{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P31277","secondaryAccessions":["A6NIS4","Q9NS02"],"uniProtkbId":"HXD11_HUMAN","entryAudit":{"firstPublicDate":"1993-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-02-10","entryVersion":202,"sequenceVersion":3},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Homeobox protein Hox-D11"}},"alternativeNames":[{"fullName":{"value":"Homeobox protein Hox-4F"}}]},"genes":[{"geneName":{"value":"HOXD11"},"synonyms":[{"value":"HOX4F"}]}],"comments":[{"texts":[{"value":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Abd-B homeobox family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Homeobox protein Hox-D11","featureId":"PRO_0000200231"},{"type":"DNA binding","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00108"}]},{"type":"Region","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Natural variant","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in dbSNP:rs376305712","featureCrossReferences":[{"database":"dbSNP","id":"rs376305712"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17236141"}],"featureId":"VAR_031647","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"in Ref. 1; AAF79045","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"PPPPAPPQPE","alternativeSequences":["RRHPRRHSPM"]}}],"keywords":[{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0371","category":"Domain","name":"Homeobox"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-C4FKTA1GFGBSR","citationType":"submission","authors":["Miwa N.","Yoshiura K.","Kantaputra P.K.","Soeda E.","Niikawa N."],"title":"The role of HOXD11 and HOXD12 for the mesomelic dysplasia Kantaptra type.","publicationDate":"MAY-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"2574852","citationType":"journal article","authors":["Acampora D.","D'Esposito M.","Faiella A.","Pannese M.","Migliaccio E.","Morelli F.","Stornaiuolo A.","Nigro V.","Simeone A.","Boncinelli E."],"citationCrossReferences":[{"database":"PubMed","id":"2574852"},{"database":"DOI","id":"10.1093/nar/17.24.10385"}],"title":"The human HOX gene family.","publicationDate":"1989","journal":"Nucleic Acids Res.","firstPage":"10385","lastPage":"10402","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-331"]},{"referenceNumber":4,"citation":{"id":"17236141","citationType":"journal article","authors":["Zhao X.","Sun M.","Zhao J.","Leyva J.A.","Zhu H.","Yang W.","Zeng X.","Ao Y.","Liu Q.","Liu G.","Lo W.H.Y.","Jabs E.W.","Amzel L.M.","Shan X.","Zhang X."],"citationCrossReferences":[{"database":"PubMed","id":"17236141"},{"database":"DOI","id":"10.1086/511387"}],"title":"Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome.","publicationDate":"2007","journal":"Am. J. Hum. Genet.","firstPage":"361","lastPage":"371","volume":"80"},"referencePositions":["VARIANT ASP-245"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF154915","properties":[{"key":"ProteinId","value":"AAF79045.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC009336","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS2265.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S14938","properties":[{"key":"EntryName","value":"S14938"}]},{"database":"RefSeq","id":"NP_067015.2","properties":[{"key":"NucleotideSequenceId","value":"NM_021192.3"}]},{"database":"AlphaFoldDB","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109477","properties":[{"key":"Interactions","value":"24"}]},{"database":"FunCoup","id":"P31277","properties":[{"key":"Number of interactors","value":"787"}]},{"database":"IntAct","id":"P31277","properties":[{"key":"Interactions","value":"6"}]},{"database":"NDEx","id":"IQUERY-CP-HOXD11","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000249504","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P31277","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HOXD11","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"223590220","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000249504","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54777","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"33904","properties":[{"key":"antibodies","value":"307 antibodies from 30 providers"}]},{"database":"DNASU","id":"3237","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000249504.7","properties":[{"key":"ProteinId","value":"ENSP00000249504.5"},{"key":"GeneId","value":"ENSG00000128713.14"}]},{"database":"GeneID","id":"3237","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3237","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000249504.7","properties":[{"key":"ProteinId","value":"ENSP00000249504.5"},{"key":"RefSeqNucleotideId","value":"NM_021192.3"},{"key":"RefSeqProteinId","value":"NP_067015.2"}]},{"database":"UCSC","id":"uc002uki.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:5134","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA29408","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3237","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3237","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HOXD11","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5134","properties":[{"key":"GeneName","value":"HOXD11"}]},{"database":"HPA","id":"ENSG00000128713","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (cervix, endometrium, intestine, kidney, vagina)"}]},{"database":"MIM","id":"142986","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000128713","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000128713","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0487","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000161308","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_079662_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CNFFTSV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6159439at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P31277","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9830674","properties":[{"key":"PathwayName","value":"Formation of the ureteric bud"}]},{"database":"SignaLink","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P31277","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3237","properties":[{"key":"hits","value":"30 hits in 1169 CRISPR screens"}]},{"database":"ChiTaRS","id":"HOXD11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"HOXD11","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3237","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P31277","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P31277","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"P31277","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000128713","properties":[{"key":"ExpressionPatterns","value":"Expressed in body of uterus and 53 other cell types or tissues"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:1990837","properties":[{"key":"GoTerm","value":"F:sequence-specific double-stranded DNA binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28473536"}]},{"database":"GO","id":"GO:0001658","properties":[{"key":"GoTerm","value":"P:branching involved in ureteric bud morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0009953","properties":[{"key":"GoTerm","value":"P:dorsal/ventral pattern formation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060272","properties":[{"key":"GoTerm","value":"P:embryonic skeletal joint morphogenesis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd00086","properties":[{"key":"EntryName","value":"homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.60:FF:000166","properties":[{"key":"EntryName","value":"homeobox protein Hox-C11"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR021918","properties":[{"key":"EntryName","value":"DUF3528"}]},{"database":"InterPro","id":"IPR001356","properties":[{"key":"EntryName","value":"HD"}]},{"database":"InterPro","id":"IPR020479","properties":[{"key":"EntryName","value":"HD_metazoa"}]},{"database":"InterPro","id":"IPR017970","properties":[{"key":"EntryName","value":"Homeobox_CS"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"PANTHER","id":"PTHR46092","properties":[{"key":"EntryName","value":"HOMEOBOX PROTEIN HOX-A11-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46092:SF2","properties":[{"key":"EntryName","value":"HOMEOBOX PROTEIN HOX-D11"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12045","properties":[{"key":"EntryName","value":"DUF3528"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00046","properties":[{"key":"EntryName","value":"Homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00024","properties":[{"key":"EntryName","value":"HOMEOBOX"}]},{"database":"SMART","id":"SM00389","properties":[{"key":"EntryName","value":"HOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00027","properties":[{"key":"EntryName","value":"HOMEOBOX_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50071","properties":[{"key":"EntryName","value":"HOMEOBOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNDFDECGQSAASMYLPGCAYYVAPSDFASKPSFLSQPSSCQMTFPYSSNLAPHVQPVREVAFRDYGLERAKWPYRGGGGGGSAGGGSSGGGPGGGGGGAGGYAPYYAAAAAAAAAAAAAEEAAMQRELLPPAGRRPDVLFKAPEPVCAAPGPPHGPAGAASNFYSAVGRNGILPQGFDQFYEAAPGPPFAGPQPPPPPAPPQPEGAADKGDPRTGAGGGGGSPCTKATPGSEPKGAAEGSGGDGEGPPGEAGAEKSSSAVAPQRSRKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLNRDRLQYFTGNPLF","length":338,"molWeight":35197,"crc64":"2960C3C983EA9A6A","md5":"854658786C19A9DAFF40E41441DDA779"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"DNA binding":1,"Region":1,"Compositional bias":2,"Natural variant":1,"Sequence conflict":1},"uniParcId":"UPI000013CC88"}}