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For instance, heparin-ANOS1 interaction favors subsequent binding to pre-existing binary FGFR1-FGF2 complex, while heparin-FGF2 complex does not interact with ANOS1-FGFR1"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P23352","intActId":"EBI-5272188"},"interactantTwo":{"uniProtKBAccession":"P11362","geneName":"FGFR1","intActId":"EBI-1028277"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23352","intActId":"EBI-5272188"},"interactantTwo":{"uniProtKBAccession":"P61601","geneName":"NCALD","intActId":"EBI-749635"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23352","intActId":"EBI-5272188"},"interactantTwo":{"uniProtKBAccession":"Q9UMX0","geneName":"UBQLN1","intActId":"EBI-741480"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Proteolytic cleavage may release it from the cell surface into the extracellular space"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8842728"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8842728"}],"value":"Peripheral membrane protein","id":"SL-9903"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8842728"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12007408"}],"value":"Expressed in the cerebellum (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8842728"}],"value":"N-glycosylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8842728"}],"value":"May be proteolytically cleaved at the cell surface and released from the cell surface"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Hypogonadotropic hypogonadism 1 with or without anosmia","diseaseAccession":"DI-00617","acronym":"HH1","description":"A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. 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In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).","diseaseCrossReference":{"database":"MIM","id":"308700"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11297579"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15001591"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15471890"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15605412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17054399"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17213338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17223984"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19696444"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20530987"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21168128"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23643382"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25077900"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8504298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8989261"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9589672"}]},"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23643382"}],"value":"The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. 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