{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P34364","uniProtkbId":"YLH0_CAEEL","entryAudit":{"firstPublicDate":"1994-02-01","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2004-03-01","entryVersion":111,"sequenceVersion":2},"annotationScore":1.0,"organism":{"scientificName":"Caenorhabditis elegans","taxonId":6239,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Nematoda","Chromadorea","Rhabditida","Rhabditina","Rhabditomorpha","Rhabditoidea","Rhabditidae","Peloderinae","Caenorhabditis"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein C48B4.10"}}},"genes":[{"orfNames":[{"value":"C48B4.10"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"Uncharacterized protein C48B4.10","featureId":"PRO_0000065251"},{"type":"Transmembrane","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"7906398","citationType":"journal article","authors":["Wilson R.","Ainscough R.","Anderson K.","Baynes C.","Berks M.","Bonfield J.","Burton J.","Connell M.","Copsey T.","Cooper J.","Coulson A.","Craxton M.","Dear S.","Du Z.","Durbin R.","Favello A.","Fraser A.","Fulton L.","Gardner A.","Green P.","Hawkins T.","Hillier L.","Jier M.","Johnston L.","Jones M.","Kershaw J.","Kirsten J.","Laisster N.","Latreille P.","Lightning J.","Lloyd C.","Mortimore B.","O'Callaghan M.","Parsons J.","Percy C.","Rifken L.","Roopra A.","Saunders D.","Shownkeen R.","Sims M.","Smaldon N.","Smith A.","Smith M.","Sonnhammer E.","Staden R.","Sulston J.","Thierry-Mieg J.","Thomas K.","Vaudin M.","Vaughan K.","Waterston R.","Watson A.","Weinstock L.","Wilkinson-Sproat J.","Wohldman P."],"citationCrossReferences":[{"database":"PubMed","id":"7906398"},{"database":"DOI","id":"10.1038/368032a0"}],"title":"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.","publicationDate":"1994","journal":"Nature","firstPage":"32","lastPage":"38","volume":"368"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Bristol N2","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9851916","citationType":"journal article","authoringGroup":["The C. elegans sequencing consortium"],"citationCrossReferences":[{"database":"PubMed","id":"9851916"},{"database":"DOI","id":"10.1126/science.282.5396.2012"}],"title":"Genome sequence of the nematode C. elegans: a platform for investigating biology.","publicationDate":"1998","journal":"Science","firstPage":"2012","lastPage":"2018","volume":"282"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Bristol N2","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z29117","properties":[{"key":"ProteinId","value":"CAA82375.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S40721","properties":[{"key":"EntryName","value":"S40721"}]},{"database":"RefSeq","id":"NP_001369841.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001382966.2"}]},{"database":"AlphaFoldDB","id":"P34364","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P34364","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P34364","properties":[{"key":"Number of interactors","value":"1524"}]},{"database":"PaxDb","id":"6239-C48B4.10.1","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P34364","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"C48B4.10.1","properties":[{"key":"ProteinId","value":"C48B4.10.1"},{"key":"GeneId","value":"WBGene00008173"}]},{"database":"GeneID","id":"183568","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"cel:CELE_C48B4.10","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"C48B4.10","properties":[{"key":"OrganismName","value":"c. elegans"}]},{"database":"AGR","id":"WB:WBGene00008173","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"183568","properties":[{"key":"Description","value":"-"}]},{"database":"WormBase","id":"C48B4.10","properties":[{"key":"ProteinId","value":"CE33604"},{"key":"GeneId","value":"WBGene00008173"},{"key":"GeneName","value":"-"}]},{"database":"eggNOG","id":"ENOG502TI4F","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_1448919_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P34364","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HYNRDAY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5805950at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P34364","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P34364","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001940","properties":[{"key":"Component","value":"Chromosome III"}]},{"database":"Bgee","id":"WBGene00008173","properties":[{"key":"ExpressionPatterns","value":"Expressed in germ line (C elegans) and 4 other cell types or tissues"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR035321","properties":[{"key":"EntryName","value":"DUF5373"}]},{"database":"Pfam","id":"PF17343","properties":[{"key":"EntryName","value":"DUF5373"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKFYDPSQPEQSYDSPKLFGIIPIKFIVSFLQLVSIVSQILWLYSENDKIYLVLLSVGIVLNVFTVVVFIKEHKLLMRAHYYSALIFTVVPFIYAVYTFISFIELFFGDKDITFNQCSPFAYAFIFLCIYIFYLAMCRVLIKASEFQPDDMPDLDTTQGLFHYNRDAYDGGERAKLMYGEV","length":182,"molWeight":21192,"crc64":"E953608F70443617","md5":"A167CEC2FB05C8755F046F424E8D1825"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Transmembrane":4},"uniParcId":"UPI0000183DC7"}}