{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P19784","uniProtkbId":"CSK22_HUMAN","entryAudit":{"firstPublicDate":"1991-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1991-02-01","entryVersion":240,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Casein kinase II subunit alpha'"},"shortNames":[{"value":"CK II alpha'"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11239457"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20545769"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21482717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22325354"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30898438"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35597237"}],"value":"2.7.11.1"}]}},"genes":[{"geneName":{"value":"CSNK2A2"},"synonyms":[{"value":"CK2A2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11239457"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11704824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16193064"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20545769"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21482717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22325354"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26811421"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30898438"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35597237"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38334665"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12631575"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19387549"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19387550"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19387551"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19387552"}],"value":"Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:30898438). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:11704824, PubMed:16193064, PubMed:30898438). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:19387551, PubMed:19387552). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387551, PubMed:19387552). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11239457"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20545769"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21482717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30898438"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:17990"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11239457"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20545769"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21482717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30898438"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35597237"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22325354"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:46609"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22325354"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization (By similarity)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O54833"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11239457"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12393879"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19193990"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38334665"}],"value":"Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1 alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation (PubMed:11239457, PubMed:12393879). Interacts with CSNK2A2IP (via C-terminus) (By similarity). Interacts with SIRT6; preventing CSNK2A2 localization to the nucleus (By similarity). Interacts with RNPS1. Interacts with HIRIP3 (PubMed:38334665)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P19784","intActId":"EBI-347451"},"interactantTwo":{"uniProtKBAccession":"Q8NDY6","geneName":"BHLHE23","intActId":"EBI-12144263"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P19784","intActId":"EBI-347451"},"interactantTwo":{"uniProtKBAccession":"P68400","geneName":"CSNK2A1","intActId":"EBI-347804"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P19784","intActId":"EBI-347451"},"interactantTwo":{"uniProtKBAccession":"P67870","geneName":"CSNK2B","intActId":"EBI-348169"},"numberOfExperiments":24,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P19784","intActId":"EBI-347451"},"interactantTwo":{"uniProtKBAccession":"O60282","geneName":"KIF5C","intActId":"EBI-717170"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P19784","intActId":"EBI-347451"},"interactantTwo":{"uniProtKBAccession":"Q9NRD5","geneName":"PICK1","intActId":"EBI-79165"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P19784","intActId":"EBI-347451"},"interactantTwo":{"uniProtKBAccession":"Q8WV44","geneName":"TRIM41","intActId":"EBI-725997"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P19784","intActId":"EBI-347451"},"interactantTwo":{"uniProtKBAccession":"Q9BS34","geneName":"ZNF670","intActId":"EBI-745276"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O54833"}],"value":"Interaction with SIRT6 prevents translocation into the nucleus"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O54833"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O54833"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"value":"Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Casein kinase II subunit alpha'","featureId":"PRO_0000085891"},{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}]},{"type":"Active site","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Modified residue","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"}]},{"type":"Modified residue","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"}]},{"type":"Modified residue","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"}]},{"type":"Natural variant","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"in dbSNP:rs55911801","featureCrossReferences":[{"database":"dbSNP","id":"rs55911801"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_040416","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5M4U"}]},{"type":"Beta strand","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Turn","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Beta strand","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6HMD"}]},{"type":"Helix","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Beta strand","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Beta strand","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Turn","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Beta strand","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Turn","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Beta strand","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Turn","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Beta strand","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Turn","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Beta strand","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Turn","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Beta strand","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TE2"}]},{"type":"Helix","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Beta strand","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Turn","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]},{"type":"Helix","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TGU"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0879","category":"Biological process","name":"Wnt signaling pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"2174700","citationType":"journal article","authors":["Lozeman F.J.","Litchfield D.W.","Piening C.","Takio K.","Walsh K.A.","Krebs E.G."],"citationCrossReferences":[{"database":"PubMed","id":"2174700"},{"database":"DOI","id":"10.1021/bi00488a034"}],"title":"Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.","publicationDate":"1990","journal":"Biochemistry","firstPage":"8436","lastPage":"8447","volume":"29"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"11239457","citationType":"journal article","authors":["Keller D.M.","Zeng X.","Wang Y.","Zhang Q.H.","Kapoor M.","Shu H.","Goodman R.","Lozano G.","Zhao Y.","Lu H."],"citationCrossReferences":[{"database":"PubMed","id":"11239457"},{"database":"DOI","id":"10.1016/s1097-2765(01)00176-9"}],"title":"A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.","publicationDate":"2001","journal":"Mol. Cell","firstPage":"283","lastPage":"292","volume":"7"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","INTERACTION WITH SSRP1 AND SUPT16H"]},{"referenceNumber":4,"citation":{"id":"11704824","citationType":"journal article","authors":["Sayed M.","Pelech S.","Wong C.","Marotta A.","Salh B."],"citationCrossReferences":[{"database":"PubMed","id":"11704824"},{"database":"DOI","id":"10.1038/sj.onc.1204894"}],"title":"Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells.","publicationDate":"2001","journal":"Oncogene","firstPage":"6994","lastPage":"7005","volume":"20"},"referencePositions":["FUNCTION IN CELL CYCLE"]},{"referenceNumber":5,"citation":{"id":"12393879","citationType":"journal article","authors":["Keller D.M.","Lu H."],"citationCrossReferences":[{"database":"PubMed","id":"12393879"},{"database":"DOI","id":"10.1074/jbc.m209820200"}],"title":"p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"50206","lastPage":"50213","volume":"277"},"referencePositions":["INTERACTION WITH SSRP1 AND SUPT16H"]},{"referenceNumber":6,"citation":{"id":"16193064","citationType":"journal article","authors":["Shin S.","Lee Y.","Kim W.","Ko H.","Choi H.","Kim K."],"citationCrossReferences":[{"database":"PubMed","id":"16193064"},{"database":"DOI","id":"10.1038/sj.emboj.7600827"}],"title":"Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.","publicationDate":"2005","journal":"EMBO J.","firstPage":"3532","lastPage":"3542","volume":"24"},"referencePositions":["FUNCTION IN APOPTOSIS"]},{"referenceNumber":7,"citation":{"id":"12631575","citationType":"journal article","authors":["Meggio F.","Pinna L.A."],"citationCrossReferences":[{"database":"PubMed","id":"12631575"},{"database":"DOI","id":"10.1096/fj.02-0473rev"}],"title":"One-thousand-and-one substrates of protein kinase CK2?","publicationDate":"2003","journal":"FASEB J.","firstPage":"349","lastPage":"368","volume":"17"},"referencePositions":["REVIEW ON FUNCTION"]},{"referenceNumber":8,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-21 AND SER-288","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"19387553","citationType":"journal article","authors":["Niefind K.","Raaf J.","Issinger O.G."],"citationCrossReferences":[{"database":"PubMed","id":"19387553"},{"database":"DOI","id":"10.1007/s00018-009-9149-8"}],"title":"Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights.","publicationDate":"2009","journal":"Cell. Mol. Life Sci.","firstPage":"1800","lastPage":"1816","volume":"66"},"referencePositions":["REVIEW ON STRUCTURE"]},{"referenceNumber":10,"citation":{"id":"19387552","citationType":"journal article","authors":["St-Denis N.A.","Litchfield D.W."],"citationCrossReferences":[{"database":"PubMed","id":"19387552"},{"database":"DOI","id":"10.1007/s00018-009-9150-2"}],"title":"Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival.","publicationDate":"2009","journal":"Cell. Mol. Life Sci.","firstPage":"1817","lastPage":"1829","volume":"66"},"referencePositions":["REVIEW ON FUNCTION"]},{"referenceNumber":11,"citation":{"id":"19387551","citationType":"journal article","authors":["Filhol O.","Cochet C."],"citationCrossReferences":[{"database":"PubMed","id":"19387551"},{"database":"DOI","id":"10.1007/s00018-009-9151-1"}],"title":"Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.","publicationDate":"2009","journal":"Cell. Mol. Life Sci.","firstPage":"1830","lastPage":"1839","volume":"66"},"referencePositions":["REVIEW ON FUNCTION"]},{"referenceNumber":12,"citation":{"id":"19387550","citationType":"journal article","authors":["Miyata Y."],"citationCrossReferences":[{"database":"PubMed","id":"19387550"},{"database":"DOI","id":"10.1007/s00018-009-9152-0"}],"title":"Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery.","publicationDate":"2009","journal":"Cell. Mol. Life Sci.","firstPage":"1840","lastPage":"1849","volume":"66"},"referencePositions":["REVIEW ON FUNCTION IN REGULATION OF HSP90"]},{"referenceNumber":13,"citation":{"id":"19387549","citationType":"journal article","authors":["Dominguez I.","Sonenshein G.E.","Seldin D.C."],"citationCrossReferences":[{"database":"PubMed","id":"19387549"},{"database":"DOI","id":"10.1007/s00018-009-9153-z"}],"title":"Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer.","publicationDate":"2009","journal":"Cell. Mol. Life Sci.","firstPage":"1850","lastPage":"1857","volume":"66"},"referencePositions":["REVIEW ON FUNCTION IN WNT SIGNALING"]},{"referenceNumber":14,"citation":{"id":"19369195","citationType":"journal article","authors":["Oppermann F.S.","Gnad F.","Olsen J.V.","Hornberger R.","Greff Z.","Keri G.","Mann M.","Daub H."],"citationCrossReferences":[{"database":"PubMed","id":"19369195"},{"database":"DOI","id":"10.1074/mcp.m800588-mcp200"}],"title":"Large-scale proteomics analysis of the human kinome.","publicationDate":"2009","journal":"Mol. Cell. Proteomics","firstPage":"1751","lastPage":"1764","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-13; SER-18; SER-21 AND SER-288","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":15,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-97","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":16,"citation":{"id":"20545769","citationType":"journal article","authors":["Takeishi Y.","Ohashi E.","Ogawa K.","Masai H.","Obuse C.","Tsurimoto T."],"citationCrossReferences":[{"database":"PubMed","id":"20545769"},{"database":"DOI","id":"10.1111/j.1365-2443.2010.01418.x"}],"title":"Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.","publicationDate":"2010","journal":"Genes Cells","firstPage":"761","lastPage":"771","volume":"15"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":17,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"21482717","citationType":"journal article","authors":["Wang J.","Gong Z.","Chen J."],"citationCrossReferences":[{"database":"PubMed","id":"21482717"},{"database":"DOI","id":"10.1083/jcb.201010026"}],"title":"MDC1 collaborates with TopBP1 in DNA replication checkpoint control.","publicationDate":"2011","journal":"J. Cell Biol.","firstPage":"267","lastPage":"273","volume":"193"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":19,"citation":{"id":"22325354","citationType":"journal article","authors":["Yata K.","Lloyd J.","Maslen S.","Bleuyard J.Y.","Skehel M.","Smerdon S.J.","Esashi F."],"citationCrossReferences":[{"database":"PubMed","id":"22325354"},{"database":"DOI","id":"10.1016/j.molcel.2011.12.028"}],"title":"Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.","publicationDate":"2012","journal":"Mol. Cell","firstPage":"371","lastPage":"383","volume":"45"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":20,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":21,"citation":{"id":"26811421","citationType":"journal article","authors":["Moudry P.","Watanabe K.","Wolanin K.M.","Bartkova J.","Wassing I.E.","Watanabe S.","Strauss R.","Troelsgaard Pedersen R.","Oestergaard V.H.","Lisby M.","Andujar-Sanchez M.","Maya-Mendoza A.","Esashi F.","Lukas J.","Bartek J."],"citationCrossReferences":[{"database":"PubMed","id":"26811421"},{"database":"DOI","id":"10.1083/jcb.201507042"}],"title":"TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.","publicationDate":"2016","journal":"J. Cell Biol.","firstPage":"281","lastPage":"288","volume":"212"},"referencePositions":["FUNCTION"]},{"referenceNumber":22,"citation":{"id":"30898438","citationType":"journal article","authors":["Leimbacher P.A.","Jones S.E.","Shorrocks A.K.","de Marco Zompit M.","Day M.","Blaauwendraad J.","Bundschuh D.","Bonham S.","Fischer R.","Fink D.","Kessler B.M.","Oliver A.W.","Pearl L.H.","Blackford A.N.","Stucki M."],"citationCrossReferences":[{"database":"PubMed","id":"30898438"},{"database":"DOI","id":"10.1016/j.molcel.2019.02.014"}],"title":"MDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis.","publicationDate":"2019","journal":"Mol. Cell","firstPage":"571","lastPage":"583","volume":"74"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":23,"citation":{"id":"35597237","citationType":"journal article","authors":["Zhao J.","Tian S.","Guo Q.","Bao K.","Yu G.","Wang X.","Shen X.","Zhang J.","Chen J.","Yang Y.","Liu L.","Li X.","Hao J.","Yang N.","Liu Z.","Ai D.","Yang J.","Zhu Y.","Yao Z.","Ma S.","Zhang K.","Shi L."],"citationCrossReferences":[{"database":"PubMed","id":"35597237"},{"database":"DOI","id":"10.1016/j.molcel.2022.04.031"}],"title":"A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.","publicationDate":"2022","journal":"Mol. Cell","firstPage":"2571","lastPage":"2587","volume":"82"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":24,"citation":{"id":"38334665","citationType":"journal article","authors":["Ignatyeva M.","Patel A.K.M.","Ibrahim A.","Albiheyri R.S.","Zari A.T.","Bahieldin A.","Bronner C.","Sabir J.S.M.","Hamiche A."],"citationCrossReferences":[{"database":"PubMed","id":"38334665"},{"database":"DOI","id":"10.3390/cells13030273"}],"title":"Identification and Characterization of HIRIP3 as a Histone H2A Chaperone.","publicationDate":"2024","journal":"Cells","firstPage":"1","lastPage":"15","volume":"13"},"referencePositions":["FUNCTION","INTERACTION WITH HIRIP3","DENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":25,"citation":{"id":"19193990","citationType":"journal article","authors":["Nakaniwa T.","Kinoshita T.","Sekiguchi Y.","Tada T.","Nakanishi I.","Kitaura K.","Suzuki Y.","Ohno H.","Hirasawa A.","Tsujimoto G."],"citationCrossReferences":[{"database":"PubMed","id":"19193990"},{"database":"DOI","id":"10.1107/s1744309108043194"}],"title":"Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor.","publicationDate":"2009","journal":"Acta Crystallogr. F","firstPage":"75","lastPage":"79","volume":"65"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 1-334 IN COMPLEX WITH INHIBITOR"]},{"referenceNumber":26,"citation":{"id":"21241709","citationType":"journal article","authors":["Bischoff N.","Olsen B.","Raaf J.","Bretner M.","Issinger O.G.","Niefind K."],"citationCrossReferences":[{"database":"PubMed","id":"21241709"},{"database":"DOI","id":"10.1016/j.jmb.2011.01.020"}],"title":"Structure of the human protein kinase CK2 catalytic subunit CK2alpha' and interaction thermodynamics with the regulatory subunit CK2beta.","publicationDate":"2011","journal":"J. Mol. Biol.","firstPage":"1","lastPage":"12","volume":"407"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS)"]},{"referenceNumber":27,"citation":{"id":"17344846","citationType":"journal article","authors":["Greenman C.","Stephens P.","Smith R.","Dalgliesh G.L.","Hunter C.","Bignell G.","Davies H.","Teague J.","Butler A.","Stevens C.","Edkins S.","O'Meara S.","Vastrik I.","Schmidt E.E.","Avis T.","Barthorpe S.","Bhamra G.","Buck G.","Choudhury B.","Clements J.","Cole J.","Dicks E.","Forbes S.","Gray K.","Halliday K.","Harrison R.","Hills K.","Hinton J.","Jenkinson A.","Jones D.","Menzies A.","Mironenko T.","Perry J.","Raine K.","Richardson D.","Shepherd R.","Small A.","Tofts C.","Varian J.","Webb T.","West S.","Widaa S.","Yates A.","Cahill D.P.","Louis D.N.","Goldstraw P.","Nicholson A.G.","Brasseur F.","Looijenga L.","Weber B.L.","Chiew Y.-E.","DeFazio A.","Greaves M.F.","Green A.R.","Campbell P.","Birney E.","Easton D.F.","Chenevix-Trench G.","Tan M.-H.","Khoo S.K.","Teh B.T.","Yuen S.T.","Leung S.Y.","Wooster R.","Futreal P.A.","Stratton M.R."],"citationCrossReferences":[{"database":"PubMed","id":"17344846"},{"database":"DOI","id":"10.1038/nature05610"}],"title":"Patterns of somatic mutation in human cancer genomes.","publicationDate":"2007","journal":"Nature","firstPage":"153","lastPage":"158","volume":"446"},"referencePositions":["VARIANT [LARGE SCALE ANALYSIS] ALA-188"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M55268","properties":[{"key":"ProteinId","value":"AAA51548.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC008812","properties":[{"key":"ProteinId","value":"AAH08812.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS10794.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"B35838","properties":[{"key":"EntryName","value":"B35838"}]},{"database":"RefSeq","id":"NP_001887.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001896.4"}]},{"database":"RefSeq","id":"XP_047289582.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047433626.1"}]},{"database":"RefSeq","id":"XP_054235601.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054379626.1"}]},{"database":"PDB","id":"3E3B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"X=1-334"}]},{"database":"PDB","id":"3OFM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"3U87","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A/B=327-350"}]},{"database":"PDB","id":"5M4U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.19 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"5M56","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.24 A"},{"key":"Chains","value":"A/B=1-350"}]},{"database":"PDB","id":"5OOI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=1-350"}]},{"database":"PDB","id":"5Y9M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.01 A"},{"key":"Chains","value":"A/X=1-334"}]},{"database":"PDB","id":"5YF9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.89 A"},{"key":"Chains","value":"B/X=1-334"}]},{"database":"PDB","id":"5YWM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.94 A"},{"key":"Chains","value":"X=1-334"}]},{"database":"PDB","id":"6HMB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.04 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"6HMC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.03 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"6HMD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.00 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"6HMQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.97 A"},{"key":"Chains","value":"A=1-346"}]},{"database":"PDB","id":"6L20","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.09 A"},{"key":"Chains","value":"A/D/G/J=1-333"}]},{"database":"PDB","id":"6QY8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C/D=1-335"}]},{"database":"PDB","id":"6QY9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=1-335"}]},{"database":"PDB","id":"6TE2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.92 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"6TEW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.08 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"6TGU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.83 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"7A1B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.29 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"7A1Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.02 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"7A22","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.01 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"7A2H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.01 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"7AT9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.05 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"7ATV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.98 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"7XYH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.04 A"},{"key":"Chains","value":"A/B=1-334"}]},{"database":"PDB","id":"8Q77","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.25 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"8Q9S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"8QBU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.09 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"8QCD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.03 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"8QCG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.04 A"},{"key":"Chains","value":"A/B=1-350"}]},{"database":"PDB","id":"8QF1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.32 A"},{"key":"Chains","value":"A/B=1-350"}]},{"database":"PDB","id":"9FBI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.16 A"},{"key":"Chains","value":"A/B=1-350"}]},{"database":"PDB","id":"9GXY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.16 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9H96","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.04 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9HK5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.49 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9IHG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.08 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9IHI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.23 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9Q8C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.90 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9Q8Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.98 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9Q9A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.03 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9Q9B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.84 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9Q9C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9Q9D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.89 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9Q9G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.94 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9QAB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.95 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9QAG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.01 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9QAK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.98 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9QB0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.01 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9QB6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.05 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9QB9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.19 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9R57","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.10 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9R5B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.09 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9R5C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.04 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9R5D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.02 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDB","id":"9R5F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.19 A"},{"key":"Chains","value":"A=1-350"}]},{"database":"PDBsum","id":"3E3B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3OFM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3U87","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5M4U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5M56","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5OOI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5Y9M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5YF9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5YWM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6HMB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6HMC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6HMD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6HMQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6L20","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6QY8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6QY9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TE2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TEW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TGU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7A1B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7A1Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7A22","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7A2H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7AT9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ATV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XYH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8Q77","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8Q9S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QBU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QCD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QCG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QF1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9FBI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9GXY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9H96","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HK5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9IHG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9IHI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9Q8C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9Q8Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9Q9A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9Q9B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9Q9C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9Q9D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9Q9G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QAB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QAG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QAK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QB0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QB6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QB9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R57","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R5B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R5C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R5D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R5F","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107842","properties":[{"key":"Interactions","value":"714"}]},{"database":"ComplexPortal","id":"CPX-2428","properties":[{"key":"EntryName","value":"Casein kinase II complex, CSNK2A2 variant"}]},{"database":"ComplexPortal","id":"CPX-2437","properties":[{"key":"EntryName","value":"Casein kinase II complex, CSNK2A1-CNSK2A2 variant"}]},{"database":"CORUM","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-318N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P19784","properties":[{"key":"Number of interactors","value":"3663"}]},{"database":"IntAct","id":"P19784","properties":[{"key":"Interactions","value":"570"}]},{"database":"MINT","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CSNK2A2","properties":[{"key":"Evidences","value":"13 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000262506","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4070","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB07546","properties":[{"key":"GenericName","value":"[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid"}]},{"database":"DrugBank","id":"DB12010","properties":[{"key":"GenericName","value":"Fostamatinib"}]},{"database":"DrugCentral","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"1550","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P19784","properties":[{"key":"glycosylation","value":"1 site, 1 glycan"}]},{"database":"GlyGen","id":"P19784","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CSNK2A2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"125266","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-5669","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-5670","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000262506","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"53686","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"15225","properties":[{"key":"antibodies","value":"333 antibodies from 36 providers"}]},{"database":"DNASU","id":"1459","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000262506.8","properties":[{"key":"ProteinId","value":"ENSP00000262506.3"},{"key":"GeneId","value":"ENSG00000070770.11"}]},{"database":"Ensembl","id":"ENST00000931140.1","properties":[{"key":"ProteinId","value":"ENSP00000601199.1"},{"key":"GeneId","value":"ENSG00000070770.11"}]},{"database":"Ensembl","id":"ENST00000931142.1","properties":[{"key":"ProteinId","value":"ENSP00000601201.1"},{"key":"GeneId","value":"ENSG00000070770.11"}]},{"database":"GeneID","id":"1459","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1459","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000262506.8","properties":[{"key":"ProteinId","value":"ENSP00000262506.3"},{"key":"RefSeqNucleotideId","value":"NM_001896.4"},{"key":"RefSeqProteinId","value":"NP_001887.1"}]},{"database":"UCSC","id":"uc002enc.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:2459","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA26959","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1459","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1459","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CSNK2A2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:2459","properties":[{"key":"GeneName","value":"CSNK2A2"}]},{"database":"HPA","id":"ENSG00000070770","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (testis)"}]},{"database":"MIM","id":"115442","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000070770","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000070770","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0668","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000004215","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ACEKRPQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10254671at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P19784","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.7.11.1","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1483191","properties":[{"key":"PathwayName","value":"Synthesis of PC"}]},{"database":"Reactome","id":"R-HSA-201688","properties":[{"key":"PathwayName","value":"WNT mediated activation of DVL"}]},{"database":"Reactome","id":"R-HSA-2514853","properties":[{"key":"PathwayName","value":"Condensation of Prometaphase Chromosomes"}]},{"database":"Reactome","id":"R-HSA-445144","properties":[{"key":"PathwayName","value":"Signal transduction by L1"}]},{"database":"Reactome","id":"R-HSA-6804756","properties":[{"key":"PathwayName","value":"Regulation of TP53 Activity through Phosphorylation"}]},{"database":"Reactome","id":"R-HSA-6814122","properties":[{"key":"PathwayName","value":"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"}]},{"database":"Reactome","id":"R-HSA-8934903","properties":[{"key":"PathwayName","value":"Receptor Mediated Mitophagy"}]},{"database":"Reactome","id":"R-HSA-8939243","properties":[{"key":"PathwayName","value":"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"}]},{"database":"Reactome","id":"R-HSA-8948751","properties":[{"key":"PathwayName","value":"Regulation of PTEN stability and activity"}]},{"database":"Reactome","id":"R-HSA-9755511","properties":[{"key":"PathwayName","value":"KEAP1-NFE2L2 pathway"}]},{"database":"Reactome","id":"R-HSA-9768727","properties":[{"key":"PathwayName","value":"Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"}]},{"database":"Reactome","id":"R-HSA-9828806","properties":[{"key":"PathwayName","value":"Maturation of hRSV A proteins"}]},{"database":"Reactome","id":"R-HSA-9929491","properties":[{"key":"PathwayName","value":"SPOP-mediated proteasomal degradation of PD-L1(CD274)"}]},{"database":"Reactome","id":"R-HSA-9931530","properties":[{"key":"PathwayName","value":"Phosphorylation and nuclear translocation of the CRY:PER:kinase complex"}]},{"database":"SignaLink","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000070770","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1459","properties":[{"key":"hits","value":"21 hits in 1210 CRISPR screens"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"CSNK2A2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P19784","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CSNK2A2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1459","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P19784","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P19784","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"P19784","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000070770","properties":[{"key":"ExpressionPatterns","value":"Expressed in secondary oocyte and 204 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P19784","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0001669","properties":[{"key":"GoTerm","value":"C:acrosomal vesicle"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22325352"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21282530"}]},{"database":"GO","id":"GO:0035102","properties":[{"key":"GoTerm","value":"C:PRC1 complex"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22325352"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0106310","properties":[{"key":"GoTerm","value":"F:protein serine kinase activity"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11239457"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20545769"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21482717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30898438"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20545769"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21482717"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22325354"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30898438"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35597237"}]},{"database":"GO","id":"GO:0021987","properties":[{"key":"GoTerm","value":"P:cerebral cortex development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006302","properties":[{"key":"GoTerm","value":"P:double-strand break repair"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22325354"}]},{"database":"GO","id":"GO:0031507","properties":[{"key":"GoTerm","value":"P:heterochromatin formation"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22325352"}]},{"database":"GO","id":"GO:0097421","properties":[{"key":"GoTerm","value":"P:liver regeneration"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:2001234","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"28031292"}]},{"database":"GO","id":"GO:0032435","properties":[{"key":"GoTerm","value":"P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"28031292"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22325352"}]},{"database":"GO","id":"GO:1903749","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to mitochondrion"},{"key":"GoEvidenceType","value":"HMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0007001","source":"PubMed","id":"24912190"}]},{"database":"GO","id":"GO:1905818","properties":[{"key":"GoTerm","value":"P:regulation of chromosome separation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11704824"}]},{"database":"GO","id":"GO:1901524","properties":[{"key":"GoTerm","value":"P:regulation of mitophagy"},{"key":"GoEvidenceType","value":"HMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0007001","source":"PubMed","id":"24912190"}]},{"database":"GO","id":"GO:0007283","properties":[{"key":"GoTerm","value":"P:spermatogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd14132","properties":[{"key":"EntryName","value":"STKc_CK2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000059","properties":[{"key":"EntryName","value":"Casein kinase II subunit alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000088","properties":[{"key":"EntryName","value":"Casein kinase II subunit alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045216","properties":[{"key":"EntryName","value":"CK2_alpha"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"PANTHER","id":"PTHR24054","properties":[{"key":"EntryName","value":"CASEIN KINASE II SUBUNIT ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24054:SF34","properties":[{"key":"EntryName","value":"CASEIN KINASE II SUBUNIT ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR","length":350,"molWeight":41213,"crc64":"3ECB92F6BD3DD7F1","md5":"E1B98E9E9860AF72C52228381C77726C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"ACTIVITY REGULATION":1,"SUBUNIT":1,"INTERACTION":7,"SUBCELLULAR LOCATION":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Active site":1,"Binding site":2,"Modified residue":5,"Natural variant":1,"Helix":25,"Beta strand":10,"Turn":7},"uniParcId":"UPI0000000C95"}}