{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P30296","uniProtkbId":"LIVM_SALTY","entryAudit":{"firstPublicDate":"1993-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1993-04-01","entryVersion":130,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)","taxonId":99287,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Salmonella"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"High-affinity branched-chain amino acid transport system permease protein LivM"}},"alternativeNames":[{"fullName":{"value":"LIV-I protein M"}}]},"genes":[{"geneName":{"value":"livM"},"synonyms":[{"value":"livE"}],"orderedLocusNames":[{"value":"STM3562"}]}],"comments":[{"texts":[{"value":"Part of the binding protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cell inner membrane","id":"SL-0037"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the binding protein-dependent transport system permease family. LivHM subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"High-affinity branched-chain amino acid transport system permease protein LivM","featureId":"PRO_0000060063"},{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0029","category":"Biological process","name":"Amino-acid transport"},{"id":"KW-0997","category":"Cellular component","name":"Cell inner membrane"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"1429514","citationType":"journal article","authors":["Matsubara K.","Ohnishi K.","Kiritani K."],"citationCrossReferences":[{"database":"PubMed","id":"1429514"},{"database":"DOI","id":"10.1093/oxfordjournals.jbchem.a123872"}],"title":"Nucleotide sequences and characterization of liv genes encoding components of the high-affinity branched-chain amino acid transport system in Salmonella typhimurium.","publicationDate":"1992","journal":"J. Biochem.","firstPage":"93","lastPage":"101","volume":"112"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"LT2","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"11677609","citationType":"journal article","authors":["McClelland M.","Sanderson K.E.","Spieth J.","Clifton S.W.","Latreille P.","Courtney L.","Porwollik S.","Ali J.","Dante M.","Du F.","Hou S.","Layman D.","Leonard S.","Nguyen C.","Scott K.","Holmes A.","Grewal N.","Mulvaney E.","Ryan E.","Sun H.","Florea L.","Miller W.","Stoneking T.","Nhan M.","Waterston R.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"11677609"},{"database":"DOI","id":"10.1038/35101614"}],"title":"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.","publicationDate":"2001","journal":"Nature","firstPage":"852","lastPage":"856","volume":"413"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"LT2 / SGSC1412 / ATCC 700720","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D12589","properties":[{"key":"ProteinId","value":"BAA02130.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AE006468","properties":[{"key":"ProteinId","value":"AAL22422.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"JH0669","properties":[{"key":"EntryName","value":"JH0669"}]},{"database":"RefSeq","id":"NP_462463.1","properties":[{"key":"NucleotideSequenceId","value":"NC_003197.2"}]},{"database":"RefSeq","id":"WP_000803766.1","properties":[{"key":"NucleotideSequenceId","value":"NC_003197.2"}]},{"database":"AlphaFoldDB","id":"P30296","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"99287.STM3562","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"99287-STM3562","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"1255085","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"stm:STM3562","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|99287.12.peg.3765","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"HOGENOM","id":"CLU_031365_1_1_6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VFWYKLQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PhylomeDB","id":"P30296","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"SENT99287:STM3562-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001014","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0015658","properties":[{"key":"GoTerm","value":"F:branched-chain amino acid transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0015803","properties":[{"key":"GoTerm","value":"P:branched-chain amino acid transport"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd06581","properties":[{"key":"EntryName","value":"TM_PBP1_LivM_like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001851","properties":[{"key":"EntryName","value":"ABC_transp_permease"}]},{"database":"InterPro","id":"IPR021807","properties":[{"key":"EntryName","value":"LivHM_N"}]},{"database":"InterPro","id":"IPR043428","properties":[{"key":"EntryName","value":"LivM-like"}]},{"database":"NCBIfam","id":"NF008450","properties":[{"key":"EntryName","value":"PRK11301.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30482","properties":[{"key":"EntryName","value":"HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT SYSTEM PERMEASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30482:SF20","properties":[{"key":"EntryName","value":"HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT SYSTEM PERMEASE PROTEIN LIVM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02653","properties":[{"key":"EntryName","value":"BPD_transp_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11862","properties":[{"key":"EntryName","value":"DUF3382"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKPMHIAMALFSAAMFFVLAGVFMGVQLELDGTKLVVDTAADIRWQWIFIGTAVVFFFQLLRPMFQKAVKHVSGPKFILPAIDGSTVKQKLFLMALLVIAVAWPFMVSRGSVDIATMTMIYIILGLGLNVVVGLSGLLVLGYGGFYAIGAYTFALLNHYYGLGFWTCLPLAGLVSAAAGFLLGFPVLRLRGDYLAIVTLGFGEIVRILLLNNTEITGGPNGISQIPKPTLFGLEFSRSTREGGWDTFSNFFGVKYDPSDRVIFLYLVALLLVVLSLFVINRLLRMPLGRAWEALREDEIACRSLGLSPTRIKLTAFTISAAFAGFAGTLFAARQGFVSPESFTFAESAFVLAIVVLGGMGSQFAVILAAVLLVVSRELMRDFNEYSMLMLGGLMVLMMIWRPQGLLPMTRPQLKLKSGQAKGEQA","length":425,"molWeight":46408,"crc64":"6E7CABF9D08F690A","md5":"41A2AFA546123410020D6C795C682270"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":11},"uniParcId":"UPI000012E745"}}