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Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20871596"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31969702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32193360"}],"value":"Inhibited by JQ1, a thieno-triazolo-1,4-diazepine derivative, which specifically inhibits members of the BET family (BRD2, BRD3 and BRD4) (PubMed:20871596). The first bromo domain is inhibited by GSK778 (iBET-BD1), which specifically inhibits the first bromo domain of members of the BET family (BRD2, BRD3 and BRD4) (PubMed:32193360). The second bromo domain is inhibited by ABBV-744, which specifically inhibits the second bromo domain of members of the BET family (BRD2, BRD3 and BRD4) (PubMed:31969702). The second bromo domain is inhibited by GSK046 (iBET-BD2), which specifically inhibits the second bromo domain of members of the BET family (BRD2, BRD3 and BRD4) (PubMed:32193360)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7JJ13"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17148447"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17848202"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20048151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20709061"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28262505"}],"value":"Homodimer (PubMed:17148447, PubMed:17848202, PubMed:20048151, PubMed:20709061). Interacts with E2F1 (PubMed:17148447). Interacts with (acetylated) STAT3; promoting STAT3 recruitment to chromatin (PubMed:28262505). Interacts with CTCF; promoting BRD2 recruitment to chromatin (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16227282"}],"value":"(Microbial infection) Interacts with herpes virus 8 protein LANA1"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P25440","intActId":"EBI-2874802"},"interactantTwo":{"uniProtKBAccession":"P62805","geneName":"H4C9","intActId":"EBI-302023"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P25440","intActId":"EBI-2874802"},"interactantTwo":{"uniProtKBAccession":"Q13761","geneName":"RUNX3","intActId":"EBI-925990"},"numberOfExperiments":8,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18406326"}],"value":"Detected on chromatin and nucleosomes"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18406326"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25593309"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18406326"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25593309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28262505"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P25440-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P25440-2"],"sequenceIds":["VSP_022600"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P25440-3"],"sequenceIds":["VSP_055029"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["P25440-4"],"sequenceIds":["VSP_055028"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20048151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20709061"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37731000"}],"value":"The first bromo domain specifically recognizes histone H4 acetylated at 'Lys-12' (H4K12ac) (PubMed:20048151). It also specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). The second bromo domain recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively) (PubMed:20709061)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31969702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32193360"}],"value":"Some specific inhibitors of BRD2 that prevent binding to acetylated histone are promising therapeutic molecules for the treatment of cancers or inflammatory diseases (PubMed:31969702, PubMed:32193360). ABBV-744, a small molecule, has been tested on tumors with success: ABBV-744 antiproliferative activity is mainly restricted to cell lines of acute myeloid leukaemia and prostate cancer and is able to displace BRD4 from chromatin (PubMed:31969702). GSK046 (iBET-BD2), which specifically inhibits the second bromo domain, is a promising therapeutic small molecule for the treatment of inflammatory and autoimmune diseases (PubMed:32193360)"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the BET family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAA68890.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"Bromodomain-containing protein 2","featureId":"PRO_0000211180"},{"type":"Domain","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"Bromo 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