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This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cell membrane","id":"SL-0039"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P30968-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"Truncated"}],"isoformIds":["P30968-2"],"sequenceIds":["VSP_001914"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Pituitary, ovary, testis, breast and prostate but not in liver and spleen"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","disease":{"diseaseId":"Hypogonadotropic hypogonadism 7 with or without anosmia","diseaseAccession":"DI-00595","acronym":"HH7","description":"A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).","diseaseCrossReference":{"database":"MIM","id":"146110"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10022417"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10084584"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10523035"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11318785"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11397842"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11397871"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11994356"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12679486"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23643382"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25077900"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9371856"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9425890"}]},"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23643382"}],"value":"The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in GNRHR as well as in other HH-associated genes including FGFR1 (PubMed:23643382)"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Gonadotropin-releasing hormone receptor","featureId":"PRO_0000069487"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological 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