{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P33993","secondaryAccessions":["A4D2A1","A4D2A2","E9PGN9","Q15076","Q96D34","Q96GL1"],"uniProtkbId":"MCM7_HUMAN","entryAudit":{"firstPublicDate":"1994-02-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2002-05-15","entryVersion":246,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"DNA replication licensing factor MCM7"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25661590"}],"value":"3.6.4.12"}]},"alternativeNames":[{"fullName":{"value":"CDC47 homolog"}},{"fullName":{"value":"P1.1-MCM3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:6950"}],"value":"MCM7"},"synonyms":[{"value":"CDC47"},{"value":"MCM2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15210935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15538388"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25661590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32453425"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34694004"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34700328"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35585232"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9305914"}],"value":"Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.12","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25661590"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25661590"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91876"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15210935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15538388"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16899510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17116885"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17296731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23711367"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28191891"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32453425"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34694004"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34700328"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9305914"}],"value":"Component of the MCM2-7 complex (PubMed:16899510, PubMed:17296731, PubMed:9305914). The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (PubMed:16899510, PubMed:17296731, PubMed:32453425, PubMed:9305914). Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex (PubMed:32453425, PubMed:34694004, PubMed:34700328). Interacts with the ATR-ATRIP complex and with RAD17 (PubMed:15210935, PubMed:15538388). Interacts with TIPIN (PubMed:17116885). Interacts with MCMBP (PubMed:17296731). Interacts with ANKRD17 (PubMed:23711367). Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR (PubMed:28191891)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q09666","geneName":"AHNAK","intActId":"EBI-2555881"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q96MA6","geneName":"AK8","intActId":"EBI-8466265"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q68D86","geneName":"CCDC102B","intActId":"EBI-10171570"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"P46527","geneName":"CDKN1B","intActId":"EBI-519280"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"P49918","geneName":"CDKN1C","intActId":"EBI-519256"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q12959","geneName":"DLG1","intActId":"EBI-357481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q15700","geneName":"DLG2","intActId":"EBI-80426"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q13451","geneName":"FKBP5","intActId":"EBI-306914"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q08379","geneName":"GOLGA2","intActId":"EBI-618309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q9UL03","geneName":"INTS6","intActId":"EBI-1381827"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q9BVG8","geneName":"KIFC3","intActId":"EBI-2125614"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P33993","intActId":"EBI-355924"},"interactantTwo":{"uniProtKBAccession":"P07948","geneName":"LYN","intActId":"EBI-79452"},"numberOfExperiments":4,"org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The MCM2-7 hexamer is the proposed physiological active complex"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the MCM family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.7"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":719,"modifier":"EXACT"}},"description":"DNA replication licensing factor MCM7","featureId":"PRO_0000194119"},{"type":"Domain","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"MCM C-terminal AAA(+) 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