Pathways"}]},{"database":"Reactome","id":"R-HSA-168325","properties":[{"key":"PathwayName","value":"Viral Messenger RNA Synthesis"}]},{"database":"Reactome","id":"R-HSA-168333","properties":[{"key":"PathwayName","value":"NEP/NS2 Interacts with the Cellular Export Machinery"}]},{"database":"Reactome","id":"R-HSA-170822","properties":[{"key":"PathwayName","value":"Regulation of Glucokinase by Glucokinase Regulatory Protein"}]},{"database":"Reactome","id":"R-HSA-180746","properties":[{"key":"PathwayName","value":"Nuclear import of Rev protein"}]},{"database":"Reactome","id":"R-HSA-180910","properties":[{"key":"PathwayName","value":"Vpr-mediated nuclear import of PICs"}]},{"database":"Reactome","id":"R-HSA-1855170","properties":[{"key":"PathwayName","value":"IPs transport between nucleus and cytosol"}]},{"database":"Reactome","id":"R-HSA-1855196","properties":[{"key":"PathwayName","value":"IP3 and IP4 transport between cytosol and nucleus"}]},{"database":"Reactome","id":"R-HSA-1855229","properties":[{"key":"PathwayName","value":"IP6 and IP7 transport between cytosol and nucleus"}]},{"database":"Reactome","id":"R-HSA-191859","properties":[{"key":"PathwayName","value":"snRNP Assembly"}]},{"database":"Reactome","id":"R-HSA-3108214","properties":[{"key":"PathwayName","value":"SUMOylation of DNA damage response and repair proteins"}]},{"database":"Reactome","id":"R-HSA-3232142","properties":[{"key":"PathwayName","value":"SUMOylation of ubiquitinylation proteins"}]},{"database":"Reactome","id":"R-HSA-3301854","properties":[{"key":"PathwayName","value":"Nuclear Pore Complex (NPC) Disassembly"}]},{"database":"Reactome","id":"R-HSA-3371453","properties":[{"key":"PathwayName","value":"Regulation of HSF1-mediated heat shock response"}]},{"database":"Reactome","id":"R-HSA-4085377","properties":[{"key":"PathwayName","value":"SUMOylation of SUMOylation proteins"}]},{"database":"Reactome","id":"R-HSA-450520","properties":[{"key":"PathwayName","value":"HuR (ELAVL1) binds and stabilizes mRNA"}]},{"database":"Reactome","id":"R-HSA-4551638","properties":[{"key":"PathwayName","value":"SUMOylation of chromatin organization proteins"}]},{"database":"Reactome","id":"R-HSA-4570464","properties":[{"key":"PathwayName","value":"SUMOylation of RNA binding proteins"}]},{"database":"Reactome","id":"R-HSA-4615885","properties":[{"key":"PathwayName","value":"SUMOylation of DNA replication proteins"}]},{"database":"Reactome","id":"R-HSA-5619107","properties":[{"key":"PathwayName","value":"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"}]},{"database":"Reactome","id":"R-HSA-6784531","properties":[{"key":"PathwayName","value":"tRNA processing in the nucleus"}]},{"database":"Reactome","id":"R-HSA-9609690","properties":[{"key":"PathwayName","value":"HCMV Early Events"}]},{"database":"Reactome","id":"R-HSA-9610379","properties":[{"key":"PathwayName","value":"HCMV Late Events"}]},{"database":"Reactome","id":"R-HSA-9705671","properties":[{"key":"PathwayName","value":"SARS-CoV-2 activates/modulates innate and adaptive immune responses"}]},{"database":"SignaLink","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000126883","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"8021","properties":[{"key":"hits","value":"739 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"NUP214","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P35658","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"NUP214","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"8021","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P35658","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P35658","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"RNAct","id":"P35658","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000126883","properties":[{"key":"ExpressionPatterns","value":"Expressed in left testis and 164 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P35658","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:1990876","properties":[{"key":"GoTerm","value":"C:cytoplasmic side of nuclear pore"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8108440"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24315095"}]},{"database":"GO","id":"GO:0005643","properties":[{"key":"GoTerm","value":"C:nuclear pore"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005049","properties":[{"key":"GoTerm","value":"F:nuclear export signal receptor activity"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10358091"}]},{"database":"GO","id":"GO:0008139","properties":[{"key":"GoTerm","value":"F:nuclear localization sequence binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0017056","properties":[{"key":"GoTerm","value":"F:structural constituent of nuclear pore"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006406","properties":[{"key":"GoTerm","value":"P:mRNA export from nucleus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10557333"}]},{"database":"GO","id":"GO:0006913","properties":[{"key":"GoTerm","value":"P:nucleocytoplasmic transport"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"27016207"}]},{"database":"GO","id":"GO:0006611","properties":[{"key":"GoTerm","value":"P:protein export from nucleus"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12191473"}]},{"database":"GO","id":"GO:0006606","properties":[{"key":"GoTerm","value":"P:protein import into nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0046822","properties":[{"key":"GoTerm","value":"P:regulation of nucleocytoplasmic transport"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11000203"}]},{"database":"GO","id":"GO:0006405","properties":[{"key":"GoTerm","value":"P:RNA export from nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"FunFam","id":"2.130.10.10:FF:000142","properties":[{"key":"EntryName","value":"Nuclear pore complex protein Nup214"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR026054","properties":[{"key":"EntryName","value":"Nucleoporin"}]},{"database":"InterPro","id":"IPR039462","properties":[{"key":"EntryName","value":"Nup159/Nup146_N"}]},{"database":"InterPro","id":"IPR041553","properties":[{"key":"EntryName","value":"Nup214_FG"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"PANTHER","id":"PTHR23193","properties":[{"key":"EntryName","value":"NUCLEAR PORE COMPLEX PROTEIN NUP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23193:SF21","properties":[{"key":"EntryName","value":"NUCLEAR PORE COMPLEX PROTEIN NUP214"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16755","properties":[{"key":"EntryName","value":"Beta-prop_NUP159_NUP214"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18617","properties":[{"key":"EntryName","value":"Nup214_FG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF117289","properties":[{"key":"EntryName","value":"Nucleoporin domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQGFGGWRS","length":2090,"molWeight":213620,"crc64":"EE6F0F3DE3D522C6","md5":"E83E2CE8D325ED9E5BC132F84AFDEBB4"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":3,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":5,"TISSUE SPECIFICITY":1,"DOMAIN":2,"PTM":1,"DISEASE":4,"SEQUENCE CAUTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Repeat":51,"Region":19,"Coiled coil":1,"Compositional bias":19,"Site":7,"Modified residue":32,"Cross-link":1,"Alternative sequence":4,"Natural variant":8,"Mutagenesis":2,"Sequence conflict":4,"Beta strand":38,"Helix":17,"Turn":4},"uniParcId":"UPI00001BBB2F"}}