{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P27797","secondaryAccessions":["Q6IAT4","Q9UDG2"],"uniProtkbId":"CALR_HUMAN","entryAudit":{"firstPublicDate":"1992-08-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1992-08-01","entryVersion":268,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9427624"}],"value":"Calreticulin"}},"alternativeNames":[{"fullName":{"value":"CRP55"}},{"fullName":{"value":"Calregulin"}},{"fullName":{"value":"Endoplasmic reticulum resident protein 60"},"shortNames":[{"value":"ERp60"}]},{"fullName":{"value":"HACBP"}},{"fullName":{"value":"grp60"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1455"}],"value":"CALR"},"synonyms":[{"value":"CRTC"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28491"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8K3H7"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11149926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7876246"}],"value":"Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P14211"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P18418"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10605026"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11149926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19154346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20801878"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23614004"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30157172"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8666824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9427624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9640257"}],"value":"Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and SPACA9 (By similarity). Interacts with TRIM21 (PubMed:8666824). Interacts with NR3C1 (PubMed:11149926). Interacts with PPIB (PubMed:20801878). Interacts (via P-domain) with PDIA5 (PubMed:23614004). Interacts with GABARAP (PubMed:19154346). Interacts with HLA-E-B2M and HLA-G-B2M complexes (PubMed:9427624, PubMed:9640257). Interacts with HLA-F (PubMed:10605026). Interacts with CLCC1 (PubMed:30157172)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"Q8N1W1-4","geneName":"ARHGEF28","intActId":"EBI-13062134"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"Q8TAB5","geneName":"C1orf216","intActId":"EBI-747505"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"O94983-5","geneName":"CAMTA2","intActId":"EBI-10176008"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"O75175","geneName":"CNOT3","intActId":"EBI-743073"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"Q6UXH1-2","geneName":"CRELD2","intActId":"EBI-21670927"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"P49184","geneName":"DNASE1L1","intActId":"EBI-20894690"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"Q8IY82","geneName":"DRC7","intActId":"EBI-10262896"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"Q99944","geneName":"EGFL8","intActId":"EBI-3924130"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"P16422","geneName":"EPCAM","intActId":"EBI-1171184"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"Q9NVM1","geneName":"EVA1B","intActId":"EBI-10314666"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"Q96GK7","geneName":"FAHD2A","intActId":"EBI-21647872"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"Q10981","geneName":"FUT2","intActId":"EBI-9090702"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"O95166","geneName":"GABARAP","intActId":"EBI-712001"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"P36382","geneName":"GJA5","intActId":"EBI-750433"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"P09471","geneName":"GNAO1","intActId":"EBI-715087"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"O15499","geneName":"GSC2","intActId":"EBI-19954058"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"P79483","geneName":"HLA-DRB3","intActId":"EBI-3910269"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"P14060","geneName":"HSD3B1","intActId":"EBI-17426018"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"P04792","geneName":"HSPB1","intActId":"EBI-352682"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"Q7Z6Z7-2","geneName":"HUWE1","intActId":"EBI-10975491"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"O75874","geneName":"IDH1","intActId":"EBI-715695"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P27797","intActId":"EBI-1049597"},"interactantTwo":{"uniProtKBAccession":"Q9ULR0","geneName":"IS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LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28491"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8K3H7"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8418194"}],"value":"Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). 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