{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P32162","secondaryAccessions":["Q2M8L8"],"uniProtkbId":"YIIS_ECOLI","entryAudit":{"firstPublicDate":"1993-10-01","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"1993-10-01","entryVersion":151,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"UPF0381 protein YiiS"}}},"genes":[{"geneName":{"value":"yiiS"},"orderedLocusNames":[{"value":"b3922"},{"value":"JW3893"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPF0381 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"UPF0381 protein YiiS","featureId":"PRO_0000169692"},{"type":"Beta strand","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2K3I"}]},{"type":"Helix","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2K3I"}]},{"type":"Turn","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2K3I"}]},{"type":"Beta strand","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2K3I"}]},{"type":"Beta strand","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2K3I"}]},{"type":"Helix","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2K3I"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"8346018","citationType":"journal article","authors":["Plunkett G. III","Burland V.","Daniels D.L.","Blattner F.R."],"citationCrossReferences":[{"database":"PubMed","id":"8346018"},{"database":"DOI","id":"10.1093/nar/21.15.3391"}],"title":"Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes.","publicationDate":"1993","journal":"Nucleic Acids Res.","firstPage":"3391","lastPage":"3398","volume":"21"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L19201","properties":[{"key":"ProteinId","value":"AAB03054.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC76904.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAE77388.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S40865","properties":[{"key":"EntryName","value":"S40865"}]},{"database":"RefSeq","id":"NP_418357.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000655989.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"PDB","id":"2K3I","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-99"}]},{"database":"PDBsum","id":"2K3I","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P32162","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P32162","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P32162","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4261395","properties":[{"key":"Interactions","value":"37"}]},{"database":"BioGRID","id":"852713","properties":[{"key":"Interactions","value":"3"}]},{"database":"FunCoup","id":"P32162","properties":[{"key":"Number of interactors","value":"87"}]},{"database":"IntAct","id":"P32162","properties":[{"key":"Interactions","value":"28"}]},{"database":"STRING","id":"511145.b3922","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P32162","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b3922","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC76904","properties":[{"key":"ProteinId","value":"AAC76904"},{"key":"GeneId","value":"b3922"}]},{"database":"GeneID","id":"948416","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW3893","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b3922","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_21200","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|511145.12.peg.4039","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB1822","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG3691","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_162758_0_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P32162","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DNEDCVY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6198608at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P32162","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:EG11876-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P32162","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P32162","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"Gene3D","id":"3.30.70.860","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005272","properties":[{"key":"EntryName","value":"DUF406"}]},{"database":"InterPro","id":"IPR035571","properties":[{"key":"EntryName","value":"UPF0234-like_C"}]},{"database":"NCBIfam","id":"TIGR00743","properties":[{"key":"EntryName","value":"DUF406 family protein"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF007435","properties":[{"key":"EntryName","value":"PRK09981.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR38769","properties":[{"key":"EntryName","value":"UPF0381 PROTEIN YFCZ-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR38769:SF1","properties":[{"key":"EntryName","value":"UPF0381 PROTEIN YFCZ-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04175","properties":[{"key":"EntryName","value":"DUF406"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKDVVDKCSTKGCAIDIGTVIDNDNCTSKFSRFFATREEAESFMTKLKELAAATSSADEGASVAYKIKDLEGQVELDAAFTFSCQAEMIIFELSLRSLA","length":99,"molWeight":10776,"crc64":"526113F9E878D802","md5":"F6C700AAE0873675089D290443B8A219"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Beta strand":3,"Helix":2,"Turn":1},"uniParcId":"UPI000013B419"}}