{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P26196","secondaryAccessions":["Q5D048"],"uniProtkbId":"DDX6_HUMAN","entryAudit":{"firstPublicDate":"1992-05-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-17","entryVersion":241,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probable ATP-dependent RNA helicase DDX6"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27342281"}],"value":"3.6.4.13"}]},"alternativeNames":[{"fullName":{"value":"ATP-dependent RNA helicase p54"}},{"fullName":{"value":"DEAD box protein 6"}},{"fullName":{"value":"Oncogene RCK"}}]},"genes":[{"geneName":{"value":"DDX6"},"synonyms":[{"value":"HLR2"},{"value":"RCK"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16364915"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25995375"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26098573"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27342281"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31422817"}],"value":"Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.13","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27342281"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30258011"}],"value":"(Microbial infection) Interacts with rotavirus A non-structural protein 2; this interaction probably plays a role in the sequestration of DDX6 in viral factories (PubMed:30258011). Interacts with rotavirus A non-structural protein 5; this interaction probably plays a role in its sequestration in viral factories (PubMed:30258011)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P54823"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16364915"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16699599"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19285948"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20616046"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23125361"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23209657"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26027925"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26184334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26489469"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27342281"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28216671"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29510985"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31422817"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31439631"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32354837"}],"value":"Interacts with LSM14A, LSM14B, EIF4ENIF1/4E-T, PATL1, EDC3 and EDC4 (PubMed:26027925, PubMed:26489469, PubMed:27342281, PubMed:28216671, PubMed:29510985, PubMed:31422817, PubMed:31439631, PubMed:32354837). Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS (PubMed:16364915, PubMed:19285948). Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046). Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599). Interacts with RC3H1 (By similarity). Interacts with ATXN2L (PubMed:23209657). Interacts with MCRIP1 (PubMed:26184334). Interacts with MCRIP2 (PubMed:26184334). Interacts with NUFIP2 (PubMed:26184334). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361). Interacts with GIGYF1 and GIGYF2 (PubMed:31439631)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q9UKV8","geneName":"AGO2","intActId":"EBI-528269"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q99700","geneName":"ATXN2","intActId":"EBI-697691"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q9BUH8","geneName":"BEGAIN","intActId":"EBI-742722"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q8N7W2-2","geneName":"BEND7","intActId":"EBI-10181188"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q96CA5","geneName":"BIRC7","intActId":"EBI-517623"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q13137","geneName":"CALCOCO2","intActId":"EBI-739580"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q49A88-3","geneName":"CCDC14","intActId":"EBI-12105646"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q8NHQ1","geneName":"CEP70","intActId":"EBI-739624"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q8TAP6","geneName":"CEP76","intActId":"EBI-742887"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q6P9H4","geneName":"CNKSR3","intActId":"EBI-10253274"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q9NPI6","geneName":"DCP1A","intActId":"EBI-374238"},"numberOfExperiments":13,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q92841","geneName":"DDX17","intActId":"EBI-746012"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"P17661","geneName":"DES","intActId":"EBI-1055572"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q9NRI5-2","geneName":"DISC1","intActId":"EBI-11988027"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q86X45","geneName":"DNAAF11","intActId":"EBI-9379658"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q96F86","geneName":"EDC3","intActId":"EBI-997311"},"numberOfExperiments":25,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q5JST6","geneName":"EFHC2","intActId":"EBI-2349927"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q9NRA8","geneName":"EIF4ENIF1","intActId":"EBI-301024"},"numberOfExperiments":17,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q96C92-2","geneName":"ENTR1","intActId":"EBI-10178036"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"A0A0C3SFZ9","geneName":"FCHO1","intActId":"EBI-11977403"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"P51114-2","geneName":"FXR1","intActId":"EBI-11022345"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"O75420","geneName":"GIGYF1","intActId":"EBI-947774"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P26196","intActId":"EBI-351257"},"interactantTwo":{"uniProtKBAccession":"Q08379","geneName":"GOLGA2","intActId":"EBI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