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Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60208"},{"database":"Rhea","id":"RHEA-COMP:15537"},{"database":"Rhea","id":"RHEA-COMP:15547"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:16842"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:30031"},{"database":"ChEBI","id":"CHEBI:61961"}],"ecNumber":"1.14.11.67","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17320160"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17320161"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17320163"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Fe(2+)","evidences":[{"evidenceCode":"ECO:0000250"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29033"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Binds 1 Fe(2+) ion per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27214401"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27427228"}],"value":"The inhibitors KDOAM-25, CPI-455 and others inhibits its demethylase activity, resulting to cell growth arrest in cancer cells"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":9.0,"unit":"uM","substrate":"2-oxoglutarate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27427228"}]},{"constant":2.9,"unit":"uM","substrate":"histone H3K4me3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27427228"}]}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27427228"}],"value":"kcat is 2.1 min(-1) and 1.9 min(-1) for 2-oxoglutarate and histone H3K4me3, respectively."}]}}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3UXZ9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11358960"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15949438"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17311883"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19430464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21960634"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7935440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8414517"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9129143"}],"value":"Interacts with SUZ12; the interaction is direct (By similarity). 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The ARID domain specifically binds to the CCGCCC motif and is required for the lysine-specific histone demethylase activity (PubMed:18270511). The PHD-type 3 zinc finger is required for the interaction with histone H3 di- and trimethylated at 'Lys-4' (PubMed:19430464)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3UXZ9"}],"value":"Ubiquitinated by the SCF(FBXO39) complex; leading to proteasomal degradation"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23531517"}],"value":"A chromosomal aberration involving KDM5A has been found in M5 type acute myeloid leukemia. 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