{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P22626","secondaryAccessions":["A0A024RA27","A0A024RA61","A8K064","P22627","Q9UC98","Q9UDJ2"],"uniProtkbId":"ROA2_HUMAN","entryAudit":{"firstPublicDate":"1991-08-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1991-11-01","entryVersion":249,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Heterogeneous nuclear ribonucleoproteins A2/B1"},"shortNames":[{"value":"hnRNP A2/B1"}]}},"genes":[{"geneName":{"value":"HNRNPA2B1"},"synonyms":[{"value":"HNRPA2B1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A7VJC2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10567417"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20010808"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24356509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26321680"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19099192"}],"value":"Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15294897"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17004321"}],"value":"(Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11991638"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15703215"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19429692"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24549040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25678563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26321680"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31320558"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37643469"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39349455"}],"value":"Homodimer; dimerization is required for nucleocytoplasmic translocation (PubMed:31320558). Identified in the spliceosome C complex (PubMed:11991638). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with IGF2BP1 (PubMed:17289661). Interacts with C9orf72 (PubMed:24549040). Interacts with DGCR8 (PubMed:26321680). Interacts with TARDBP (PubMed:19429692). Interacts with CKAP5 (PubMed:15703215). Interacts with TBK1 (PubMed:31320558). Interacts with STING1 (PubMed:31320558). Interacts with SRC (PubMed:31320558). Interacts with PPIA/CYPA (PubMed:25678563). Interacts (via C-terminus) with FAM76B; the interaction results in retention of HNRNPA2B1 in the nucleus and inhibition of the NF-kappa-B-mediated inflammatory pathway (PubMed:37643469). Interacts with NF-kappa-B inhibitors NFKBIA and NFKBIE; the interaction may be mediated by the RRM2 domain of HNRNPA2B1, and HNRNPA2B1 may interact simultaneously with FAM76B and either NFKBIA or NFKBIE to form a complex (PubMed:37643469). Interacts with CEP112 (PubMed:39349455)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"Q13936","geneName":"CACNA1C","intActId":"EBI-1038838"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"Q08211","geneName":"DHX9","intActId":"EBI-352022"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"O60741","geneName":"HCN1","intActId":"EBI-11173743"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"Q13151","geneName":"HNRNPA0","intActId":"EBI-724092"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"P09651","geneName":"HNRNPA1","intActId":"EBI-352662"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"P51991","geneName":"HNRNPA3","intActId":"EBI-1050760"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"Q99729","geneName":"HNRNPAB","intActId":"EBI-1044873"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"P07910","geneName":"HNRNPC","intActId":"EBI-357966"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"Q14103","geneName":"HNRNPD","intActId":"EBI-299674"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"O14979","geneName":"HNRNPDL","intActId":"EBI-299727"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"P61978","geneName":"HNRNPK","intActId":"EBI-304185"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"P14866","geneName":"HNRNPL","intActId":"EBI-719024"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"P14866-1","geneName":"HNRNPL","intActId":"EBI-16071645"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"P52272","geneName":"HNRNPM","intActId":"EBI-486809"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"Q12906","geneName":"ILF3","intActId":"EBI-78756"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"Q5T7N2","geneName":"L1TD1","intActId":"EBI-7216220"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"Q96PV0","geneName":"SYNGAP1","intActId":"EBI-2682386"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626","intActId":"EBI-299649"},"interactantTwo":{"uniProtKBAccession":"Q9HA38","geneName":"ZMAT3","intActId":"EBI-2548480"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P22626-2","intActId":"EBI-432522"},"interactantTwo":{"uniProtKBAccession":"P22626-2","geneName":"HNRNPA2B1","intActId":"EBI-432522"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24356509"}],"value":"Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Component of ribonucleosomes (PubMed:17289661). Not found in the nucleolus (PubMed:17289661). Found in exosomes following sumoylation (PubMed:24356509)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31320558"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37643469"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"}],"value":"Nucleus, nucleoplasm","id":"SL-0190"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31320558"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37643469"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24356509"}],"value":"Cytoplasmic granule","id":"SL-0281"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24356509"}],"value":"Secreted, extracellular exosome","id":"SL-0466"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform A2","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"}],"value":"Predominantly nucleoplasmic, however is also found in the cytoplasm of cells in some tissues (PubMed:17289661)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10772824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24098712"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10772824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"B1"},"synonyms":[{"value":"hnRNP B1"}],"isoformIds":["P22626-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"A2"},"synonyms":[{"value":"hnRNP A2"}],"isoformIds":["P22626-2"],"sequenceIds":["VSP_005830"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"value":"The disordered region, when incubated at high concentration, is able to polymerize into labile, amyloid-like fibers and form cross-beta polymerization structures, probably driving the formation of hydrogels. In contrast to irreversible, pathogenic amyloids, the fibers polymerized from low complexity (LC) regions disassemble upon dilution. A number of evidence suggests that formation of cross-beta structures by LC regions mediate the formation of RNA granules, liquid-like droplets, and hydrogels"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24356509"}],"value":"Sumoylated in exosomes, promoting miRNAs-binding"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A7VJC2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10772824"}],"value":"Asymmetric dimethylation at Arg-266 constitutes the major methylation site (By similarity). According to a report, methylation affects subcellular location and promotes nuclear localization (PubMed:10772824). According to another report, methylation at Arg-266 does not influence nucleocytoplasmic shuttling (By similarity)"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2","diseaseAccession":"DI-03892","acronym":"IBMPFD2","description":"An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance.","diseaseCrossReference":{"database":"MIM","id":"615422"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23455423"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Oculopharyngeal muscular dystrophy 2","diseaseAccession":"DI-06737","acronym":"OPMD2","description":"An autosomal dominant, early-onset myopathy characterized by progressive muscle weakness, ptosis, ophthalmoplegia, dysphagia, and variable degrees of respiratory insufficiency.","diseaseCrossReference":{"database":"MIM","id":"620460"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35484142"}]},"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35484142"}],"value":"The disease is caused by variants affecting the gene represented in this entry. The disease is caused by frameshift variants that cluster in the low complexity disordered region. They abolish the native stop codon, and extend the reading frame resulting in a common C-terminal sequence. All variants escape degradation by the RNA quality control system, and mutant proteins accumulate in the cytoplasm due to impaired nucleocytoplasmic trafficking"}]}}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"Heterogeneous nuclear ribonucleoproteins A2/B1","featureId":"PRO_0000081836"},{"type":"Domain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"RRM 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00176"}]},{"type":"Domain","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"RRM 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00176"}]},{"type":"Region","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}]},{"type":"Region","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Nuclear targeting sequence","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Motif","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88569"}]},{"type":"Modified residue","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"N6,N6-dimethyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"}]},{"type":"Modified residue","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88569"}]},{"type":"Modified residue","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Dimethylated arginine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"}]},{"type":"Modified residue","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Omega-N-methylarginine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"15782174"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88569"}]},{"type":"Modified residue","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Dimethylated arginine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"}]},{"type":"Modified residue","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Omega-N-methylarginine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31320558"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17924679"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18220336"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A7VJC2"}]},{"type":"Modified residue","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"Omega-N-methylarginine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17924679"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18220336"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Cross-link","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"}]},{"type":"Alternative sequence","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"in isoform A2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2557628"}],"featureId":"VSP_005830","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"in IBMPFD2; dbSNP:rs397515326","featureCrossReferences":[{"database":"dbSNP","id":"rs397515326"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23455423"}],"featureId":"VAR_070591","alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"About 10-fold increase in interferon beta production.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"Slightly affects hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Slightly affects hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"Impairs hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"Slightly affects hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Impairs hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Impairs hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Slightly affects hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Impairs hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"Slightly affects hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Slightly affects hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Impairs hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Impairs hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Slightly affects hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"Does not affect hydrogel-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26544936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"in Ref. 4; BAF82118","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Helix","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EN1"}]},{"type":"Helix","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Beta strand","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Helix","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Helix","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Beta strand","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Turn","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Beta strand","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Helix","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Beta strand","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Beta strand","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Helix","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Helix","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Turn","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Beta strand","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Helix","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Helix","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Beta strand","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Turn","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Beta strand","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Helix","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Beta strand","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Beta strand","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Helix","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5WWF"}]},{"type":"Helix","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WM3"}]},{"type":"Turn","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6WQK"}]},{"type":"Beta strand","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6WQK"}]},{"type":"Beta strand","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6WQK"}]},{"type":"Beta strand","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6WQK"}]},{"type":"Beta strand","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6WQK"}]},{"type":"Beta strand","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DUW"}]},{"type":"Beta strand","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6WQK"}]},{"type":"Beta strand","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6WQK"}]},{"type":"Cross-link","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"},"sequence":"P22626-2"},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0507","category":"Biological process","name":"mRNA processing"},{"id":"KW-0508","category":"Biological process","name":"mRNA splicing"},{"id":"KW-0509","category":"Biological process","name":"mRNA transport"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0687","category":"Molecular function","name":"Ribonucleoprotein"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0747","category":"Cellular component","name":"Spliceosome"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"2557628","citationType":"journal article","authors":["Burd C.G.","Swanson M.S.","Goerlach M.","Dreyfuss G."],"citationCrossReferences":[{"database":"PubMed","id":"2557628"},{"database":"DOI","id":"10.1073/pnas.86.24.9788"}],"title":"Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.","publicationDate":"1989","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9788","lastPage":"9792","volume":"86"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B1 AND A2)"]},{"referenceNumber":2,"citation":{"id":"8029005","citationType":"journal article","authors":["Biamonti G.","Ruggiu M.","Saccone S.","Della Valle G.","Riva S."],"citationCrossReferences":[{"database":"PubMed","id":"8029005"},{"database":"DOI","id":"10.1093/nar/22.11.1996"}],"title":"Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1.","publicationDate":"1994","journal":"Nucleic Acids Res.","firstPage":"1996","lastPage":"2002","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"7789969","citationType":"journal article","authors":["Kozu T.","Henrich B.","Schaefer K.P."],"citationCrossReferences":[{"database":"PubMed","id":"7789969"},{"database":"DOI","id":"10.1016/0888-7543(95)80035-k"}],"title":"Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1.","publicationDate":"1995","journal":"Genomics","firstPage":"365","lastPage":"371","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B1)"],"referenceComments":[{"value":"Glial tumor","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"CI-7J9E4GC7NR12E","citationType":"submission","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W.","Dozynkiewicz M.","Norman J.C."],"publicationDate":"JUN-2009","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 1-12; 22-59; 63-89; 100-147; 153-185; 201-266 AND 326-350","ACETYLATION AT MET-1","METHYLATION AT LYS-104; ARG-203 AND ARG-213","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Ovarian carcinoma","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"CI-5JLPE8IQ42OFK","citationType":"submission","authors":["Lubec G.","Vishwanath V.","Chen W.-Q.","Sun Y."],"publicationDate":"DEC-2008","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 22-38; 154-168; 174-185; 214-228 AND 326-350","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Cajal-Retzius cell","type":"TISSUE"},{"value":"Fetal brain cortex","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"1522214","citationType":"journal article","authors":["Steiner G.","Hartmuth K.","Skriner K.","Maurer-Fogy I.","Sinski A.","Thalmann E.","Hassfeld W.","Barta A.","Smolen J.S."],"citationCrossReferences":[{"database":"PubMed","id":"1522214"},{"database":"DOI","id":"10.1172/jci115921"}],"title":"Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex.","publicationDate":"1992","journal":"J. Clin. Invest.","firstPage":"1061","lastPage":"1066","volume":"90"},"referencePositions":["PROTEIN SEQUENCE OF 39-46; 154-168; 204-228 AND 267-286"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"7980541","citationType":"journal article","authors":["Prasad S.","Walent J.","Dritschilo A."],"citationCrossReferences":[{"database":"PubMed","id":"7980541"},{"database":"DOI","id":"10.1006/bbrc.1994.2526"}],"title":"ADP-ribosylation of heterogeneous ribonucleoproteins in HeLa cells.","publicationDate":"1994","journal":"Biochem. Biophys. Res. Commun.","firstPage":"772","lastPage":"779","volume":"204"},"referencePositions":["PROTEIN SEQUENCE OF 80-100"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"3733753","citationType":"journal article","authors":["Kumar A.","Willams K.R.","Szer W."],"citationCrossReferences":[{"database":"PubMed","id":"3733753"},{"database":"DOI","id":"10.1016/s0021-9258(18)67378-8"}],"title":"Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins.","publicationDate":"1986","journal":"J. Biol. Chem.","firstPage":"11266","lastPage":"11273","volume":"261"},"referencePositions":["PROTEIN SEQUENCE OF 100-107; 121-128 AND 174-180"]},{"referenceNumber":11,"citation":{"id":"1699755","citationType":"journal article","authors":["Bauw G.","Rasmussen H.H.","van den Bulcke M.","van Damme J.","Puype M.","Gesser B.","Celis J.E.","Vandekerckhove J."],"citationCrossReferences":[{"database":"PubMed","id":"1699755"},{"database":"DOI","id":"10.1002/elps.1150110703"}],"title":"Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes.","publicationDate":"1990","journal":"Electrophoresis","firstPage":"528","lastPage":"536","volume":"11"},"referencePositions":["PROTEIN SEQUENCE OF 154-160; 204-212 AND 214-228"]},{"referenceNumber":12,"citation":{"id":"10567417","citationType":"journal article","authors":["Munro T.P.","Magee R.J.","Kidd G.J.","Carson J.H.","Barbarese E.","Smith L.M.","Smith R."],"citationCrossReferences":[{"database":"PubMed","id":"10567417"},{"database":"DOI","id":"10.1074/jbc.274.48.34389"}],"title":"Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"34389","lastPage":"34395","volume":"274"},"referencePositions":["FUNCTION","RNA-BINDING"]},{"referenceNumber":13,"citation":{"id":"10772824","citationType":"journal article","authors":["Nichols R.C.","Wang X.W.","Tang J.","Hamilton B.J.","High F.A.","Herschman H.R.","Rigby W.F."],"citationCrossReferences":[{"database":"PubMed","id":"10772824"},{"database":"DOI","id":"10.1006/excr.2000.4827"}],"title":"The RGG domain in hnRNP A2 affects subcellular localization.","publicationDate":"2000","journal":"Exp. Cell Res.","firstPage":"522","lastPage":"532","volume":"256"},"referencePositions":["SUBCELLULAR LOCATION (ISOFORM A2)","METHYLATION"]},{"referenceNumber":14,"citation":{"id":"11991638","citationType":"journal article","authors":["Jurica M.S.","Licklider L.J.","Gygi S.P.","Grigorieff N.","Moore M.J."],"citationCrossReferences":[{"database":"PubMed","id":"11991638"},{"database":"DOI","id":"10.1017/s1355838202021088"}],"title":"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.","publicationDate":"2002","journal":"RNA","firstPage":"426","lastPage":"439","volume":"8"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY","IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX"]},{"referenceNumber":15,"citation":{"id":"14654843","citationType":"journal article","authors":["Andersen J.S.","Wilkinson C.J.","Mayor T.","Mortensen P.","Nigg E.A.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"14654843"},{"database":"DOI","id":"10.1038/nature02166"}],"title":"Proteomic characterization of the human centrosome by protein correlation profiling.","publicationDate":"2003","journal":"Nature","firstPage":"570","lastPage":"574","volume":"426"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Lymphoblast","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"15294897","citationType":"journal article","authors":["Beriault V.","Clement J.F.","Levesque K.","Lebel C.","Yong X.","Chabot B.","Cohen E.A.","Cochrane A.W.","Rigby W.F.","Mouland A.J."],"citationCrossReferences":[{"database":"PubMed","id":"15294897"},{"database":"DOI","id":"10.1074/jbc.m404691200"}],"title":"A late role for the association of hnRNP A2 with the HIV-1 hnRNP A2 response elements in genomic RNA, Gag, and Vpr localization.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"44141","lastPage":"44153","volume":"279"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)"]},{"referenceNumber":17,"citation":{"id":"15782174","citationType":"journal article","authors":["Ong S.E.","Mittler G.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"15782174"},{"database":"DOI","id":"10.1038/nmeth715"}],"title":"Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.","publicationDate":"2004","journal":"Nat. Methods","firstPage":"119","lastPage":"126","volume":"1"},"referencePositions":["METHYLATION [LARGE SCALE ANALYSIS] AT ARG-203","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"15703215","citationType":"journal article","authors":["Kosturko L.D.","Maggipinto M.J.","D'Sa C.","Carson J.H.","Barbarese E."],"citationCrossReferences":[{"database":"PubMed","id":"15703215"},{"database":"DOI","id":"10.1091/mbc.e04-08-0709"}],"title":"The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2.","publicationDate":"2005","journal":"Mol. Biol. Cell","firstPage":"1938","lastPage":"1947","volume":"16"},"referencePositions":["INTERACTION WITH CKAP5"]},{"referenceNumber":19,"citation":{"id":"17004321","citationType":"journal article","authors":["Levesque K.","Halvorsen M.","Abrahamyan L.","Chatel-Chaix L.","Poupon V.","Gordon H.","DesGroseillers L.","Gatignol A.","Mouland A.J."],"citationCrossReferences":[{"database":"PubMed","id":"17004321"},{"database":"DOI","id":"10.1111/j.1600-0854.2006.00461.x"}],"title":"Trafficking of HIV-1 RNA is mediated by heterogeneous nuclear ribonucleoprotein A2 expression and impacts on viral assembly.","publicationDate":"2006","journal":"Traffic","firstPage":"1177","lastPage":"1193","volume":"7"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)"]},{"referenceNumber":20,"citation":{"id":"17924679","citationType":"journal article","authors":["Yu L.R.","Zhu Z.","Chan K.C.","Issaq H.J.","Dimitrov D.S.","Veenstra T.D."],"citationCrossReferences":[{"database":"PubMed","id":"17924679"},{"database":"DOI","id":"10.1021/pr070152u"}],"title":"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.","publicationDate":"2007","journal":"J. Proteome Res.","firstPage":"4150","lastPage":"4162","volume":"6"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259 AND SER-341","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":21,"citation":{"id":"17289661","citationType":"journal article","authors":["Joeson L.","Vikesaa J.","Krogh A.","Nielsen L.K.","Hansen T.","Borup R.","Johnsen A.H.","Christiansen J.","Nielsen F.C."],"citationCrossReferences":[{"database":"PubMed","id":"17289661"},{"database":"DOI","id":"10.1074/mcp.m600346-mcp200"}],"title":"Molecular composition of IMP1 ribonucleoprotein granules.","publicationDate":"2007","journal":"Mol. Cell. Proteomics","firstPage":"798","lastPage":"811","volume":"6"},"referencePositions":["IDENTIFICATION IN A MRNP GRANULE COMPLEX","INTERACTION WITH IGF2BP1","SUBCELLULAR LOCATION","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":22,"citation":{"id":"18220336","citationType":"journal article","authors":["Cantin G.T.","Yi W.","Lu B.","Park S.K.","Xu T.","Lee J.-D.","Yates J.R. III"],"citationCrossReferences":[{"database":"PubMed","id":"18220336"},{"database":"DOI","id":"10.1021/pr0705441"}],"title":"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"1346","lastPage":"1351","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259 AND SER-341","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259; SER-341 AND SER-344","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":25,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":26,"citation":{"id":"19099192","citationType":"journal article","authors":["He Y.","Smith R."],"citationCrossReferences":[{"database":"PubMed","id":"19099192"},{"database":"DOI","id":"10.1007/s00018-008-8532-1"}],"title":"Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B.","publicationDate":"2009","journal":"Cell. Mol. Life Sci.","firstPage":"1239","lastPage":"1256","volume":"66"},"referencePositions":["REVIEW"]},{"referenceNumber":27,"citation":{"id":"19369195","citationType":"journal article","authors":["Oppermann F.S.","Gnad F.","Olsen J.V.","Hornberger R.","Greff Z.","Keri G.","Mann M.","Daub H."],"citationCrossReferences":[{"database":"PubMed","id":"19369195"},{"database":"DOI","id":"10.1074/mcp.m800588-mcp200"}],"title":"Large-scale proteomics analysis of the human kinome.","publicationDate":"2009","journal":"Mol. Cell. Proteomics","firstPage":"1751","lastPage":"1764","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":28,"citation":{"id":"19429692","citationType":"journal article","authors":["D'Ambrogio A.","Buratti E.","Stuani C.","Guarnaccia C.","Romano M.","Ayala Y.M.","Baralle F.E."],"citationCrossReferences":[{"database":"PubMed","id":"19429692"},{"database":"DOI","id":"10.1093/nar/gkp342"}],"title":"Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo.","publicationDate":"2009","journal":"Nucleic Acids Res.","firstPage":"4116","lastPage":"4126","volume":"37"},"referencePositions":["INTERACTION WITH TARDBP"]},{"referenceNumber":29,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-212; SER-259 AND SER-344","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":30,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-168 AND LYS-173","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":31,"citation":{"id":"20010808","citationType":"journal article","authors":["David C.J.","Chen M.","Assanah M.","Canoll P.","Manley J.L."],"citationCrossReferences":[{"database":"PubMed","id":"20010808"},{"database":"DOI","id":"10.1038/nature08697"}],"title":"HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.","publicationDate":"2010","journal":"Nature","firstPage":"364","lastPage":"368","volume":"463"},"referencePositions":["FUNCTION","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":32,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-149; SER-212; SER-225; SER-231; SER-259; SER-341 AND SER-344","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":33,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":34,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212; SER-225; SER-231; SER-236; SER-259; SER-324; TYR-331 AND SER-344","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":35,"citation":{"id":"22905912","citationType":"journal article","authors":["Rosenow A.","Noben J.P.","Jocken J.","Kallendrusch S.","Fischer-Posovszky P.","Mariman E.C.","Renes J."],"citationCrossReferences":[{"database":"PubMed","id":"22905912"},{"database":"DOI","id":"10.1021/pr300539b"}],"title":"Resveratrol-induced changes of the human adipocyte secretion profile.","publicationDate":"2012","journal":"J. Proteome Res.","firstPage":"4733","lastPage":"4743","volume":"11"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":36,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":37,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-4; SER-29; THR-140; THR-159; THR-176; SER-189; SER-201; SER-212; SER-225; SER-259; SER-324; TYR-331; SER-341 AND SER-344","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":38,"citation":{"id":"24356509","citationType":"journal article","authors":["Villarroya-Beltri C.","Gutierrez-Vazquez C.","Sanchez-Cabo F.","Perez-Hernandez D.","Vazquez J.","Martin-Cofreces N.","Martinez-Herrera D.J.","Pascual-Montano A.","Mittelbrunn M.","Sanchez-Madrid F."],"citationCrossReferences":[{"database":"PubMed","id":"24356509"},{"database":"DOI","id":"10.1038/ncomms3980"}],"title":"Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs.","publicationDate":"2013","journal":"Nat. Commun.","firstPage":"2980","lastPage":"2980","volume":"4"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","SUMOYLATION"]},{"referenceNumber":39,"citation":{"id":"24098712","citationType":"journal article","authors":["Friend L.R.","Landsberg M.J.","Nouwens A.S.","Wei Y.","Rothnagel J.A.","Smith R."],"citationCrossReferences":[{"database":"PubMed","id":"24098712"},{"database":"DOI","id":"10.1371/journal.pone.0075669"}],"title":"Arginine methylation of hnRNP A2 does not directly govern its subcellular localization.","publicationDate":"2013","journal":"PLoS ONE","firstPage":"E75669","lastPage":"E75669","volume":"8"},"referencePositions":["SUBCELLULAR LOCATION (ISOFORM A2)"]},{"referenceNumber":40,"citation":{"id":"24549040","citationType":"journal article","authors":["Farg M.A.","Sundaramoorthy V.","Sultana J.M.","Yang S.","Atkinson R.A.","Levina V.","Halloran M.A.","Gleeson P.A.","Blair I.P.","Soo K.Y.","King A.E.","Atkin J.D."],"citationCrossReferences":[{"database":"PubMed","id":"24549040"},{"database":"DOI","id":"10.1093/hmg/ddu068"}],"title":"C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.","publicationDate":"2014","journal":"Hum. Mol. Genet.","firstPage":"3579","lastPage":"3595","volume":"23"},"referencePositions":["INTERACTION WITH C9ORF72"]},{"referenceNumber":41,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-85; SER-212; SER-225; SER-231; SER-341; SER-344 AND TYR-347","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":42,"citation":{"id":"24129315","citationType":"journal article","authors":["Guo A.","Gu H.","Zhou J.","Mulhern D.","Wang Y.","Lee K.A.","Yang V.","Aguiar M.","Kornhauser J.","Jia X.","Ren J.","Beausoleil S.A.","Silva J.C.","Vemulapalli V.","Bedford M.T.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"24129315"},{"database":"DOI","id":"10.1074/mcp.o113.027870"}],"title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.","publicationDate":"2014","journal":"Mol. Cell. Proteomics","firstPage":"372","lastPage":"387","volume":"13"},"referencePositions":["METHYLATION [LARGE SCALE ANALYSIS] AT ARG-203; ARG-213; ARG-228; ARG-238; ARG-266; ARG-325 AND ARG-350","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Colon carcinoma","type":"TISSUE"}]},{"referenceNumber":43,"citation":{"id":"25218447","citationType":"journal article","authors":["Hendriks I.A.","D'Souza R.C.","Yang B.","Verlaan-de Vries M.","Mann M.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25218447"},{"database":"DOI","id":"10.1038/nsmb.2890"}],"title":"Uncovering global SUMOylation signaling networks in a site-specific manner.","publicationDate":"2014","journal":"Nat. Struct. Mol. Biol.","firstPage":"927","lastPage":"936","volume":"21"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-120 AND LYS-186","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":44,"citation":{"id":"25678563","citationType":"journal article","authors":["Lauranzano E.","Pozzi S.","Pasetto L.","Stucchi R.","Massignan T.","Paolella K.","Mombrini M.","Nardo G.","Lunetta C.","Corbo M.","Mora G.","Bendotti C.","Bonetto V."],"citationCrossReferences":[{"database":"PubMed","id":"25678563"},{"database":"DOI","id":"10.1093/brain/awv005"}],"title":"Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.","publicationDate":"2015","journal":"Brain","firstPage":"974","lastPage":"991","volume":"138"},"referencePositions":["INTERACTION WITH PPIA"]},{"referenceNumber":45,"citation":{"id":"26544936","citationType":"journal article","authors":["Xiang S.","Kato M.","Wu L.C.","Lin Y.","Ding M.","Zhang Y.","Yu Y.","McKnight S.L."],"citationCrossReferences":[{"database":"PubMed","id":"26544936"},{"database":"DOI","id":"10.1016/j.cell.2015.10.040"}],"title":"The LC domain of hnRNPA2 adopts similar conformations in hydrogel polymers, liquid-like droplets, and nuclei.","publicationDate":"2015","journal":"Cell","firstPage":"829","lastPage":"839","volume":"163"},"referencePositions":["DOMAIN","MUTAGENESIS OF PHE-207; PHE-209; PHE-219; PHE-227; TYR-234; PHE-240; TYR-244; TYR-247; PHE-256; TYR-262; TYR-269; TYR-276; TYR-283; TYR-287; TYR-290; TYR-295; TYR-300; PHE-303; TYR-306; TYR-313; PHE-321; TYR-331; TYR-336; TYR-347 AND TYR-353"]},{"referenceNumber":46,"citation":{"id":"26321680","citationType":"journal article","authors":["Alarcon C.R.","Goodarzi H.","Lee H.","Liu X.","Tavazoie S.","Tavazoie S.F."],"citationCrossReferences":[{"database":"PubMed","id":"26321680"},{"database":"DOI","id":"10.1016/j.cell.2015.08.011"}],"title":"HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events.","publicationDate":"2015","journal":"Cell","firstPage":"1299","lastPage":"1308","volume":"162"},"referencePositions":["FUNCTION","MIRNA-BINDING","INTERACTION WITH DGCR8"]},{"referenceNumber":47,"citation":{"id":"25755297","citationType":"journal article","authors":["Xiao Z.","Chang J.G.","Hendriks I.A.","Sigurdsson J.O.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25755297"},{"database":"DOI","id":"10.1074/mcp.o114.044792"}],"title":"System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.","publicationDate":"2015","journal":"Mol. Cell. Proteomics","firstPage":"1419","lastPage":"1434","volume":"14"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-120","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":48,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":49,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-22; LYS-104; LYS-112; LYS-120; LYS-137; LYS-152; LYS-168 AND LYS-173","SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-5 (ISOFORM A2)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":50,"citation":{"id":"31320558","citationType":"journal article","authors":["Wang L.","Wen M.","Cao X."],"citationCrossReferences":[{"database":"PubMed","id":"31320558"},{"database":"DOI","id":"10.1126/science.aav0758"}],"title":"Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.","publicationDate":"2019","journal":"Science","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["FUNCTION","SUBUNIT","INTERACTION WITH TBK1; STING1 AND SRC","SUBCELLULAR LOCATION","MUTAGENESIS OF ARG-228","METHYLATION AT ARG-228"]},{"referenceNumber":51,"citation":{"id":"37643469","citationType":"journal article","authors":["Wang D.","Zheng X.","Chai L.","Zhao J.","Zhu J.","Li Y.","Yang P.","Mao Q.","Xia H."],"citationCrossReferences":[{"database":"PubMed","id":"37643469"},{"database":"DOI","id":"10.7554/elife.85659"}],"title":"FAM76B regulates NF-kappaB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1.","publicationDate":"2023","journal":"Elife","firstPage":"0","lastPage":"0","volume":"12"},"referencePositions":["INTERACTION WITH FAM76B; NFKBIA AND NFKBIE","SUBCELLULAR LOCATION"]},{"referenceNumber":52,"citation":{"id":"39349455","citationType":"journal article","authors":["Zhang X.","Huang G.","Jiang T.","Meng L.","Li T.","Zhang G.","Wu N.","Chen X.","Zhao B.","Li N.","Wu S.","Guo J.","Zheng R.","Ji Z.","Xu Z.","Wang Z.","Deng D.","Tan Y.","Xu W."],"citationCrossReferences":[{"database":"PubMed","id":"39349455"},{"database":"DOI","id":"10.1038/s41467-024-52705-8"}],"title":"CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice.","publicationDate":"2024","journal":"Nat. Commun.","firstPage":"8465","lastPage":"8465","volume":"15"},"referencePositions":["INTERACTION WITH CEP112"]},{"referenceNumber":53,"citation":{"id":"CI-3D86096T2K5PL","citationType":"submission","authoringGroup":["RIKEN structural genomics initiative (RSGI)"],"title":"Solution structure of RRM domain in heterogeneous nuclear ribonucleoproteins A2/B1.","publicationDate":"NOV-2005","submissionDatabase":"PDB data bank"},"referencePositions":["STRUCTURE BY NMR OF 1-103"]},{"referenceNumber":54,"citation":{"id":"23455423","citationType":"journal article","authors":["Kim H.J.","Kim N.C.","Wang Y.D.","Scarborough E.A.","Moore J.","Diaz Z.","MacLea K.S.","Freibaum B.","Li S.","Molliex A.","Kanagaraj A.P.","Carter R.","Boylan K.B.","Wojtas A.M.","Rademakers R.","Pinkus J.L.","Greenberg S.A.","Trojanowski J.Q.","Traynor B.J.","Smith B.N.","Topp S.","Gkazi A.S.","Miller J.","Shaw C.E.","Kottlors M.","Kirschner J.","Pestronk A.","Li Y.R.","Ford A.F.","Gitler A.D.","Benatar M.","King O.D.","Kimonis V.E.","Ross E.D.","Weihl C.C.","Shorter J.","Taylor J.P."],"citationCrossReferences":[{"database":"PubMed","id":"23455423"},{"database":"DOI","id":"10.1038/nature11922"}],"title":"Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.","publicationDate":"2013","journal":"Nature","firstPage":"467","lastPage":"473","volume":"495"},"referencePositions":["VARIANT IBMPFD2 VAL-302"]},{"referenceNumber":55,"citation":{"id":"35484142","citationType":"journal article","authors":["Kim H.J.","Mohassel P.","Donkervoort S.","Guo L.","O'Donovan K.","Coughlin M.","Lornage X.","Foulds N.","Hammans S.R.","Foley A.R.","Fare C.M.","Ford A.F.","Ogasawara M.","Sato A.","Iida A.","Munot P.","Ambegaonkar G.","Phadke R.","O'Donovan D.G.","Buchert R.","Grimmel M.","Toepf A.","Zaharieva I.T.","Brady L.","Hu Y.","Lloyd T.E.","Klein A.","Steinlin M.","Kuster A.","Mercier S.","Marcorelles P.","Pereon Y.","Fleurence E.","Manzur A.","Ennis S.","Upstill-Goddard R.","Bello L.","Bertolin C.","Pegoraro E.","Salviati L.","French C.E.","Shatillo A.","Raymond F.L.","Haack T.B.","Quijano-Roy S.","Boehm J.","Nelson I.","Stojkovic T.","Evangelista T.","Straub V.","Romero N.B.","Laporte J.","Muntoni F.","Nishino I.","Tarnopolsky M.A.","Shorter J.","Boennemann C.G.","Taylor J.P."],"citationCrossReferences":[{"database":"PubMed","id":"35484142"},{"database":"DOI","id":"10.1038/s41467-022-30015-1"}],"title":"Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy.","publicationDate":"2022","journal":"Nat. Commun.","firstPage":"2306","lastPage":"2306","volume":"13"},"referencePositions":["INVOLVEMENT IN OPMD2"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M29064","properties":[{"key":"ProteinId","value":"AAA60271.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M29065","properties":[{"key":"ProteinId","value":"AAA36574.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U09123","properties":[{"key":"ProteinId","value":"AAB60650.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U09120","properties":[{"key":"ProteinId","value":"AAB60650.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U09121","properties":[{"key":"ProteinId","value":"AAB60650.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U09122","properties":[{"key":"ProteinId","value":"AAB60650.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"D28877","properties":[{"key":"ProteinId","value":"BAA06031.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"D28877","properties":[{"key":"ProteinId","value":"BAA06032.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK289429","properties":[{"key":"ProteinId","value":"BAF82118.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471073","properties":[{"key":"ProteinId","value":"EAW93835.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471073","properties":[{"key":"ProteinId","value":"EAW93836.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471073","properties":[{"key":"ProteinId","value":"EAW93837.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471073","properties":[{"key":"ProteinId","value":"EAW93839.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS43557.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P22626-1"},{"database":"CCDS","id":"CCDS5397.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P22626-2"},{"database":"PIR","id":"A56845","properties":[{"key":"EntryName","value":"B34504"}]},{"database":"RefSeq","id":"NP_001424992.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001438063.1"}],"isoformId":"P22626-2"},{"database":"RefSeq","id":"NP_001425497.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001438568.1"}],"isoformId":"P22626-1"},{"database":"RefSeq","id":"NP_001425498.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001438569.1"}],"isoformId":"P22626-1"},{"database":"RefSeq","id":"NP_001425499.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001438570.1"}],"isoformId":"P22626-1"},{"database":"RefSeq","id":"NP_001425500.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001438571.1"}],"isoformId":"P22626-2"},{"database":"RefSeq","id":"NP_001425501.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001438572.1"}],"isoformId":"P22626-2"},{"database":"RefSeq","id":"NP_002128.1","properties":[{"key":"NucleotideSequenceId","value":"NM_002137.4"}],"isoformId":"P22626-2"},{"database":"RefSeq","id":"NP_112533.1","properties":[{"key":"NucleotideSequenceId","value":"NM_031243.4"}],"isoformId":"P22626-1"},{"database":"PDB","id":"1X4B","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-103"}]},{"database":"PDB","id":"5EN1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.58 A"},{"key":"Chains","value":"A=12-195"}]},{"database":"PDB","id":"5HO4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=15-193"}]},{"database":"PDB","id":"5WWE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=12-195"}]},{"database":"PDB","id":"5WWF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A/C=12-195"}]},{"database":"PDB","id":"5WWG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"A=12-195"}]},{"database":"PDB","id":"6WPQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.10 A"},{"key":"Chains","value":"A=298-303"}]},{"database":"PDB","id":"6WQK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B/C/D/E=193-353"}]},{"database":"PDB","id":"7WM3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.62 A"},{"key":"Chains","value":"A/B/C/D=15-193"}]},{"database":"PDB","id":"8DU2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=193-353"}]},{"database":"PDB","id":"8DUW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=193-353"}]},{"database":"PDB","id":"8EC7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O=193-353"}]},{"database":"PDB","id":"8HNI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.64 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=15-193"}]},{"database":"PDBsum","id":"1X4B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5EN1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5HO4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5WWE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5WWF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5WWG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WPQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WQK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WM3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8DU2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8DUW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8EC7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HNI","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21871","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-27713","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-27728","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-28014","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109422","properties":[{"key":"Interactions","value":"844"}]},{"database":"CORUM","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-32877N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P22626","properties":[{"key":"Number of interactors","value":"3584"}]},{"database":"IntAct","id":"P22626","properties":[{"key":"Interactions","value":"307"}]},{"database":"MINT","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"MUSIC2-C5228-HNRNPA2B1","properties":[{"key":"Evidences","value":"Osteosarcoma (U2OS) cell map - RNA metabolism and nuclear transport regulation (23 proteins)"}]},{"database":"STRING","id":"9606.ENSP00000346694","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3124741","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB11638","properties":[{"key":"GenericName","value":"Artenimol"}]},{"database":"DrugBank","id":"DB09130","properties":[{"key":"GenericName","value":"Copper"}]},{"database":"GlyCosmos","id":"P22626","properties":[{"key":"glycosylation","value":"2 sites, 2 glycans"}]},{"database":"GlyGen","id":"P22626","properties":[{"key":"glycosylation","value":"4 sites, 2 O-linked glycans (4 sites)"}]},{"database":"iPTMnet","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HNRNPA2B1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"133257","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"IPI00396378","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"IPI00414696","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000346694","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54010","properties":[{"key":"Description","value":"-"}],"isoformId":"P22626-1"},{"database":"ProteomicsDB","id":"54011","properties":[{"key":"Description","value":"-"}],"isoformId":"P22626-2"},{"database":"Pumba","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P22626-1","properties":[{"key":"Description","value":"-"}],"isoformId":"P22626-1"},{"database":"TopDownProteomics","id":"P22626-2","properties":[{"key":"Description","value":"-"}],"isoformId":"P22626-2"},{"database":"Antibodypedia","id":"3240","properties":[{"key":"antibodies","value":"477 antibodies from 36 providers"}]},{"database":"DNASU","id":"3181","properties":[{"key":"Description","value":"-"}]},{"database":"YCharOS","id":"P22626","properties":[{"key":"antibodies","value":"Tested 8 antibodies from 6 manufacturers"}]},{"database":"Ensembl","id":"ENST00000354667.8","properties":[{"key":"ProteinId","value":"ENSP00000346694.4"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000356674.8","properties":[{"key":"ProteinId","value":"ENSP00000349101.8"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000360787.8","properties":[{"key":"ProteinId","value":"ENSP00000354021.4"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000608362.2","properties":[{"key":"ProteinId","value":"ENSP00000497298.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000618183.5","properties":[{"key":"ProteinId","value":"ENSP00000478691.2"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000676497.1","properties":[{"key":"ProteinId","value":"ENSP00000503836.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000676524.1","properties":[{"key":"ProteinId","value":"ENSP00000504831.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000676746.1","properties":[{"key":"ProteinId","value":"ENSP00000504329.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000676749.1","properties":[{"key":"ProteinId","value":"ENSP00000504799.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000676903.1","properties":[{"key":"ProteinId","value":"ENSP00000504660.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000677339.1","properties":[{"key":"ProteinId","value":"ENSP00000503242.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000677396.1","properties":[{"key":"ProteinId","value":"ENSP00000503703.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000677574.1","properties":[{"key":"ProteinId","value":"ENSP00000503021.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000677631.1","properties":[{"key":"ProteinId","value":"ENSP00000503452.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000677656.1","properties":[{"key":"ProteinId","value":"ENSP00000503060.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000677839.1","properties":[{"key":"ProteinId","value":"ENSP00000504439.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000677906.1","properties":[{"key":"ProteinId","value":"ENSP00000503870.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000678431.1","properties":[{"key":"ProteinId","value":"ENSP00000503833.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000678449.1","properties":[{"key":"ProteinId","value":"ENSP00000503375.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000678501.1","properties":[{"key":"ProteinId","value":"ENSP00000503961.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000678675.1","properties":[{"key":"ProteinId","value":"ENSP00000503476.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000678697.1","properties":[{"key":"ProteinId","value":"ENSP00000503047.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000678779.1","properties":[{"key":"ProteinId","value":"ENSP00000503429.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000678884.1","properties":[{"key":"ProteinId","value":"ENSP00000503501.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000678935.1","properties":[{"key":"ProteinId","value":"ENSP00000504023.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000678962.1","properties":[{"key":"ProteinId","value":"ENSP00000504721.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000678998.1","properties":[{"key":"ProteinId","value":"ENSP00000503460.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000679001.1","properties":[{"key":"ProteinId","value":"ENSP00000503514.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000679021.1","properties":[{"key":"ProteinId","value":"ENSP00000503885.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000679123.1","properties":[{"key":"ProteinId","value":"ENSP00000503360.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000679243.1","properties":[{"key":"ProteinId","value":"ENSP00000504415.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000679318.1","properties":[{"key":"ProteinId","value":"ENSP00000504571.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000868111.1","properties":[{"key":"ProteinId","value":"ENSP00000538170.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000868113.1","properties":[{"key":"ProteinId","value":"ENSP00000538172.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000868114.1","properties":[{"key":"ProteinId","value":"ENSP00000538173.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000868116.1","properties":[{"key":"ProteinId","value":"ENSP00000538175.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000868118.1","properties":[{"key":"ProteinId","value":"ENSP00000538177.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000868121.1","properties":[{"key":"ProteinId","value":"ENSP00000538180.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000923778.1","properties":[{"key":"ProteinId","value":"ENSP00000593837.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000923780.1","properties":[{"key":"ProteinId","value":"ENSP00000593839.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-2"},{"database":"Ensembl","id":"ENST00000923782.1","properties":[{"key":"ProteinId","value":"ENSP00000593841.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"Ensembl","id":"ENST00000923783.1","properties":[{"key":"ProteinId","value":"ENSP00000593842.1"},{"key":"GeneId","value":"ENSG00000122566.24"}],"isoformId":"P22626-1"},{"database":"GeneID","id":"3181","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3181","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000618183.5","properties":[{"key":"ProteinId","value":"ENSP00000478691.2"},{"key":"RefSeqNucleotideId","value":"NM_002137.4"},{"key":"RefSeqProteinId","value":"NP_002128.1"}],"isoformId":"P22626-2"},{"database":"UCSC","id":"uc003sxr.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P22626-1"},{"database":"AGR","id":"HGNC:5033","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162391140","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3181","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3181","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HNRNPA2B1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"HNRNPA2B1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5033","properties":[{"key":"GeneName","value":"HNRNPA2B1"}]},{"database":"HPA","id":"ENSG00000122566","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"HNRNPA2B1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"600124","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"615422","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"620460","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000122566","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"52430","properties":[{"key":"Disease","value":"Inclusion body myopathy with Paget disease of bone and frontotemporal dementia"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000122566","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0118","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000154431","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_012062_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MDFNRYM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"1875751at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P22626","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-72163","properties":[{"key":"PathwayName","value":"mRNA Splicing - Major Pathway"}]},{"database":"Reactome","id":"R-HSA-72203","properties":[{"key":"PathwayName","value":"Processing of Capped Intron-Containing Pre-mRNA"}]},{"database":"Reactome","id":"R-HSA-8950505","properties":[{"key":"PathwayName","value":"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"}]},{"database":"Reactome","id":"R-HSA-9770562","properties":[{"key":"PathwayName","value":"mRNA Polyadenylation"}]},{"database":"Reactome","id":"R-HSA-9918481","properties":[{"key":"PathwayName","value":"Dengue Virus-Host Interactions"}]},{"database":"SignaLink","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000122566","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"3181","properties":[{"key":"hits","value":"210 hits in 1176 CRISPR screens"}]},{"database":"CD-CODE","id":"232F8A39","properties":[{"key":"EntryName","value":"P-body"}]},{"database":"CD-CODE","id":"2612F8DB","properties":[{"key":"EntryName","value":"Synthetic Condensate 000313"}]},{"database":"CD-CODE","id":"2C224C76","properties":[{"key":"EntryName","value":"Synthetic Condensate 000284"}]},{"database":"CD-CODE","id":"5506006C","properties":[{"key":"EntryName","value":"Synthetic Condensate 000177"}]},{"database":"CD-CODE","id":"6209F224","properties":[{"key":"EntryName","value":"Synthetic Condensate 000281"}]},{"database":"CD-CODE","id":"804901D1","properties":[{"key":"EntryName","value":"Nuclear speckle"}]},{"database":"CD-CODE","id":"85C30F04","properties":[{"key":"EntryName","value":"Synthetic Condensate 000057"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"92722620","properties":[{"key":"EntryName","value":"Synthetic Condensate 000059"}]},{"database":"CD-CODE","id":"A3F53DF0","properties":[{"key":"EntryName","value":"Synthetic Condensate 000272"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"CD-CODE","id":"F85A2E29","properties":[{"key":"EntryName","value":"IMP1 RNP granule"}]},{"database":"ChiTaRS","id":"HNRNPA2B1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P22626","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"HNRPA2B1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3181","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P22626","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P22626","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"RNAct","id":"P22626","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000122566","properties":[{"key":"ExpressionPatterns","value":"Expressed in epithelium of nasopharynx and 215 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P22626","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0015030","properties":[{"key":"GoTerm","value":"C:Cajal body"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0071013","properties":[{"key":"GoTerm","value":"C:catalytic step 2 spliceosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11991638"}]},{"database":"GO","id":"GO:0000781","properties":[{"key":"GoTerm","value":"C:chromosome, telomeric region"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24356509"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24356509"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0016363","properties":[{"key":"GoTerm","value":"C:nuclear matrix"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22720776"}]},{"database":"GO","id":"GO:1990904","properties":[{"key":"GoTerm","value":"C:ribonucleoprotein complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17289661"}]},{"database":"GO","id":"GO:0005681","properties":[{"key":"GoTerm","value":"C:spliceosomal complex"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9731529"}]},{"database":"GO","id":"GO:0070182","properties":[{"key":"GoTerm","value":"F:DNA polymerase binding"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0098505","properties":[{"key":"GoTerm","value":"F:G-rich strand telomeric DNA binding"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}]},{"database":"GO","id":"GO:0035198","properties":[{"key":"GoTerm","value":"F:miRNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24356509"}]},{"database":"GO","id":"GO:0140693","properties":[{"key":"GoTerm","value":"F:molecular condensate scaffold activity"},{"key":"GoEvidenceType","value":"IDA:DisProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29358076"}]},{"database":"GO","id":"GO:0003730","properties":[{"key":"GoTerm","value":"F:mRNA 3'-UTR binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10567417"}]},{"database":"GO","id":"GO:1990247","properties":[{"key":"GoTerm","value":"F:N6-methyladenosine-containing RNA reader activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26321680"}]},{"database":"GO","id":"GO:0097157","properties":[{"key":"GoTerm","value":"F:pre-mRNA intronic binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15659580"}]},{"database":"GO","id":"GO:0043047","properties":[{"key":"GoTerm","value":"F:single-stranded telomeric DNA binding"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15659580"}]},{"database":"GO","id":"GO:0032392","properties":[{"key":"GoTerm","value":"P:DNA geometric change"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:1990428","properties":[{"key":"GoTerm","value":"P:miRNA transport"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24356509"}]},{"database":"GO","id":"GO:0006406","properties":[{"key":"GoTerm","value":"P:mRNA export from nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10567417"}]},{"database":"GO","id":"GO:0006397","properties":[{"key":"GoTerm","value":"P:mRNA processing"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2557628"}]},{"database":"GO","id":"GO:0000398","properties":[{"key":"GoTerm","value":"P:mRNA splicing, via spliceosome"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26321680"}]},{"database":"GO","id":"GO:0051028","properties":[{"key":"GoTerm","value":"P:mRNA transport"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:1904358","properties":[{"key":"GoTerm","value":"P:positive regulation of telomere maintenance via telomere lengthening"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0031053","properties":[{"key":"GoTerm","value":"P:primary miRNA processing"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26321680"}]},{"database":"GO","id":"GO:0050658","properties":[{"key":"GoTerm","value":"P:RNA transport"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17004321"}]},{"database":"CDD","id":"cd12762","properties":[{"key":"EntryName","value":"RRM1_hnRNPA2B1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd12581","properties":[{"key":"EntryName","value":"RRM2_hnRNPA2B1"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP01109","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"3.30.70.330:FF:000040","properties":[{"key":"EntryName","value":"Heterogeneous nuclear ribonucleoprotein A2/B1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.330:FF:000108","properties":[{"key":"EntryName","value":"Heterogeneous nuclear ribonucleoproteins A2/B1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.330","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR021662","properties":[{"key":"EntryName","value":"HnRNPA1/A2_C"}]},{"database":"InterPro","id":"IPR034486","properties":[{"key":"EntryName","value":"hnRNPA2B1_RRM1"}]},{"database":"InterPro","id":"IPR012677","properties":[{"key":"EntryName","value":"Nucleotide-bd_a/b_plait_sf"}]},{"database":"InterPro","id":"IPR035979","properties":[{"key":"EntryName","value":"RBD_domain_sf"}]},{"database":"InterPro","id":"IPR000504","properties":[{"key":"EntryName","value":"RRM_dom"}]},{"database":"PANTHER","id":"PTHR48026:SF13","properties":[{"key":"EntryName","value":"HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2_B1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR48026","properties":[{"key":"EntryName","value":"HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11627","properties":[{"key":"EntryName","value":"HnRNPA1_LC"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00076","properties":[{"key":"EntryName","value":"RRM_1"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00360","properties":[{"key":"EntryName","value":"RRM"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF54928","properties":[{"key":"EntryName","value":"RNA-binding domain, RBD"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50102","properties":[{"key":"EntryName","value":"RRM"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY","length":353,"molWeight":37430,"crc64":"4C2560A3D8E99D62","md5":"388BDBC10EA0CB2884AA8C4789B26D14"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"INTERACTION":19,"SUBCELLULAR LOCATION":2,"ALTERNATIVE PRODUCTS":2,"DOMAIN":1,"PTM":2,"DISEASE":2},"countByFeatureType":{"Chain":1,"Domain":2,"Region":2,"Motif":1,"Compositional bias":2,"Modified residue":36,"Cross-link":10,"Alternative sequence":1,"Natural variant":1,"Mutagenesis":26,"Sequence conflict":1,"Helix":12,"Beta strand":17,"Turn":4},"uniParcId":"UPI000002F091"}}