{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P35579","secondaryAccessions":["A8K6E4","O60805","Q60FE2","Q86T83"],"uniProtkbId":"MYH9_HUMAN","entryAudit":{"firstPublicDate":"1994-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":264,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Myosin-9"}},"alternativeNames":[{"fullName":{"value":"Cellular myosin heavy chain, type A"}},{"fullName":{"value":"Myosin heavy chain 9"}},{"fullName":{"value":"Myosin heavy chain, non-muscle IIa"}},{"fullName":{"value":"Non-muscle myosin heavy chain A"},"shortNames":[{"value":"NMMHC-A"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20944748"}],"value":"Non-muscle myosin heavy chain IIa"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20944748"}],"value":"NMMHC II-a"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20944748"}],"value":"NMMHC-IIA"}]}]},"genes":[{"geneName":{"value":"MYH9"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8VDD5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16707441"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20052411"}],"value":"Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20944748"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39048823"}],"value":"(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62812"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8VDD5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12917436"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16707441"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17925381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22229724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22693546"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27325790"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28228547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28345668"}],"value":"Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1 (By similarity). Interacts with DDR1 (By similarity). Interacts with PDLIM2 (By similarity). Interacts with SVIL (PubMed:12917436, PubMed:17925381). Interacts with HTRA3 (PubMed:22229724). Interacts with Myo7a (By similarity). Interacts with CFAP95 (PubMed:28345668). Interacts with LIMCH1; independently of the integration of MYH9 into the myosin complex (PubMed:28228547). Interacts with RAB3A (PubMed:27325790). Interacts with ZBED4 (PubMed:22693546). Interacts with S100A4; this interaction increases cell motility (PubMed:16707441). Interacts with myosin KRT6A and KRT6B; the interaction stabilizes MYH9 (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20944748"}],"value":"(Microbial infection) Interacts with herpes simplex virus 1/HHV-1 envelope glycoprotein B"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P61073","geneName":"CXCR4","intActId":"EBI-489411"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"Q9UJY5","geneName":"GGA1","intActId":"EBI-447141"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P62993","geneName":"GRB2","intActId":"EBI-401755"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"O00255","geneName":"MEN1","intActId":"EBI-592789"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"O00255-2","geneName":"MEN1","intActId":"EBI-9869387"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P35579","geneName":"MYH9","intActId":"EBI-350338"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P19338","geneName":"NCL","intActId":"EBI-346967"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P23297","geneName":"S100A1","intActId":"EBI-743686"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P29034","geneName":"S100A2","intActId":"EBI-752230"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P26447","geneName":"S100A4","intActId":"EBI-717058"},"numberOfExperiments":20,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P33763","geneName":"S100A5","intActId":"EBI-7211732"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P06703","geneName":"S100A6","intActId":"EBI-352877"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P04271","geneName":"S100B","intActId":"EBI-458391"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P25815","geneName":"S100P","intActId":"EBI-743700"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"P0DTC2","geneName":"S","intActId":"EBI-25474821"},"numberOfExperiments":8,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P35579","intActId":"EBI-350338"},"interactantTwo":{"uniProtKBAccession":"O46385","geneName":"SVIL","intActId":"EBI-6995105"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20052411"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27331610"}],"value":"Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22693546"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8VDD5"}],"value":"Cytoplasm, cell cortex","id":"SL-0138"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8VDD5"}],"value":"Cytoplasmic vesicle, secretory vesicle, Cortical granule","id":"SL-0541"}},{"location":{"value":"Cell membrane","id":"SL-0039"}}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20944748"}],"value":"(Microbial infection) Localizes at the surface of the cell membrane following infection by herpes simplex virus 1/HHV-1,"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20944748"}],"value":"Cell membrane","id":"SL-0039"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P35579-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P35579-2"],"sequenceIds":["VSP_035409","VSP_035410"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11752022"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1912569"}],"value":"In the kidney, expressed in the glomeruli. Also expressed in leukocytes"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16139798"}],"value":"ISGylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27331610"}],"value":"Ubiquitination"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss","diseaseAccession":"DI-01951","acronym":"MATINS","description":"An autosomal dominant disorder characterized by thrombocytopenia, giant platelets and Dohle body-like inclusions in peripheral blood leukocytes with variable ultrastructural appearance. Some affected individuals lack leukocyte inclusion bodies on classic staining of peripheral blood smears. Alport syndrome-like features of nephritis, hearing loss, and eye abnormalities are present in some patients.","diseaseCrossReference":{"database":"MIM","id":"155100"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10973259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10973260"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11590545"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11752022"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11776386"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11935325"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12533692"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12621333"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12649151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12792306"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16969870"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Deafness, autosomal dominant, 17","diseaseAccession":"DI-00845","acronym":"DFNA17","description":"A form of deafness characterized by progressive high frequency hearing impairment and cochleosaccular degeneration.","diseaseCrossReference":{"database":"MIM","id":"603622"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11023810"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30872814"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","note":{"texts":[{"value":"Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures"}]}},{"commentType":"DISEASE","note":{"texts":[{"value":"Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD)"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"CAD89954.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/481/MYH9","ftp":false}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":1960,"modifier":"EXACT"}},"description":"Myosin-9","featureId":"PRO_0000123416"},{"type":"Domain","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Myosin N-terminal 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