{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P28700","uniProtkbId":"RXRA_MOUSE","entryAudit":{"firstPublicDate":"1992-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1992-12-01","entryVersion":233,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Retinoic acid receptor RXR-alpha"}},"alternativeNames":[{"fullName":{"value":"Nuclear receptor subfamily 2 group B member 1"}},{"fullName":{"value":"Retinoid X receptor alpha"}}]},"genes":[{"geneName":{"value":"Rxra"},"synonyms":[{"value":"Nr2b1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12032153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1310259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25417649"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26463675"}],"value":"Receptor for retinoic acid that acts as a transcription factor (PubMed:10383391, PubMed:12032153, PubMed:25417649). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10383391, PubMed:1310259). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:1310259). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:10383391, PubMed:25417649). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (By similarity). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:1310259). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (By similarity). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (By similarity). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity). Acts as an enhancer of RARA binding to RARE DNA element (By similarity). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (By similarity). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10788465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10882070"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15528208"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16606617"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17595322"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20078863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7838715"}],"value":"Homodimer (By similarity). Heterodimer with RARA; required for ligand-dependent retinoic acid receptor transcriptional activity (PubMed:10882070). Heterodimer with PPARA (via the leucine-like zipper in the LBD); the interaction is required for PPARA transcriptional activity (By similarity). Heterodimerizes with PPARG (PubMed:7838715). Heterodimerizes (via NR LBD) with RARB (By similarity). Heterodimerizes with NR1H4; the heterodimerization enhances the binding affinity for LXXLL motifs from coactivators (By similarity). Interacts with coactivator NCO6 (PubMed:10788465). Interacts with coactivator NCO3 (By similarity). Interacts with coactivator FAM120B (PubMed:17595322). Interacts with coactivator PELP1, SENP6, SFPQ, DNTTIP2 and RNF8 (By similarity). Interacts with PRMT2 (By similarity). Interacts with ASXL1 (PubMed:16606617). Interacts with BHLHE40/DEC1, BHLHE41/DEC2, NCOR1 and NCOR2 (By similarity). Interacts in a ligand-dependent fashion with MED1 and NCOA1 (PubMed:15528208, PubMed:16606617). Interacts with VDR (By similarity). Interacts with EP300; the interaction is decreased by 9-cis retinoic acid (By similarity). Heterodimer (via C-terminus) with NR4A1 (via DNA-binding domain); the interaction is enhanced by 9-cis retinoic acid (By similarity). NR4A1 competes with EP300 for interaction with RXRA and thereby attenuates EP300 mediated acetylation of RXRA (By similarity). In the absence of hormonal ligand, interacts with TACC1 (PubMed:20078863). Interacts ith IGFBP3 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P28700","intActId":"EBI-346715"},"interactantTwo":{"uniProtKBAccession":"P59598","geneName":"Asxl1","intActId":"EBI-5743705"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P28700","intActId":"EBI-346715"},"interactantTwo":{"uniProtKBAccession":"Q64337","geneName":"Sqstm1","intActId":"EBI-645025"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P28700","intActId":"EBI-346715"},"interactantTwo":{"uniProtKBAccession":"Q8IXJ9","geneName":"ASXL1","intActId":"EBI-1646500"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P28700","intActId":"EBI-346715"},"interactantTwo":{"uniProtKBAccession":"Q71SY5","geneName":"MED25","intActId":"EBI-394558"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P28700","intActId":"EBI-346715"},"interactantTwo":{"uniProtKBAccession":"P23246-1","geneName":"SFPQ","intActId":"EBI-355463"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P28700","intActId":"EBI-346715"},"interactantTwo":{"uniProtKBAccession":"Q13501","geneName":"SQSTM1","intActId":"EBI-307104"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P28700","intActId":"EBI-346715"},"interactantTwo":{"uniProtKBAccession":"P11473","geneName":"VDR","intActId":"EBI-286357"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"value":"Localization to the nucleus is enhanced by vitamin D3 (By similarity). Nuclear localization may be enhanced by the interaction with heterodimerization partner VDR (By similarity). Translocation to the mitochondrion upon interaction with NR4A1 (By similarity). Increased nuclear localization upon pulsatile shear stress (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26463675"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25417649"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26463675"}],"value":"Expressed in macrophages (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25417649"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26463675"}],"value":"Down-regulated by infection with viruses, such as VSV, HSV-1 and MHV68 (PubMed:25417649). Down-regulated by aging (PubMed:26463675)"}],"commentType":"INDUCTION"},{"texts":[{"value":"Composed of three domains: a modulating N-terminal or AF1 domain, a DNA-binding domain and a C-terminal ligand-binding or AF2 domain"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"value":"Acetylated by EP300; acetylation enhances DNA binding and transcriptional activity"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12032153"}],"value":"Phosphorylated on serine and threonine residues mainly in the N-terminal modulating domain (PubMed:10383391, PubMed:12032153). Constitutively phosphorylated on Ser-22 in the presence or absence of ligand (PubMed:10383391, PubMed:12032153). Under stress conditions, hyperphosphorylated by activated JNK on Ser-61, Ser-75, Thr-87 and Ser-265 (PubMed:10383391). Phosphorylated on Ser-28, in vitro, by PKA (By similarity). This phosphorylation is required for repression of cAMP-mediated transcriptional activity of RARA (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"value":"Ubiquitinated by UBR5, leading to its degradation: UBR5 specifically recognizes and binds ligand-bound RXRA when it is not associated with coactivators (NCOAs). In presence of NCOAs, the UBR5-degron is not accessible, preventing its ubiquitination and degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"value":"Sumoylation negatively regulates transcriptional activity. Desumoylated specifically by SENP6"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26463675"}],"value":"Reduced myelin debris uptake by bone marrow-derived macrophages (PubMed:26463675). Conditional knockout in myeloid cells results in reduced myelin debris clearing by macrophages, delayed oligodendrocyte progenitor cell differentiation and slowern remyelination after induced focal demyelination (PubMed:26463675)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the nuclear hormone receptor family. NR2 subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"Retinoic acid receptor RXR-alpha","featureId":"PRO_0000053567"},{"type":"Domain","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":463,"modifier":"EXACT"}},"description":"NR LBD","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01189"}]},{"type":"DNA binding","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Nuclear receptor","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00407"}]},{"type":"Zinc finger","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"NR C4-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00407"}]},{"type":"Zinc finger","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"NR C4-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00407"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"Modulating domain","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}]},{"type":"Region","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Hinge"},{"type":"Region","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Required for nuclear export","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}]},{"type":"Compositional bias","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:78630"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15528208"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1XDK"}],"ligand":{"name":"9-cis-retinoate","id":"ChEBI:CHEBI:78630"}},{"type":"Binding site","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:35291"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"ligand":{"name":"all-trans-retinoate","id":"ChEBI:CHEBI:35291"}},{"type":"Binding site","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:78630"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15528208"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1XDK"}],"ligand":{"name":"9-cis-retinoate","id":"ChEBI:CHEBI:78630"}},{"type":"Binding site","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:35291"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}],"ligand":{"name":"all-trans-retinoate","id":"ChEBI:CHEBI:35291"}},{"type":"Modified residue","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12032153"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}]},{"type":"Modified residue","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Phosphoserine; by MAPK8 and MAPK9","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}]},{"type":"Modified residue","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Phosphoserine; by MAPK8 and MAPK9","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}]},{"type":"Modified residue","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"Phosphothreonine; by MAPK8 and MAPK9","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}]},{"type":"Modified residue","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}]},{"type":"Modified residue","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}]},{"type":"Modified residue","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}]},{"type":"Modified residue","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Phosphoserine; by MAPK8 and MAPK9","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}]},{"type":"Cross-link","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19793"}]},{"type":"Cross-link","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Mutagenesis","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Loss of constituitive phosphorylation. No effect on RXRA transcriptional activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12032153"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"No effect on constituitive phosphorylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"No effect on constituitive phosphorylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"No effect on constituitive phosphorylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"No effect on constituitive phosphorylation, decreased stress-induced phosphorylation but no effect on RXRA transcriptional activity. Abolishes stress-induced phosphorylation but no effect on RXRA transcriptional activity; when associated with A-75 and A-87. No effect on RXRA transcriptional activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"No effect on constituitive phosphorylation, decreased stress-induced phosphorylation but no effect on RXRA transcriptional activity. Abolishes stress-induced phosphorylation but no effect on RXRA transcriptional activity; when associated with A-61 and A-87.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"No effect on constituitive phosphorylation, decreased stress-induced phosphorylation but no effect on RXRA transcriptional activity. Abolishes stress-induced phosphorylation but no effect on RXRA transcriptional activity; when associated with A-61 and A-75. phosphorylation. No effect on RXRA transcriptional activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"No effect on constituitive phosphorylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"No effect on constituitive phosphorylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"No effect on constiuitive phosphorylation but loss of stress-induced phosphorylation. No effect on RXRA transcriptional activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10383391"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":455,"modifier":"EXACT"},"end":{"value":456,"modifier":"EXACT"}},"description":"Abolishes interaction with ASXL1 and NCOA1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16606617"}],"alternativeSequence":{"originalSequence":"FL","alternativeSequences":["AA"]}},{"type":"Mutagenesis","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":460,"modifier":"EXACT"}},"description":"Abolishes interaction with ASXL1 and NCOA1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16606617"}],"alternativeSequence":{"originalSequence":"ML","alternativeSequences":["AA"]}},{"type":"Turn","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8J54"}]},{"type":"Beta strand","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8J54"}]},{"type":"Helix","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8J54"}]},{"type":"Beta strand","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8J54"}]},{"type":"Turn","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8J54"}]},{"type":"Helix","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8J54"}]},{"type":"Helix","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8J54"}]},{"type":"Helix","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1DKF"}]},{"type":"Helix","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Turn","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Beta strand","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Beta strand","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]},{"type":"Helix","location":{"start":{"value":451,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3A9E"}]},{"type":"Helix","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":459,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PDQ"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"1310259","citationType":"journal article","authors":["Leid M.","Kastner P.","Lyons R.","Nakshatri H.","Saunders M.","Zacharewsi T.","Chen J.Y.","Staub A.","Garnier J.-M.","Mader S.","Chambon P."],"citationCrossReferences":[{"database":"PubMed","id":"1310259"}],"title":"Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.","publicationDate":"1992","journal":"Cell","firstPage":"377","lastPage":"395","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","HETERODIMERIZATION WITH RARA","FUNCTION"]},{"referenceNumber":2,"citation":{"id":"1312497","citationType":"journal article","authors":["Mangelsdorf D.J.","Borgmeyer U.","Heyman R.A.","Zhou J.Y.","Ong E.S.","Oro A.E.","Kakizuka A.","Evans R.M."],"citationCrossReferences":[{"database":"PubMed","id":"1312497"},{"database":"DOI","id":"10.1101/gad.6.3.329"}],"title":"Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.","publicationDate":"1992","journal":"Genes Dev.","firstPage":"329","lastPage":"344","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","IDENTIFICATION OF LIGAND"]},{"referenceNumber":3,"citation":{"id":"7838715","citationType":"journal article","authors":["Tontonoz P.","Graves R.A.","Budavari A.I.","Erdjument-Bromage H.","Lui M.","Hu E.","Tempst P.","Spiegelman B.M."],"citationCrossReferences":[{"database":"PubMed","id":"7838715"},{"database":"DOI","id":"10.1093/nar/22.25.5628"}],"title":"Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha.","publicationDate":"1994","journal":"Nucleic Acids Res.","firstPage":"5628","lastPage":"5634","volume":"22"},"referencePositions":["PROTEIN SEQUENCE OF 5-16; 27-46; 291-307 AND 446-465","SUBUNIT"],"referenceComments":[{"value":"Adipose tissue","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"10383391","citationType":"journal article","authors":["Adam-Stitah S.","Penna L.","Chambon P.","Rochette-Egly C."],"citationCrossReferences":[{"database":"PubMed","id":"10383391"},{"database":"DOI","id":"10.1074/jbc.274.27.18932"}],"title":"Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"18932","lastPage":"18941","volume":"274"},"referencePositions":["FUNCTION","PHOSPHORYLATION AT SER-22; SER-61; SER-75; THR-87 AND SER-265","MUTAGENESIS OF SER-22; SER-44; SER-48; SER-54; SER-61; SER-75; THR-87; SER-96; SER-101 AND SER-265"]},{"referenceNumber":5,"citation":{"id":"10788465","citationType":"journal article","authors":["Zhu Y.-J.","Kan L.","Qi C.","Kanwar Y.S.","Yeldandi A.V.","Rao M.S.","Reddy J.K."],"citationCrossReferences":[{"database":"PubMed","id":"10788465"},{"database":"DOI","id":"10.1074/jbc.275.18.13510"}],"title":"Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"13510","lastPage":"13516","volume":"275"},"referencePositions":["INTERACTION WITH NCOA6"]},{"referenceNumber":6,"citation":{"id":"12032153","citationType":"journal article","authors":["Bastien J.","Adam-Stitah S.","Plassat J.L.","Chambon P.","Rochette-Egly C."],"citationCrossReferences":[{"database":"PubMed","id":"12032153"},{"database":"DOI","id":"10.1074/jbc.m203623200"}],"title":"The phosphorylation site located in the A region of retinoic X receptor alpha is required for the antiproliferative effect of retinoic acid (RA) and the activation of RA target genes in F9 cells.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"28683","lastPage":"28689","volume":"277"},"referencePositions":["FUNCTION","PHOSPHORYLATION AT SER-22","MUTAGENESIS OF SER-22"]},{"referenceNumber":7,"citation":{"id":"16606617","citationType":"journal article","authors":["Cho Y.S.","Kim E.J.","Park U.H.","Sin H.S.","Um S.J."],"citationCrossReferences":[{"database":"PubMed","id":"16606617"},{"database":"DOI","id":"10.1074/jbc.m512616200"}],"title":"Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"17588","lastPage":"17598","volume":"281"},"referencePositions":["INTERACTION WITH ASXL1 AND NCOA1","MUTAGENESIS OF 455-PHE-LEU-456 AND 459-MET-LEU-460"]},{"referenceNumber":8,"citation":{"id":"17595322","citationType":"journal article","authors":["Li D.","Kang Q.","Wang D.-M."],"citationCrossReferences":[{"database":"PubMed","id":"17595322"},{"database":"DOI","id":"10.1210/me.2006-0520"}],"title":"Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis.","publicationDate":"2007","journal":"Mol. Endocrinol.","firstPage":"2320","lastPage":"2333","volume":"21"},"referencePositions":["INTERACTION WITH FAM120B"]},{"referenceNumber":9,"citation":{"id":"20078863","citationType":"journal article","authors":["Guyot R.","Vincent S.","Bertin J.","Samarut J.","Ravel-Chapuis P."],"citationCrossReferences":[{"database":"PubMed","id":"20078863"},{"database":"DOI","id":"10.1186/1471-2199-11-3"}],"title":"The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.","publicationDate":"2010","journal":"BMC Mol. Biol.","firstPage":"3","lastPage":"3","volume":"11"},"referencePositions":["INTERACTION WITH TACC1"]},{"referenceNumber":10,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Kidney","type":"TISSUE"},{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"10882070","citationType":"journal article","authors":["Bourguet W.","Vivat V.","Wurtz J.M.","Chambon P.","Gronemeyer H.","Moras D."],"citationCrossReferences":[{"database":"PubMed","id":"10882070"},{"database":"DOI","id":"10.1016/s1097-2765(00)80424-4"}],"title":"Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains.","publicationDate":"2000","journal":"Mol. Cell","firstPage":"289","lastPage":"298","volume":"5"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 230-462 OF MUTANT ALA-318 IN COMPLEX WITH H.SAPIENS RARA"]},{"referenceNumber":12,"citation":{"id":"15528208","citationType":"journal article","authors":["Pogenberg V.","Guichou J.F.","Vivat-Hannah V.","Kammerer S.","Perez E.","Germain P.","de Lera A.R.","Gronemeyer H.","Royer C.A.","Bourguet W."],"citationCrossReferences":[{"database":"PubMed","id":"15528208"},{"database":"DOI","id":"10.1074/jbc.m409302200"}],"title":"Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"1625","lastPage":"1633","volume":"280"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 230-467 IN COMPLEX WITH RARB AND MED1"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1XDK"}]},{"referenceNumber":13,"citation":{"id":"21152046","citationType":"journal article","authors":["Sato Y.","Ramalanjaona N.","Huet T.","Potier N.","Osz J.","Antony P.","Peluso-Iltis C.","Poussin-Courmontagne P.","Ennifar E.","Mely Y.","Dejaegere A.","Moras D.","Rochel N."],"citationCrossReferences":[{"database":"PubMed","id":"21152046"},{"database":"DOI","id":"10.1371/journal.pone.0015119"}],"title":"The 'phantom effect' of the rexinoid LG100754: structural and functional insights.","publicationDate":"2010","journal":"PLoS ONE","firstPage":"e15119","lastPage":"e15119","volume":"5"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 228-467 IN COMPLEX WITH HUMAN RARA AND HUMAN NCOA2"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3A9E"}]},{"referenceNumber":14,"citation":{"id":"25417649","citationType":"journal article","authors":["Ma F.","Liu S.Y.","Razani B.","Arora N.","Li B.","Kagechika H.","Tontonoz P.","Nunez V.","Ricote M.","Cheng G."],"citationCrossReferences":[{"database":"PubMed","id":"25417649"},{"database":"DOI","id":"10.1038/ncomms6494"}],"title":"Retinoid X receptor alpha attenuates host antiviral response by suppressing type I interferon.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"5494","lastPage":"5494","volume":"5"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","INDUCTION BY VIRAL INFECTION"]},{"referenceNumber":15,"citation":{"id":"26463675","citationType":"journal article","authors":["Natrajan M.S.","de la Fuente A.G.","Crawford A.H.","Linehan E.","Nunez V.","Johnson K.R.","Wu T.","Fitzgerald D.C.","Ricote M.","Bielekova B.","Franklin R.J."],"citationCrossReferences":[{"database":"PubMed","id":"26463675"},{"database":"DOI","id":"10.1093/brain/awv289"}],"title":"Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.","publicationDate":"2015","journal":"Brain","firstPage":"3581","lastPage":"3597","volume":"138"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","REPRESSION BY AGING","DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M84817","properties":[{"key":"ProteinId","value":"AAA40080.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X66223","properties":[{"key":"ProteinId","value":"CAA46962.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS15830.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S26668","properties":[{"key":"EntryName","value":"S26668"}]},{"database":"RefSeq","id":"NP_035435.1","properties":[{"key":"NucleotideSequenceId","value":"NM_011305.3"}]},{"database":"PDB","id":"1DKF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=230-462"}]},{"database":"PDB","id":"1XDK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A/E=230-467"}]},{"database":"PDB","id":"3A9E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"A=228-467"}]},{"database":"PDB","id":"7AOS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"A=230-467"}]},{"database":"PDB","id":"7PDQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"A=227-467"}]},{"database":"PDB","id":"7PDT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A/B=227-467"}]},{"database":"PDB","id":"7QAA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.76 A"},{"key":"Chains","value":"A=230-462"}]},{"database":"PDB","id":"8J54","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.72 A"},{"key":"Chains","value":"C/D/E/F=135-217"}]},{"database":"PDBsum","id":"1DKF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1XDK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3A9E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7AOS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7PDQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7PDT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7QAA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8J54","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"SASBDB","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"203038","properties":[{"key":"Interactions","value":"24"}]},{"database":"ComplexPortal","id":"CPX-505","properties":[{"key":"EntryName","value":"RXRalpha-PXR nuclear receptor complex"}]},{"database":"ComplexPortal","id":"CPX-5343","properties":[{"key":"EntryName","value":"RXRalpha-NCOA1 activated retinoic acid receptor complex"}]},{"database":"ComplexPortal","id":"CPX-584","properties":[{"key":"EntryName","value":"RXRalpha-RARalpha retinoic acid receptor complex"}]},{"database":"ComplexPortal","id":"CPX-643","properties":[{"key":"EntryName","value":"RXRalpha-NCOA2 activated retinoic acid receptor complex"}]},{"database":"ComplexPortal","id":"CPX-672","properties":[{"key":"EntryName","value":"RXRalpha-RXRalpha retinoic acid receptor complex"}]},{"database":"ComplexPortal","id":"CPX-673","properties":[{"key":"EntryName","value":"RXRalpha-VDR nuclear hormone receptor complex"}]},{"database":"ComplexPortal","id":"CPX-679","properties":[{"key":"EntryName","value":"RXRalpha-LXRbeta nuclear hormone receptor complex"}]},{"database":"ComplexPortal","id":"CPX-708","properties":[{"key":"EntryName","value":"RXRalpha-LXRalpha nuclear hormone receptor complex"}]},{"database":"ComplexPortal","id":"CPX-710","properties":[{"key":"EntryName","value":"RXRalpha-TRbeta nuclear hormone receptor complex"}]},{"database":"ComplexPortal","id":"CPX-713","properties":[{"key":"EntryName","value":"RXRalpha-TRalpha nuclear hormone receptor complex"}]},{"database":"ComplexPortal","id":"CPX-818","properties":[{"key":"EntryName","value":"RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex"}]},{"database":"CORUM","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P28700","properties":[{"key":"Number of interactors","value":"1018"}]},{"database":"IntAct","id":"P28700","properties":[{"key":"Interactions","value":"22"}]},{"database":"MINT","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000076491","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3084","properties":[{"key":"Description","value":"-"}]},{"database":"DrugCentral","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"610","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P28700","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000076491","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"260961","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3881","properties":[{"key":"antibodies","value":"431 antibodies from 43 providers"}]},{"database":"DNASU","id":"20181","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000077257.12","properties":[{"key":"ProteinId","value":"ENSMUSP00000076491.6"},{"key":"GeneId","value":"ENSMUSG00000015846.17"}]},{"database":"GeneID","id":"20181","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:20181","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008ixs.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:98214","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6256","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:98214","properties":[{"key":"GeneName","value":"Rxra"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000015846","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3575","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000159789","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ILLRAXF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"35623at9989","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-159418","properties":[{"key":"PathwayName","value":"Recycling of bile acids and salts"}]},{"database":"Reactome","id":"R-MMU-192105","properties":[{"key":"PathwayName","value":"Synthesis of bile acids and bile salts"}]},{"database":"Reactome","id":"R-MMU-193368","properties":[{"key":"PathwayName","value":"Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"}]},{"database":"Reactome","id":"R-MMU-193807","properties":[{"key":"PathwayName","value":"Synthesis of bile acids and bile salts via 27-hydroxycholesterol"}]},{"database":"Reactome","id":"R-MMU-200425","properties":[{"key":"PathwayName","value":"Carnitine shuttle"}]},{"database":"Reactome","id":"R-MMU-211976","properties":[{"key":"PathwayName","value":"Endogenous sterols"}]},{"database":"Reactome","id":"R-MMU-381340","properties":[{"key":"PathwayName","value":"Transcriptional regulation of white adipocyte differentiation"}]},{"database":"Reactome","id":"R-MMU-383280","properties":[{"key":"PathwayName","value":"Nuclear Receptor transcription pathway"}]},{"database":"Reactome","id":"R-MMU-400206","properties":[{"key":"PathwayName","value":"Regulation of lipid metabolism by PPARalpha"}]},{"database":"Reactome","id":"R-MMU-4090294","properties":[{"key":"PathwayName","value":"SUMOylation of intracellular receptors"}]},{"database":"Reactome","id":"R-MMU-5362517","properties":[{"key":"PathwayName","value":"Signaling by Retinoic Acid"}]},{"database":"Reactome","id":"R-MMU-9029569","properties":[{"key":"PathwayName","value":"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"}]},{"database":"Reactome","id":"R-MMU-9616222","properties":[{"key":"PathwayName","value":"Transcriptional regulation of granulopoiesis"}]},{"database":"Reactome","id":"R-MMU-9623433","properties":[{"key":"PathwayName","value":"NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis"}]},{"database":"Reactome","id":"R-MMU-9707564","properties":[{"key":"PathwayName","value":"Cytoprotection by HMOX1"}]},{"database":"Reactome","id":"R-MMU-9841922","properties":[{"key":"PathwayName","value":"MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"}]},{"database":"BioGRID-ORCS","id":"20181","properties":[{"key":"hits","value":"4 hits in 83 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"P28700","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P28700","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"P28700","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000015846","properties":[{"key":"ExpressionPatterns","value":"Expressed in lip and 262 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P28700","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10385625"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17952069"}]},{"database":"GO","id":"GO:0090575","properties":[{"key":"GoTerm","value":"C:RNA polymerase II transcription regulator complex"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17107947"}]},{"database":"GO","id":"GO:0043235","properties":[{"key":"GoTerm","value":"C:signaling receptor complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"21152046"}]},{"database":"GO","id":"GO:0031490","properties":[{"key":"GoTerm","value":"F:chromatin DNA binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17952069"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29431742"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15601870"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15681609"}]},{"database":"GO","id":"GO:0050692","properties":[{"key":"GoTerm","value":"F:DNA binding domain binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"7760852"}]},{"database":"GO","id":"GO:0003690","properties":[{"key":"GoTerm","value":"F:double-stranded DNA binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0019899","properties":[{"key":"GoTerm","value":"F:enzyme binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"ISO:MGI"}]},{"database":"GO","id":"GO:0050693","properties":[{"key":"GoTerm","value":"F:LBD domain binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0004879","properties":[{"key":"GoTerm","value":"F:nuclear receptor activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312497"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15322135"}]},{"database":"GO","id":"GO:0042974","properties":[{"key":"GoTerm","value":"F:nuclear retinoic acid receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0003707","properties":[{"key":"GoTerm","value":"F:nuclear steroid receptor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046966","properties":[{"key":"GoTerm","value":"F:nuclear thyroid hormone receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0042809","properties":[{"key":"GoTerm","value":"F:nuclear vitamin D receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0042277","properties":[{"key":"GoTerm","value":"F:peptide binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0019904","properties":[{"key":"GoTerm","value":"F:protein domain specific binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0044877","properties":[{"key":"GoTerm","value":"F:protein-containing complex binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0001972","properties":[{"key":"GoTerm","value":"F:retinoic acid binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0044323","properties":[{"key":"GoTerm","value":"F:retinoic acid-responsive element binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15319426"}]},{"database":"GO","id":"GO:0001162","properties":[{"key":"GoTerm","value":"F:RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12015306"}]},{"database":"GO","id":"GO:0000977","properties":[{"key":"GoTerm","value":"F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"ISO:MGI"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"7823919"}]},{"database":"GO","id":"GO:1990837","properties":[{"key":"GoTerm","value":"F:sequence-specific double-stranded DNA binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0001223","properties":[{"key":"GoTerm","value":"F:transcription coactivator binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"17641689"}]},{"database":"GO","id":"GO:0001221","properties":[{"key":"GoTerm","value":"F:transcription coregulator binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0070644","properties":[{"key":"GoTerm","value":"F:vitamin D response element binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0060978","properties":[{"key":"GoTerm","value":"P:angiogenesis involved in coronary vascular morphogenesis"},{"key":"GoEvidenceType","value":"TAS:DFLAT"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"20299672"}]},{"database":"GO","id":"GO:0043010","properties":[{"key":"GoTerm","value":"P:camera-type eye development"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"9376317"}]},{"database":"GO","id":"GO:0055007","properties":[{"key":"GoTerm","value":"P:cardiac muscle cell differentiation"},{"key":"GoEvidenceType","value":"TAS:DFLAT"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"20299672"}]},{"database":"GO","id":"GO:0060038","properties":[{"key":"GoTerm","value":"P:cardiac muscle cell proliferation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9428411"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048469","properties":[{"key":"GoTerm","value":"P:cell maturation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0071404","properties":[{"key":"GoTerm","value":"P:cellular response to low-density lipoprotein particle stimulus"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007566","properties":[{"key":"GoTerm","value":"P:embryo implantation"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"9892670"}]},{"database":"GO","id":"GO:0010467","properties":[{"key":"GoTerm","value":"P:gene expression"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29431742"}]},{"database":"GO","id":"GO:0007507","properties":[{"key":"GoTerm","value":"P:heart development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9550726"}]},{"database":"GO","id":"GO:0003007","properties":[{"key":"GoTerm","value":"P:heart morphogenesis"},{"key":"GoEvidenceType","value":"TAS:DFLAT"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"20299672"}]},{"database":"GO","id":"GO:0009755","properties":[{"key":"GoTerm","value":"P:hormone-mediated signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0001701","properties":[{"key":"GoTerm","value":"P:in utero embryonic development"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"9892670"}]},{"database":"GO","id":"GO:0001893","properties":[{"key":"GoTerm","value":"P:maternal placenta development"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"9892670"}]},{"database":"GO","id":"GO:0060485","properties":[{"key":"GoTerm","value":"P:mesenchyme development"},{"key":"GoEvidenceType","value":"TAS:DFLAT"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"20299672"}]},{"database":"GO","id":"GO:0030224","properties":[{"key":"GoTerm","value":"P:monocyte differentiation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0042789","properties":[{"key":"GoTerm","value":"P:mRNA transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312497"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8910441"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0010629","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression"},{"key":"GoEvidenceType","value":"TAS:DFLAT"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"20299672"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"22001906"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0071630","properties":[{"key":"GoTerm","value":"P:nuclear protein quality control by the ubiquitin-proteasome system"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0035357","properties":[{"key":"GoTerm","value":"P:peroxisome proliferator activated receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0001890","properties":[{"key":"GoTerm","value":"P:placenta development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9356169"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0030501","properties":[{"key":"GoTerm","value":"P:positive regulation of bone mineralization"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"27184385"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"7744009"}]},{"database":"GO","id":"GO:0140077","properties":[{"key":"GoTerm","value":"P:positive regulation of lipoprotein transport"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0002157","properties":[{"key":"GoTerm","value":"P:positive regulation of thyroid hormone receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8910441"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17107947"}]},{"database":"GO","id":"GO:0045994","properties":[{"key":"GoTerm","value":"P:positive regulation of translational initiation by iron"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"23775127"}]},{"database":"GO","id":"GO:0070564","properties":[{"key":"GoTerm","value":"P:positive regulation of vitamin D receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0060687","properties":[{"key":"GoTerm","value":"P:regulation of branching involved in prostate gland morphogenesis"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12183441"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15322135"}]},{"database":"GO","id":"GO:0031641","properties":[{"key":"GoTerm","value":"P:regulation of myelination"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"7760852"}]},{"database":"GO","id":"GO:0051384","properties":[{"key":"GoTerm","value":"P:response to glucocorticoid"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0032526","properties":[{"key":"GoTerm","value":"P:response to retinoic acid"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0048384","properties":[{"key":"GoTerm","value":"P:retinoic acid receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312497"}]},{"database":"GO","id":"GO:0060528","properties":[{"key":"GoTerm","value":"P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12183441"}]},{"database":"GO","id":"GO:0055012","properties":[{"key":"GoTerm","value":"P:ventricular cardiac muscle cell differentiation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9428411"}]},{"database":"GO","id":"GO:0055010","properties":[{"key":"GoTerm","value":"P:ventricular cardiac muscle tissue morphogenesis"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9428411"}]},{"database":"GO","id":"GO:0061032","properties":[{"key":"GoTerm","value":"P:visceral serous pericardium development"},{"key":"GoEvidenceType","value":"TAS:DFLAT"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"20299672"}]},{"database":"CDD","id":"cd06956","properties":[{"key":"EntryName","value":"NR_DBD_RXR"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd06943","properties":[{"key":"EntryName","value":"NR_LBD_RXR_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.565.10:FF:000002","properties":[{"key":"EntryName","value":"Retinoic acid receptor RXR-alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.50.10:FF:000005","properties":[{"key":"EntryName","value":"Retinoic acid receptor RXR-alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.50.10","properties":[{"key":"EntryName","value":"Erythroid Transcription Factor GATA-1, subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.565.10","properties":[{"key":"EntryName","value":"Retinoid X Receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR035500","properties":[{"key":"EntryName","value":"NHR-like_dom_sf"}]},{"database":"InterPro","id":"IPR021780","properties":[{"key":"EntryName","value":"Nuc_recep-AF1"}]},{"database":"InterPro","id":"IPR000536","properties":[{"key":"EntryName","value":"Nucl_hrmn_rcpt_lig-bd"}]},{"database":"InterPro","id":"IPR050274","properties":[{"key":"EntryName","value":"Nuclear_hormone_rcpt_NR2"}]},{"database":"InterPro","id":"IPR001723","properties":[{"key":"EntryName","value":"Nuclear_hrmn_rcpt"}]},{"database":"InterPro","id":"IPR000003","properties":[{"key":"EntryName","value":"Retinoid-X_rcpt/HNF4"}]},{"database":"InterPro","id":"IPR001628","properties":[{"key":"EntryName","value":"Znf_hrmn_rcpt"}]},{"database":"InterPro","id":"IPR013088","properties":[{"key":"EntryName","value":"Znf_NHR/GATA"}]},{"database":"PANTHER","id":"PTHR24083","properties":[{"key":"EntryName","value":"NUCLEAR HORMONE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00104","properties":[{"key":"EntryName","value":"Hormone_recep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11825","properties":[{"key":"EntryName","value":"Nuc_recep-AF1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00105","properties":[{"key":"EntryName","value":"zf-C4"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00545","properties":[{"key":"EntryName","value":"RETINOIDXR"}]},{"database":"PRINTS","id":"PR00398","properties":[{"key":"EntryName","value":"STRDHORMONER"}]},{"database":"PRINTS","id":"PR00047","properties":[{"key":"EntryName","value":"STROIDFINGER"}]},{"database":"SMART","id":"SM00430","properties":[{"key":"EntryName","value":"HOLI"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00399","properties":[{"key":"EntryName","value":"ZnF_C4"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57716","properties":[{"key":"EntryName","value":"Glucocorticoid receptor-like (DNA-binding domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48508","properties":[{"key":"EntryName","value":"Nuclear receptor ligand-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51843","properties":[{"key":"EntryName","value":"NR_LBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00031","properties":[{"key":"EntryName","value":"NUCLEAR_REC_DBD_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51030","properties":[{"key":"EntryName","value":"NUCLEAR_REC_DBD_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDTKHFLPLDFSTQVNSSSLNSPTGRGSMAVPSLHPSLGPGIGSPLGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFGTGSPQLNSPMNPVSSTEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQAT","length":467,"molWeight":51217,"crc64":"0AF62396BCDC87DB","md5":"35E80B91C8DF653AE68462D3F7A01CAE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":7,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1,"PTM":4,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"DNA binding":1,"Zinc finger":2,"Region":6,"Compositional bias":5,"Binding site":12,"Modified residue":9,"Cross-link":2,"Mutagenesis":12,"Turn":3,"Beta strand":4,"Helix":18},"uniParcId":"UPI0000028D9C"}}