{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P20800","secondaryAccessions":["Q5T1R3"],"uniProtkbId":"EDN2_HUMAN","entryAudit":{"firstPublicDate":"1991-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1991-11-01","entryVersion":204,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Endothelin-2"},"shortNames":[{"value":"ET-2"}]},"alternativeNames":[{"fullName":{"value":"Preproendothelin-2"},"shortNames":[{"value":"PPET2"}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"EDN2"}}],"comments":[{"texts":[{"value":"Endothelins are endothelium-derived vasoconstrictor peptides"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9284755"}],"value":"Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the endothelin/sarafotoxin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"","featureId":"PRO_0000008093"},{"type":"Peptide","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Endothelin-2","featureId":"PRO_0000008094"},{"type":"Propeptide","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","featureId":"PRO_0000008095"},{"type":"Region","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Endothelin-like"},{"type":"Region","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Cleavage; by KEL"},{"type":"Disulfide bond","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Natural variant","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"in dbSNP:rs5798","featureCrossReferences":[{"database":"dbSNP","id":"rs5798"}],"featureId":"VAR_033914","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in dbSNP:rs11572371","featureCrossReferences":[{"database":"dbSNP","id":"rs11572371"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_018817","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}}],"keywords":[{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0838","category":"Molecular function","name":"Vasoactive"},{"id":"KW-0839","category":"Molecular function","name":"Vasoconstrictor"}],"references":[{"referenceNumber":1,"citation":{"id":"1701397","citationType":"journal article","authors":["Ohkubo S.","Ogi K.","Hosoya M.","Matsumoto H.","Suzuki N.","Kimura C.","Onda H.","Fujino M."],"citationCrossReferences":[{"database":"PubMed","id":"1701397"},{"database":"DOI","id":"10.1016/0014-5793(90)81348-r"}],"title":"Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization.","publicationDate":"1990","journal":"FEBS Lett.","firstPage":"136","lastPage":"140","volume":"274"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"1840558","citationType":"journal article","authors":["Bloch K.D.","Hong C.C.","Eddy R.L. Jr.","Shows T.B.","Quertermous T."],"citationCrossReferences":[{"database":"PubMed","id":"1840558"},{"database":"DOI","id":"10.1016/0888-7543(91)90505-9"}],"title":"cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2.","publicationDate":"1991","journal":"Genomics","firstPage":"236","lastPage":"242","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"1725387","citationType":"journal article","authors":["Onda H.","Ohkubo S.","Kosaka T.","Yasuhara T.","Ogi K.","Hosoya M.","Matsumoto H.","Suzuki N.","Kitada C.","Ishibashi Y.","Kimura C.","Kubo K.","Fujino M."],"citationCrossReferences":[{"database":"PubMed","id":"1725387"},{"database":"DOI","id":"10.1097/00005344-199100177-00011"}],"title":"Expression of endothelin-2 (ET-2) gene in a human renal adenocarcinoma cell line: purification and cDNA cloning of ET-2.","publicationDate":"1991","journal":"J. Cardiovasc. Pharmacol.","firstPage":"S39","lastPage":"S43","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":4,"citation":{"id":"CI-86AL9GH7VDJIK","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"JAN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT LEU-168"]},{"referenceNumber":5,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Colon","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Stomach","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"2649896","citationType":"journal article","authors":["Inoue A.","Yanagisawa M.","Kimura S.","Kasuya Y.","Miyauchi T.","Goto K.","Masaki T."],"citationCrossReferences":[{"database":"PubMed","id":"2649896"},{"database":"DOI","id":"10.1073/pnas.86.8.2863"}],"title":"The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.","publicationDate":"1989","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2863","lastPage":"2867","volume":"86"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-73"]},{"referenceNumber":9,"citation":{"id":"10438732","citationType":"journal article","authors":["Lee S.","Lin M.","Mele A.","Cao Y.","Farmar J.","Russo D.","Redman C."],"citationCrossReferences":[{"database":"PubMed","id":"10438732"},{"database":"DOI","id":"10.1182/blood.v94.4.1440"}],"title":"Proteolytic processing of big endothelin-3 by the kell blood group protein.","publicationDate":"1999","journal":"Blood","firstPage":"1440","lastPage":"1450","volume":"94"},"referencePositions":["PARTIAL PROTEIN SEQUENCE","CLEAVAGE BY KELL","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":10,"citation":{"id":"9284755","citationType":"journal article","authors":["Bourgeois C.","Robert B.","Rebourcet R.","Mondon F.","Mignot T.-M.","Duc-Goiran P.","Ferre F."],"citationCrossReferences":[{"database":"PubMed","id":"9284755"},{"database":"DOI","id":"10.1210/jcem.82.9.4209"}],"title":"Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.","publicationDate":"1997","journal":"J. Clin. Endocrinol. Metab.","firstPage":"3116","lastPage":"3123","volume":"82"},"referencePositions":["TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X55177","properties":[{"key":"ProteinId","value":"CAA38962.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M65199","properties":[{"key":"ProteinId","value":"AAA52404.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY518541","properties":[{"key":"ProteinId","value":"AAR89914.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445933","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471059","properties":[{"key":"ProteinId","value":"EAX07175.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC034393","properties":[{"key":"ProteinId","value":"AAH34393.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M25550","properties":[{"key":"ProteinId","value":"AAA52340.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS462.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A39070","properties":[{"key":"EntryName","value":"A39070"}]},{"database":"RefSeq","id":"NP_001289198.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001302269.2"}]},{"database":"RefSeq","id":"NP_001947.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001956.5"}]},{"database":"AlphaFoldDB","id":"P20800","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P20800","properties":[{"key":"Number of interactors","value":"872"}]},{"database":"NDEx","id":"IQUERY-CP-EDN2","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000361668","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P20800","properties":[{"key":"glycosylation","value":"4 sites, 1 O-linked glycan (4 sites)"}]},{"database":"iPTMnet","id":"P20800","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P20800","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"EDN2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"119615","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P20800","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000361668","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P20800","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"32186","properties":[{"key":"antibodies","value":"200 antibodies from 27 providers"}]},{"database":"DNASU","id":"1907","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000372587.5","properties":[{"key":"ProteinId","value":"ENSP00000361668.4"},{"key":"GeneId","value":"ENSG00000127129.11"}]},{"database":"GeneID","id":"1907","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1907","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000372587.5","properties":[{"key":"ProteinId","value":"ENSP00000361668.4"},{"key":"RefSeqNucleotideId","value":"NM_001956.5"},{"key":"RefSeqProteinId","value":"NP_001947.1"}]},{"database":"UCSC","id":"uc001cgx.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:3177","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA27615","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1907","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1907","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"EDN2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3177","properties":[{"key":"GeneName","value":"EDN2"}]},{"database":"HPA","id":"ENSG00000127129","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (cervix, esophagus, vagina)"}]},{"database":"MIM","id":"131241","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000127129","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000127129","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S5KM","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183053","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_090013_2_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P20800","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PTAWCSV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9362154at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P20800","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P20800","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P20800","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-375276","properties":[{"key":"PathwayName","value":"Peptide ligand-binding receptors"}]},{"database":"Reactome","id":"R-HSA-416476","properties":[{"key":"PathwayName","value":"G alpha (q) signalling events"}]},{"database":"SignaLink","id":"P20800","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000127129","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1907","properties":[{"key":"hits","value":"12 hits in 1147 CRISPR screens"}]},{"database":"GeneWiki","id":"Endothelin_2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1907","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P20800","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P20800","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"P20800","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000127129","properties":[{"key":"ExpressionPatterns","value":"Expressed in lower esophagus mucosa and 112 other cell types or tissues"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15691296"}]},{"database":"GO","id":"GO:0031708","properties":[{"key":"GoTerm","value":"F:endothelin B receptor binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"1713452"}]},{"database":"GO","id":"GO:0005179","properties":[{"key":"GoTerm","value":"F:hormone activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2649896"}]},{"database":"GO","id":"GO:0001525","properties":[{"key":"GoTerm","value":"P:angiogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0014824","properties":[{"key":"GoTerm","value":"P:artery smooth muscle contraction"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8982507"}]},{"database":"GO","id":"GO:0048675","properties":[{"key":"GoTerm","value":"P:axon extension"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IC:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"2649896"}]},{"database":"GO","id":"GO:0009932","properties":[{"key":"GoTerm","value":"P:cell tip growth"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0019221","properties":[{"key":"GoTerm","value":"P:cytokine-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12207323"}]},{"database":"GO","id":"GO:0043542","properties":[{"key":"GoTerm","value":"P:endothelial cell migration"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0086100","properties":[{"key":"GoTerm","value":"P:endothelin receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9492062"}]},{"database":"GO","id":"GO:0003058","properties":[{"key":"GoTerm","value":"P:hormonal regulation of the force of heart contraction"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1652300"}]},{"database":"GO","id":"GO:0006874","properties":[{"key":"GoTerm","value":"P:intracellular calcium ion homeostasis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0042116","properties":[{"key":"GoTerm","value":"P:macrophage activation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12207323"}]},{"database":"GO","id":"GO:0048246","properties":[{"key":"GoTerm","value":"P:macrophage chemotaxis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12207323"}]},{"database":"GO","id":"GO:0030593","properties":[{"key":"GoTerm","value":"P:neutrophil chemotaxis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9696419"}]},{"database":"GO","id":"GO:0050850","properties":[{"key":"GoTerm","value":"P:positive regulation of calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1917960"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1917960"}]},{"database":"GO","id":"GO:0010460","properties":[{"key":"GoTerm","value":"P:positive regulation of heart rate"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2649896"}]},{"database":"GO","id":"GO:0002690","properties":[{"key":"GoTerm","value":"P:positive regulation of leukocyte chemotaxis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9696419"}]},{"database":"GO","id":"GO:0031394","properties":[{"key":"GoTerm","value":"P:positive regulation of prostaglandin biosynthetic process"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9492062"}]},{"database":"GO","id":"GO:0045987","properties":[{"key":"GoTerm","value":"P:positive regulation of smooth muscle contraction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0003099","properties":[{"key":"GoTerm","value":"P:positive regulation of the force of heart contraction by chemical signal"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1652300"}]},{"database":"GO","id":"GO:0003100","properties":[{"key":"GoTerm","value":"P:regulation of systemic arterial blood pressure by endothelin"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2649896"}]},{"database":"GO","id":"GO:0019229","properties":[{"key":"GoTerm","value":"P:regulation of vasoconstriction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042310","properties":[{"key":"GoTerm","value":"P:vasoconstriction"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2649896"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8982507"}]},{"database":"GO","id":"GO:0014826","properties":[{"key":"GoTerm","value":"P:vein smooth muscle contraction"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8982507"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9422810"}]},{"database":"InterPro","id":"IPR020475","properties":[{"key":"EntryName","value":"Endothelin"}]},{"database":"InterPro","id":"IPR019764","properties":[{"key":"EntryName","value":"Endothelin_toxin_CS"}]},{"database":"InterPro","id":"IPR001928","properties":[{"key":"EntryName","value":"Endothln-like_toxin"}]},{"database":"PANTHER","id":"PTHR13874","properties":[{"key":"EntryName","value":"ENDOTHELIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13874:SF9","properties":[{"key":"EntryName","value":"ENDOTHELIN-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00322","properties":[{"key":"EntryName","value":"Endothelin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00365","properties":[{"key":"EntryName","value":"ENDOTHELIN"}]},{"database":"SMART","id":"SM00272","properties":[{"key":"EntryName","value":"END"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00270","properties":[{"key":"EntryName","value":"ENDOTHELIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MVSVPTTWCSVALALLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPACATFCLRRPWTEAGAVPSRKSPADVFQTGKTGATTGELLQRLRDISTVKSLFAKRQQEAMREPRSTHSRWRKR","length":178,"molWeight":19960,"crc64":"7711B2B6F075CFB4","md5":"52A5B5789D0B2CAC452AA9E4B7015C21"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Propeptide":2,"Peptide":1,"Region":2,"Compositional bias":1,"Site":1,"Disulfide bond":2,"Natural variant":2},"uniParcId":"UPI0000040AF7"}}