{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P26358","secondaryAccessions":["A0AV63","B7ZLW6","Q9UHG5","Q9ULA2","Q9UMZ6"],"uniProtkbId":"DNMT1_HUMAN","entryAudit":{"firstPublicDate":"1992-05-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-01-11","entryVersion":253,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"DNA (cytosine-5)-methyltransferase 1"},"shortNames":[{"value":"Dnmt1"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21745816"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"}],"value":"2.1.1.37"}]},"alternativeNames":[{"fullName":{"value":"CXXC-type zinc finger protein 9"}},{"fullName":{"value":"DNA methyltransferase HsaI"},"shortNames":[{"value":"DNA MTase HsaI"},{"value":"M.HsaI"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9302295"}],"value":"MCMT"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2976"}],"value":"DNMT1"},"synonyms":[{"value":"AIM"},{"value":"CXXC9"},{"value":"DNMT"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10888872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16357870"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17200670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18413740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18754681"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21745816"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24623306"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"}],"value":"DNA methyltransferase that methylates CpG residues (PubMed:17200670, PubMed:18754681, PubMed:21745816, PubMed:26070743). Preferentially methylates hemimethylated DNA (PubMed:21745816, PubMed:26070743). Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance (PubMed:17200670, PubMed:21745816). Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication (PubMed:21745816). It is responsible for maintaining methylation patterns established in development (PubMed:21745816). DNA methylation is coordinated with methylation of histones (PubMed:16357870). Mediates transcriptional repression by direct binding to HDAC2 (PubMed:10888872). In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9 (PubMed:18413740). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13681"},{"database":"Rhea","id":"RHEA-COMP:11369"},{"database":"Rhea","id":"RHEA-COMP:11370"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:85452"},{"database":"ChEBI","id":"CHEBI:85454"}],"ecNumber":"2.1.1.37","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10018"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21745816"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P13864"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10888872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10888886"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10947852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12145218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16357870"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19173286"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19450230"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21745816"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24492612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24623306"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29691401"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32051553"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9302295"}],"value":"Homodimer (PubMed:19173286). Forms a stable complex with E2F1, BB1 and HDAC1 (PubMed:10888886). Forms a complex with DMAP1 and HDAC2, with direct interaction (PubMed:10888872). Interacts with the PRC2/EED-EZH2 complex (PubMed:16357870). Probably part of a corepressor complex containing ZNF304, TRIM28, SETDB1 and DNMT1 (PubMed:24623306). Interacts with UHRF1; promoting its recruitment to hemimethylated DNA (PubMed:21745816). Interacts with USP7, promoting its deubiquitination (PubMed:21745816). Interacts with PCNA (PubMed:9302295). Interacts with MBD2 and MBD3 (PubMed:10947852). Interacts with DNMT3A and DNMT3B (PubMed:12145218). Interacts with UBC9 (PubMed:19450230). Interacts with CSNK1D (By similarity). Interacts with HDAC1 (By similarity). Interacts with BAZ2A/TIP5 (By similarity). Interacts with SIRT7 (By similarity). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (PubMed:32051553). Interacts with L3MBTL3 and DCAF5; the interaction requires DNMT1 methylation at Lys-142 and is necessary to target DNMT1 for ubiquitination by the CRL4-DCAF5 E3 ubiquitin ligase complex and proteasomal degradation (PubMed:29691401). Interacts with PHF20L1; the interaction requires DNMT1 methylation at Lys-142 and protects DNMT1 from ubiquitination and proteasomal degradation (PubMed:24492612)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"P31749","geneName":"AKT1","intActId":"EBI-296087"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"P35222","geneName":"CTNNB1","intActId":"EBI-491549"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"Q96JK2","geneName":"DCAF5","intActId":"EBI-3253159"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"O75530","geneName":"EED","intActId":"EBI-923794"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"Q15910","geneName":"EZH2","intActId":"EBI-530054"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"Q96JM7","geneName":"L3MBTL3","intActId":"EBI-2686809"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"P48552","geneName":"NRIP1","intActId":"EBI-746484"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"P09874","geneName":"PARP1","intActId":"EBI-355676"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"Q9NRD5","geneName":"PICK1","intActId":"EBI-79165"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"Q8WTS6","geneName":"SETD7","intActId":"EBI-1268586"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"Q96EB6","geneName":"SIRT1","intActId":"EBI-1802965"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"Q96T88","geneName":"UHRF1","intActId":"EBI-1548946"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"P63104","geneName":"YWHAZ","intActId":"EBI-347088"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"Q77UV9","geneName":"KIE-2","intActId":"EBI-2608731"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P26358","intActId":"EBI-719459"},"interactantTwo":{"uniProtKBAccession":"Q9QR71","geneName":"LANA1","intActId":"EBI-15602554"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24492612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29053958"}],"value":"Associates with replication foci during S-phase: recruited to hemimethylated DNA sites via its RFTS domain, which specifically recognizes and binds histone H3 ubiquitinated at 'Lys-14', 'Lys-18' and 'Lys-23' (H3K14ub, H3K18ub and H3K23ub, respectively) (PubMed:29053958). Localized to the perinucleolar region (PubMed:24492612)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12145218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24492612"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29053958"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P26358-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"Dnmt1b"}],"isoformIds":["P26358-2"],"sequenceIds":["VSP_005618"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P26358-3"],"sequenceIds":["VSP_005617"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10325416"}],"value":"Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10888872"}],"value":"Its abundance is reduced to non detectable levels at the G0 phase of the cell cycle and is dramatically induced upon entrance into the S-phase of the cell cycle"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29053958"}],"value":"The RFTS domain specifically recognizes and binds histone H3 monoubiquitinated at two sites, either at 'Lys-14', 'Lys-18' and/or 'Lys-23' (H3K14ub, H3K18ub and H3K23ub, respectively) (PubMed:29053958). These histone marks are present at hemimethylated DNA sites at replication forks and act as docking site for DNMT1 (PubMed:29053958). In absence of H3K14ub, H3K18ub and H3K23ub chromatin marks, the RFTS domain inhibits the DNA methyltransferase activity by forming hydrogen bonds with the catalytic center (PubMed:29053958). Binding to ubiquitinated histones relieves inhibition (PubMed:29053958)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"}],"value":"The CXXC-type zinc finger specifically binds to unmethylated CpG dinucleotides, positioning the autoinhibitory linker between the DNA and the active site, thus providing a mechanism to ensure that only hemimethylated CpG dinucleotides undergo methylation"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19450230"}],"value":"Sumoylated; sumoylation increases activity"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}],"value":"Acetylation on multiple lysines, mainly by KAT2B/PCAF, regulates cell cycle G(2)/M transition (PubMed:21947282). Deacetylation of Lys-1349 and Lys-1415 by SIRT1 increases methyltransferase activity (PubMed:21947282)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21151116"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21565170"}],"value":"Phosphorylation of Ser-154 by CDKs is important for enzymatic activity and protein stability. Phosphorylation of Ser-143 by AKT1 prevents methylation by SETD7 thereby increasing DNMT1 stability"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18438403"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21151116"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24492612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29691401"}],"value":"Methylation at Lys-142 by SETD7 is necessary for the regulation of DNMT1 proteasomal degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P13864"}],"value":"Ubiquitinated by UHRF1; interaction with USP7 counteracts ubiquitination by UHRF1 by promoting deubiquitination and preventing degradation by the proteasome"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Neuropathy, hereditary sensory, 1E","diseaseAccession":"DI-03189","acronym":"HSN1E","description":"A neurodegenerative disorder characterized by adult onset of progressive peripheral sensory loss associated with progressive hearing impairment and early-onset dementia.","diseaseCrossReference":{"database":"MIM","id":"614116"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21532572"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant","diseaseAccession":"DI-03793","acronym":"ADCADN","description":"An autosomal dominant neurologic disorder characterized by adult onset of progressive cerebellar ataxia, narcolepsy, cataplexy, sensorineural deafness, and dementia. More variable features include optic atrophy, sensory neuropathy, psychosis, and depression.","diseaseCrossReference":{"database":"MIM","id":"604121"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22328086"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01016"}],"value":"Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAD54507.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/40347/DNMT1","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1616,"modifier":"EXACT"}},"description":"DNA (cytosine-5)-methyltransferase 1","featureId":"PRO_0000088034"},{"type":"Domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"DMAP1-binding","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01260"}]},{"type":"Domain","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"RFTS","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21389349"}]},{"type":"Domain","location":{"start":{"value":755,"modifier":"EXACT"},"end":{"value":880,"modifier":"EXACT"}},"description":"BAH 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00370"}]},{"type":"Domain","location":{"start":{"value":972,"modifier":"EXACT"},"end":{"value":1100,"modifier":"EXACT"}},"description":"BAH 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00370"}]},{"type":"Repeat","location":{"start":{"value":1109,"modifier":"EXACT"},"end":{"value":1110,"modifier":"EXACT"}},"description":"1"},{"type":"Repeat","location":{"start":{"value":1111,"modifier":"EXACT"},"end":{"value":1112,"modifier":"EXACT"}},"description":"2"},{"type":"Repeat","location":{"start":{"value":1113,"modifier":"EXACT"},"end":{"value":1114,"modifier":"EXACT"}},"description":"3"},{"type":"Repeat","location":{"start":{"value":1115,"modifier":"EXACT"},"end":{"value":1116,"modifier":"EXACT"}},"description":"4"},{"type":"Repeat","location":{"start":{"value":1117,"modifier":"EXACT"},"end":{"value":1118,"modifier":"EXACT"}},"description":"5"},{"type":"Repeat","location":{"start":{"value":1119,"modifier":"EXACT"},"end":{"value":1120,"modifier":"EXACT"}},"description":"6; approximate"},{"type":"Domain","location":{"start":{"value":1139,"modifier":"EXACT"},"end":{"value":1599,"modifier":"EXACT"}},"description":"SAM-dependent MTase C5-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01016"}]},{"type":"Zinc finger","location":{"start":{"value":646,"modifier":"EXACT"},"end":{"value":692,"modifier":"EXACT"}},"description":"CXXC-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Interaction with the PRC2/EED-EZH2 complex","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P13864"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"Interaction with DNMT3A","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12145218"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Interaction with DMAP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10888872"}]},{"type":"Region","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Interaction with DNMT3B","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12145218"}]},{"type":"Region","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Interaction with PCNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9302295"}]},{"type":"Region","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":606,"modifier":"EXACT"}},"description":"Interaction with the PRC2/EED-EZH2 complex","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P13864"}]},{"type":"Region","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":502,"modifier":"EXACT"}},"description":"Homodimerization","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"}]},{"type":"Region","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Ubiquitin-interacting motif (UIM)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P13864"}]},{"type":"Region","location":{"start":{"value":651,"modifier":"EXACT"},"end":{"value":697,"modifier":"EXACT"}},"description":"Required for activity","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"}]},{"type":"Region","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":754,"modifier":"EXACT"}},"description":"Autoinhibitory linker","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"}]},{"type":"Region","location":{"start":{"value":699,"modifier":"EXACT"},"end":{"value":729,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1095,"modifier":"EXACT"},"end":{"value":1130,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1109,"modifier":"EXACT"},"end":{"value":1120,"modifier":"EXACT"}},"description":"6 X 2 AA tandem repeats of K-G"},{"type":"Region","location":{"start":{"value":1121,"modifier":"EXACT"},"end":{"value":1616,"modifier":"EXACT"}},"description":"Interaction with the PRC2/EED-EZH2 complex","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P13864"}]},{"type":"Motif","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":699,"modifier":"EXACT"},"end":{"value":709,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":716,"modifier":"EXACT"},"end":{"value":728,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1110,"modifier":"EXACT"},"end":{"value":1120,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":1226,"modifier":"EXACT"},"end":{"value":1226,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19450230"}]},{"type":"Binding site","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21389349"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29053958"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5WVO"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21389349"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29053958"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5WVO"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21389349"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29053958"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5WVO"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":418,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21389349"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29053958"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5WVO"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":653,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3PTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":656,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3PTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":659,"modifier":"EXACT"},"end":{"value":659,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3PTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":664,"modifier":"EXACT"},"end":{"value":664,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":667,"modifier":"EXACT"},"end":{"value":667,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3PTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":670,"modifier":"EXACT"},"end":{"value":670,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":686,"modifier":"EXACT"},"end":{"value":686,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3PTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":691,"modifier":"EXACT"},"end":{"value":691,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":793,"modifier":"EXACT"},"end":{"value":793,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":820,"modifier":"EXACT"},"end":{"value":820,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":893,"modifier":"EXACT"},"end":{"value":893,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":896,"modifier":"EXACT"},"end":{"value":896,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":1150,"modifier":"EXACT"},"end":{"value":1150,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":1151,"modifier":"EXACT"},"end":{"value":1151,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":1168,"modifier":"EXACT"},"end":{"value":1168,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3PTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":1169,"modifier":"EXACT"},"end":{"value":1169,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3PTA"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":1190,"modifier":"EXACT"},"end":{"value":1190,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":1191,"modifier":"EXACT"},"end":{"value":1191,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3PTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":1476,"modifier":"EXACT"},"end":{"value":1476,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":1478,"modifier":"EXACT"},"end":{"value":1478,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":1485,"modifier":"EXACT"},"end":{"value":1485,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":1502,"modifier":"EXACT"},"end":{"value":1502,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":1578,"modifier":"EXACT"},"end":{"value":1578,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21163962"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3PTA"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":1580,"modifier":"EXACT"},"end":{"value":1580,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Modified residue","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"N6,N6-dimethyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18438403"}]},{"type":"Modified residue","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P13864"}]},{"type":"Modified residue","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"N6-methyllysine; by SETD7","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21151116"}]},{"type":"Modified residue","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Phosphoserine; by PKB/AKT1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21151116"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21565170"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":509,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P13864"}]},{"type":"Modified residue","location":{"start":{"value":549,"modifier":"EXACT"},"end":{"value":549,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":714,"modifier":"EXACT"},"end":{"value":714,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":732,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18220336"}]},{"type":"Modified residue","location":{"start":{"value":749,"modifier":"EXACT"},"end":{"value":749,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":878,"modifier":"EXACT"},"end":{"value":878,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":891,"modifier":"EXACT"},"end":{"value":891,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":957,"modifier":"EXACT"},"end":{"value":957,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":961,"modifier":"EXACT"},"end":{"value":961,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":975,"modifier":"EXACT"},"end":{"value":975,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":1054,"modifier":"EXACT"},"end":{"value":1054,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":1111,"modifier":"EXACT"},"end":{"value":1111,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1113,"modifier":"EXACT"},"end":{"value":1113,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1115,"modifier":"EXACT"},"end":{"value":1115,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1117,"modifier":"EXACT"},"end":{"value":1117,"modifier":"EXACT"}},"description":"N6-acetyllysine; by EHMT2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":1119,"modifier":"EXACT"},"end":{"value":1119,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P13864"}]},{"type":"Modified residue","location":{"start":{"value":1121,"modifier":"EXACT"},"end":{"value":1121,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P13864"}]},{"type":"Modified residue","location":{"start":{"value":1349,"modifier":"EXACT"},"end":{"value":1349,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Modified residue","location":{"start":{"value":1415,"modifier":"EXACT"},"end":{"value":1415,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947282"}]},{"type":"Cross-link","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":1609,"modifier":"EXACT"},"end":{"value":1609,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_005617","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_005618","alternativeSequence":{"originalSequence":"P","alternativeSequences":["RSRDPPASASQVTGIRA"]}},{"type":"Natural variant","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"in dbSNP:rs16999593","featureCrossReferences":[{"database":"dbSNP","id":"rs16999593"}],"featureId":"VAR_024605","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"in dbSNP:rs2228612","featureCrossReferences":[{"database":"dbSNP","id":"rs2228612"}],"featureId":"VAR_051960","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":490,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"in HSN1E; unstable protein with decreased enzymatic activity and impaired heterochromatin binding ability after the S phase; dbSNP:rs199473691","featureCrossReferences":[{"database":"dbSNP","id":"rs199473691"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21532572"}],"featureId":"VAR_065965","alternativeSequence":{"originalSequence":"DP","alternativeSequences":["EY"]}},{"type":"Natural variant","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"in HSN1E; unstable protein with decreased enzymatic activity and impaired heterochromatin binding ability after the S phase; dbSNP:rs199473690","featureCrossReferences":[{"database":"dbSNP","id":"rs199473690"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21532572"}],"featureId":"VAR_065966","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":554,"modifier":"EXACT"},"end":{"value":554,"modifier":"EXACT"}},"description":"in ADCADN; dbSNP:rs397509392","featureCrossReferences":[{"database":"dbSNP","id":"rs397509392"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22328086"}],"featureId":"VAR_070055","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":589,"modifier":"EXACT"},"end":{"value":589,"modifier":"EXACT"}},"description":"in ADCADN; dbSNP:rs397509393","featureCrossReferences":[{"database":"dbSNP","id":"rs397509393"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22328086"}],"featureId":"VAR_070056","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":590,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"in ADCADN; dbSNP:rs397509391","featureCrossReferences":[{"database":"dbSNP","id":"rs397509391"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22328086"}],"featureId":"VAR_070057","alternativeSequence":{"originalSequence":"V","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Loss of interaction with L3MBTL3 and DCAF5. Loss of ubiquitination by the CRL4-DCAF5 E3 ubiquitin ligase complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29691401"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"Abolishes interaction with PCNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9302295"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"Abolishes interaction with PCNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9302295"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"Abolishes interaction with PCNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9302295"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"Abolishes interaction with PCNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9302295"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"No loss of interaction with PCNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9302295"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Abolishes interaction with PCNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9302295"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Abolishes interaction with PCNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9302295"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"No loss of interaction with PCNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9302295"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"No loss of interaction with PCNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9302295"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"Slightly increased association with hemimethylated DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26070743"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":653,"modifier":"EXACT"}},"description":"Reduces activity about 10-fold; when associated with G-656; G-659; G-664; G-667 and G-670.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18754681"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":656,"modifier":"EXACT"}},"description":"Reduces activity about 10-fold; when associated with G-653; G-659; G-664; G-667 and G-670.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18754681"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":659,"modifier":"EXACT"},"end":{"value":659,"modifier":"EXACT"}},"description":"Reduces activity about 10-fold; when associated with G-653; G-656; G-664; G-667 and G-670.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18754681"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":664,"modifier":"EXACT"},"end":{"value":664,"modifier":"EXACT"}},"description":"Reduces activity about 10-fold; when associated with G-653; G-656; G-659; G-667 and G-670.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18754681"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":667,"modifier":"EXACT"},"end":{"value":667,"modifier":"EXACT"}},"description":"Reduces activity about 10-fold; when associated with G-653; G-656; G-659; G-664 and G-670.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18754681"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":670,"modifier":"EXACT"},"end":{"value":670,"modifier":"EXACT"}},"description":"Reduces activity about 10-fold; when associated with G-653; G-656; G-659; G-664 and G-667.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18754681"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":1226,"modifier":"EXACT"},"end":{"value":1226,"modifier":"EXACT"}},"description":"Loss of activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19450230"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8V9U"}]},{"type":"Helix","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8V9U"}]},{"type":"Helix","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8V9U"}]},{"type":"Helix","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8V9U"}]},{"type":"Helix","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6K3A"}]},{"type":"Turn","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5YDR"}]},{"type":"Beta strand","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5YDR"}]},{"type":"Helix","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5YDR"}]},{"type":"Helix","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Helix","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Beta strand","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Beta strand","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Beta strand","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Beta strand","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Turn","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":430,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Beta strand","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Beta strand","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Beta strand","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Beta strand","location":{"start":{"value":470,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Beta strand","location":{"start":{"value":476,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Beta strand","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Turn","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Helix","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Helix","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Helix","location":{"start":{"value":535,"modifier":"EXACT"},"end":{"value":537,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Helix","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3EPZ"}]},{"type":"Helix","location":{"start":{"value":542,"modifier":"EXACT"},"end":{"value":545,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5YDR"}]},{"type":"Helix","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":551,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Helix","location":{"start":{"value":554,"modifier":"EXACT"},"end":{"value":566,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Beta strand","location":{"start":{"value":575,"modifier":"EXACT"},"end":{"value":578,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Helix","location":{"start":{"value":579,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WVO"}]},{"type":"Helix","location":{"start":{"value":592,"modifier":"EXACT"},"end":{"value":597,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5YDR"}]},{"type":"Helix","location":{"start":{"value":615,"modifier":"EXACT"},"end":{"value":617,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XIB"}]},{"type":"Helix","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":628,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XIB"}]},{"type":"Turn","location":{"start":{"value":629,"modifier":"EXACT"},"end":{"value":631,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XIB"}]},{"type":"Turn","location":{"start":{"value":633,"modifier":"EXACT"},"end":{"value":635,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XIB"}]},{"type":"Turn","location":{"start":{"value":657,"modifier":"EXACT"},"end":{"value":659,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3SWR"}]},{"type":"Beta strand","location":{"start":{"value":665,"modifier":"EXACT"},"end":{"value":667,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XI9"}]},{"type":"Helix","location":{"start":{"value":670,"modifier":"EXACT"},"end":{"value":672,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3SWR"}]},{"type":"Helix","location":{"start":{"value":674,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XI9"}]},{"type":"Helix","location":{"start":{"value":684,"modifier":"EXACT"},"end":{"value":686,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WXX"}]},{"type":"Helix","location":{"start":{"value":687,"modifier":"EXACT"},"end":{"value":689,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3SWR"}]},{"type":"Helix","location":{"start":{"value":692,"modifier":"EXACT"},"end":{"value":703,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WXX"}]},{"type":"Helix","location":{"start":{"value":714,"modifier":"EXACT"},"end":{"value":717,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WXX"}]},{"type":"Helix","location":{"start":{"value":724,"modifier":"EXACT"},"end":{"value":726,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3SWR"}]},{"type":"Beta strand","location":{"start":{"value":731,"modifier":"EXACT"},"end":{"value":733,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SFC"}]},{"type":"Beta strand","location":{"start":{"value":738,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":744,"modifier":"EXACT"},"end":{"value":746,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":748,"modifier":"EXACT"},"end":{"value":752,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":755,"modifier":"EXACT"},"end":{"value":758,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":762,"modifier":"EXACT"},"end":{"value":765,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":767,"modifier":"EXACT"},"end":{"value":769,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3SWR"}]},{"type":"Beta strand","location":{"start":{"value":775,"modifier":"EXACT"},"end":{"value":785,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Turn","location":{"start":{"value":786,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":789,"modifier":"EXACT"},"end":{"value":799,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":800,"modifier":"EXACT"},"end":{"value":802,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":803,"modifier":"EXACT"},"end":{"value":805,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4YOC"}]},{"type":"Helix","location":{"start":{"value":806,"modifier":"EXACT"},"end":{"value":808,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":813,"modifier":"EXACT"},"end":{"value":824,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":825,"modifier":"EXACT"},"end":{"value":827,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":828,"modifier":"EXACT"},"end":{"value":832,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":834,"modifier":"EXACT"},"end":{"value":836,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":838,"modifier":"EXACT"},"end":{"value":840,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":843,"modifier":"EXACT"},"end":{"value":845,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":851,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":860,"modifier":"EXACT"},"end":{"value":870,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Turn","location":{"start":{"value":871,"modifier":"EXACT"},"end":{"value":874,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":875,"modifier":"EXACT"},"end":{"value":877,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":878,"modifier":"EXACT"},"end":{"value":880,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":882,"modifier":"EXACT"},"end":{"value":885,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9K"}]},{"type":"Turn","location":{"start":{"value":886,"modifier":"EXACT"},"end":{"value":891,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":894,"modifier":"EXACT"},"end":{"value":906,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":909,"modifier":"EXACT"},"end":{"value":916,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":918,"modifier":"EXACT"},"end":{"value":928,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":931,"modifier":"EXACT"},"end":{"value":934,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":938,"modifier":"EXACT"},"end":{"value":941,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":943,"modifier":"EXACT"},"end":{"value":945,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":952,"modifier":"EXACT"},"end":{"value":955,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SFF"}]},{"type":"Helix","location":{"start":{"value":957,"modifier":"EXACT"},"end":{"value":959,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9K"}]},{"type":"Helix","location":{"start":{"value":962,"modifier":"EXACT"},"end":{"value":964,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WXX"}]},{"type":"Turn","location":{"start":{"value":966,"modifier":"EXACT"},"end":{"value":968,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":972,"modifier":"EXACT"},"end":{"value":975,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":976,"modifier":"EXACT"},"end":{"value":980,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3SWR"}]},{"type":"Helix","location":{"start":{"value":987,"modifier":"EXACT"},"end":{"value":991,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":992,"modifier":"EXACT"},"end":{"value":1003,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1005,"modifier":"EXACT"},"end":{"value":1009,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9I"}]},{"type":"Beta strand","location":{"start":{"value":1011,"modifier":"EXACT"},"end":{"value":1013,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8XQC"}]},{"type":"Beta strand","location":{"start":{"value":1015,"modifier":"EXACT"},"end":{"value":1022,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1024,"modifier":"EXACT"},"end":{"value":1026,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1027,"modifier":"EXACT"},"end":{"value":1029,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1031,"modifier":"EXACT"},"end":{"value":1034,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1035,"modifier":"EXACT"},"end":{"value":1037,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XIB"}]},{"type":"Beta strand","location":{"start":{"value":1041,"modifier":"EXACT"},"end":{"value":1052,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1053,"modifier":"EXACT"},"end":{"value":1055,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1058,"modifier":"EXACT"},"end":{"value":1064,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1065,"modifier":"EXACT"},"end":{"value":1067,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1068,"modifier":"EXACT"},"end":{"value":1070,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XIB"}]},{"type":"Helix","location":{"start":{"value":1072,"modifier":"EXACT"},"end":{"value":1077,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1078,"modifier":"EXACT"},"end":{"value":1090,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Turn","location":{"start":{"value":1091,"modifier":"EXACT"},"end":{"value":1094,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1095,"modifier":"EXACT"},"end":{"value":1097,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SFC"}]},{"type":"Helix","location":{"start":{"value":1098,"modifier":"EXACT"},"end":{"value":1100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SFC"}]},{"type":"Helix","location":{"start":{"value":1101,"modifier":"EXACT"},"end":{"value":1103,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SFC"}]},{"type":"Helix","location":{"start":{"value":1136,"modifier":"EXACT"},"end":{"value":1138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1139,"modifier":"EXACT"},"end":{"value":1145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1150,"modifier":"EXACT"},"end":{"value":1158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1160,"modifier":"EXACT"},"end":{"value":1167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1171,"modifier":"EXACT"},"end":{"value":1180,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1185,"modifier":"EXACT"},"end":{"value":1187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1191,"modifier":"EXACT"},"end":{"value":1199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1211,"modifier":"EXACT"},"end":{"value":1213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XI9"}]},{"type":"Turn","location":{"start":{"value":1214,"modifier":"EXACT"},"end":{"value":1216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1219,"modifier":"EXACT"},"end":{"value":1222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Turn","location":{"start":{"value":1227,"modifier":"EXACT"},"end":{"value":1229,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9I"}]},{"type":"Beta strand","location":{"start":{"value":1231,"modifier":"EXACT"},"end":{"value":1233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1237,"modifier":"EXACT"},"end":{"value":1244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1247,"modifier":"EXACT"},"end":{"value":1258,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1261,"modifier":"EXACT"},"end":{"value":1268,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1269,"modifier":"EXACT"},"end":{"value":1272,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1274,"modifier":"EXACT"},"end":{"value":1290,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1293,"modifier":"EXACT"},"end":{"value":1300,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1301,"modifier":"EXACT"},"end":{"value":1304,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1311,"modifier":"EXACT"},"end":{"value":1318,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1323,"modifier":"EXACT"},"end":{"value":1330,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1336,"modifier":"EXACT"},"end":{"value":1338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1343,"modifier":"EXACT"},"end":{"value":1345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1348,"modifier":"EXACT"},"end":{"value":1350,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1363,"modifier":"EXACT"},"end":{"value":1365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1367,"modifier":"EXACT"},"end":{"value":1371,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1372,"modifier":"EXACT"},"end":{"value":1374,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8XQC"}]},{"type":"Beta strand","location":{"start":{"value":1384,"modifier":"EXACT"},"end":{"value":1386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1389,"modifier":"EXACT"},"end":{"value":1391,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XIB"}]},{"type":"Helix","location":{"start":{"value":1395,"modifier":"EXACT"},"end":{"value":1401,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1408,"modifier":"EXACT"},"end":{"value":1410,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XIB"}]},{"type":"Helix","location":{"start":{"value":1419,"modifier":"EXACT"},"end":{"value":1426,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1436,"modifier":"EXACT"},"end":{"value":1438,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1447,"modifier":"EXACT"},"end":{"value":1449,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9I"}]},{"type":"Beta strand","location":{"start":{"value":1451,"modifier":"EXACT"},"end":{"value":1453,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1454,"modifier":"EXACT"},"end":{"value":1456,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XIB"}]},{"type":"Beta strand","location":{"start":{"value":1459,"modifier":"EXACT"},"end":{"value":1461,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9I"}]},{"type":"Turn","location":{"start":{"value":1462,"modifier":"EXACT"},"end":{"value":1464,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1474,"modifier":"EXACT"},"end":{"value":1476,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XIB"}]},{"type":"Helix","location":{"start":{"value":1477,"modifier":"EXACT"},"end":{"value":1480,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1481,"modifier":"EXACT"},"end":{"value":1483,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1484,"modifier":"EXACT"},"end":{"value":1486,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XIB"}]},{"type":"Helix","location":{"start":{"value":1487,"modifier":"EXACT"},"end":{"value":1489,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1493,"modifier":"EXACT"},"end":{"value":1496,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1499,"modifier":"EXACT"},"end":{"value":1503,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1504,"modifier":"EXACT"},"end":{"value":1506,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1508,"modifier":"EXACT"},"end":{"value":1510,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Turn","location":{"start":{"value":1511,"modifier":"EXACT"},"end":{"value":1514,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1524,"modifier":"EXACT"},"end":{"value":1526,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Beta strand","location":{"start":{"value":1534,"modifier":"EXACT"},"end":{"value":1536,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SFF"}]},{"type":"Beta strand","location":{"start":{"value":1542,"modifier":"EXACT"},"end":{"value":1547,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1550,"modifier":"EXACT"},"end":{"value":1556,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1569,"modifier":"EXACT"},"end":{"value":1577,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]},{"type":"Helix","location":{"start":{"value":1582,"modifier":"EXACT"},"end":{"value":1598,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X9J"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0209","category":"Disease","name":"Deafness"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"id":"KW-0622","category":"Disease","name":"Neuropathy"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0949","category":"Ligand","name":"S-adenosyl-L-methionine"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"1594447","citationType":"journal article","authors":["Yen R.-W.C.","Vertino P.M.","Nelkin B.D.","Yu J.J.","Deiry W.E.","Cumaraswamy A.","Lennon G.G.","Trask B.J.","Celano P.","Baylin S.B."],"citationCrossReferences":[{"database":"PubMed","id":"1594447"},{"database":"DOI","id":"10.1093/nar/20.9.2287"}],"title":"Isolation and characterization of the cDNA encoding human DNA methyltransferase.","publicationDate":"1992","journal":"Nucleic Acids Res.","firstPage":"2287","lastPage":"2291","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"8940105","citationType":"journal article","authors":["Yoder J.A.","Yen R.-W.C.","Vertino P.M.","Bestor T.H.","Baylin S.B."],"citationCrossReferences":[{"database":"PubMed","id":"8940105"},{"database":"DOI","id":"10.1074/jbc.271.49.31092"}],"title":"New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.","publicationDate":"1996","journal":"J. Biol. Chem.","firstPage":"31092","lastPage":"31097","volume":"271"},"referencePositions":["SEQUENCE REVISION TO N-TERMINUS"]},{"referenceNumber":3,"citation":{"id":"CI-F6NMO9G0QQPUH","citationType":"submission","authors":["Li L.C.","Au H.","Chui R.","Dahiya R."],"title":"Human DNA methyltransferase (DNMT1) is alternatively spliced.","publicationDate":"AUG-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)"],"referenceComments":[{"value":"Prostatic carcinoma","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.S.","Terry A.","Schmutz J.","Lamerdin J.E.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.V.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.-H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.M.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"]},{"referenceNumber":6,"citation":{"id":"10449766","citationType":"journal article","authors":["Hsu D.-W.","Lin M.-J.","Lee T.-L.","Wen S.-C.","Chen X.","Shen C.-K.J."],"citationCrossReferences":[{"database":"PubMed","id":"10449766"},{"database":"DOI","id":"10.1073/pnas.96.17.9751"}],"title":"Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues.","publicationDate":"1999","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9751","lastPage":"9756","volume":"96"},"referencePositions":["PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2)"]},{"referenceNumber":7,"citation":{"id":"10753866","citationType":"journal article","authors":["Bonfils C.","Beaulieu N.","Chan E.","Cotton-Montpetit J.","MacLeod A.R."],"citationCrossReferences":[{"database":"PubMed","id":"10753866"},{"database":"DOI","id":"10.1074/jbc.275.15.10754"}],"title":"Characterization of the human DNA methyltransferase splice variant Dnmt1b.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"10754","lastPage":"10760","volume":"275"},"referencePositions":["PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2)"]},{"referenceNumber":8,"citation":{"id":"9302295","citationType":"journal article","authors":["Chuang L.S.-H.","Ian H.-I.","Koh T.-W.","Ng H.-H.","Xu G.","Li B.F.L."],"citationCrossReferences":[{"database":"PubMed","id":"9302295"},{"database":"DOI","id":"10.1126/science.277.5334.1996"}],"title":"Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1.","publicationDate":"1997","journal":"Science","firstPage":"1996","lastPage":"2000","volume":"277"},"referencePositions":["INTERACTION WITH PCNA","MUTAGENESIS OF ARG-163; GLN-164; THR-166; ILE-167; SER-169; HIS-170; PHE-171; ALA-172 AND LYS-173"]},{"referenceNumber":9,"citation":{"id":"10947852","citationType":"journal article","authors":["Tatematsu K.","Yamazaki T.","Ishikawa F."],"citationCrossReferences":[{"database":"PubMed","id":"10947852"},{"database":"DOI","id":"10.1046/j.1365-2443.2000.00359.x"}],"title":"MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase.","publicationDate":"2000","journal":"Genes Cells","firstPage":"677","lastPage":"688","volume":"5"},"referencePositions":["INTERACTION WITH MBD2 AND MBD3"]},{"referenceNumber":10,"citation":{"id":"10888872","citationType":"journal article","authors":["Rountree M.R.","Bachman K.E.","Baylin S.B."],"citationCrossReferences":[{"database":"PubMed","id":"10888872"},{"database":"DOI","id":"10.1038/77023"}],"title":"DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.","publicationDate":"2000","journal":"Nat. Genet.","firstPage":"269","lastPage":"277","volume":"25"},"referencePositions":["FUNCTION","INDUCTION","INTERACTION WITH HDAC2 AND DMAP1"]},{"referenceNumber":11,"citation":{"id":"10888886","citationType":"journal article","authors":["Robertson K.D.","Ait-Si-Ali S.","Yokochi T.","Wade P.A.","Jones P.L.","Wolffe A.P."],"citationCrossReferences":[{"database":"PubMed","id":"10888886"},{"database":"DOI","id":"10.1038/77124"}],"title":"DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.","publicationDate":"2000","journal":"Nat. Genet.","firstPage":"338","lastPage":"342","volume":"25"},"referencePositions":["INTERACTION WITH RB1; E2F1 AND HDAC1"]},{"referenceNumber":12,"citation":{"id":"10325416","citationType":"journal article","authors":["Robertson K.D.","Uzvolgyi E.","Liang G.","Talmadge C.","Sumegi J.","Gonzales F.A.","Jones P.A."],"citationCrossReferences":[{"database":"PubMed","id":"10325416"},{"database":"DOI","id":"10.1093/nar/27.11.2291"}],"title":"The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.","publicationDate":"1999","journal":"Nucleic Acids Res.","firstPage":"2291","lastPage":"2298","volume":"27"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":13,"citation":{"id":"12145218","citationType":"journal article","authors":["Kim G.-D.","Ni J.","Kelesoglu N.","Roberts R.J.","Pradhan S."],"citationCrossReferences":[{"database":"PubMed","id":"12145218"},{"database":"DOI","id":"10.1093/emboj/cdf401"}],"title":"Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases.","publicationDate":"2002","journal":"EMBO J.","firstPage":"4183","lastPage":"4195","volume":"21"},"referencePositions":["INTERACTION WITH DNMT3A AND DNMT3B","SUBCELLULAR LOCATION"]},{"referenceNumber":14,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127 AND SER-714","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"16357870","citationType":"journal article","authors":["Vire E.","Brenner C.","Deplus R.","Blanchon L.","Fraga M.","Didelot C.","Morey L.","Van Eynde A.","Bernard D.","Vanderwinden J.-M.","Bollen M.","Esteller M.","Di Croce L.","de Launoit Y.","Fuks F."],"citationCrossReferences":[{"database":"PubMed","id":"16357870"},{"database":"DOI","id":"10.1038/nature04431"}],"title":"The Polycomb group protein EZH2 directly controls DNA methylation.","publicationDate":"2006","journal":"Nature","firstPage":"871","lastPage":"874","volume":"439"},"referencePositions":["FUNCTION","INTERACTION WITH EED AND EZH2"]},{"referenceNumber":16,"citation":{"id":"CI-3F6KIQOE87A5N","citationType":"journal article","authors":["Vire E.","Brenner C.","Deplus R.","Blanchon L.","Fraga M.","Didelot C.","Morey L.","Van Eynde A.","Bernard D.","Vanderwinden J.-M.","Bollen M.","Esteller M.","Di Croce L.","de Launoit Y.","Fuks F."],"publicationDate":"2006","journal":"Nature","firstPage":"824","lastPage":"824","volume":"446"},"referencePositions":["ERRATUM OF PUBMED:16357870"]},{"referenceNumber":17,"citation":{"id":"17200670","citationType":"journal article","authors":["Schlesinger Y.","Straussman R.","Keshet I.","Farkash S.","Hecht M.","Zimmerman J.","Eden E.","Yakhini Z.","Ben-Shushan E.","Reubinoff B.E.","Bergman Y.","Simon I.","Cedar H."],"citationCrossReferences":[{"database":"PubMed","id":"17200670"},{"database":"DOI","id":"10.1038/ng1950"}],"title":"Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.","publicationDate":"2007","journal":"Nat. Genet.","firstPage":"232","lastPage":"236","volume":"39"},"referencePositions":["FUNCTION","DE NOVO DNA METHYLATION OF TARGET GENES"]},{"referenceNumber":18,"citation":{"id":"18754681","citationType":"journal article","authors":["Pradhan M.","Esteve P.-O.","Chin H.G.","Samaranayke M.","Kim G.-D.","Pradhan S."],"citationCrossReferences":[{"database":"PubMed","id":"18754681"},{"database":"DOI","id":"10.1021/bi8011725"}],"title":"CXXC domain of human DNMT1 is essential for enzymatic activity.","publicationDate":"2008","journal":"Biochemistry","firstPage":"10000","lastPage":"10009","volume":"47"},"referencePositions":["FUNCTION","MUTAGENESIS OF CYS-653; CYS-656; CYS-659; CYS-664; CYS-667 AND CYS-670"]},{"referenceNumber":19,"citation":{"id":"18413740","citationType":"journal article","authors":["Sun L.","Huang L.","Nguyen P.","Bisht K.S.","Bar-Sela G.","Ho A.S.","Bradbury C.M.","Yu W.","Cui H.","Lee S.","Trepel J.B.","Feinberg A.P.","Gius D."],"citationCrossReferences":[{"database":"PubMed","id":"18413740"},{"database":"DOI","id":"10.1158/0008-5472.can-07-6654"}],"title":"DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation.","publicationDate":"2008","journal":"Cancer Res.","firstPage":"2726","lastPage":"2735","volume":"68"},"referencePositions":["FUNCTION"]},{"referenceNumber":20,"citation":{"id":"18220336","citationType":"journal article","authors":["Cantin G.T.","Yi W.","Lu B.","Park S.K.","Xu T.","Lee J.-D.","Yates J.R. III"],"citationCrossReferences":[{"database":"PubMed","id":"18220336"},{"database":"DOI","id":"10.1021/pr0705441"}],"title":"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"1346","lastPage":"1351","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-732","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":21,"citation":{"id":"18438403","citationType":"journal article","authors":["Rathert P.","Dhayalan A.","Murakami M.","Zhang X.","Tamas R.","Jurkowska R.","Komatsu Y.","Shinkai Y.","Cheng X.","Jeltsch A."],"citationCrossReferences":[{"database":"PubMed","id":"18438403"},{"database":"DOI","id":"10.1038/nchembio.88"}],"title":"Protein lysine methyltransferase G9a acts on non-histone targets.","publicationDate":"2008","journal":"Nat. Chem. Biol.","firstPage":"344","lastPage":"346","volume":"4"},"referencePositions":["METHYLATION AT LYS-70","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":22,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127; SER-143; SER-152; SER-154 AND SER-394","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":24,"citation":{"id":"19450230","citationType":"journal article","authors":["Lee B.","Muller M.T."],"citationCrossReferences":[{"database":"PubMed","id":"19450230"},{"database":"DOI","id":"10.1042/bj20090142"}],"title":"SUMOylation enhances DNA methyltransferase 1 activity.","publicationDate":"2009","journal":"Biochem. J.","firstPage":"449","lastPage":"461","volume":"421"},"referencePositions":["SUMOYLATION","ACTIVE SITE","INTERACTION WITH UBC9","MUTAGENESIS OF CYS-1226"]},{"referenceNumber":25,"citation":{"id":"19173286","citationType":"journal article","authors":["Fellinger K.","Rothbauer U.","Felle M.","Laengst G.","Leonhardt H."],"citationCrossReferences":[{"database":"PubMed","id":"19173286"},{"database":"DOI","id":"10.1002/jcb.22071"}],"title":"Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain.","publicationDate":"2009","journal":"J. Cell. Biochem.","firstPage":"521","lastPage":"528","volume":"106"},"referencePositions":["HOMODIMERIZATION"]},{"referenceNumber":26,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-173; LYS-1111; LYS-1113 AND LYS-1115","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":28,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394 AND SER-714","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":29,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":30,"citation":{"id":"21565170","citationType":"journal article","authors":["Lavoie G.","St-Pierre Y."],"citationCrossReferences":[{"database":"PubMed","id":"21565170"},{"database":"DOI","id":"10.1016/j.bbrc.2011.04.115"}],"title":"Phosphorylation of human DNMT1: implication of cyclin-dependent kinases.","publicationDate":"2011","journal":"Biochem. Biophys. Res. Commun.","firstPage":"187","lastPage":"192","volume":"409"},"referencePositions":["PHOSPHORYLATION AT SER-154"]},{"referenceNumber":31,"citation":{"id":"21947282","citationType":"journal article","authors":["Peng L.","Yuan Z.","Ling H.","Fukasawa K.","Robertson K.","Olashaw N.","Koomen J.","Chen J.","Lane W.S.","Seto E."],"citationCrossReferences":[{"database":"PubMed","id":"21947282"},{"database":"DOI","id":"10.1128/mcb.06147-11"}],"title":"SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.","publicationDate":"2011","journal":"Mol. Cell. Biol.","firstPage":"4720","lastPage":"4734","volume":"31"},"referencePositions":["ACETYLATION AT LYS-160; LYS-188; LYS-259; LYS-366; LYS-749; LYS-891; LYS-957; LYS-961; LYS-975; LYS-1054; LYS-1111; LYS-1113; LYS-1115; LYS-1117; LYS-1349 AND LYS-1415","DEACETYLATION BY SIRT1"]},{"referenceNumber":32,"citation":{"id":"21151116","citationType":"journal article","authors":["Esteve P.O.","Chang Y.","Samaranayake M.","Upadhyay A.K.","Horton J.R.","Feehery G.R.","Cheng X.","Pradhan S."],"citationCrossReferences":[{"database":"PubMed","id":"21151116"},{"database":"DOI","id":"10.1038/nsmb.1939"}],"title":"A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.","publicationDate":"2011","journal":"Nat. Struct. Mol. Biol.","firstPage":"42","lastPage":"48","volume":"18"},"referencePositions":["METHYLATION AT LYS-142","PHOSPHORYLATION AT SER-143"]},{"referenceNumber":33,"citation":{"id":"21745816","citationType":"journal article","authors":["Felle M.","Joppien S.","Nemeth A.","Diermeier S.","Thalhammer V.","Dobner T.","Kremmer E.","Kappler R.","Langst G."],"citationCrossReferences":[{"database":"PubMed","id":"21745816"},{"database":"DOI","id":"10.1093/nar/gkr528"}],"title":"The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.","publicationDate":"2011","journal":"Nucleic Acids Res.","firstPage":"8355","lastPage":"8365","volume":"39"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","INTERACTION WITH USP7 AND UHRF1"]},{"referenceNumber":34,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127; SER-133 AND SER-714","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":35,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127; THR-137; SER-143; SER-154; THR-166; SER-312; SER-394; SER-398; SER-549; SER-714 AND SER-878","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":36,"citation":{"id":"24623306","citationType":"journal article","authors":["Serra R.W.","Fang M.","Park S.M.","Hutchinson L.","Green M.R."],"citationCrossReferences":[{"database":"PubMed","id":"24623306"},{"database":"DOI","id":"10.7554/elife.02313"}],"title":"A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.","publicationDate":"2014","journal":"Elife","firstPage":"E02313","lastPage":"E02313","volume":"3"},"referencePositions":["FUNCTION","POSSIBLE IDENTIFICATION IN A COREPRESSOR COMPLEX","CHROMATIN-BINDING"]},{"referenceNumber":37,"citation":{"id":"24492612","citationType":"journal article","authors":["Esteve P.O.","Terragni J.","Deepti K.","Chin H.G.","Dai N.","Espejo A.","Correa I.R. Jr.","Bedford M.T.","Pradhan S."],"citationCrossReferences":[{"database":"PubMed","id":"24492612"},{"database":"DOI","id":"10.1074/jbc.m113.525279"}],"title":"Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation.","publicationDate":"2014","journal":"J. Biol. Chem.","firstPage":"8277","lastPage":"8287","volume":"289"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH PHF20L1"]},{"referenceNumber":38,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":39,"citation":{"id":"25772364","citationType":"journal article","authors":["Hendriks I.A.","Treffers L.W.","Verlaan-de Vries M.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25772364"},{"database":"DOI","id":"10.1016/j.celrep.2015.02.033"}],"title":"SUMO-2 orchestrates chromatin modifiers in response to DNA damage.","publicationDate":"2015","journal":"Cell Rep.","firstPage":"1778","lastPage":"1791","volume":"10"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-1609","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":40,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-259 AND LYS-1609","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":41,"citation":{"id":"29691401","citationType":"journal article","authors":["Leng F.","Yu J.","Zhang C.","Alejo S.","Hoang N.","Sun H.","Lu F.","Zhang H."],"citationCrossReferences":[{"database":"PubMed","id":"29691401"},{"database":"DOI","id":"10.1038/s41467-018-04019-9"}],"title":"Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase.","publicationDate":"2018","journal":"Nat. Commun.","firstPage":"1641","lastPage":"1641","volume":"9"},"referencePositions":["INTERACTION WITH DCAF5 AND L3MBTL3","MUTAGENESIS OF LYS-142"]},{"referenceNumber":42,"citation":{"id":"32051553","citationType":"journal article","authors":["Yu Z.","Feng J.","Wang W.","Deng Z.","Zhang Y.","Xiao L.","Wang Z.","Liu C.","Liu Q.","Chen S.","Wu M."],"citationCrossReferences":[{"database":"PubMed","id":"32051553"},{"database":"DOI","id":"10.1038/s41388-020-1206-7"}],"title":"The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.","publicationDate":"2020","journal":"Oncogene","firstPage":"3163","lastPage":"3178","volume":"39"},"referencePositions":["INTERACTION WITH ZNF263"]},{"referenceNumber":43,"citation":{"id":"21389349","citationType":"journal article","authors":["Syeda F.","Fagan R.L.","Wean M.","Avvakumov G.V.","Walker J.R.","Xue S.","Dhe-Paganon S.","Brenner C."],"citationCrossReferences":[{"database":"PubMed","id":"21389349"},{"database":"DOI","id":"10.1074/jbc.m110.209882"}],"title":"The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.","publicationDate":"2011","journal":"J. Biol. Chem.","firstPage":"15344","lastPage":"15351","volume":"286"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.31 ANGSTROMS) OF 351-600 IN COMPLEX WITH ZINC IONS","DOMAIN"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3EPZ"}]},{"referenceNumber":44,"citation":{"id":"21163962","citationType":"journal article","authors":["Song J.","Rechkoblit O.","Bestor T.H.","Patel D.J."],"citationCrossReferences":[{"database":"PubMed","id":"21163962"},{"database":"DOI","id":"10.1126/science.1195380"}],"title":"Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.","publicationDate":"2011","journal":"Science","firstPage":"1036","lastPage":"1040","volume":"331"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 646-1600 IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE AND DNA","AUTOINHIBITORY LINKER"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3PTA"}]},{"referenceNumber":45,"citation":{"id":"26070743","citationType":"journal article","authors":["Zhang Z.M.","Liu S.","Lin K.","Luo Y.","Perry J.J.","Wang Y.","Song J."],"citationCrossReferences":[{"database":"PubMed","id":"26070743"},{"database":"DOI","id":"10.1016/j.jmb.2015.06.001"}],"title":"Crystal Structure of Human DNA Methyltransferase 1.","publicationDate":"2015","journal":"J. Mol. Biol.","firstPage":"2520","lastPage":"2531","volume":"427"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.62 ANGSTROMS) OF 351-1600 IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE AND ZN(2+)","FUNCTION","CATALYTIC ACTIVITY","MUTAGENESIS OF ARG-582"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4WXX"}]},{"referenceNumber":46,"citation":{"id":"29053958","citationType":"journal article","authors":["Ishiyama S.","Nishiyama A.","Saeki Y.","Moritsugu K.","Morimoto D.","Yamaguchi L.","Arai N.","Matsumura R.","Kawakami T.","Mishima Y.","Hojo H.","Shimamura S.","Ishikawa F.","Tajima S.","Tanaka K.","Ariyoshi M.","Shirakawa M.","Ikeguchi M.","Kidera A.","Suetake I.","Arita K.","Nakanishi M."],"citationCrossReferences":[{"database":"PubMed","id":"29053958"},{"database":"DOI","id":"10.1016/j.molcel.2017.09.037"}],"title":"Structure of the Dnmt1 reader module complexed with a unique two-mono-ubiquitin mark on histone H3 reveals the basis for DNA methylation maintenance.","publicationDate":"2017","journal":"Mol. Cell","firstPage":"350","lastPage":"360","volume":"68"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 351-600 IN COMPLEX WITH HISTONE H3 AND ZN(2+)","SUBCELLULAR LOCATION","DOMAIN"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5WVO"}]},{"referenceNumber":47,"citation":{"id":"21532572","citationType":"journal article","authors":["Klein C.J.","Botuyan M.V.","Wu Y.","Ward C.J.","Nicholson G.A.","Hammans S.","Hojo K.","Yamanishi H.","Karpf A.R.","Wallace D.C.","Simon M.","Lander C.","Boardman L.A.","Cunningham J.M.","Smith G.E.","Litchy W.J.","Boes B.","Atkinson E.J.","Middha S.","Dyck P.J.B.","Parisi J.E.","Mer G.","Smith D.I.","Dyck P.J."],"citationCrossReferences":[{"database":"PubMed","id":"21532572"},{"database":"DOI","id":"10.1038/ng.830"}],"title":"Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.","publicationDate":"2011","journal":"Nat. Genet.","firstPage":"595","lastPage":"600","volume":"43"},"referencePositions":["VARIANTS HSN1E 490-ASP-PRO-491 DELINS GLU-TYR AND CYS-495","CHARACTERIZATION OF VARIANTS HSN1E 490-ASP-PRO-491 DELINS GLU-TYR AND CYS-495"]},{"referenceNumber":48,"citation":{"id":"22328086","citationType":"journal article","authors":["Winkelmann J.","Lin L.","Schormair B.","Kornum B.R.","Faraco J.","Plazzi G.","Melberg A.","Cornelio F.","Urban A.E.","Pizza F.","Poli F.","Grubert F.","Wieland T.","Graf E.","Hallmayer J.","Strom T.M.","Mignot E."],"citationCrossReferences":[{"database":"PubMed","id":"22328086"},{"database":"DOI","id":"10.1093/hmg/dds035"}],"title":"Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy.","publicationDate":"2012","journal":"Hum. Mol. Genet.","firstPage":"2205","lastPage":"2210","volume":"21"},"referencePositions":["VARIANTS ADCADN VAL-554; ALA-589 AND PHE-590"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X63692","properties":[{"key":"ProteinId","value":"CAA45219.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF180682","properties":[{"key":"ProteinId","value":"AAF23609.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC010077","properties":[{"key":"ProteinId","value":"AAD54507.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC011511","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC020931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC126227","properties":[{"key":"ProteinId","value":"AAI26228.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC144093","properties":[{"key":"ProteinId","value":"AAI44094.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AH008119","properties":[{"key":"ProteinId","value":"AAD51619.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS12228.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P26358-1"},{"database":"CCDS","id":"CCDS45958.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P26358-2"},{"database":"PIR","id":"S22610","properties":[{"key":"EntryName","value":"S22610"}]},{"database":"RefSeq","id":"NP_001124295.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001130823.3"}],"isoformId":"P26358-2"},{"database":"RefSeq","id":"NP_001305659.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318730.2"}]},{"database":"RefSeq","id":"NP_001305660.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318731.2"}]},{"database":"RefSeq","id":"NP_001370.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001379.4"}],"isoformId":"P26358-1"},{"database":"PDB","id":"3EPZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.31 A"},{"key":"Chains","value":"A/B=351-600"}]},{"database":"PDB","id":"3PTA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A=646-1600"}]},{"database":"PDB","id":"3SWR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.49 A"},{"key":"Chains","value":"A=601-1600"}]},{"database":"PDB","id":"4WXX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.62 A"},{"key":"Chains","value":"A/B=351-1600"}]},{"database":"PDB","id":"4YOC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.92 A"},{"key":"Chains","value":"A=600-1600"}]},{"database":"PDB","id":"4Z96","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"C=1097-1129"}]},{"database":"PDB","id":"4Z97","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"C=1098-1129"}]},{"database":"PDB","id":"5WVO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"C=351-600"}]},{"database":"PDB","id":"5YDR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"B=351-599"}]},{"database":"PDB","id":"6K3A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/D/F=161-180"}]},{"database":"PDB","id":"6L1F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=140-145"}]},{"database":"PDB","id":"6X9I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=729-1600"}]},{"database":"PDB","id":"6X9J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=729-1600"}]},{"database":"PDB","id":"6X9K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"A=729-1600"}]},{"database":"PDB","id":"7SFC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.97 A"},{"key":"Chains","value":"A=729-1600"}]},{"database":"PDB","id":"7SFD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"A=729-1600"}]},{"database":"PDB","id":"7SFE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"A=729-1600"}]},{"database":"PDB","id":"7SFF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=729-1600"}]},{"database":"PDB","id":"7SFG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.43 A"},{"key":"Chains","value":"A=729-1600"}]},{"database":"PDB","id":"7XI9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.52 A"},{"key":"Chains","value":"A=351-1616"}]},{"database":"PDB","id":"7XIB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.23 A"},{"key":"Chains","value":"A=351-1616"}]},{"database":"PDB","id":"8V9U","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=16-93"}]},{"database":"PDB","id":"8XQC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.25 A"},{"key":"Chains","value":"A=351-1616"}]},{"database":"PDB","id":"9K2W","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.54 A"},{"key":"Chains","value":"B=351-1616"}]},{"database":"PDB","id":"9K2X","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.75 A"},{"key":"Chains","value":"B=351-1616"}]},{"database":"PDB","id":"9V36","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.77 A"},{"key":"Chains","value":"A=698-1616"}]},{"database":"PDB","id":"9V5P","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"A=698-1616"}]},{"database":"PDBsum","id":"3EPZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3PTA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3SWR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4WXX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4YOC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4Z96","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4Z97","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5WVO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5YDR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6K3A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6L1F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X9I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X9J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X9K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SFC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SFD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SFE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SFF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SFG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XI9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XIB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8V9U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8XQC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9K2W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9K2X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9V36","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9V5P","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33200","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33201","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-38573","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-61999","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62000","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-64750","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-64791","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"108123","properties":[{"key":"Interactions","value":"266"}]},{"database":"CORUM","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-39693N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P26358","properties":[{"key":"Number of interactors","value":"2622"}]},{"database":"IntAct","id":"P26358","properties":[{"key":"Interactions","value":"83"}]},{"database":"MINT","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-DNMT1","properties":[{"key":"Evidences","value":"16 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000352516","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1993","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB12326","properties":[{"key":"GenericName","value":"Antroquinonol"}]},{"database":"DrugBank","id":"DB00928","properties":[{"key":"GenericName","value":"Azacitidine"}]},{"database":"DrugBank","id":"DB01262","properties":[{"key":"GenericName","value":"Decitabine"}]},{"database":"DrugBank","id":"DB12116","properties":[{"key":"GenericName","value":"Epigallocatechin gallate"}]},{"database":"DrugBank","id":"DB01099","properties":[{"key":"GenericName","value":"Flucytosine"}]},{"database":"DrugBank","id":"DB16168","properties":[{"key":"GenericName","value":"Fluorocyclopentenylcytosine"}]},{"database":"DrugBank","id":"DB11918","properties":[{"key":"GenericName","value":"Guadecitabine"}]},{"database":"DrugBank","id":"DB06544","properties":[{"key":"GenericName","value":"MG98"}]},{"database":"DrugBank","id":"DB05668","properties":[{"key":"GenericName","value":"Palifosfamide"}]},{"database":"DrugBank","id":"DB01035","properties":[{"key":"GenericName","value":"Procainamide"}]},{"database":"DrugBank","id":"DB00721","properties":[{"key":"GenericName","value":"Procaine"}]},{"database":"DrugCentral","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"2605","properties":[{"key":"Description","value":"-"}]},{"database":"REBASE","id":"1161","properties":[{"key":"EntryName","value":"M.HsaDnmt1A"}]},{"database":"REBASE","id":"4240","properties":[{"key":"EntryName","value":"M.HsaDnmt1B"}]},{"database":"GlyGen","id":"P26358","properties":[{"key":"glycosylation","value":"3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"DNMT1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"12231019","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000352516","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54320","properties":[{"key":"Description","value":"-"}],"isoformId":"P26358-1"},{"database":"ProteomicsDB","id":"54321","properties":[{"key":"Description","value":"-"}],"isoformId":"P26358-2"},{"database":"ProteomicsDB","id":"54322","properties":[{"key":"Description","value":"-"}],"isoformId":"P26358-3"},{"database":"Pumba","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P26358","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"Antibodypedia","id":"1052","properties":[{"key":"antibodies","value":"1599 antibodies from 52 providers"}]},{"database":"DNASU","id":"1786","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000340748.8","properties":[{"key":"ProteinId","value":"ENSP00000345739.3"},{"key":"GeneId","value":"ENSG00000130816.18"}],"isoformId":"P26358-1"},{"database":"Ensembl","id":"ENST00000359526.9","properties":[{"key":"ProteinId","value":"ENSP00000352516.3"},{"key":"GeneId","value":"ENSG00000130816.18"}],"isoformId":"P26358-2"},{"database":"GeneID","id":"1786","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1786","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000359526.9","properties":[{"key":"ProteinId","value":"ENSP00000352516.3"},{"key":"RefSeqNucleotideId","value":"NM_001130823.3"},{"key":"RefSeqProteinId","value":"NP_001124295.1"}],"isoformId":"P26358-2"},{"database":"UCSC","id":"uc002mng.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P26358-1"},{"database":"AGR","id":"HGNC:2976","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"1786","properties":[{"key":"Number of evidences","value":"2 evidence items across 1 molecular profile"}]},{"database":"ClinPGx","id":"PA27443","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1786","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1786","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"DNMT1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"DNMT1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:2976","properties":[{"key":"GeneName","value":"DNMT1"}]},{"database":"HPA","id":"ENSG00000130816","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"DNMT1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"126375","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"604121","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"614116","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000130816","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"314404","properties":[{"key":"Disease","value":"Autosomal dominant cerebellar ataxia-deafness-narcolepsy syndrome"}]},{"database":"Orphanet","id":"456318","properties":[{"key":"Disease","value":"Hereditary sensory neuropathy-deafness-dementia syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000130816","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QPKK","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000005100","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_003040_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CKEMAPL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PAN-GO","id":"P26358","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.1.1.37","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-212300","properties":[{"key":"PathwayName","value":"PRC2 methylates histones and DNA"}]},{"database":"Reactome","id":"R-HSA-427413","properties":[{"key":"PathwayName","value":"NoRC negatively regulates rRNA expression"}]},{"database":"Reactome","id":"R-HSA-4655427","properties":[{"key":"PathwayName","value":"SUMOylation of DNA methylation proteins"}]},{"database":"Reactome","id":"R-HSA-5334118","properties":[{"key":"PathwayName","value":"DNA methylation"}]},{"database":"Reactome","id":"R-HSA-9701898","properties":[{"key":"PathwayName","value":"STAT3 nuclear events downstream of ALK signaling"}]},{"database":"Reactome","id":"R-HSA-9710421","properties":[{"key":"PathwayName","value":"Defective pyroptosis"}]},{"database":"Reactome","id":"R-HSA-9725371","properties":[{"key":"PathwayName","value":"Nuclear events stimulated by ALK signaling in cancer"}]},{"database":"SignaLink","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000130816","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1786","properties":[{"key":"hits","value":"363 hits in 1188 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"DNMT1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P26358","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"DNMT1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1786","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P26358","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P26358","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"P26358","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000130816","properties":[{"key":"ExpressionPatterns","value":"Expressed in oocyte and 185 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P26358","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29053958"}]},{"database":"GO","id":"GO:0000792","properties":[{"key":"GoTerm","value":"C:heterochromatin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29053958"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"HTP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0006056","source":"PubMed","id":"34800366"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12145218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24492612"}]},{"database":"GO","id":"GO:0005721","properties":[{"key":"GoTerm","value":"C:pericentric heterochromatin"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005657","properties":[{"key":"GoTerm","value":"C:replication fork"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003886","properties":[{"key":"GoTerm","value":"F:DNA (cytosine-5-)-methyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21745816"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26070743"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18754681"}]},{"database":"GO","id":"GO:0009008","properties":[{"key":"GoTerm","value":"F:DNA-methyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18754681"}]},{"database":"GO","id":"GO:0140258","properties":[{"key":"GoTerm","value":"F:histone H3K14ub reader activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29053958"}]},{"database":"GO","id":"GO:0140254","properties":[{"key":"GoTerm","value":"F:histone H3K18ub reader activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29053958"}]},{"database":"GO","id":"GO:0140257","properties":[{"key":"GoTerm","value":"F:histone H3K23ub reader activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29053958"}]},{"database":"GO","id":"GO:0106222","properties":[{"key":"GoTerm","value":"F:lncRNA binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008327","properties":[{"key":"GoTerm","value":"F:methyl-CpG binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1990841","properties":[{"key":"GoTerm","value":"F:promoter-specific chromatin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24623306"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0141119","properties":[{"key":"GoTerm","value":"P:chromosomal DNA methylation maintenance following DNA replication"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26070743"}]},{"database":"GO","id":"GO:0006346","properties":[{"key":"GoTerm","value":"P:DNA methylation-dependent constitutive heterochromatin formation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0010629","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27021683"}]},{"database":"GO","id":"GO:0044027","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression via chromosomal CpG island methylation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18754681"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21745816"}]},{"database":"GO","id":"GO:1900240","properties":[{"key":"GoTerm","value":"P:negative regulation of phenotypic switching"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27021683"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10888872"}]},{"database":"GO","id":"GO:1905460","properties":[{"key":"GoTerm","value":"P:negative regulation of vascular associated smooth muscle cell apoptotic process"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27021683"}]},{"database":"GO","id":"GO:1905064","properties":[{"key":"GoTerm","value":"P:negative regulation of vascular associated smooth muscle cell differentiation"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27021683"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18413740"}]},{"database":"GO","id":"GO:1904707","properties":[{"key":"GoTerm","value":"P:positive regulation of vascular associated smooth muscle cell proliferation"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27021683"}]},{"database":"CDD","id":"cd04760","properties":[{"key":"EntryName","value":"BAH_Dnmt1_I"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd04711","properties":[{"key":"EntryName","value":"BAH_Dnmt1_II"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.2230:FF:000001","properties":[{"key":"EntryName","value":"DNA (cytosine-5)-methyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.490:FF:000004","properties":[{"key":"EntryName","value":"DNA (cytosine-5)-methyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.490:FF:000006","properties":[{"key":"EntryName","value":"DNA (cytosine-5)-methyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.150:FF:000036","properties":[{"key":"EntryName","value":"DNA (cytosine-5)-methyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.120.10:FF:000001","properties":[{"key":"EntryName","value":"DNA (cytosine-5)-methyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.2230","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.30.490","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.120.10","properties":[{"key":"EntryName","value":"DNA Methylase, subunit A, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.150","properties":[{"key":"EntryName","value":"Vaccinia Virus protein VP39"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001025","properties":[{"key":"EntryName","value":"BAH_dom"}]},{"database":"InterPro","id":"IPR043151","properties":[{"key":"EntryName","value":"BAH_sf"}]},{"database":"InterPro","id":"IPR050390","properties":[{"key":"EntryName","value":"C5-Methyltransferase"}]},{"database":"InterPro","id":"IPR018117","properties":[{"key":"EntryName","value":"C5_DNA_meth_AS"}]},{"database":"InterPro","id":"IPR001525","properties":[{"key":"EntryName","value":"C5_MeTfrase"}]},{"database":"InterPro","id":"IPR031303","properties":[{"key":"EntryName","value":"C5_meth_CS"}]},{"database":"InterPro","id":"IPR010506","properties":[{"key":"EntryName","value":"DMAP1-bd"}]},{"database":"InterPro","id":"IPR022702","properties":[{"key":"EntryName","value":"DNMT1-RFD"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"InterPro","id":"IPR002857","properties":[{"key":"EntryName","value":"Znf_CXXC"}]},{"database":"PANTHER","id":"PTHR10629","properties":[{"key":"EntryName","value":"CYTOSINE-SPECIFIC METHYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10629:SF52","properties":[{"key":"EntryName","value":"DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01426","properties":[{"key":"EntryName","value":"BAH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF06464","properties":[{"key":"EntryName","value":"DMAP_binding"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00145","properties":[{"key":"EntryName","value":"DNA_methylase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12047","properties":[{"key":"EntryName","value":"DNMT1-RFD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02008","properties":[{"key":"EntryName","value":"zf-CXXC"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF037404","properties":[{"key":"EntryName","value":"DNMT1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00105","properties":[{"key":"EntryName","value":"C5METTRFRASE"}]},{"database":"SMART","id":"SM00439","properties":[{"key":"EntryName","value":"BAH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM01137","properties":[{"key":"EntryName","value":"DMAP_binding"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53335","properties":[{"key":"EntryName","value":"S-adenosyl-L-methionine-dependent methyltransferases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51038","properties":[{"key":"EntryName","value":"BAH"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00094","properties":[{"key":"EntryName","value":"C5_MTASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00095","properties":[{"key":"EntryName","value":"C5_MTASE_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51912","properties":[{"key":"EntryName","value":"DMAP1_BIND"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51679","properties":[{"key":"EntryName","value":"SAM_MT_C5"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51058","properties":[{"key":"EntryName","value":"ZF_CXXC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLCPIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQARRQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPSENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD","length":1616,"molWeight":183165,"crc64":"1E833192D22AFA5B","md5":"AA4D2DF629C398A84BFE0389AD4BB83A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"INTERACTION":15,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":2,"PTM":5,"DISEASE":2,"SIMILARITY":1,"SEQUENCE CAUTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Domain":5,"Repeat":6,"Zinc finger":1,"Region":15,"Motif":1,"Compositional bias":7,"Active site":1,"Binding site":28,"Modified residue":37,"Cross-link":2,"Alternative sequence":2,"Natural variant":7,"Mutagenesis":18,"Helix":77,"Turn":15,"Beta strand":65},"uniParcId":"UPI0000129694"}}