{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P32436","uniProtkbId":"DEGV_BACSU","entryAudit":{"firstPublicDate":"1993-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-02-01","entryVersion":131,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Bacillus subtilis (strain 168)","taxonId":224308,"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Bacillaceae","Bacillus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein DegV"}}},"genes":[{"geneName":{"value":"degV"},"synonyms":[{"value":"yviA"}],"orderedLocusNames":[{"value":"BSU35480"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19390149"}],"value":"Binds long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19390149"}],"value":"Monomer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8412657"}],"value":"No growth phenotype, no effect on competence"}],"commentType":"DISRUPTION PHENOTYPE"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"Protein DegV","featureId":"PRO_0000209751"},{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"DegV","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00815"}]},{"type":"Binding site","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:7896"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19390149"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3FYS"}],"ligand":{"name":"hexadecanoate","id":"ChEBI:CHEBI:7896"}},{"type":"Binding site","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:7896"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19390149"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3FYS"}],"ligand":{"name":"hexadecanoate","id":"ChEBI:CHEBI:7896"}},{"type":"Beta strand","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Turn","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Turn","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Turn","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Turn","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Turn","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Turn","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Helix","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]},{"type":"Beta strand","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3FYS"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0446","category":"Ligand","name":"Lipid-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"8412657","citationType":"journal article","authors":["Londono-Vallejo J.A.","Dubnau D."],"citationCrossReferences":[{"database":"PubMed","id":"8412657"},{"database":"DOI","id":"10.1111/j.1365-2958.1993.tb01674.x"}],"title":"comF, a Bacillus subtilis late competence locus, encodes a protein similar to ATP-dependent RNA/DNA helicases.","publicationDate":"1993","journal":"Mol. Microbiol.","firstPage":"119","lastPage":"131","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","DISRUPTION PHENOTYPE"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"8969505","citationType":"journal article","authors":["Soldo B.","Lazarevic V.","Mauel C.","Karamata D."],"citationCrossReferences":[{"database":"PubMed","id":"8969505"},{"database":"DOI","id":"10.1099/13500872-142-11-3079"}],"title":"Sequence of the 305 degrees-307 degrees region of the Bacillus subtilis chromosome.","publicationDate":"1996","journal":"Microbiology","firstPage":"3079","lastPage":"3088","volume":"142"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"9384377","citationType":"journal article","authors":["Kunst F.","Ogasawara N.","Moszer I.","Albertini A.M.","Alloni G.","Azevedo V.","Bertero M.G.","Bessieres P.","Bolotin A.","Borchert S.","Borriss R.","Boursier L.","Brans A.","Braun M.","Brignell S.C.","Bron S.","Brouillet S.","Bruschi C.V.","Caldwell B.","Capuano V.","Carter N.M.","Choi S.-K.","Codani J.-J.","Connerton I.F.","Cummings N.J.","Daniel R.A.","Denizot F.","Devine K.M.","Duesterhoeft A.","Ehrlich S.D.","Emmerson P.T.","Entian K.-D.","Errington J.","Fabret C.","Ferrari E.","Foulger D.","Fritz C.","Fujita M.","Fujita Y.","Fuma S.","Galizzi A.","Galleron N.","Ghim S.-Y.","Glaser P.","Goffeau A.","Golightly E.J.","Grandi G.","Guiseppi G.","Guy B.J.","Haga K.","Haiech J.","Harwood C.R.","Henaut A.","Hilbert H.","Holsappel S.","Hosono S.","Hullo M.-F.","Itaya M.","Jones L.-M.","Joris B.","Karamata D.","Kasahara Y.","Klaerr-Blanchard M.","Klein C.","Kobayashi Y.","Koetter P.","Koningstein G.","Krogh S.","Kumano M.","Kurita K.","Lapidus A.","Lardinois S.","Lauber J.","Lazarevic V.","Lee S.-M.","Levine A.","Liu H.","Masuda S.","Mauel C.","Medigue C.","Medina N.","Mellado R.P.","Mizuno M.","Moestl D.","Nakai S.","Noback M.","Noone D.","O'Reilly M.","Ogawa K.","Ogiwara A.","Oudega B.","Park S.-H.","Parro V.","Pohl T.M.","Portetelle D.","Porwollik S.","Prescott A.M.","Presecan E.","Pujic P.","Purnelle B.","Rapoport G.","Rey M.","Reynolds S.","Rieger M.","Rivolta C.","Rocha E.","Roche B.","Rose M.","Sadaie Y.","Sato T.","Scanlan E.","Schleich S.","Schroeter R.","Scoffone F.","Sekiguchi J.","Sekowska A.","Seror S.J.","Serror P.","Shin B.-S.","Soldo B.","Sorokin A.","Tacconi E.","Takagi T.","Takahashi H.","Takemaru K.","Takeuchi M.","Tamakoshi A.","Tanaka T.","Terpstra P.","Tognoni A.","Tosato V.","Uchiyama S.","Vandenbol M.","Vannier F.","Vassarotti A.","Viari A.","Wambutt R.","Wedler E.","Wedler H.","Weitzenegger T.","Winters P.","Wipat A.","Yamamoto H.","Yamane K.","Yasumoto K.","Yata K.","Yoshida K.","Yoshikawa H.-F.","Zumstein E.","Yoshikawa H.","Danchin A."],"citationCrossReferences":[{"database":"PubMed","id":"9384377"},{"database":"DOI","id":"10.1038/36786"}],"title":"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.","publicationDate":"1997","journal":"Nature","firstPage":"249","lastPage":"256","volume":"390"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"3141378","citationType":"journal article","authors":["Henner D.J.","Yang M.","Ferrari E."],"citationCrossReferences":[{"database":"PubMed","id":"3141378"},{"database":"DOI","id":"10.1128/jb.170.11.5102-5109.1988"}],"title":"Localization of Bacillus subtilis sacU(Hy) mutations to two linked genes with similarities to the conserved procaryotic family of two-component signalling systems.","publicationDate":"1988","journal":"J. Bacteriol.","firstPage":"5102","lastPage":"5109","volume":"170"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-107"]},{"referenceNumber":5,"citation":{"id":"19390149","citationType":"journal article","authors":["Nan J.","Zhou Y.","Yang C.","Brostromer E.","Kristensen O.","Su X.D."],"citationCrossReferences":[{"database":"PubMed","id":"19390149"},{"database":"DOI","id":"10.1107/s0907444909007756"}],"title":"Structure of a fatty-acid-binding protein from Bacillus subtilis determined by sulfur-SAD phasing using in-house chromium radiation.","publicationDate":"2009","journal":"Acta Crystallogr. D","firstPage":"440","lastPage":"448","volume":"65"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH PALMITIC ACID","FUNCTION","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3FYS"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z18629","properties":[{"key":"ProteinId","value":"CAA79225.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U56901","properties":[{"key":"ProteinId","value":"AAC44939.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL009126","properties":[{"key":"ProteinId","value":"CAB15565.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M23558","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"I40386","properties":[{"key":"EntryName","value":"D30191"}]},{"database":"RefSeq","id":"WP_003244125.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000964.3"}]},{"database":"PDB","id":"3FYS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-281"}]},{"database":"PDBsum","id":"3FYS","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P32436","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P32436","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P32436","properties":[{"key":"Number of interactors","value":"123"}]},{"database":"STRING","id":"224308.BSU35480","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"224308-BSU35480","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"CAB15565","properties":[{"key":"ProteinId","value":"CAB15565"},{"key":"GeneId","value":"BSU_35480"}]},{"database":"GeneID","id":"936763","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"bsu:BSU35480","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|224308.179.peg.3839","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"eggNOG","id":"COG1307","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"P32436","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9775494at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P32436","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"BSUB:BSU35480-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"EvolutionaryTrace","id":"P32436","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001570","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P32436","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"3.30.1180.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.10170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003797","properties":[{"key":"EntryName","value":"DegV"}]},{"database":"InterPro","id":"IPR043168","properties":[{"key":"EntryName","value":"DegV_C"}]},{"database":"InterPro","id":"IPR050270","properties":[{"key":"EntryName","value":"DegV_domain_contain"}]},{"database":"NCBIfam","id":"TIGR00762","properties":[{"key":"EntryName","value":"DegV"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33434","properties":[{"key":"EntryName","value":"DEGV DOMAIN-CONTAINING PROTEIN DR_1986-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33434:SF2","properties":[{"key":"EntryName","value":"FATTY ACID-BINDING PROTEIN TM_1468"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02645","properties":[{"key":"EntryName","value":"DegV"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82549","properties":[{"key":"EntryName","value":"DAK1/DegV-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51482","properties":[{"key":"EntryName","value":"DEGV"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELDWKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAADSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFMVDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLDEDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGICWCFK","length":281,"molWeight":31580,"crc64":"737B6DC65D6FCE64","md5":"98C65153669967F880E44966C5B8CBFD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"DISRUPTION PHENOTYPE":1},"countByFeatureType":{"Chain":1,"Domain":1,"Binding site":2,"Beta strand":13,"Helix":14,"Turn":6},"uniParcId":"UPI0000060B25"}}