{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P22387","secondaryAccessions":["P70203","P97338"],"uniProtkbId":"EDN1_MOUSE","entryAudit":{"firstPublicDate":"1991-08-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":206,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Endothelin-1"},"shortNames":[{"value":"ET-1"}]},"alternativeNames":[{"fullName":{"value":"Preproendothelin-1"},"shortNames":[{"value":"PPET1"}]}],"contains":[{"recommendedName":{"fullName":{"value":"Big endothelin-1"}}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"Edn1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P05305"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P09558"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16293765"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20495147"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21525433"}],"value":"Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G protein-coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:16293765). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (PubMed:20495147, PubMed:21525433). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (PubMed:20495147)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8824799"}],"value":"Highest expression in the adult is in lung. Lower levels found in heart, kidney, brain and intestine. In the embryo, expressed in outer and inner pharyngeal arch surfaces. Also expressed in endothelium of dorsal aorta and arch arteries, and in epithelium of pharyngeal pouches"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8824799"}],"value":"Expression in lung is low at 17.5 dpc fetal mice and increases progressively into adulthood"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20495147"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21525433"}],"value":"Induced by intermittent hypoxia in the lung (PubMed:20495147). Induced by chronic hypoxia in the intrapulmonary arteries (PubMed:21525433)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the endothelin/sarafotoxin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P22388"}],"featureId":"PRO_0000008062"},{"type":"Peptide","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Big endothelin-1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P22388"}],"featureId":"PRO_0000436397"},{"type":"Peptide","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Endothelin-1","featureId":"PRO_0000008063"},{"type":"Propeptide","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","featureId":"PRO_0000008064"},{"type":"Region","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Endothelin-like"},{"type":"Site","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"Cleavage; by KEL","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P05305"}]},{"type":"Disulfide bond","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P05305"}]},{"type":"Disulfide bond","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P05305"}]},{"type":"Sequence conflict","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"in Ref. 3; BAA11109","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"in Ref. 2; BAA07830","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0838","category":"Molecular function","name":"Vasoactive"},{"id":"KW-0839","category":"Molecular function","name":"Vasoconstrictor"}],"references":[{"referenceNumber":1,"citation":{"id":"8575440","citationType":"journal article","authors":["Chan T.S.","Lin C.X.","Chan W.Y.","Chung S.S.","Chung S.K."],"citationCrossReferences":[{"database":"PubMed","id":"8575440"},{"database":"DOI","id":"10.1111/j.1432-1033.1995.819_a.x"}],"title":"Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic development.","publicationDate":"1995","journal":"Eur. J. Biochem.","firstPage":"819","lastPage":"826","volume":"234"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"C57BL/6 X CBA","type":"STRAIN"},{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"8688455","citationType":"journal article","authors":["Kurama M.","Ishida N.","Matsui M.","Saida K.","Mitsui Y."],"citationCrossReferences":[{"database":"PubMed","id":"8688455"},{"database":"DOI","id":"10.1016/0167-4781(96)00066-8"}],"title":"Sequence and neuronal expression of mouse endothelin-1 cDNA.","publicationDate":"1996","journal":"Biochim. Biophys. Acta","firstPage":"249","lastPage":"253","volume":"1307"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"BALB/cJ","type":"STRAIN"},{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"8824799","citationType":"journal article","authors":["Maemura K.","Kurihara H.","Kurihara Y.","Oda H.","Ishikawa T.","Copeland N.G.","Gilbert D.J.","Jenkins N.A.","Yazaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"8824799"},{"database":"DOI","id":"10.1006/geno.1996.0029"}],"title":"Sequence analysis, chromosomal location, and developmental expression of the mouse preproendothelin-1 gene.","publicationDate":"1996","journal":"Genomics","firstPage":"177","lastPage":"184","volume":"31"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"BALB/cJ","type":"STRAIN"},{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"FVB/N-3","type":"STRAIN"},{"value":"Mammary gland","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"7883980","citationType":"journal article","authors":["Harats D.","Kurihara H.","Belloni P.","Oakley H.","Ziober A.","Ackley D.","Cain G.","Kurihara Y.","Lawn R.","Sigal E."],"citationCrossReferences":[{"database":"PubMed","id":"7883980"},{"database":"DOI","id":"10.1172/jci117784"}],"title":"Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter.","publicationDate":"1995","journal":"J. Clin. Invest.","firstPage":"1335","lastPage":"1344","volume":"95"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21"],"referenceComments":[{"value":"BALB/cJ","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"8238383","citationType":"journal article","authors":["Chen M.","Todd-Turla K.","Wang W.H.","Cao X.","Smart A.","Brosius F.C.","Killen P.D.","Keiser J.A.","Briggs J.P.","Schnermann J."],"citationCrossReferences":[{"database":"PubMed","id":"8238383"},{"database":"DOI","id":"10.1152/ajprenal.1993.265.4.f542"}],"title":"Endothelin-1 mRNA in glomerular and epithelial cells of kidney.","publicationDate":"1993","journal":"Am. J. Physiol.","firstPage":"F542","lastPage":"F550","volume":"265"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 36-76"],"referenceComments":[{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"2768235","citationType":"journal article","authors":["Saida K.","Mitsui Y.","Ishida N."],"citationCrossReferences":[{"database":"PubMed","id":"2768235"},{"database":"DOI","id":"10.1016/s0021-9258(18)63739-1"}],"title":"A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity.","publicationDate":"1989","journal":"J. Biol. Chem.","firstPage":"14613","lastPage":"14616","volume":"264"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-77"]},{"referenceNumber":8,"citation":{"id":"CI-DHLEILD3HP6AK","citationType":"submission","authors":["Lubec G.","Sunyer B.","Chen W.-Q."],"publicationDate":"JAN-2009","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 155-165","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"OF1","type":"STRAIN"},{"value":"Hippocampus","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"16293765","citationType":"journal article","authors":["Herrera V.L.","Ponce L.R.","Bagamasbad P.D.","VanPelt B.D.","Didishvili T.","Ruiz-Opazo N."],"citationCrossReferences":[{"database":"PubMed","id":"16293765"},{"database":"DOI","id":"10.1152/physiolgenomics.00144.2005"}],"title":"Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis.","publicationDate":"2005","journal":"Physiol. Genomics","firstPage":"257","lastPage":"268","volume":"23"},"referencePositions":["FUNCTION"]},{"referenceNumber":10,"citation":{"id":"20495147","citationType":"journal article","authors":["de Frutos S.","Caldwell E.","Nitta C.H.","Kanagy N.L.","Wang J.","Wang W.","Walker M.K.","Gonzalez Bosc L.V."],"citationCrossReferences":[{"database":"PubMed","id":"20495147"},{"database":"DOI","id":"10.1152/ajpheart.00341.2010"}],"title":"NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice.","publicationDate":"2010","journal":"Am. J. Physiol.","firstPage":"H356","lastPage":"H363","volume":"299"},"referencePositions":["FUNCTION","INDUCTION BY HYPOXIA"]},{"referenceNumber":11,"citation":{"id":"21525433","citationType":"journal article","authors":["de Frutos S.","Diaz J.M.","Nitta C.H.","Sherpa M.L.","Bosc L.V."],"citationCrossReferences":[{"database":"PubMed","id":"21525433"},{"database":"DOI","id":"10.1152/ajpcell.00029.2011"}],"title":"Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries.","publicationDate":"2011","journal":"Am. J. Physiol.","firstPage":"C441","lastPage":"C450","volume":"301"},"referencePositions":["FUNCTION","INDUCTION BY HYPOXIA"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U35233","properties":[{"key":"ProteinId","value":"AAA97608.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D43775","properties":[{"key":"ProteinId","value":"BAA07830.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D70842","properties":[{"key":"ProteinId","value":"BAA11109.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC029547","properties":[{"key":"ProteinId","value":"AAH29547.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U07982","properties":[{"key":"ProteinId","value":"AAA74439.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"S66650","properties":[{"key":"ProteinId","value":"AAP13983.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M26497","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS26474.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S63538","properties":[{"key":"EntryName","value":"S63538"}]},{"database":"RefSeq","id":"NP_034234.1","properties":[{"key":"NucleotideSequenceId","value":"NM_010104.4"}]},{"database":"AlphaFoldDB","id":"P22387","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P22387","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P22387","properties":[{"key":"Number of interactors","value":"809"}]},{"database":"STRING","id":"10090.ENSMUSP00000021796","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P22387","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"PhosphoSitePlus","id":"P22387","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000021796","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"277682","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"10136","properties":[{"key":"antibodies","value":"771 antibodies from 40 providers"}]},{"database":"DNASU","id":"13614","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000021796.9","properties":[{"key":"ProteinId","value":"ENSMUSP00000021796.8"},{"key":"GeneId","value":"ENSMUSG00000021367.9"}]},{"database":"GeneID","id":"13614","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:13614","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007qfl.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:95283","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1906","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:95283","properties":[{"key":"GeneName","value":"Edn1"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000021367","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S1NV","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183053","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_090013_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P22387","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TDHRNRC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8873756at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P22387","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-375276","properties":[{"key":"PathwayName","value":"Peptide ligand-binding receptors"}]},{"database":"Reactome","id":"R-MMU-416476","properties":[{"key":"PathwayName","value":"G alpha (q) signalling events"}]},{"database":"BioGRID-ORCS","id":"13614","properties":[{"key":"hits","value":"0 hits in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:P22387","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"RNAct","id":"P22387","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000021367","properties":[{"key":"ExpressionPatterns","value":"Expressed in trunk blood vessel and 201 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P22387","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0045178","properties":[{"key":"GoTerm","value":"C:basal part of cell"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15314687"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24722437"}]},{"database":"GO","id":"GO:0048237","properties":[{"key":"GoTerm","value":"C:rough endoplasmic reticulum lumen"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0033093","properties":[{"key":"GoTerm","value":"C:Weibel-Palade body"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005125","properties":[{"key":"GoTerm","value":"F:cytokine activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0031707","properties":[{"key":"GoTerm","value":"F:endothelin A receptor binding"},{"key":"GoEvidenceType","value":"IPI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"9449664"}]},{"database":"GO","id":"GO:0031708","properties":[{"key":"GoTerm","value":"F:endothelin B receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005179","properties":[{"key":"GoTerm","value":"F:hormone activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0048018","properties":[{"key":"GoTerm","value":"F:receptor ligand activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24722437"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2542249"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8680799"}]},{"database":"GO","id":"GO:0007193","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2542249"}]},{"database":"GO","id":"GO:0014824","properties":[{"key":"GoTerm","value":"P:artery smooth muscle contraction"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0048675","properties":[{"key":"GoTerm","value":"P:axon extension"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18401410"}]},{"database":"GO","id":"GO:0007411","properties":[{"key":"GoTerm","value":"P:axon guidance"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30735130"}]},{"database":"GO","id":"GO:0060385","properties":[{"key":"GoTerm","value":"P:axonogenesis involved in innervation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24875861"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30735130"}]},{"database":"GO","id":"GO:0048514","properties":[{"key":"GoTerm","value":"P:blood vessel morphogenesis"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7615798"}]},{"database":"GO","id":"GO:0007589","properties":[{"key":"GoTerm","value":"P:body fluid secretion"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15314687"}]},{"database":"GO","id":"GO:0001569","properties":[{"key":"GoTerm","value":"P:branching involved in blood vessel morphogenesis"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23933587"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7615798"}]},{"database":"GO","id":"GO:0070588","properties":[{"key":"GoTerm","value":"P:calcium ion transmembrane transport"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24722437"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0141156","properties":[{"key":"GoTerm","value":"P:cAMP/PKA signal transduction"},{"key":"GoEvidenceType","value":"ISO:MGI"}],"evidences":[{"evidenceCode":"ECO:0000266","source":"PubMed","id":"30990108"}]},{"database":"GO","id":"GO:0060070","properties":[{"key":"GoTerm","value":"P:canonical Wnt signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24722437"}]},{"database":"GO","id":"GO:0003253","properties":[{"key":"GoTerm","value":"P:cardiac neural crest cell migration involved in outflow tract morphogenesis"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31219639"}]},{"database":"GO","id":"GO:0051216","properties":[{"key":"GoTerm","value":"P:cartilage development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8152482"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007267","properties":[{"key":"GoTerm","value":"P:cell-cell signaling"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0071277","properties":[{"key":"GoTerm","value":"P:cellular response to calcium ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071398","properties":[{"key":"GoTerm","value":"P:cellular response to fatty acid"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071372","properties":[{"key":"GoTerm","value":"P:cellular response to follicle-stimulating hormone stimulus"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19111534"}]},{"database":"GO","id":"GO:0071385","properties":[{"key":"GoTerm","value":"P:cellular response to glucocorticoid stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0044751","properties":[{"key":"GoTerm","value":"P:cellular response to human chorionic gonadotropin stimulus"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19111534"}]},{"database":"GO","id":"GO:0070301","properties":[{"key":"GoTerm","value":"P:cellular response to hydrogen peroxide"},{"key":"GoEvidenceType","value":"ISO:MGI"}],"evidences":[{"evidenceCode":"ECO:0000266","source":"PubMed","id":"30990108"}]},{"database":"GO","id":"GO:0071456","properties":[{"key":"GoTerm","value":"P:cellular response to hypoxia"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071347","properties":[{"key":"GoTerm","value":"P:cellular response to interleukin-1"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071373","properties":[{"key":"GoTerm","value":"P:cellular response to luteinizing hormone stimulus"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19111534"}]},{"database":"GO","id":"GO:0071389","properties":[{"key":"GoTerm","value":"P:cellular response to mineralocorticoid stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097237","properties":[{"key":"GoTerm","value":"P:cellular response to toxic substance"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30990108"}]},{"database":"GO","id":"GO:0071560","properties":[{"key":"GoTerm","value":"P:cellular response to transforming growth factor beta stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071356","properties":[{"key":"GoTerm","value":"P:cellular response to tumor necrosis factor"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071346","properties":[{"key":"GoTerm","value":"P:cellular response to type II interferon"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071466","properties":[{"key":"GoTerm","value":"P:cellular response to xenobiotic stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009953","properties":[{"key":"GoTerm","value":"P:dorsal/ventral pattern formation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15110048"}]},{"database":"GO","id":"GO:0035050","properties":[{"key":"GoTerm","value":"P:embryonic heart tube development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24875861"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30735130"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"31219639"}]},{"database":"GO","id":"GO:0086100","properties":[{"key":"GoTerm","value":"P:endothelin receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24722437"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31219639"}]},{"database":"GO","id":"GO:0042045","properties":[{"key":"GoTerm","value":"P:epithelial fluid transport"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0070371","properties":[{"key":"GoTerm","value":"P:ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20929948"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0010467","properties":[{"key":"GoTerm","value":"P:gene expression"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20929948"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24722437"}]},{"database":"GO","id":"GO:0072011","properties":[{"key":"GoTerm","value":"P:glomerular endothelium development"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31402170"}]},{"database":"GO","id":"GO:0003094","properties":[{"key":"GoTerm","value":"P:glomerular filtration"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31402170"}]},{"database":"GO","id":"GO:0007507","properties":[{"key":"GoTerm","value":"P:heart development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24875861"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7615798"}]},{"database":"GO","id":"GO:0003015","properties":[{"key":"GoTerm","value":"P:heart process"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25197047"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"31219639"}]},{"database":"GO","id":"GO:0001821","properties":[{"key":"GoTerm","value":"P:histamine secretion"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0001701","properties":[{"key":"GoTerm","value":"P:in utero embryonic development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15327783"}]},{"database":"GO","id":"GO:0006874","properties":[{"key":"GoTerm","value":"P:intracellular calcium ion homeostasis"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30990108"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000165","properties":[{"key":"GoTerm","value":"P:MAPK cascade"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19111534"}]},{"database":"GO","id":"GO:0060137","properties":[{"key":"GoTerm","value":"P:maternal process involved in parturition"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1903537","properties":[{"key":"GoTerm","value":"P:meiotic cell cycle process involved in oocyte maturation"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19111534"}]},{"database":"GO","id":"GO:0051899","properties":[{"key":"GoTerm","value":"P:membrane depolarization"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0042474","properties":[{"key":"GoTerm","value":"P:middle ear morphogenesis"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8152482"}]},{"database":"GO","id":"GO:0007005","properties":[{"key":"GoTerm","value":"P:mitochondrion organization"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27899487"}]},{"database":"GO","id":"GO:0010629","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0046888","properties":[{"key":"GoTerm","value":"P:negative regulation of hormone secretion"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0160195","properties":[{"key":"GoTerm","value":"P:negative regulation of phospholipase C/protein kinase C signal transduction"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0051248","properties":[{"key":"GoTerm","value":"P:negative regulation of protein metabolic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0034392","properties":[{"key":"GoTerm","value":"P:negative regulation of smooth muscle cell apoptotic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0014032","properties":[{"key":"GoTerm","value":"P:neural crest cell development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15327783"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9671575"}]},{"database":"GO","id":"GO:0014033","properties":[{"key":"GoTerm","value":"P:neural crest cell differentiation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23933587"}]},{"database":"GO","id":"GO:0014034","properties":[{"key":"GoTerm","value":"P:neural crest cell fate commitment"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23933587"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24875861"}]},{"database":"GO","id":"GO:0030185","properties":[{"key":"GoTerm","value":"P:nitric oxide transport"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0003357","properties":[{"key":"GoTerm","value":"P:noradrenergic neuron differentiation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24875861"}]},{"database":"GO","id":"GO:0030072","properties":[{"key":"GoTerm","value":"P:peptide hormone secretion"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0061626","properties":[{"key":"GoTerm","value":"P:pharyngeal arch artery morphogenesis"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23933587"}]},{"database":"GO","id":"GO:0043491","properties":[{"key":"GoTerm","value":"P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007200","properties":[{"key":"GoTerm","value":"P:phospholipase C-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2542249"}]},{"database":"GO","id":"GO:0031583","properties":[{"key":"GoTerm","value":"P:phospholipase D-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8978712"}]},{"database":"GO","id":"GO:0072112","properties":[{"key":"GoTerm","value":"P:podocyte differentiation"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31402170"}]},{"database":"GO","id":"GO:1905653","properties":[{"key":"GoTerm","value":"P:positive regulation of artery morphogenesis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20495147"}]},{"database":"GO","id":"GO:0050850","properties":[{"key":"GoTerm","value":"P:positive regulation of calcium-mediated signaling"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0010613","properties":[{"key":"GoTerm","value":"P:positive regulation of cardiac muscle hypertrophy"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:2001259","properties":[{"key":"GoTerm","value":"P:positive regulation of cation channel activity"},{"key":"GoEvidenceType","value":"ISO:MGI"}],"evidences":[{"evidenceCode":"ECO:0000266","source":"PubMed","id":"30990108"}]},{"database":"GO","id":"GO:0061051","properties":[{"key":"GoTerm","value":"P:positive regulation of cell growth involved in cardiac muscle cell development"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2542249"}]},{"database":"GO","id":"GO:0045793","properties":[{"key":"GoTerm","value":"P:positive regulation of cell size"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0070101","properties":[{"key":"GoTerm","value":"P:positive regulation of chemokine-mediated signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0010460","properties":[{"key":"GoTerm","value":"P:positive regulation of heart rate"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0046887","properties":[{"key":"GoTerm","value":"P:positive regulation of hormone secretion"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0046330","properties":[{"key":"GoTerm","value":"P:positive regulation of JNK cascade"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045840","properties":[{"key":"GoTerm","value":"P:positive regulation of mitotic nuclear division"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0090023","properties":[{"key":"GoTerm","value":"P:positive regulation of neutrophil chemotaxis"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:1901224","properties":[{"key":"GoTerm","value":"P:positive regulation of non-canonical NF-kappaB signal transduction"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0042482","properties":[{"key":"GoTerm","value":"P:positive regulation of odontogenesis"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0031394","properties":[{"key":"GoTerm","value":"P:positive regulation of prostaglandin biosynthetic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0032308","properties":[{"key":"GoTerm","value":"P:positive regulation of prostaglandin secretion"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:1900182","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to nucleus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21525433"}]},{"database":"GO","id":"GO:0035815","properties":[{"key":"GoTerm","value":"P:positive regulation of renal sodium excretion"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15314687"}]},{"database":"GO","id":"GO:0060298","properties":[{"key":"GoTerm","value":"P:positive regulation of sarcomere organization"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0048661","properties":[{"key":"GoTerm","value":"P:positive regulation of smooth muscle cell proliferation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045987","properties":[{"key":"GoTerm","value":"P:positive regulation of smooth muscle contraction"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8010105"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0035810","properties":[{"key":"GoTerm","value":"P:positive regulation of urine volume"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15632412"}]},{"database":"GO","id":"GO:1904707","properties":[{"key":"GoTerm","value":"P:positive regulation of vascular associated smooth muscle cell proliferation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0006468","properties":[{"key":"GoTerm","value":"P:protein phosphorylation"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31219639"}]},{"database":"GO","id":"GO:0008217","properties":[{"key":"GoTerm","value":"P:regulation of blood pressure"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10626068"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15314687"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16868309"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20516397"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8152482"}]},{"database":"GO","id":"GO:0010827","properties":[{"key":"GoTerm","value":"P:regulation of D-glucose transmembrane transport"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11546805"}]},{"database":"GO","id":"GO:0006885","properties":[{"key":"GoTerm","value":"P:regulation of pH"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11413164"}]},{"database":"GO","id":"GO:0003100","properties":[{"key":"GoTerm","value":"P:regulation of systemic arterial blood pressure by endothelin"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0019229","properties":[{"key":"GoTerm","value":"P:regulation of vasoconstriction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0070294","properties":[{"key":"GoTerm","value":"P:renal sodium ion absorption"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23698114"}]},{"database":"GO","id":"GO:0007585","properties":[{"key":"GoTerm","value":"P:respiratory gaseous exchange by respiratory system"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10626068"}]},{"database":"GO","id":"GO:0014823","properties":[{"key":"GoTerm","value":"P:response to activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043200","properties":[{"key":"GoTerm","value":"P:response to amino acid"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001975","properties":[{"key":"GoTerm","value":"P:response to amphetamine"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24875861"}]},{"database":"GO","id":"GO:0071548","properties":[{"key":"GoTerm","value":"P:response to dexamethasone"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001666","properties":[{"key":"GoTerm","value":"P:response to hypoxia"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8764295"}]},{"database":"GO","id":"GO:0044321","properties":[{"key":"GoTerm","value":"P:response to leptin"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032496","properties":[{"key":"GoTerm","value":"P:response to lipopolysaccharide"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0035994","properties":[{"key":"GoTerm","value":"P:response to muscle stretch"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0035094","properties":[{"key":"GoTerm","value":"P:response to nicotine"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0010193","properties":[{"key":"GoTerm","value":"P:response to ozone"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034696","properties":[{"key":"GoTerm","value":"P:response to prostaglandin F"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1902074","properties":[{"key":"GoTerm","value":"P:response to salt"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0033574","properties":[{"key":"GoTerm","value":"P:response to testosterone"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043179","properties":[{"key":"GoTerm","value":"P:rhythmic excitation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8764295"}]},{"database":"GO","id":"GO:0071526","properties":[{"key":"GoTerm","value":"P:semaphorin-plexin signaling pathway"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30735130"}]},{"database":"GO","id":"GO:0023019","properties":[{"key":"GoTerm","value":"P:signal transduction involved in regulation of gene expression"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0001501","properties":[{"key":"GoTerm","value":"P:skeletal system development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8152482"}]},{"database":"GO","id":"GO:0042554","properties":[{"key":"GoTerm","value":"P:superoxide anion generation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0097492","properties":[{"key":"GoTerm","value":"P:sympathetic neuron axon guidance"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30735130"}]},{"database":"GO","id":"GO:0030878","properties":[{"key":"GoTerm","value":"P:thyroid gland development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26506449"}]},{"database":"GO","id":"GO:0006366","properties":[{"key":"GoTerm","value":"P:transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27026367"}]},{"database":"GO","id":"GO:0042310","properties":[{"key":"GoTerm","value":"P:vasoconstriction"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0014826","properties":[{"key":"GoTerm","value":"P:vein smooth muscle contraction"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"InterPro","id":"IPR020475","properties":[{"key":"EntryName","value":"Endothelin"}]},{"database":"InterPro","id":"IPR019764","properties":[{"key":"EntryName","value":"Endothelin_toxin_CS"}]},{"database":"InterPro","id":"IPR001928","properties":[{"key":"EntryName","value":"Endothln-like_toxin"}]},{"database":"PANTHER","id":"PTHR13874","properties":[{"key":"EntryName","value":"ENDOTHELIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13874:SF10","properties":[{"key":"EntryName","value":"ENDOTHELIN-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00322","properties":[{"key":"EntryName","value":"Endothelin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00365","properties":[{"key":"EntryName","value":"ENDOTHELIN"}]},{"database":"SMART","id":"SM00272","properties":[{"key":"EntryName","value":"END"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00270","properties":[{"key":"EntryName","value":"ENDOTHELIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MDYFPVIFSLLFVTFQGAPETAVLGAELSTGAENGVQSPPPSTPWRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPERVVPYGLGGSSRSKRSLKDLLPNKATDQAVRCQCAHQKDKKCWNFCQAGKELRAQSTMQKSLKDSKKGKPCSKLGKKCIYQQLVEGRKLRRLEAISNSIKASFRVAKLKAELYRDQKLTHNRAH","length":202,"molWeight":22809,"crc64":"3A0C1E1DFA797411","md5":"DE74A5C9E0D368E3910F081154A635A3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"INDUCTION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Propeptide":2,"Peptide":2,"Region":1,"Site":1,"Disulfide bond":2,"Sequence conflict":2},"uniParcId":"UPI00000010A2"}}