{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P31663","secondaryAccessions":["Q2MCG4"],"uniProtkbId":"PANC_ECOLI","entryAudit":{"firstPublicDate":"1993-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1993-07-01","entryVersion":186,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Pantothenate synthetase"},"shortNames":[{"value":"PS"}],"ecNumbers":[{"value":"6.3.2.1"}]},"alternativeNames":[{"fullName":{"value":"Pantoate--beta-alanine ligase"}},{"fullName":{"value":"Pantoate-activating enzyme"}}]},"genes":[{"geneName":{"value":"panC"},"orderedLocusNames":[{"value":"b0133"},{"value":"JW0129"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"357689"}],"value":"Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10912"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15980"},{"database":"ChEBI","id":"CHEBI:29032"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:57966"},{"database":"ChEBI","id":"CHEBI:456215"}],"ecNumber":"6.3.2.1"}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"357689"}],"value":"Activation requires a combination of a divalent cation, magnesium or manganese, and a monovalent cation, potassium or ammonium. Above the optimum concentration for activation, magnesium and manganese are rather inhibitory. Also activated by 2-mercaptoethanol, dithiothreitol, cysteine and glutathione. Inhibited by divalent cations (mercury, cobalt, zinc, copper, silver), chelating agents (EDTA, EGTA and o-phenanthroline), and analogs of beta-alanine (taurine, gamma-aminobutyrate, gamma-amino-beta-hydroxybutyrate)"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":63.0,"unit":"uM","substrate":"pantoate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"357689"}]},{"constant":100.0,"unit":"uM","substrate":"ATP","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"357689"}]},{"constant":150.0,"unit":"uM","substrate":"beta-alanine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"357689"}]},{"constant":2000.0,"unit":"uM","substrate":"magnesium","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"357689"}]},{"constant":5500.0,"unit":"uM","substrate":"manganese","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"357689"}]}]},"phDependence":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"357689"}],"value":"Optimum pH is 10. Stable from pH 5.0 to 11.0."}]},"temperatureDependence":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"357689"}],"value":"Optimum temperature is 30 degrees Celsius. Stable up to 37 degrees Celsius and loses activity almost completely when incubated at 60 degrees Celsius for 10 minutes."}]}},{"texts":[{"value":"Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11377204"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P31663","intActId":"EBI-545354"},"interactantTwo":{"uniProtKBAccession":"P31663","geneName":"panC","intActId":"EBI-545354"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P31663","intActId":"EBI-545354"},"interactantTwo":{"uniProtKBAccession":"P65556","geneName":"yfcD","intActId":"EBI-545346"},"numberOfExperiments":6,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"MASS SPECTROMETRY","method":"Electrospray","molWeight":31601.2,"molWeightError":3.4,"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11377204"}]},{"texts":[{"value":"The reaction proceeds by a bi uni uni bi ping pong mechanism"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the pantothenate synthetase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"Pantothenate synthetase","featureId":"PRO_0000128229"},{"type":"Active site","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Binding site","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:15980"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"(R)-pantoate","id":"ChEBI:CHEBI:15980"}},{"type":"Binding site","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57966"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"beta-alanine","id":"ChEBI:CHEBI:57966"}},{"type":"Binding site","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:15980"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"(R)-pantoate","id":"ChEBI:CHEBI:15980"}},{"type":"Binding site","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Beta strand","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Helix","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Beta strand","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Helix","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Helix","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Beta strand","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Helix","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Helix","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Helix","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Beta strand","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Helix","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Beta strand","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Helix","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IHO"}]},{"type":"Helix","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IHO"}]},{"type":"Helix","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Beta strand","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Helix","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Beta strand","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GUZ"}]},{"type":"Helix","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IHO"}]},{"type":"Helix","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IHO"}]},{"type":"Helix","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IHO"}]},{"type":"Helix","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IHO"}]},{"type":"Helix","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IHO"}]},{"type":"Beta strand","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IHO"}]},{"type":"Turn","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IHO"}]},{"type":"Beta strand","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IHO"}]},{"type":"Beta strand","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IHO"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0436","category":"Molecular function","name":"Ligase"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0566","category":"Biological process","name":"Pantothenate biosynthesis"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"8837478","citationType":"journal article","authors":["Merkel W.K.","Nichols B.P."],"citationCrossReferences":[{"database":"PubMed","id":"8837478"},{"database":"DOI","id":"10.1111/j.1574-6968.1996.tb08488.x"}],"title":"Characterization and sequence of the Escherichia coli panBCD gene cluster.","publicationDate":"1996","journal":"FEMS Microbiol. Lett.","firstPage":"247","lastPage":"252","volume":"143"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"357689","citationType":"journal article","authors":["Miyatake K.","Nakano Y.","Kitaoka S."],"citationCrossReferences":[{"database":"PubMed","id":"357689"},{"database":"DOI","id":"10.3177/jnsv.24.243"}],"title":"Enzymological properties of pantothenate synthetase from Escherichia coli B.","publicationDate":"1978","journal":"J. Nutr. Sci. Vitaminol.","firstPage":"243","lastPage":"253","volume":"24"},"referencePositions":["FUNCTION","BIOPHYSICOCHEMICAL PROPERTIES","REACTION MECHANISM","ACTIVITY REGULATION"],"referenceComments":[{"value":"B","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"11377204","citationType":"journal article","authors":["von Delft F.","Lewendon A.","Dhanaraj V.","Blundell T.L.","Abell C.","Smith A.G."],"citationCrossReferences":[{"database":"PubMed","id":"11377204"},{"database":"DOI","id":"10.1016/s0969-2126(01)00604-9"}],"title":"The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily.","publicationDate":"2001","journal":"Structure","firstPage":"439","lastPage":"450","volume":"9"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS)","MASS SPECTROMETRY","SUBUNIT"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L17086","properties":[{"key":"ProteinId","value":"AAA24272.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC73244.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAE76042.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"E64736","properties":[{"key":"EntryName","value":"E64736"}]},{"database":"RefSeq","id":"NP_414675.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000905383.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"PDB","id":"1IHO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=1-283"}]},{"database":"PDB","id":"3GUZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.67 A"},{"key":"Chains","value":"A/B=1-176"}]},{"database":"PDBsum","id":"1IHO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GUZ","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P31663","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P31663","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P31663","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4261166","properties":[{"key":"Interactions","value":"164"}]},{"database":"BioGRID","id":"849355","properties":[{"key":"Interactions","value":"1"}]},{"database":"DIP","id":"DIP-10437N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P31663","properties":[{"key":"Number of interactors","value":"801"}]},{"database":"IntAct","id":"P31663","properties":[{"key":"Interactions","value":"11"}]},{"database":"MINT","id":"P31663","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"511145.b0133","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P31663","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b0133","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC73244","properties":[{"key":"ProteinId","value":"AAC73244"},{"key":"GeneId","value":"b0133"}]},{"database":"GeneID","id":"75202052","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"944958","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW0129","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b0133","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_00570","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.2148","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB1696","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG0414","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_047148_0_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P31663","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CNHKLEP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9773087at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P31663","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:PANTOATE-BETA-ALANINE-LIG-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:PANTOATE-BETA-ALANINE-LIG-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"6.3.2.1","properties":[{"key":"OrganismId","value":"2026"}]},{"database":"SABIO-RK","id":"P31663","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00028","properties":[{"key":"RectionId","value":"UER00005"}]},{"database":"EvolutionaryTrace","id":"P31663","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P31663","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P31663","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15911532"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18304323"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16858726"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"20059543"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"24627523"}]},{"database":"GO","id":"GO:0004592","properties":[{"key":"GoTerm","value":"F:pantoate-beta-alanine ligase activity"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16990935"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11377204"}]},{"database":"GO","id":"GO:0015940","properties":[{"key":"GoTerm","value":"P:pantothenate biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7037743"}]},{"database":"CDD","id":"cd00560","properties":[{"key":"EntryName","value":"PanC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1300.10:FF:000001","properties":[{"key":"EntryName","value":"Pantothenate synthetase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.620:FF:000013","properties":[{"key":"EntryName","value":"Pantothenate synthetase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.620","properties":[{"key":"EntryName","value":"HUPs"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1300.10","properties":[{"key":"EntryName","value":"Pantoate-beta-alanine ligase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00158","properties":[{"key":"EntryName","value":"PanC"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004821","properties":[{"key":"EntryName","value":"Cyt_trans-like"}]},{"database":"InterPro","id":"IPR003721","properties":[{"key":"EntryName","value":"Pantoate_ligase"}]},{"database":"InterPro","id":"IPR042176","properties":[{"key":"EntryName","value":"Pantoate_ligase_C"}]},{"database":"InterPro","id":"IPR014729","properties":[{"key":"EntryName","value":"Rossmann-like_a/b/a_fold"}]},{"database":"NCBIfam","id":"TIGR00125","properties":[{"key":"EntryName","value":"cyt_tran_rel"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR00018","properties":[{"key":"EntryName","value":"panC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21299","properties":[{"key":"EntryName","value":"CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21299:SF1","properties":[{"key":"EntryName","value":"PANTOATE--BETA-ALANINE LIGASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02569","properties":[{"key":"EntryName","value":"Pantoate_ligase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52374","properties":[{"key":"EntryName","value":"Nucleotidylyl transferase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKIAPGLYKVLSSIADKLQAGERDLDEIITIAGQELNEKGFRADDIQIRDADTLLEVSETSKRAVILVAAWLGDARLIDNKMVELA","length":283,"molWeight":31598,"crc64":"4246647C6FDAFB20","md5":"4B6B69C8934CE88643461A12C57BFC30"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"ACTIVITY REGULATION":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"PATHWAY":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"MASS SPECTROMETRY":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Active site":1,"Binding site":7,"Beta strand":10,"Helix":16,"Turn":1},"uniParcId":"UPI0000111D9B"}}