{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P20815","secondaryAccessions":["A4D289","B7Z5I7","Q53WY8","Q75MV0","Q9HB56"],"uniProtkbId":"CP3A5_HUMAN","entryAudit":{"firstPublicDate":"1991-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1991-02-01","entryVersion":229,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11502729"}],"value":"Cytochrome P450 3A5"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11093772"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12865317"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2732228"}],"value":"1.14.14.1"}]},"alternativeNames":[{"fullName":{"value":"CYPIIIA5"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2732228"}],"value":"Cytochrome P450-PCN3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8569713"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2638"}],"value":"CYP3A5"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10681376"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11093772"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12865317"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2732228"}],"value":"A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). 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