{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P21675","secondaryAccessions":["A5CVC8","A5CVC9","A5CVD0","A5CVD1","B1Q2X3","Q59FZ3","Q6IUZ1","Q70Q86","Q70Q87","Q70T00","Q70T01","Q70T02","Q70T03"],"uniProtkbId":"TAF1_HUMAN","entryAudit":{"firstPublicDate":"1991-05-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2023-11-08","entryVersion":251,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Transcription initiation factor TFIID subunit 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15870300"}],"value":"2.3.1.48"},{"value":"2.7.11.1"}]},"alternativeNames":[{"fullName":{"value":"Cell cycle gene 1 protein"}},{"fullName":{"value":"TBP-associated factor 250 kDa"},"shortNames":[{"value":"p250"}]},{"fullName":{"value":"Transcription initiation factor TFIID 250 kDa subunit"},"shortNames":[{"value":"TAF(II)250"},{"value":"TAFII-250"},{"value":"TAFII250"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:11535"}],"value":"TAF1"},"synonyms":[{"value":"BA2R"},{"value":"CCG1"},{"value":"CCGS"},{"value":"TAF2A"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11278496"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15053879"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15870300"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2038334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25412659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27007846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33795473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8450888"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8625415"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9858607"}],"value":"The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly (PubMed:25412659, PubMed:27007846, PubMed:33795473). TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 (PubMed:33795473). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors (PubMed:25412659, PubMed:8625415). Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 (PubMed:25412659). Phosphorylates GTF2A1 and GTF2F1 on Ser residues (PubMed:25412659). Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1"}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1"}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45948"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:10731"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:61930"}],"ecNumber":"2.3.1.48","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15870300"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11592977"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22711989"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8625415"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9858607"}],"value":"Autophosphorylates on Ser residues (PubMed:8625415). Inhibited by retinoblastoma tumor suppressor protein, RB1 (PubMed:9858607). Binding to TAF7 or CIITA inhibits the histone acetyltransferase activity (PubMed:11592977, PubMed:22711989)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10759893"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11592977"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12093919"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12842904"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15053879"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15960975"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22464331"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25412659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27007846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33795473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7680771"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9858607"}],"value":"Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:7680771). Interacts with TAF7; the interaction is direct (PubMed:11592977, PubMed:25412659). TAF1, when part of the TFIID complex, interacts with C-terminus of TP53 (PubMed:15053879). Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27007846). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). RB1 interacts with the N-terminal domain of TAF1 (PubMed:9858607). Interacts with ASF1A and ASF1B (PubMed:10759893, PubMed:12093919, PubMed:12842904). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro) (PubMed:22464331)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8647434"}],"value":"(Microbial infection) Interacts with SV40 Large T antigen"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8649420"}],"value":"(Microbial infection) Interacts with herpes simplex virus 1 ICP4"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P21675","intActId":"EBI-491289"},"interactantTwo":{"uniProtKBAccession":"P35269","geneName":"GTF2F1","intActId":"EBI-457886"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P21675","intActId":"EBI-491289"},"interactantTwo":{"uniProtKBAccession":"P20226","geneName":"TBP","intActId":"EBI-355371"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P21675","intActId":"EBI-491289"},"interactantTwo":{"uniProtKBAccession":"P03255","intActId":"EBI-2603114"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2038334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25593309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27007846"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing","Alternative initiation"],"isoforms":[{"name":{"value":"2"},"isoformIds":["P21675-2"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"1"},"isoformIds":["P21675-1"],"sequenceIds":["VSP_061988"],"isoformSequenceStatus":"Described"},{"name":{"value":"13"},"isoformIds":["P21675-13"],"sequenceIds":["VSP_061987","VSP_061988"],"isoformSequenceStatus":"Described"},{"name":{"value":"14"},"isoformIds":["P21675-14"],"sequenceIds":["VSP_061987"],"isoformSequenceStatus":"Described"},{"name":{"value":"15"},"isoformIds":["P21675-15"],"sequenceIds":["VSP_061999","VSP_062000"],"isoformSequenceStatus":"Described"},{"name":{"value":"16"},"isoformIds":["P21675-16"],"sequenceIds":["VSP_061996","VSP_061998"],"isoformSequenceStatus":"Described"},{"name":{"value":"N-TAF1"},"synonyms":[{"value":"TA14-391"}],"isoformIds":["P21675-17"],"sequenceIds":["VSP_061995"],"isoformSequenceStatus":"Described"},{"name":{"value":"2a"},"isoformIds":["P21675-18"],"sequenceIds":["VSP_061997","VSP_061998"],"isoformSequenceStatus":"Described"},{"name":{"value":"2c"},"isoformIds":["P21675-19"],"sequenceIds":["VSP_061998"],"isoformSequenceStatus":"Described"},{"name":{"value":"2d"},"isoformIds":["P21675-20"],"sequenceIds":["VSP_061995","VSP_061998"],"isoformSequenceStatus":"Described"},{"name":{"value":"2e"},"isoformIds":["P21675-21"],"sequenceIds":["VSP_061993","VSP_061994"],"isoformSequenceStatus":"Described"},{"name":{"value":"2g"},"isoformIds":["P21675-22"],"sequenceIds":["VSP_061995","VSP_061997","VSP_061998"],"isoformSequenceStatus":"Described"},{"name":{"value":"2h"},"isoformIds":["P21675-23"],"sequenceIds":["VSP_061990","VSP_061991"],"isoformSequenceStatus":"Described"},{"name":{"value":"2i"},"isoformIds":["P21675-24"],"sequenceIds":["VSP_061989","VSP_061992"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["P21675-25"],"sequenceIds":["VSP_061997"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17952504"}],"value":"the TAF1/DYT3 multiple transcript system is composed of 38 evolutionary conserved exons plus 5 downstream exons referred to as exons d1-d5 that are primate-specific. Multiple highly polymorphic variants can be generated by splicing exons d3 and d4 to various combinations of exons 1-37."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22464331"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26365797"}],"value":"The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions (PubMed:22464331). The second domain also recognizes and binds histones that are butyrylated and crotonylated (PubMed:26365797)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8625415"}],"value":"Phosphorylated by casein kinase II in vitro"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Dystonia 3, torsion, X-linked","diseaseAccession":"DI-00414","acronym":"DYT3","description":"An X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. It has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.","diseaseCrossReference":{"database":"MIM","id":"314250"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12928496"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17273961"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Intellectual developmental disorder, X-linked, syndromic 33","diseaseAccession":"DI-04617","acronym":"MRXS33","description":"A syndrome characterized by intellectual deficit, delayed psychomotor development, delayed speech and language, and characteristic facial features.","diseaseCrossReference":{"database":"MIM","id":"300966"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26637982"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 16"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17952504"}],"value":"May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2a"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17952504"}],"value":"May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2c"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17952504"}],"value":"May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2d"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17952504"}],"value":"May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2e"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17952504"}],"value":"May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2h"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17952504"}],"value":"May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay (Probable). Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2i"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17952504"}],"value":"Includes a downstream (d) exon and is preferentially expressed in brain (Probable). May play a role in the regulation of genes involved in dopamine processing and transport (Probable)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2g"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"May be produced at very low levels due to a premature stop CC codon in the mRNA, leading to nonsense-mediated mRNA decay"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 15"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Only detected in brain, highest expression in the caudate nucleus"}],"commentType":"MISCELLANEOUS","molecule":"Isoform N-TAF1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TAF1 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"CAA30073.1","note":"Contaminating sequence. Sequence of unknown origin in the N-terminal and C-terminal part.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1893,"modifier":"EXACT"}},"description":"Transcription initiation factor TFIID subunit 1","featureId":"PRO_0000211215"},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"Protein kinase 1"},{"type":"Domain","location":{"start":{"value":1397,"modifier":"EXACT"},"end":{"value":1505,"modifier":"EXACT"}},"description":"Bromo 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00035"}]},{"type":"Domain","location":{"start":{"value":1446,"modifier":"EXACT"},"end":{"value":1893,"modifier":"EXACT"}},"description":"Protein kinase 2"},{"type":"Domain","location":{"start":{"value":1519,"modifier":"EXACT"},"end":{"value":1628,"modifier":"EXACT"}},"description":"Bromo 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00035"}]},{"type":"DNA binding","location":{"start":{"value":1216,"modifier":"EXACT"},"end":{"value":1294,"modifier":"EXACT"}},"description":"HMG box; involved in promoter binding","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EDX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EG7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EG8"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EG9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGB"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGD"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGE"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGH"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGI"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGJ"}]},{"type":"Region","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":534,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":997,"modifier":"EXACT"}},"description":"Histone acetyltransferase (HAT)"},{"type":"Region","location":{"start":{"value":990,"modifier":"EXACT"},"end":{"value":1009,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1128,"modifier":"EXACT"},"end":{"value":1148,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1158,"modifier":"EXACT"},"end":{"value":1177,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1254,"modifier":"EXACT"},"end":{"value":1278,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1363,"modifier":"EXACT"},"end":{"value":1650,"modifier":"EXACT"}},"description":"Interaction with ASF1A and ASF1B","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12842904"}]},{"type":"Region","location":{"start":{"value":1651,"modifier":"EXACT"},"end":{"value":1676,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1696,"modifier":"EXACT"},"end":{"value":1893,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":1372,"modifier":"EXACT"},"end":{"value":1379,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":995,"modifier":"EXACT"},"end":{"value":1004,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1139,"modifier":"EXACT"},"end":{"value":1148,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1254,"modifier":"EXACT"},"end":{"value":1270,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1659,"modifier":"EXACT"},"end":{"value":1668,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1709,"modifier":"EXACT"},"end":{"value":1723,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1741,"modifier":"EXACT"},"end":{"value":1756,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1830,"modifier":"EXACT"},"end":{"value":1840,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1846,"modifier":"EXACT"},"end":{"value":1857,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1860,"modifier":"EXACT"},"end":{"value":1869,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Phosphoserine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8625415"}]},{"type":"Modified residue","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Phosphoserine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8625415"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":565,"modifier":"EXACT"},"end":{"value":565,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80UV9"}]},{"type":"Modified residue","location":{"start":{"value":1690,"modifier":"EXACT"},"end":{"value":1690,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80UV9"}]},{"type":"Modified residue","location":{"start":{"value":1693,"modifier":"EXACT"},"end":{"value":1693,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80UV9"}]},{"type":"Modified residue","location":{"start":{"value":1799,"modifier":"EXACT"},"end":{"value":1799,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80UV9"}]},{"type":"Modified residue","location":{"start":{"value":1802,"modifier":"EXACT"},"end":{"value":1802,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80UV9"}]},{"type":"Modified residue","location":{"start":{"value":1820,"modifier":"EXACT"},"end":{"value":1820,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80UV9"}]},{"type":"Modified residue","location":{"start":{"value":1847,"modifier":"EXACT"},"end":{"value":1847,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Cross-link","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":583,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"in isoform 13 and isoform 14","featureId":"VSP_061987","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"in isoform 1 and isoform 13","featureId":"VSP_061988","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1546,"modifier":"EXACT"},"end":{"value":1561,"modifier":"EXACT"}},"description":"in isoform 2i","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17952504"}],"featureId":"VSP_061989","alternativeSequence":{"originalSequence":"SWPFHHPVNKKFVPDY","alternativeSequences":["VSCLCAKYFLAISSPS"]}},{"type":"Alternative sequence","location":{"start":{"value":1546,"modifier":"EXACT"},"end":{"value":1549,"modifier":"EXACT"}},"description":"in isoform 2h","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17952504"}],"featureId":"VSP_061990","alternativeSequence":{"originalSequence":"SWPF","alternativeSequences":["IITK"]}},{"type":"Alternative sequence","location":{"start":{"value":1550,"modifier":"EXACT"},"end":{"value":1893,"modifier":"EXACT"}},"description":"in isoform 2h","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17952504"}],"featureId":"VSP_061991","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1562,"modifier":"EXACT"},"end":{"value":1893,"modifier":"EXACT"}},"description":"in isoform 2i","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17952504"}],"featureId":"VSP_061992","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1606,"modifier":"EXACT"},"end":{"value":1613,"modifier":"EXACT"}},"description":"in isoform 2e","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12928496"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17952504"}],"featureId":"VSP_061993","alternativeSequence":{"originalSequence":"PESQYTKT","alternativeSequences":["YMCTTCRT"]}},{"type":"Alternative sequence","location":{"start":{"value":1614,"modifier":"EXACT"},"end":{"value":1893,"modifier":"EXACT"}},"description":"in isoform 2e","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12928496"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17952504"}],"featureId":"VSP_061994","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1666,"modifier":"EXACT"},"end":{"value":1666,"modifier":"EXACT"}},"description":"in isoform N-TAF1, isoform 2d and isoform 2g","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12928496"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17273961"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17952504"}],"featureId":"VSP_061995","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["QAK"]}},{"type":"Alternative sequence","location":{"start":{"value":1706,"modifier":"EXACT"},"end":{"value":1708,"modifier":"EXACT"}},"description":"in isoform 16","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12928496"}],"featureId":"VSP_061996","alternativeSequence":{"originalSequence":"VTQ","alternativeSequences":["MRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP"]}},{"type":"Alternative sequence","location":{"start":{"value":1708,"modifier":"EXACT"},"end":{"value":1708,"modifier":"EXACT"}},"description":"in isoform 4, isoform 2a and isoform 2g","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12928496"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17952504"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.7"}],"featureId":"VSP_061997","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["QMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP"]}},{"type":"Alternative sequence","location":{"start":{"value":1820,"modifier":"EXACT"},"end":{"value":1893,"modifier":"EXACT"}},"description":"in isoform 2a, isoform 16, isoform 2c, isoform 2d and isoform 2g","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12928496"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17952504"}],"featureId":"VSP_061998","alternativeSequence":{"originalSequence":"SYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE","alternativeSequences":["RYQ"]}},{"type":"Alternative sequence","location":{"start":{"value":1820,"modifier":"EXACT"},"end":{"value":1820,"modifier":"EXACT"}},"description":"in isoform 15","featureId":"VSP_061999","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Alternative sequence","location":{"start":{"value":1821,"modifier":"EXACT"},"end":{"value":1893,"modifier":"EXACT"}},"description":"in isoform 15","featureId":"VSP_062000","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"in dbSNP:rs28382158","featureCrossReferences":[{"database":"dbSNP","id":"rs28382158"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_020678","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"in dbSNP:rs35317750","featureCrossReferences":[{"database":"dbSNP","id":"rs35317750"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_041930","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":474,"modifier":"EXACT"}},"description":"in a colorectal adenocarcinoma sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_041931","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":493,"modifier":"EXACT"}},"description":"found in a patient with X-linked intellectual disability; uncertain significance; dbSNP:rs200177996","featureCrossReferences":[{"database":"dbSNP","id":"rs200177996"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25644381"}],"featureId":"VAR_077838","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":596,"modifier":"EXACT"},"end":{"value":596,"modifier":"EXACT"}},"description":"in MRXS33; dbSNP:rs864321630","featureCrossReferences":[{"database":"dbSNP","id":"rs864321630"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26637982"}],"featureId":"VAR_076394","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":672,"modifier":"EXACT"},"end":{"value":672,"modifier":"EXACT"}},"description":"in a metastatic melanoma sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_041932","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":712,"modifier":"EXACT"},"end":{"value":712,"modifier":"EXACT"}},"description":"in a lung bronchoalveolar carcinoma sample; somatic mutation; dbSNP:rs2148297629","featureCrossReferences":[{"database":"dbSNP","id":"rs2148297629"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_041933","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":807,"modifier":"EXACT"},"end":{"value":807,"modifier":"EXACT"}},"description":"in MRXS33; dbSNP:rs864321628","featureCrossReferences":[{"database":"dbSNP","id":"rs864321628"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26637982"}],"featureId":"VAR_076395","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":976,"modifier":"EXACT"},"end":{"value":976,"modifier":"EXACT"}},"description":"in MRXS33; dbSNP:rs864321631","featureCrossReferences":[{"database":"dbSNP","id":"rs864321631"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26637982"}],"featureId":"VAR_076396","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":1190,"modifier":"EXACT"},"end":{"value":1190,"modifier":"EXACT"}},"description":"found in a patient with X-linked intellectual disability; uncertain significance; dbSNP:rs1569301036","featureCrossReferences":[{"database":"dbSNP","id":"rs1569301036"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25644381"}],"featureId":"VAR_077839","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":1246,"modifier":"EXACT"},"end":{"value":1246,"modifier":"EXACT"}},"description":"in MRXS33; dbSNP:rs864321629","featureCrossReferences":[{"database":"dbSNP","id":"rs864321629"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26637982"}],"featureId":"VAR_076397","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":1337,"modifier":"EXACT"},"end":{"value":1337,"modifier":"EXACT"}},"description":"in MRXS33; dbSNP:rs864321627","featureCrossReferences":[{"database":"dbSNP","id":"rs864321627"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26637982"}],"featureId":"VAR_076398","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":1404,"modifier":"EXACT"},"end":{"value":1404,"modifier":"EXACT"}},"description":"in dbSNP:rs7050748","featureCrossReferences":[{"database":"dbSNP","id":"rs7050748"}],"featureId":"VAR_048433","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":1452,"modifier":"EXACT"},"end":{"value":1452,"modifier":"EXACT"}},"description":"in MRXS33; uncertain significance; dbSNP:rs2148488251","featureCrossReferences":[{"database":"dbSNP","id":"rs2148488251"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26637982"}],"featureId":"VAR_076399","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":1517,"modifier":"EXACT"},"end":{"value":1517,"modifier":"EXACT"}},"description":"in MRXS33; uncertain significance; dbSNP:rs1602624914","featureCrossReferences":[{"database":"dbSNP","id":"rs1602624914"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26637982"}],"featureId":"VAR_076400","alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Mutagenesis","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"No decrease in kinase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"Reduces kinase activity; when associated with A-147; A-149; A-150; A-152 and A-154.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"Reduces kinase activity; when associated with A-145; A-149; A-150; A-152 and A-154.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"Reduces kinase activity; when associated with A-145; A-147; A-150; A-152 and A-154.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Reduces kinase activity; when associated with A-145; A-147; A-149; A-152 and A-154.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Reduces kinase activity; when associated with A-145; A-147; A-149; A-150 and A-154.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Reduces kinase activity; when associated with A-145; A-147; A-149; A-150 and A-152.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"Reduces kinase activity; when associated with A-328; A-329; A-330 and A-331.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Reduces kinase activity; when associated with A-326; A-329; A-330 and A-331.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"Reduces kinase activity; when associated with A-326; A-328; A-330 and A-331.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"Reduces kinase activity; when associated with A-326; A-328; A-329 and A-331.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Reduces kinase activity; when associated with A-326; A-328; A-329 and A-330.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9660973"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":742,"modifier":"EXACT"},"end":{"value":742,"modifier":"EXACT"}},"description":"25% decrease in histone acetylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15870300"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":848,"modifier":"EXACT"},"end":{"value":850,"modifier":"EXACT"}},"description":"Dramatic decrease in histone acetylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15870300"}],"alternativeSequence":{}},{"type":"Beta strand","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Beta strand","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":490,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":494,"modifier":"EXACT"},"end":{"value":498,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":504,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Beta strand","location":{"start":{"value":509,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":518,"modifier":"EXACT"},"end":{"value":521,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Beta strand","location":{"start":{"value":525,"modifier":"EXACT"},"end":{"value":527,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":591,"modifier":"EXACT"},"end":{"value":594,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":614,"modifier":"EXACT"},"end":{"value":617,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Turn","location":{"start":{"value":621,"modifier":"EXACT"},"end":{"value":623,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":630,"modifier":"EXACT"},"end":{"value":634,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Turn","location":{"start":{"value":635,"modifier":"EXACT"},"end":{"value":637,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":639,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":644,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Beta strand","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":648,"modifier":"EXACT"},"end":{"value":650,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":651,"modifier":"EXACT"},"end":{"value":653,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":655,"modifier":"EXACT"},"end":{"value":659,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":661,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Turn","location":{"start":{"value":677,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":689,"modifier":"EXACT"},"end":{"value":692,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":696,"modifier":"EXACT"},"end":{"value":706,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":718,"modifier":"EXACT"},"end":{"value":725,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":726,"modifier":"EXACT"},"end":{"value":728,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Beta strand","location":{"start":{"value":729,"modifier":"EXACT"},"end":{"value":731,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":735,"modifier":"EXACT"},"end":{"value":737,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":739,"modifier":"EXACT"},"end":{"value":745,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":750,"modifier":"EXACT"},"end":{"value":753,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":754,"modifier":"EXACT"},"end":{"value":756,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":760,"modifier":"EXACT"},"end":{"value":777,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":782,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":795,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":799,"modifier":"EXACT"},"end":{"value":803,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":811,"modifier":"EXACT"},"end":{"value":814,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":818,"modifier":"EXACT"},"end":{"value":838,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":841,"modifier":"EXACT"},"end":{"value":843,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":845,"modifier":"EXACT"},"end":{"value":847,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":848,"modifier":"EXACT"},"end":{"value":854,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":860,"modifier":"EXACT"},"end":{"value":868,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":871,"modifier":"EXACT"},"end":{"value":874,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":877,"modifier":"EXACT"},"end":{"value":879,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":882,"modifier":"EXACT"},"end":{"value":885,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":889,"modifier":"EXACT"},"end":{"value":893,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":894,"modifier":"EXACT"},"end":{"value":900,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":903,"modifier":"EXACT"},"end":{"value":921,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":926,"modifier":"EXACT"},"end":{"value":928,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":946,"modifier":"EXACT"},"end":{"value":949,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":952,"modifier":"EXACT"},"end":{"value":963,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":968,"modifier":"EXACT"},"end":{"value":973,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":979,"modifier":"EXACT"},"end":{"value":983,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":985,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Helix","location":{"start":{"value":1014,"modifier":"EXACT"},"end":{"value":1018,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":1020,"modifier":"EXACT"},"end":{"value":1031,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":1035,"modifier":"EXACT"},"end":{"value":1039,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":1043,"modifier":"EXACT"},"end":{"value":1055,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1099,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RGW"}]},{"type":"Beta strand","location":{"start":{"value":1186,"modifier":"EXACT"},"end":{"value":1191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Turn","location":{"start":{"value":1195,"modifier":"EXACT"},"end":{"value":1197,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Beta strand","location":{"start":{"value":1201,"modifier":"EXACT"},"end":{"value":1206,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":1209,"modifier":"EXACT"},"end":{"value":1224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":1238,"modifier":"EXACT"},"end":{"value":1262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EGH"}]},{"type":"Helix","location":{"start":{"value":1399,"modifier":"EXACT"},"end":{"value":1401,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FIC"}]},{"type":"Helix","location":{"start":{"value":1402,"modifier":"EXACT"},"end":{"value":1418,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7LB1"}]},{"type":"Helix","location":{"start":{"value":1424,"modifier":"EXACT"},"end":{"value":1426,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7LB1"}]},{"type":"Helix","location":{"start":{"value":1429,"modifier":"EXACT"},"end":{"value":1431,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3UV5"}]},{"type":"Turn","location":{"start":{"value":1432,"modifier":"EXACT"},"end":{"value":1434,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7LB1"}]},{"type":"Helix","location":{"start":{"value":1438,"modifier":"EXACT"},"end":{"value":1441,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7LB1"}]},{"type":"Helix","location":{"start":{"value":1448,"modifier":"EXACT"},"end":{"value":1456,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7LB1"}]},{"type":"Helix","location":{"start":{"value":1463,"modifier":"EXACT"},"end":{"value":1480,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7LB1"}]},{"type":"Beta strand","location":{"start":{"value":1483,"modifier":"EXACT"},"end":{"value":1485,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3AAD"}]},{"type":"Helix","location":{"start":{"value":1486,"modifier":"EXACT"},"end":{"value":1504,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7LB1"}]},{"type":"Helix","location":{"start":{"value":1506,"modifier":"EXACT"},"end":{"value":1516,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7LB1"}]},{"type":"Helix","location":{"start":{"value":1518,"modifier":"EXACT"},"end":{"value":1521,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7LB1"}]},{"type":"Helix","location":{"start":{"value":1523,"modifier":"EXACT"},"end":{"value":1534,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I29"}]},{"type":"Helix","location":{"start":{"value":1535,"modifier":"EXACT"},"end":{"value":1540,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I29"}]},{"type":"Helix","location":{"start":{"value":1547,"modifier":"EXACT"},"end":{"value":1549,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I29"}]},{"type":"Helix","location":{"start":{"value":1552,"modifier":"EXACT"},"end":{"value":1554,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I29"}]},{"type":"Turn","location":{"start":{"value":1555,"modifier":"EXACT"},"end":{"value":1557,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I29"}]},{"type":"Beta strand","location":{"start":{"value":1558,"modifier":"EXACT"},"end":{"value":1560,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P3A"}]},{"type":"Helix","location":{"start":{"value":1561,"modifier":"EXACT"},"end":{"value":1564,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I29"}]},{"type":"Beta strand","location":{"start":{"value":1565,"modifier":"EXACT"},"end":{"value":1567,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P3A"}]},{"type":"Helix","location":{"start":{"value":1571,"modifier":"EXACT"},"end":{"value":1579,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I29"}]},{"type":"Helix","location":{"start":{"value":1586,"modifier":"EXACT"},"end":{"value":1604,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I29"}]},{"type":"Beta strand","location":{"start":{"value":1606,"modifier":"EXACT"},"end":{"value":1608,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7K6F"}]},{"type":"Helix","location":{"start":{"value":1609,"modifier":"EXACT"},"end":{"value":1627,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I29"}]},{"type":"Helix","location":{"start":{"value":1629,"modifier":"EXACT"},"end":{"value":1655,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I29"}]},{"type":"Modified residue","location":{"start":{"value":1718,"modifier":"EXACT"},"end":{"value":1718,"modifier":"EXACT"},"sequence":"P21675-16"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":1721,"modifier":"EXACT"},"end":{"value":1721,"modifier":"EXACT"},"sequence":"P21675-18"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":1723,"modifier":"EXACT"},"end":{"value":1723,"modifier":"EXACT"},"sequence":"P21675-22"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":1721,"modifier":"EXACT"},"end":{"value":1721,"modifier":"EXACT"},"sequence":"P21675-25"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"id":"KW-0024","category":"Coding sequence diversity","name":"Alternative initiation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0103","category":"Domain","name":"Bromodomain"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1023","category":"Disease","name":"Dystonia"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0991","category":"Disease","name":"Intellectual disability"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0908","category":"Disease","name":"Parkinsonism"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"2038334","citationType":"journal article","authors":["Sekiguchi T.","Nohiro Y.","Nakamura Y.","Hisamoto N.","Nishimoto T."],"citationCrossReferences":[{"database":"PubMed","id":"2038334"},{"database":"DOI","id":"10.1128/mcb.11.6.3317-3325.1991"}],"title":"The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein.","publicationDate":"1991","journal":"Mol. Cell. Biol.","firstPage":"3317","lastPage":"3325","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","SUBCELLULAR LOCATION"],"referenceComments":[{"value":"Laryngeal carcinoma","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"7680771","citationType":"journal article","authors":["Ruppert S.","Wang E.H.","Tjian R."],"citationCrossReferences":[{"database":"PubMed","id":"7680771"},{"database":"DOI","id":"10.1038/362175a0"}],"title":"Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation.","publicationDate":"1993","journal":"Nature","firstPage":"175","lastPage":"179","volume":"362"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","INTERACTION WITH TBP AND TAFS"]},{"referenceNumber":3,"citation":{"id":"17273961","citationType":"journal article","authors":["Makino S.","Kaji R.","Ando S.","Tomizawa M.","Yasuno K.","Goto S.","Matsumoto S.","Tabuena M.D.","Maranon E.","Dantes M.","Lee L.V.","Ogasawara K.","Tooyama I.","Akatsu H.","Nishimura M.","Tamiya G."],"citationCrossReferences":[{"database":"PubMed","id":"17273961"},{"database":"DOI","id":"10.1086/512129"}],"title":"Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism.","publicationDate":"2007","journal":"Am. J. Hum. Genet.","firstPage":"393","lastPage":"406","volume":"80"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM N-TAF1)","INVOLVEMENT IN DYT3"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-86ALQ4R1NM59V","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"MAY-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2)","VARIANT VAL-290"]},{"referenceNumber":5,"citation":{"id":"15772651","citationType":"journal article","authors":["Ross M.T.","Grafham D.V.","Coffey A.J.","Scherer S.","McLay K.","Muzny D.","Platzer M.","Howell G.R.","Burrows C.","Bird C.P.","Frankish A.","Lovell F.L.","Howe K.L.","Ashurst J.L.","Fulton R.S.","Sudbrak R.","Wen G.","Jones M.C.","Hurles M.E.","Andrews T.D.","Scott C.E.","Searle S.","Ramser J.","Whittaker A.","Deadman R.","Carter N.P.","Hunt S.E.","Chen R.","Cree A.","Gunaratne P.","Havlak P.","Hodgson A.","Metzker M.L.","Richards S.","Scott G.","Steffen D.","Sodergren E.","Wheeler D.A.","Worley K.C.","Ainscough R.","Ambrose K.D.","Ansari-Lari M.A.","Aradhya S.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Ballabio A.","Banerjee R.","Barker G.E.","Barlow K.F.","Barrett I.P.","Bates K.N.","Beare D.M.","Beasley H.","Beasley O.","Beck A.","Bethel G.","Blechschmidt K.","Brady N.","Bray-Allen S.","Bridgeman A.M.","Brown A.J.","Brown M.J.","Bonnin D.","Bruford E.A.","Buhay C.","Burch P.","Burford D.","Burgess J.","Burrill W.","Burton J.","Bye J.M.","Carder C.","Carrel L.","Chako J.","Chapman J.C.","Chavez D.","Chen E.","Chen G.","Chen Y.","Chen Z.","Chinault C.","Ciccodicola A.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Clerc-Blankenburg K.","Clifford K.","Cobley V.","Cole C.G.","Conquer J.S.","Corby N.","Connor R.E.","David R.","Davies J.","Davis C.","Davis J.","Delgado O.","Deshazo D.","Dhami P.","Ding Y.","Dinh H.","Dodsworth S.","Draper H.","Dugan-Rocha S.","Dunham A.","Dunn M.","Durbin K.J.","Dutta I.","Eades T.","Ellwood M.","Emery-Cohen A.","Errington H.","Evans K.L.","Faulkner L.","Francis F.","Frankland J.","Fraser A.E.","Galgoczy P.","Gilbert J.","Gill R.","Gloeckner G.","Gregory S.G.","Gribble S.","Griffiths C.","Grocock R.","Gu Y.","Gwilliam R.","Hamilton C.","Hart E.A.","Hawes A.","Heath P.D.","Heitmann K.","Hennig S.","Hernandez J.","Hinzmann B.","Ho S.","Hoffs M.","Howden P.J.","Huckle E.J.","Hume J.","Hunt P.J.","Hunt A.R.","Isherwood J.","Jacob L.","Johnson D.","Jones S.","de Jong P.J.","Joseph S.S.","Keenan S.","Kelly S.","Kershaw J.K.","Khan Z.","Kioschis P.","Klages S.","Knights A.J.","Kosiura A.","Kovar-Smith C.","Laird G.K.","Langford C.","Lawlor S.","Leversha M.","Lewis L.","Liu W.","Lloyd C.","Lloyd D.M.","Loulseged H.","Loveland J.E.","Lovell J.D.","Lozado R.","Lu J.","Lyne R.","Ma J.","Maheshwari M.","Matthews L.H.","McDowall J.","McLaren S.","McMurray A.","Meidl P.","Meitinger T.","Milne S.","Miner G.","Mistry S.L.","Morgan M.","Morris S.","Mueller I.","Mullikin J.C.","Nguyen N.","Nordsiek G.","Nyakatura G.","O'dell C.N.","Okwuonu G.","Palmer S.","Pandian R.","Parker D.","Parrish J.","Pasternak S.","Patel D.","Pearce A.V.","Pearson D.M.","Pelan S.E.","Perez L.","Porter K.M.","Ramsey Y.","Reichwald K.","Rhodes S.","Ridler K.A.","Schlessinger D.","Schueler M.G.","Sehra H.K.","Shaw-Smith C.","Shen H.","Sheridan E.M.","Shownkeen R.","Skuce C.D.","Smith M.L.","Sotheran E.C.","Steingruber H.E.","Steward C.A.","Storey R.","Swann R.M.","Swarbreck D.","Tabor P.E.","Taudien S.","Taylor T.","Teague B.","Thomas K.","Thorpe A.","Timms K.","Tracey A.","Trevanion S.","Tromans A.C.","d'Urso M.","Verduzco D.","Villasana D.","Waldron L.","Wall M.","Wang Q.","Warren J.","Warry G.L.","Wei X.","West A.","Whitehead S.L.","Whiteley M.N.","Wilkinson J.E.","Willey D.L.","Williams G.","Williams L.","Williamson A.","Williamson H.","Wilming L.","Woodmansey R.L.","Wray P.W.","Yen J.","Zhang J.","Zhou J.","Zoghbi H.","Zorilla S.","Buck D.","Reinhardt R.","Poustka A.","Rosenthal A.","Lehrach H.","Meindl A.","Minx P.J.","Hillier L.W.","Willard H.F.","Wilson R.K.","Waterston R.H.","Rice C.M.","Vaudin M.","Coulson A.","Nelson D.L.","Weinstock G.","Sulston J.E.","Durbin R.M.","Hubbard T.","Gibbs R.A.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"15772651"},{"database":"DOI","id":"10.1038/nature03440"}],"title":"The DNA sequence of the human X chromosome.","publicationDate":"2005","journal":"Nature","firstPage":"325","lastPage":"337","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"3169001","citationType":"journal article","authors":["Sekiguchi T.","Miyata T.","Nishimoto T."],"citationCrossReferences":[{"database":"PubMed","id":"3169001"},{"database":"DOI","id":"10.1002/j.1460-2075.1988.tb02996.x"}],"title":"Molecular cloning of the cDNA of human X chromosomal gene (CCG1) which complements the temperature-sensitive G1 mutants, tsBN462 and ts13, of the BHK cell line.","publicationDate":"1988","journal":"EMBO J.","firstPage":"1683","lastPage":"1687","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 61-1604 (ISOFORM 1)"]},{"referenceNumber":7,"citation":{"id":"CI-6FM9UGIHPC7GG","citationType":"submission","authors":["Totoki Y.","Toyoda A.","Takeda T.","Sakaki Y.","Tanaka A.","Yokoyama S.","Ohara O.","Nagase T.","Kikuno R.F."],"publicationDate":"MAR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 858-1893 (ISOFORM 4)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"12928496","citationType":"journal article","authors":["Nolte D.","Niemann S.","Muller U."],"citationCrossReferences":[{"database":"PubMed","id":"12928496"},{"database":"DOI","id":"10.1073/pnas.1831949100"}],"title":"Specific sequence changes in multiple transcript system DYT3 are associated with X-linked dystonia parkinsonism.","publicationDate":"2003","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10347","lastPage":"10352","volume":"100"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1368-1893 (ISOFORMS 2A; 2C; 2D AND 2E)","NUCLEOTIDE SEQUENCE [MRNA] OF 1519-1893 (ISOFORM 16)","NUCLEOTIDE SEQUENCE [MRNA] OF 1749-1893 (ISOFORM 15)","INVOLVEMENT IN DYT3"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"17952504","citationType":"journal article","authors":["Herzfeld T.","Nolte D.","Muller U."],"citationCrossReferences":[{"database":"PubMed","id":"17952504"},{"database":"DOI","id":"10.1007/s00335-007-9063-z"}],"title":"Structural and functional analysis of the human TAF1/DYT3 multiple transcript system.","publicationDate":"2007","journal":"Mamm. Genome","firstPage":"787","lastPage":"795","volume":"18"},"referencePositions":["SEQUENCE REVISION (ISOFORMS 2A; 2C; 2D AND 2E)","NUCLEOTIDE SEQUENCE [MRNA] OF 1368-1893 (ISOFORMS 2E; 2G; 2H AND 2I)","ALTERNATIVE SPLICING"]},{"referenceNumber":10,"citation":{"id":"8450888","citationType":"journal article","authors":["Hisatake K.","Hasegawa S.","Takada R.","Nakatani Y.","Horikoshi M.","Roeder R.G."],"citationCrossReferences":[{"database":"PubMed","id":"8450888"},{"database":"DOI","id":"10.1038/362179a0"}],"title":"The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1.","publicationDate":"1993","journal":"Nature","firstPage":"179","lastPage":"181","volume":"362"},"referencePositions":["FUNCTION"]},{"referenceNumber":11,"citation":{"id":"8625415","citationType":"journal article","authors":["Dikstein R.","Ruppert S.","Tjian R."],"citationCrossReferences":[{"database":"PubMed","id":"8625415"},{"database":"DOI","id":"10.1016/s0092-8674(00)81055-7"}],"title":"TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74.","publicationDate":"1996","journal":"Cell","firstPage":"781","lastPage":"790","volume":"84"},"referencePositions":["FUNCTION","ACTIVITY REGULATION","PHOSPHORYLATION AT SER-137 AND SER-328","ATP-BINDING"]},{"referenceNumber":12,"citation":{"id":"8647434","citationType":"journal article","authors":["Damania B.","Alwine J.C."],"citationCrossReferences":[{"database":"PubMed","id":"8647434"},{"database":"DOI","id":"10.1101/gad.10.11.1369"}],"title":"TAF-like function of SV40 large T antigen.","publicationDate":"1996","journal":"Genes Dev.","firstPage":"1369","lastPage":"1381","volume":"10"},"referencePositions":["INTERACTION WITH SV40 LARGE T ANTIGEN (MICROBIAL INFECTION)"]},{"referenceNumber":13,"citation":{"id":"8649420","citationType":"journal article","authors":["Carrozza M.J.","DeLuca N.A."],"citationCrossReferences":[{"database":"PubMed","id":"8649420"},{"database":"DOI","id":"10.1128/mcb.16.6.3085"}],"title":"Interaction of the viral activator protein ICP4 with TFIID through TAF250.","publicationDate":"1996","journal":"Mol. Cell. Biol.","firstPage":"3085","lastPage":"3093","volume":"16"},"referencePositions":["INTERACTION WITH HERPES SIMPLEX VIRUS 1 ICP4 (MICROBIAL INFECTION)"]},{"referenceNumber":14,"citation":{"id":"9660973","citationType":"journal article","authors":["O'Brien T.","Tjian R."],"citationCrossReferences":[{"database":"PubMed","id":"9660973"},{"database":"DOI","id":"10.1016/s1097-2765(00)80089-1"}],"title":"Functional analysis of the human TAFII250 N-terminal kinase domain.","publicationDate":"1998","journal":"Mol. Cell","firstPage":"905","lastPage":"911","volume":"1"},"referencePositions":["FUNCTION","MUTAGENESIS"]},{"referenceNumber":15,"citation":{"id":"9858607","citationType":"journal article","authors":["Siegert J.L.","Robbins P.D."],"citationCrossReferences":[{"database":"PubMed","id":"9858607"},{"database":"DOI","id":"10.1128/mcb.19.1.846"}],"title":"Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250.","publicationDate":"1999","journal":"Mol. Cell. Biol.","firstPage":"846","lastPage":"854","volume":"19"},"referencePositions":["FUNCTION","ACTIVITY REGULATION","INTERACTION WITH RB1","ATP-BINDING"]},{"referenceNumber":16,"citation":{"id":"10759893","citationType":"journal article","authors":["Munakata T.","Adachi N.","Yokoyama N.","Kuzuhara T.","Horikoshi M."],"citationCrossReferences":[{"database":"PubMed","id":"10759893"},{"database":"DOI","id":"10.1046/j.1365-2443.2000.00319.x"}],"title":"A human homologue of yeast anti-silencing factor has histone chaperone activity.","publicationDate":"2000","journal":"Genes Cells","firstPage":"221","lastPage":"233","volume":"5"},"referencePositions":["INTERACTION WITH ASF1A"]},{"referenceNumber":17,"citation":{"id":"11278496","citationType":"journal article","authors":["Solow S.","Salunek M.","Ryan R.","Lieberman P.M."],"citationCrossReferences":[{"database":"PubMed","id":"11278496"},{"database":"DOI","id":"10.1074/jbc.m009385200"}],"title":"Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"15886","lastPage":"15892","volume":"276"},"referencePositions":["FUNCTION"]},{"referenceNumber":18,"citation":{"id":"11592977","citationType":"journal article","authors":["Gegonne A.","Weissman J.D.","Singer D.S."],"citationCrossReferences":[{"database":"PubMed","id":"11592977"},{"database":"DOI","id":"10.1073/pnas.211444798"}],"title":"TAFII55 binding to TAFII250 inhibits its acetyltransferase activity.","publicationDate":"2001","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12432","lastPage":"12437","volume":"98"},"referencePositions":["ACTIVITY REGULATION","INTERACTION WITH TAF7"]},{"referenceNumber":19,"citation":{"id":"12093919","citationType":"journal article","authors":["Chimura T.","Kuzuhara T.","Horikoshi M."],"citationCrossReferences":[{"database":"PubMed","id":"12093919"},{"database":"DOI","id":"10.1073/pnas.142627899"}],"title":"Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID.","publicationDate":"2002","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9334","lastPage":"9339","volume":"99"},"referencePositions":["INTERACTION WITH ASF1A"]},{"referenceNumber":20,"citation":{"id":"12842904","citationType":"journal article","authors":["Umehara T.","Horikoshi M."],"citationCrossReferences":[{"database":"PubMed","id":"12842904"},{"database":"DOI","id":"10.1074/jbc.m303549200"}],"title":"Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"35660","lastPage":"35667","volume":"278"},"referencePositions":["INTERACTION WITH ASF1A AND ASF1B"]},{"referenceNumber":21,"citation":{"id":"15053879","citationType":"journal article","authors":["Li H.-H.","Li A.G.","Sheppard H.M.","Liu X."],"citationCrossReferences":[{"database":"PubMed","id":"15053879"},{"database":"DOI","id":"10.1016/s1097-2765(04)00123-6"}],"title":"Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.","publicationDate":"2004","journal":"Mol. Cell","firstPage":"867","lastPage":"878","volume":"13"},"referencePositions":["FUNCTION","INTERACTION WITH TP53"]},{"referenceNumber":22,"citation":{"id":"15960975","citationType":"journal article","authors":["Dou Y.","Milne T.A.","Tackett A.J.","Smith E.R.","Fukuda A.","Wysocka J.","Allis C.D.","Chait B.T.","Hess J.L.","Roeder R.G."],"citationCrossReferences":[{"database":"PubMed","id":"15960975"},{"database":"DOI","id":"10.1016/j.cell.2005.04.031"}],"title":"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.","publicationDate":"2005","journal":"Cell","firstPage":"873","lastPage":"885","volume":"121"},"referencePositions":["IDENTIFICATION IN THE MLL1/MLL COMPLEX"]},{"referenceNumber":23,"citation":{"id":"15870300","citationType":"journal article","authors":["Hilton T.L.","Li Y.","Dunphy E.L.","Wang E.H."],"citationCrossReferences":[{"database":"PubMed","id":"15870300"},{"database":"DOI","id":"10.1128/mcb.25.10.4321-4332.2005"}],"title":"TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter.","publicationDate":"2005","journal":"Mol. Cell. Biol.","firstPage":"4321","lastPage":"4332","volume":"25"},"referencePositions":["HISTONE ACETYLTRANSFERASE ACTIVITY","MUTAGENESIS OF GLU-742 AND 848-MET--ASP-850"]},{"referenceNumber":24,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":25,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1847","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1721 (ISOFORMS 2A AND 4)","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1723 (ISOFORM 2G)","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1718 (ISOFORM 16)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"22711989","citationType":"journal article","authors":["Kloet S.L.","Whiting J.L.","Gafken P.","Ranish J.","Wang E.H."],"citationCrossReferences":[{"database":"PubMed","id":"22711989"},{"database":"DOI","id":"10.1128/mcb.00416-12"}],"title":"Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.","publicationDate":"2012","journal":"Mol. Cell. Biol.","firstPage":"3358","lastPage":"3369","volume":"32"},"referencePositions":["ACTIVITY REGULATION"]},{"referenceNumber":28,"citation":{"id":"23184149","citationType":"journal article","authors":["Herzfeld T.","Nolte D.","Grznarova M.","Hofmann A.","Schultze J.L.","Muller U."],"citationCrossReferences":[{"database":"PubMed","id":"23184149"},{"database":"DOI","id":"10.1093/hmg/dds499"}],"title":"X-linked dystonia parkinsonism syndrome (XDP, lubag): disease-specific sequence change DSC3 in TAF1/DYT3 affects genes in vesicular transport and dopamine metabolism.","publicationDate":"2013","journal":"Hum. Mol. Genet.","firstPage":"941","lastPage":"951","volume":"22"},"referencePositions":["MISCELLANEOUS"]},{"referenceNumber":29,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":30,"citation":{"id":"25593309","citationType":"journal article","authors":["Gong F.","Chiu L.Y.","Cox B.","Aymard F.","Clouaire T.","Leung J.W.","Cammarata M.","Perez M.","Agarwal P.","Brodbelt J.S.","Legube G.","Miller K.M."],"citationCrossReferences":[{"database":"PubMed","id":"25593309"},{"database":"DOI","id":"10.1101/gad.252189.114"}],"title":"Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.","publicationDate":"2015","journal":"Genes Dev.","firstPage":"197","lastPage":"211","volume":"29"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":31,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-570 AND LYS-583","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":32,"citation":{"id":"10827952","citationType":"journal article","authors":["Jacobson R.H.","Ladurner A.G.","King D.S.","Tjian R."],"citationCrossReferences":[{"database":"PubMed","id":"10827952"},{"database":"DOI","id":"10.1126/science.288.5470.1422"}],"title":"Structure and function of a human TAFII250 double bromodomain module.","publicationDate":"2000","journal":"Science","firstPage":"1422","lastPage":"1425","volume":"288"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1380-1659"]},{"referenceNumber":33,"citation":{"id":"22464331","citationType":"journal article","authors":["Filippakopoulos P.","Picaud S.","Mangos M.","Keates T.","Lambert J.P.","Barsyte-Lovejoy D.","Felletar I.","Volkmer R.","Muller S.","Pawson T.","Gingras A.C.","Arrowsmith C.H.","Knapp S."],"citationCrossReferences":[{"database":"PubMed","id":"22464331"},{"database":"DOI","id":"10.1016/j.cell.2012.02.013"}],"title":"Histone recognition and large-scale structural analysis of the human bromodomain family.","publicationDate":"2012","journal":"Cell","firstPage":"214","lastPage":"231","volume":"149"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) OF 1522-1656","SUBUNIT"]},{"referenceNumber":34,"citation":{"id":"25412659","citationType":"journal article","authors":["Wang H.","Curran E.C.","Hinds T.R.","Wang E.H.","Zheng N."],"citationCrossReferences":[{"database":"PubMed","id":"25412659"},{"database":"DOI","id":"10.1038/cr.2014.148"}],"title":"Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module.","publicationDate":"2014","journal":"Cell Res.","firstPage":"1433","lastPage":"1444","volume":"24"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 600-1236 IN COMPLEX WITH TAF7","FUNCTION","INTERACTION WITH TAF7"]},{"referenceNumber":35,"citation":{"id":"26365797","citationType":"journal article","authors":["Flynn E.M.","Huang O.W.","Poy F.","Oppikofer M.","Bellon S.F.","Tang Y.","Cochran A.G."],"citationCrossReferences":[{"database":"PubMed","id":"26365797"},{"database":"DOI","id":"10.1016/j.str.2015.08.004"}],"title":"A subset of human bromodomains recognizes butyryllysine and crotonyllysine histone peptide modifications.","publicationDate":"2015","journal":"Structure","firstPage":"1801","lastPage":"1814","volume":"23"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 1518-1659 IN COMPLEX WITH CROTONYLATED OR BUTYRYLATED HISTONE H4"]},{"referenceNumber":36,"citation":{"id":"27007846","citationType":"journal article","authors":["Louder R.K.","He Y.","Lopez-Blanco J.R.","Fang J.","Chacon P.","Nogales E."],"citationCrossReferences":[{"database":"PubMed","id":"27007846"},{"database":"DOI","id":"10.1038/nature17394"}],"title":"Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.","publicationDate":"2016","journal":"Nature","firstPage":"604","lastPage":"609","volume":"531"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (8.50 ANGSTROMS)","SUBCELLULAR LOCATION"]},{"referenceNumber":37,"citation":{"id":"CI-D548BHK9120O4","citationType":"submission","authors":["Mathea S.","Suh J.L.","Salah E.","Tallant C.","Siejka P.","Pike A.C.W.","von Delft F.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","James L.I.","Frye S.V.","Knapp S."],"title":"Bivalent Inhibitor UNC4512 Bound to the TAF1 Bromodomain Tandem.","publicationDate":"JAN-2018","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 1380-1659"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6FIC"}]},{"referenceNumber":38,"citation":{"id":"CI-9SB187SMM9L0G","citationType":"submission","authors":["Seo H.-S.","Dhe-Paganon S."],"title":"Crystal Structure Analysis of TAF1 Bromodomain.","publicationDate":"MAY-2019","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.94 ANGSTROMS) OF 1521-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6P39"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6P3A"}]},{"referenceNumber":39,"citation":{"id":"CI-D5UOE7B96794S","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ATR kinase inhibitor AZ20.","publicationDate":"JUL-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 1522-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7JJG"}]},{"referenceNumber":40,"citation":{"id":"CI-AR7T3HKEM9J66","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the unliganded tandem bromodomain (BD1, BD2) of human TAF1.","publicationDate":"JUL-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 1394-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7JJH"}]},{"referenceNumber":41,"citation":{"id":"CI-60KNRQIU760NT","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the second bromodomain (BD2) of human TAF1 bound to the ATR kinase inhibitor AZD6738.","publicationDate":"AUG-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 1522-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7JSP"}]},{"referenceNumber":42,"citation":{"id":"CI-854SI4IT217OH","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ZS1-322.","publicationDate":"AUG-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1522-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7JTC"}]},{"referenceNumber":43,"citation":{"id":"CI-FKOGST4U44DD0","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ATR kinase inhibitor AZD6738.","publicationDate":"SEP-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 1394-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7K03"}]},{"referenceNumber":44,"citation":{"id":"CI-CJPMAA12LC9OF","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to mTORC1/2 inhibitor AZD3147.","publicationDate":"SEP-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 1394-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7K0D"}]},{"referenceNumber":45,"citation":{"id":"CI-CPJI0R8S00QLF","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the second bromodomain (BD2) of human TAF1 bound to PLK1 kinase inhibitor BI2536.","publicationDate":"SEP-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 1522-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7K0U"}]},{"referenceNumber":46,"citation":{"id":"CI-1M3BRI7LP20CJ","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the second bromodomain (BD2) of human TAF1 bound to bromosporine.","publicationDate":"SEP-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 1522-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7K1P"}]},{"referenceNumber":47,"citation":{"id":"CI-4P4EVI9LM4P8J","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ATR inhibitor AZ20.","publicationDate":"SEP-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 1394-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7K27"}]},{"referenceNumber":48,"citation":{"id":"CI-QVFOI5C418TU","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the unliganded second bromodomain (BD2) of human TAF1.","publicationDate":"SEP-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 1522-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7K3O"}]},{"referenceNumber":49,"citation":{"id":"CI-IFVUCGCPPVR0","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the second bromodomain (BD2) of human TAF1 bound to dioxane.","publicationDate":"SEP-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 1522-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7K42"}]},{"referenceNumber":50,"citation":{"id":"CI-4SO2SF4ADCNIE","citationType":"submission","authors":["Karim M.R.","Bikowitz M.J.","Schonbrunn E."],"title":"Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 in complex with MES (2-(N-morpholino)ethanesulfonic acid).","publicationDate":"SEP-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS) OF 1394-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7K6F"}]},{"referenceNumber":51,"citation":{"id":"CI-4OHHAO6EI6MPE","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to GNE-371.","publicationDate":"DEC-2020","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 1394-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7L6X"}]},{"referenceNumber":52,"citation":{"id":"CI-DU3M5PR9PMEBN","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-295.","publicationDate":"JAN-2021","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.33 ANGSTROMS) OF 1394-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7LB0"}]},{"referenceNumber":53,"citation":{"id":"CI-3I65IPS63A67O","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-585.","publicationDate":"JAN-2021","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 1394-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7LB1"}]},{"referenceNumber":54,"citation":{"id":"CI-5A65RE3T7P9OE","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-589.","publicationDate":"JAN-2021","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 1394-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7LB2"}]},{"referenceNumber":55,"citation":{"id":"CI-3APC97RCT6HFJ","citationType":"submission","authors":["Karim M.R.","Schonbrunn E."],"title":"Crystal structure of the tandem bromodomain of human TAF1 (TAF1-T) bound to ZS1-681.","publicationDate":"JUN-2021","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 1394-1656"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7N42"}]},{"referenceNumber":56,"citation":{"id":"33795473","citationType":"journal article","authors":["Chen X.","Qi Y.","Wu Z.","Wang X.","Li J.","Zhao D.","Hou H.","Li Y.","Yu Z.","Liu W.","Wang M.","Ren Y.","Li Z.","Yang H.","Xu Y."],"citationCrossReferences":[{"database":"PubMed","id":"33795473"},{"database":"DOI","id":"10.1126/science.aba8490"}],"title":"Structural insights into preinitiation complex assembly on core promoters.","publicationDate":"2021","journal":"Science","firstPage":"0","lastPage":"0","volume":"372"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.04 ANGSTROMS)","FUNCTION","IDENTIFICATION IN THE TFIID COMPLEX","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EDX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EG7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EG8"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EG9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGB"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGD"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGE"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EGH"}]},{"referenceNumber":57,"citation":{"id":"17344846","citationType":"journal article","authors":["Greenman C.","Stephens P.","Smith R.","Dalgliesh G.L.","Hunter C.","Bignell G.","Davies H.","Teague J.","Butler A.","Stevens C.","Edkins S.","O'Meara S.","Vastrik I.","Schmidt E.E.","Avis T.","Barthorpe S.","Bhamra G.","Buck G.","Choudhury B.","Clements J.","Cole J.","Dicks E.","Forbes S.","Gray K.","Halliday K.","Harrison R.","Hills K.","Hinton J.","Jenkinson A.","Jones D.","Menzies A.","Mironenko T.","Perry J.","Raine K.","Richardson D.","Shepherd R.","Small A.","Tofts C.","Varian J.","Webb T.","West S.","Widaa S.","Yates A.","Cahill D.P.","Louis D.N.","Goldstraw P.","Nicholson A.G.","Brasseur F.","Looijenga L.","Weber B.L.","Chiew Y.-E.","DeFazio A.","Greaves M.F.","Green A.R.","Campbell P.","Birney E.","Easton D.F.","Chenevix-Trench G.","Tan M.-H.","Khoo S.K.","Teh B.T.","Yuen S.T.","Leung S.Y.","Wooster R.","Futreal P.A.","Stratton M.R."],"citationCrossReferences":[{"database":"PubMed","id":"17344846"},{"database":"DOI","id":"10.1038/nature05610"}],"title":"Patterns of somatic mutation in human cancer genomes.","publicationDate":"2007","journal":"Nature","firstPage":"153","lastPage":"158","volume":"446"},"referencePositions":["VARIANTS [LARGE SCALE ANALYSIS] VAL-290; GLY-318; ASP-474; LYS-672 AND ILE-712"]},{"referenceNumber":58,"citation":{"id":"26637982","citationType":"journal article","authors":["O'Rawe J.A.","Wu Y.","Doerfel M.J.","Rope A.F.","Au P.Y.","Parboosingh J.S.","Moon S.","Kousi M.","Kosma K.","Smith C.S.","Tzetis M.","Schuette J.L.","Hufnagel R.B.","Prada C.E.","Martinez F.","Orellana C.","Crain J.","Caro-Llopis A.","Oltra S.","Monfort S.","Jimenez-Barron L.T.","Swensen J.","Ellingwood S.","Smith R.","Fang H.","Ospina S.","Stegmann S.","Den Hollander N.","Mittelman D.","Highnam G.","Robison R.","Yang E.","Faivre L.","Roubertie A.","Riviere J.B.","Monaghan K.G.","Wang K.","Davis E.E.","Katsanis N.","Kalscheuer V.M.","Wang E.H.","Metcalfe K.","Kleefstra T.","Innes A.M.","Kitsiou-Tzeli S.","Rosello M.","Keegan C.E.","Lyon G.J."],"citationCrossReferences":[{"database":"PubMed","id":"26637982"},{"database":"DOI","id":"10.1016/j.ajhg.2015.11.005"}],"title":"TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations.","publicationDate":"2015","journal":"Am. J. Hum. Genet.","firstPage":"922","lastPage":"932","volume":"97"},"referencePositions":["INVOLVEMENT IN MRXS33","VARIANTS MRXS33 SER-596; ARG-807; HIS-976; TRP-1246; THR-1337; HIS-1452 AND HIS-1517"]},{"referenceNumber":59,"citation":{"id":"25644381","citationType":"journal article","authors":["Hu H.","Haas S.A.","Chelly J.","Van Esch H.","Raynaud M.","de Brouwer A.P.","Weinert S.","Froyen G.","Frints S.G.","Laumonnier F.","Zemojtel T.","Love M.I.","Richard H.","Emde A.K.","Bienek M.","Jensen C.","Hambrock M.","Fischer U.","Langnick C.","Feldkamp M.","Wissink-Lindhout W.","Lebrun N.","Castelnau L.","Rucci J.","Montjean R.","Dorseuil O.","Billuart P.","Stuhlmann T.","Shaw M.","Corbett M.A.","Gardner A.","Willis-Owen S.","Tan C.","Friend K.L.","Belet S.","van Roozendaal K.E.","Jimenez-Pocquet M.","Moizard M.P.","Ronce N.","Sun R.","O'Keeffe S.","Chenna R.","van Boemmel A.","Goeke J.","Hackett A.","Field M.","Christie L.","Boyle J.","Haan E.","Nelson J.","Turner G.","Baynam G.","Gillessen-Kaesbach G.","Mueller U.","Steinberger D.","Budny B.","Badura-Stronka M.","Latos-Bielenska A.","Ousager L.B.","Wieacker P.","Rodriguez Criado G.","Bondeson M.L.","Anneren G.","Dufke A.","Cohen M.","Van Maldergem L.","Vincent-Delorme C.","Echenne B.","Simon-Bouy B.","Kleefstra T.","Willemsen M.","Fryns J.P.","Devriendt K.","Ullmann R.","Vingron M.","Wrogemann K.","Wienker T.F.","Tzschach A.","van Bokhoven H.","Gecz J.","Jentsch T.J.","Chen W.","Ropers H.H.","Kalscheuer V.M."],"citationCrossReferences":[{"database":"PubMed","id":"25644381"},{"database":"DOI","id":"10.1038/mp.2014.193"}],"title":"X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.","publicationDate":"2016","journal":"Mol. Psychiatry","firstPage":"133","lastPage":"148","volume":"21"},"referencePositions":["VARIANTS ASP-493 AND CYS-1190"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D90359","properties":[{"key":"ProteinId","value":"BAA14374.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB300418","properties":[{"key":"ProteinId","value":"BAG15901.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY623109","properties":[{"key":"ProteinId","value":"AAT38105.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590762","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590763","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X07024","properties":[{"key":"ProteinId","value":"CAA30073.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB209316","properties":[{"key":"ProteinId","value":"BAD92553.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ549247","properties":[{"key":"ProteinId","value":"CAD70490.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ549248","properties":[{"key":"ProteinId","value":"CAD70491.3"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ549249","properties":[{"key":"ProteinId","value":"CAD70492.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ549250","properties":[{"key":"ProteinId","value":"CAD70493.3"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ555148","properties":[{"key":"ProteinId","value":"CAD87527.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ555149","properties":[{"key":"ProteinId","value":"CAD87528.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AM711892","properties":[{"key":"ProteinId","value":"CAM98555.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AM711893","properties":[{"key":"ProteinId","value":"CAM98556.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AM711894","properties":[{"key":"ProteinId","value":"CAM98557.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AM711895","properties":[{"key":"ProteinId","value":"CAM98558.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS14412.2","properties":[{"key":"Description","value":"-"}],"isoformId":"P21675-14"},{"database":"CCDS","id":"CCDS35325.2","properties":[{"key":"Description","value":"-"}],"isoformId":"P21675-13"},{"database":"PIR","id":"A40262","properties":[{"key":"EntryName","value":"A40262"}]},{"database":"RefSeq","id":"NP_001273003.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001286074.2"}]},{"database":"RefSeq","id":"NP_004597.3","properties":[{"key":"NucleotideSequenceId","value":"NM_004606.5"}],"isoformId":"P21675-14"},{"database":"RefSeq","id":"NP_620278.2","properties":[{"key":"NucleotideSequenceId","value":"NM_138923.4"}],"isoformId":"P21675-13"},{"database":"RefSeq","id":"XP_047298351.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047442395.1"}],"isoformId":"P21675-14"},{"database":"RefSeq","id":"XP_047298355.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047442399.1"}],"isoformId":"P21675-13"},{"database":"RefSeq","id":"XP_054183607.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054327632.1"}],"isoformId":"P21675-14"},{"database":"RefSeq","id":"XP_054183611.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054327636.1"}],"isoformId":"P21675-13"},{"database":"PDB","id":"1EQF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1380-1659"}]},{"database":"PDB","id":"3AAD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A=1363-1650"}]},{"database":"PDB","id":"3UV4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.89 A"},{"key":"Chains","value":"A/B=1522-1656"}]},{"database":"PDB","id":"3UV5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"4RGW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=600-1236"}]},{"database":"PDB","id":"4YYM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=1518-1659"}]},{"database":"PDB","id":"4YYN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B=1518-1659"}]},{"database":"PDB","id":"5FUR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"8.50 A"},{"key":"Chains","value":"G=1-177, G=199-1893"}]},{"database":"PDB","id":"5I1Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=1518-1659"}]},{"database":"PDB","id":"5I29","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.21 A"},{"key":"Chains","value":"A=1518-1659"}]},{"database":"PDB","id":"5MG2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=1522-1656"}]},{"database":"PDB","id":"6BQD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.14 A"},{"key":"Chains","value":"A/B=1522-1651"}]},{"database":"PDB","id":"6FIC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.18 A"},{"key":"Chains","value":"T=1380-1659"}]},{"database":"PDB","id":"6MZD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"9.80 A"},{"key":"Chains","value":"A=21-1893"}]},{"database":"PDB","id":"6MZL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"23.00 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"6MZM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.50 A"},{"key":"Chains","value":"A=609-1104"}]},{"database":"PDB","id":"6P38","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1522-1656"}]},{"database":"PDB","id":"6P39","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.94 A"},{"key":"Chains","value":"A=1521-1656"}]},{"database":"PDB","id":"6P3A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.99 A"},{"key":"Chains","value":"A/B=1522-1656"}]},{"database":"PDB","id":"7EDX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.50 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7EG7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.20 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7EG8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.40 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7EG9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7EGA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.10 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7EGB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7EGC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7EGD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.75 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7EGE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"9.00 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7EGH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.04 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7EGI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"9.82 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7EGJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"8.64 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"7ENA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.07 A"},{"key":"Chains","value":"DA=1-1893"}]},{"database":"PDB","id":"7ENC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.13 A"},{"key":"Chains","value":"DA=1-1893"}]},{"database":"PDB","id":"7JJG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1522-1656"}]},{"database":"PDB","id":"7JJH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"7JSP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1522-1656"}]},{"database":"PDB","id":"7JTC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=1522-1656"}]},{"database":"PDB","id":"7K03","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"7K0D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"7K0U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.52 A"},{"key":"Chains","value":"A/B=1522-1656"}]},{"database":"PDB","id":"7K1P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A=1522-1656"}]},{"database":"PDB","id":"7K27","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"7K3O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=1522-1656"}]},{"database":"PDB","id":"7K42","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=1522-1656"}]},{"database":"PDB","id":"7K6F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.86 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"7L6X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"7LB0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.33 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"7LB1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"7LB2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"7LB3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1522-1656"}]},{"database":"PDB","id":"7N42","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"7P4S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.17 A"},{"key":"Chains","value":"A=1522-1656"}]},{"database":"PDB","id":"7T2I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.89 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"7T36","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=1394-1656"}]},{"database":"PDB","id":"8GXQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.04 A"},{"key":"Chains","value":"DA=1-1893"}]},{"database":"PDB","id":"8GXS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.16 A"},{"key":"Chains","value":"DA=1-1893"}]},{"database":"PDB","id":"8WAK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.47 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"8WAL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"8.52 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"8WAN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.07 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"8WAO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.40 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"8WAP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.85 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"8WAQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.29 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"8WAR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.20 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDB","id":"8WAS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.13 A"},{"key":"Chains","value":"A=1-1893"}]},{"database":"PDBsum","id":"1EQF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3AAD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3UV4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3UV5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4RGW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4YYM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4YYN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5FUR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5I1Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5I29","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MG2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6BQD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FIC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MZD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MZL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MZM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6P38","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6P39","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6P3A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EDX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EG7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EG8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EG9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EGA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EGB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EGC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EGD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EGE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EGH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EGI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EGJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ENA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ENC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JJG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JJH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JSP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JTC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7K03","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7K0D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7K0U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7K1P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7K27","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7K3O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7K42","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7K6F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7L6X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7LB0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7LB1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7LB2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7LB3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7N42","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7P4S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7T2I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7T36","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GXQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GXS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WAK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WAL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WAN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WAO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WAP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WAQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WAR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WAS","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31075","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31107","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31108","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31109","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31110","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31111","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31112","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31113","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31114","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31117","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31118","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31119","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31204","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31207","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-34359","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-34360","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37395","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37396","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37398","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37399","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37400","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37401","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37402","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37403","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9302","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9305","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9306","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"SASBDB","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112735","properties":[{"key":"Interactions","value":"260"}]},{"database":"ComplexPortal","id":"CPX-915","properties":[{"key":"EntryName","value":"General transcription factor complex TFIID"}]},{"database":"ComplexPortal","id":"CPX-930","properties":[{"key":"EntryName","value":"General transcription factor complex TFIID, TAF4B variant"}]},{"database":"CORUM","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-147N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P21675","properties":[{"key":"Number of interactors","value":"3231"}]},{"database":"IntAct","id":"P21675","properties":[{"key":"Interactions","value":"82"}]},{"database":"MINT","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-TAF1","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000406549","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3217390","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"2231","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P21675","properties":[{"key":"glycosylation","value":"1 site, 1 glycan"}]},{"database":"GlyGen","id":"P21675","properties":[{"key":"glycosylation","value":"3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"TAF1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"115942","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000406549","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"3401","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"53886","properties":[{"key":"Description","value":"-"}],"isoformId":"P21675-1"},{"database":"ProteomicsDB","id":"53887","properties":[{"key":"Description","value":"-"}],"isoformId":"P21675-2"},{"database":"Pumba","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P21675","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"Antibodypedia","id":"346","properties":[{"key":"antibodies","value":"306 antibodies from 41 providers"}]},{"database":"DNASU","id":"6872","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000373790.9","properties":[{"key":"ProteinId","value":"ENSP00000362895.5"},{"key":"GeneId","value":"ENSG00000147133.19"}],"isoformId":"P21675-13"},{"database":"Ensembl","id":"ENST00000423759.6","properties":[{"key":"ProteinId","value":"ENSP00000406549.2"},{"key":"GeneId","value":"ENSG00000147133.19"}],"isoformId":"P21675-14"},{"database":"Ensembl","id":"ENST00000715246.1","properties":[{"key":"ProteinId","value":"ENSP00000520427.1"},{"key":"GeneId","value":"ENSG00000147133.19"}],"isoformId":"P21675-2"},{"database":"GeneID","id":"6872","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6872","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000423759.6","properties":[{"key":"ProteinId","value":"ENSP00000406549.2"},{"key":"RefSeqNucleotideId","value":"NM_004606.5"},{"key":"RefSeqProteinId","value":"NP_004597.3"}],"isoformId":"P21675-14"},{"database":"UCSC","id":"uc004dzt.6","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P21675-2"},{"database":"AGR","id":"HGNC:11535","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA36310","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6872","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6872","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TAF1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"TAF1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11535","properties":[{"key":"GeneName","value":"TAF1"}]},{"database":"HPA","id":"ENSG00000147133","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"TAF1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"300966","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"313650","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"314250","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000147133","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"53351","properties":[{"key":"Disease","value":"X-linked dystonia-parkinsonism"}]},{"database":"Orphanet","id":"480907","properties":[{"key":"Disease","value":"X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000147133","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0008","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155242","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000572_3_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PARIWYD","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5752at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P21675","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.3.1.48","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-167161","properties":[{"key":"PathwayName","value":"HIV Transcription Initiation"}]},{"database":"Reactome","id":"R-HSA-167162","properties":[{"key":"PathwayName","value":"RNA Polymerase II HIV Promoter Escape"}]},{"database":"Reactome","id":"R-HSA-167172","properties":[{"key":"PathwayName","value":"Transcription of the HIV genome"}]},{"database":"Reactome","id":"R-HSA-674695","properties":[{"key":"PathwayName","value":"RNA Polymerase II Pre-transcription Events"}]},{"database":"Reactome","id":"R-HSA-6804756","properties":[{"key":"PathwayName","value":"Regulation of TP53 Activity through Phosphorylation"}]},{"database":"Reactome","id":"R-HSA-73776","properties":[{"key":"PathwayName","value":"RNA Polymerase II Promoter Escape"}]},{"database":"Reactome","id":"R-HSA-73779","properties":[{"key":"PathwayName","value":"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"}]},{"database":"Reactome","id":"R-HSA-75953","properties":[{"key":"PathwayName","value":"RNA Polymerase II Transcription Initiation"}]},{"database":"Reactome","id":"R-HSA-76042","properties":[{"key":"PathwayName","value":"RNA Polymerase II Transcription Initiation And Promoter Clearance"}]},{"database":"SignaLink","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000147133","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6872","properties":[{"key":"hits","value":"343 hits in 821 CRISPR screens"}]},{"database":"ChiTaRS","id":"TAF1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P21675","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"TAF1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6872","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P21675","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P21675","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome X"}]},{"database":"RNAct","id":"P21675","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000147133","properties":[{"key":"ExpressionPatterns","value":"Expressed in sural nerve and 182 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P21675","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20181722"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:0071339","properties":[{"key":"GoTerm","value":"C:MLL1 complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15960975"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25593309"}]},{"database":"GO","id":"GO:0005669","properties":[{"key":"GoTerm","value":"C:transcription factor TFIID complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27007846"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25412659"}]},{"database":"GO","id":"GO:0004402","properties":[{"key":"GoTerm","value":"F:histone acetyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8980232"}]},{"database":"GO","id":"GO:0140046","properties":[{"key":"GoTerm","value":"F:histone H4K16ac reader activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17996705"}]},{"database":"GO","id":"GO:0016301","properties":[{"key":"GoTerm","value":"F:kinase activity"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18548200"}]},{"database":"GO","id":"GO:0016922","properties":[{"key":"GoTerm","value":"F:nuclear receptor binding"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"20181722"}]},{"database":"GO","id":"GO:0002039","properties":[{"key":"GoTerm","value":"F:p53 binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15053879"}]},{"database":"GO","id":"GO:0046982","properties":[{"key":"GoTerm","value":"F:protein heterodimerization activity"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25412659"}]},{"database":"GO","id":"GO:0004672","properties":[{"key":"GoTerm","value":"F:protein kinase activity"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:0106310","properties":[{"key":"GoTerm","value":"F:protein serine kinase activity"},{"key":"GoEvidenceType","value":"IEA:RHEA"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8625415"}]},{"database":"GO","id":"GO:0061733","properties":[{"key":"GoTerm","value":"F:protein-lysine-acetyltransferase activity"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15870300"}]},{"database":"GO","id":"GO:0001181","properties":[{"key":"GoTerm","value":"F:RNA polymerase I general transcription initiation factor activity"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12498690"}]},{"database":"GO","id":"GO:0000979","properties":[{"key":"GoTerm","value":"F:RNA polymerase II core promoter sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25412659"}]},{"database":"GO","id":"GO:0016251","properties":[{"key":"GoTerm","value":"F:RNA polymerase II general transcription initiation factor activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17996705"}]},{"database":"GO","id":"GO:0001091","properties":[{"key":"GoTerm","value":"F:RNA polymerase II general transcription initiation factor binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"8625415"}]},{"database":"GO","id":"GO:0061629","properties":[{"key":"GoTerm","value":"F:RNA polymerase II-specific DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0017025","properties":[{"key":"GoTerm","value":"F:TBP-class protein binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"9660973"}]},{"database":"GO","id":"GO:0140416","properties":[{"key":"GoTerm","value":"F:transcription regulator inhibitor activity"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:0061631","properties":[{"key":"GoTerm","value":"F:ubiquitin conjugating enzyme activity"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20181722"}]},{"database":"GO","id":"GO:0071318","properties":[{"key":"GoTerm","value":"P:cellular response to ATP"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:0034644","properties":[{"key":"GoTerm","value":"P:cellular response to UV"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:0006974","properties":[{"key":"GoTerm","value":"P:DNA damage response"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:0030901","properties":[{"key":"GoTerm","value":"P:midbrain development"},{"key":"GoEvidenceType","value":"IGI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"26637982"}]},{"database":"GO","id":"GO:0042789","properties":[{"key":"GoTerm","value":"P:mRNA transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17884155"}]},{"database":"GO","id":"GO:0010629","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17237821"}]},{"database":"GO","id":"GO:1905524","properties":[{"key":"GoTerm","value":"P:negative regulation of protein autoubiquitination"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17237821"}]},{"database":"GO","id":"GO:1901797","properties":[{"key":"GoTerm","value":"P:negative regulation of signal transduction by p53 class mediator"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18548200"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24289924"}]},{"database":"GO","id":"GO:2000059","properties":[{"key":"GoTerm","value":"P:negative regulation of ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17237821"}]},{"database":"GO","id":"GO:0160207","properties":[{"key":"GoTerm","value":"P:positive regulation of androgen receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20181722"}]},{"database":"GO","id":"GO:0032436","properties":[{"key":"GoTerm","value":"P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15053879"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20181722"}]},{"database":"GO","id":"GO:0060261","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription initiation by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17884155"}]},{"database":"GO","id":"GO:0046777","properties":[{"key":"GoTerm","value":"P:protein autophosphorylation"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"15053879"}]},{"database":"GO","id":"GO:0000209","properties":[{"key":"GoTerm","value":"P:protein polyubiquitination"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20181722"}]},{"database":"GO","id":"GO:0050821","properties":[{"key":"GoTerm","value":"P:protein stabilization"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17237821"}]},{"database":"GO","id":"GO:1902806","properties":[{"key":"GoTerm","value":"P:regulation of cell cycle G1/S phase transition"},{"key":"GoEvidenceType","value":"TAS:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"12498690"}]},{"database":"GO","id":"GO:1901796","properties":[{"key":"GoTerm","value":"P:regulation of signal transduction by p53 class mediator"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0051123","properties":[{"key":"GoTerm","value":"P:RNA polymerase II preinitiation complex assembly"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"27007846"}]},{"database":"GO","id":"GO:0006366","properties":[{"key":"GoTerm","value":"P:transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IGI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"9660973"}]},{"database":"GO","id":"GO:0006361","properties":[{"key":"GoTerm","value":"P:transcription initiation at RNA polymerase I promoter"},{"key":"GoEvidenceType","value":"IGI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"12498690"}]},{"database":"GO","id":"GO:0006367","properties":[{"key":"GoTerm","value":"P:transcription initiation at RNA polymerase II promoter"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17996705"}]},{"database":"GO","id":"GO:0006511","properties":[{"key":"GoTerm","value":"P:ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20181722"}]},{"database":"CDD","id":"cd05511","properties":[{"key":"EntryName","value":"Bromo_TFIID"},{"key":"MatchStatus","value":"2"}]},{"database":"DisProt","id":"DP03451","properties":[{"key":"Description","value":"-"}],"isoformId":"P21675-1"},{"database":"FunFam","id":"1.10.1100.10:FF:000001","properties":[{"key":"EntryName","value":"Transcription initiation factor TFIID subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.920.10:FF:000019","properties":[{"key":"EntryName","value":"Transcription initiation factor TFIID subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.920.10:FF:000020","properties":[{"key":"EntryName","value":"Transcription initiation factor TFIID subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.920.10","properties":[{"key":"EntryName","value":"Bromodomain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.1100.10","properties":[{"key":"EntryName","value":"TAFII-230 TBP-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00545","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR001487","properties":[{"key":"EntryName","value":"Bromodomain"}]},{"database":"InterPro","id":"IPR036427","properties":[{"key":"EntryName","value":"Bromodomain-like_sf"}]},{"database":"InterPro","id":"IPR018359","properties":[{"key":"EntryName","value":"Bromodomain_CS"}]},{"database":"InterPro","id":"IPR040240","properties":[{"key":"EntryName","value":"TAF1"}]},{"database":"InterPro","id":"IPR011177","properties":[{"key":"EntryName","value":"TAF1_animal"}]},{"database":"InterPro","id":"IPR022591","properties":[{"key":"EntryName","value":"TAF1_HAT_dom"}]},{"database":"InterPro","id":"IPR009067","properties":[{"key":"EntryName","value":"TAF_II_230-bd"}]},{"database":"InterPro","id":"IPR036741","properties":[{"key":"EntryName","value":"TAFII-230_TBP-bd_sf"}]},{"database":"InterPro","id":"IPR041670","properties":[{"key":"EntryName","value":"Znf-CCHC_6"}]},{"database":"PANTHER","id":"PTHR13900","properties":[{"key":"EntryName","value":"TRANSCRIPTION INITIATION FACTOR TFIID"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13900:SF0","properties":[{"key":"EntryName","value":"TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00439","properties":[{"key":"EntryName","value":"Bromodomain"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF12157","properties":[{"key":"EntryName","value":"DUF3591"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09247","properties":[{"key":"EntryName","value":"TBP-binding"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15288","properties":[{"key":"EntryName","value":"zf-CCHC_6"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF003047","properties":[{"key":"EntryName","value":"TAF1_animal"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00503","properties":[{"key":"EntryName","value":"BROMODOMAIN"}]},{"database":"SMART","id":"SM00297","properties":[{"key":"EntryName","value":"BROMO"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF47370","properties":[{"key":"EntryName","value":"Bromodomain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF47055","properties":[{"key":"EntryName","value":"TAF(II)230 TBP-binding fragment"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00633","properties":[{"key":"EntryName","value":"BROMODOMAIN_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50014","properties":[{"key":"EntryName","value":"BROMODOMAIN_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDESRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSENGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE","length":1893,"molWeight":214714,"crc64":"AE148C222B418BB4","md5":"35E8327499BFB92C7D5F13A036D13F4A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":3,"COFACTOR":1,"ACTIVITY REGULATION":1,"SUBUNIT":3,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":15,"DOMAIN":1,"PTM":1,"DISEASE":2,"MISCELLANEOUS":10,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":4,"DNA binding":1,"Region":11,"Motif":1,"Compositional bias":11,"Modified residue":13,"Cross-link":2,"Alternative sequence":14,"Natural variant":15,"Mutagenesis":14,"Beta strand":30,"Helix":54,"Turn":6},"uniParcId":"UPI000013DA9F"}}