{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P23497","secondaryAccessions":["B4DDX5","B8ZZD8","E7EUA7","E9PH61","F8WFE2","O75450","Q13343","Q8TE34","Q96F70","Q96T24","Q96T95","Q9NP33","Q9UE32"],"uniProtkbId":"SP100_HUMAN","entryAudit":{"firstPublicDate":"1991-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-04-27","entryVersion":255,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Nuclear autoantigen Sp-100"}},"alternativeNames":[{"fullName":{"value":"Nuclear dot-associated Sp100 protein"}},{"fullName":{"value":"Speckled 100 kDa"}}]},"genes":[{"geneName":{"value":"SP100"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11909962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14647468"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15247905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15592518"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15767676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16177824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17245429"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21274506"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21880768"}],"value":"Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. 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Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11313457"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11909962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12470659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14647468"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15247905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15767676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15882967"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17245429"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27211601"}],"value":"Homodimer; isoforms are able to heterodimerize. Interacts with members of the HP1 family of nonhistone chromosomal protein, such as CBX5 and CBX3 via the PxVxL motif. Interacts with ETS1; the interaction is direct and modulates ETS1 transcriptional activity. Interacts with the MRN complex which is composed of two heterodimers RAD50/MRE11 associated with a single NBN; recruits the complex to PML-related bodies. Interacts with HIPK2; positively regulates TP53-dependent transcription. Interacts with CASP8AP2; may negatively regulate CASP8AP2 export from the nucleus to the cytoplasm. 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