{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P18146","uniProtkbId":"EGR1_HUMAN","entryAudit":{"firstPublicDate":"1990-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1990-11-01","entryVersion":224,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2377485"}],"value":"Early growth response protein 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2377485"}],"value":"EGR-1"}]},"alternativeNames":[{"fullName":{"value":"AT225"}},{"fullName":{"value":"Nerve growth factor-induced protein A"},"shortNames":[{"value":"NGFI-A"}]},{"fullName":{"value":"Transcription factor ETR103"}},{"fullName":{"value":"Transcription factor Zif268"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2110381"}],"value":"Zinc finger protein 225"}},{"fullName":{"value":"Zinc finger protein Krox-24"}}]},"genes":[{"geneName":{"value":"EGR1"},"synonyms":[{"value":"KROX24"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2110381"}],"value":"ZNF225"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P08046"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20121949"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25258363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25999311"}],"value":"Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20121949"}],"value":"Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P18146","intActId":"EBI-2834611"},"interactantTwo":{"uniProtKBAccession":"Q8N726","geneName":"CDKN2A","intActId":"EBI-625922"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P18146","intActId":"EBI-2834611"},"interactantTwo":{"uniProtKBAccession":"P35222","geneName":"CTNNB1","intActId":"EBI-491549"},"numberOfExperiments":7,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20363028"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20363028"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20363028"}],"value":"Detected in neutrophils (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20363028"}],"value":"By growth factors"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25258363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25999311"}],"value":"Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers (PubMed:25258363, PubMed:25999311). The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (PubMed:25258363)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the EGR C2H2-type zinc-finger protein family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/496/EGR1","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":543,"modifier":"EXACT"}},"description":"Early growth response protein 1","featureId":"PRO_0000047109"},{"type":"Zinc finger","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"C2H2-type 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00042"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25258363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25999311"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2D"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4X9J"}]},{"type":"Zinc finger","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"C2H2-type 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00042"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25258363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25999311"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2D"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4X9J"}]},{"type":"Zinc finger","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"C2H2-type 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00042"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25258363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25999311"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2D"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4X9J"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":487,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":486,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25258363"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2A"}]},{"type":"Site","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P08046"}]},{"type":"Site","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P08046"}]},{"type":"Site","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25258363"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2A"}]},{"type":"Site","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P08046"}]},{"type":"Site","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25258363"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2A"}]},{"type":"Site","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25999311"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4X9J"}]},{"type":"Site","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25258363"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2A"}]},{"type":"Site","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25258363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25999311"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4X9J"}]},{"type":"Cross-link","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Natural variant","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"in dbSNP:rs13181973","featureCrossReferences":[{"database":"dbSNP","id":"rs13181973"}],"featureId":"VAR_052712","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"in dbSNP:rs28365166","featureCrossReferences":[{"database":"dbSNP","id":"rs28365166"}],"featureId":"VAR_029330","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"in dbSNP:rs28365164","featureCrossReferences":[{"database":"dbSNP","id":"rs28365164"}],"featureId":"VAR_029331","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"in dbSNP:rs28365165","featureCrossReferences":[{"database":"dbSNP","id":"rs28365165"}],"featureId":"VAR_029332","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Beta strand","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4X9J"}]},{"type":"Helix","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4X9J"}]},{"type":"Turn","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4X9J"}]},{"type":"Beta strand","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4X9J"}]},{"type":"Helix","location":{"start":{"value":380,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4X9J"}]},{"type":"Turn","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4X9J"}]},{"type":"Beta strand","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4X9J"}]},{"type":"Helix","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4X9J"}]},{"type":"Helix","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4X9J"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"2377485","citationType":"journal article","authors":["Suggs S.V.","Katzowitz J.L.","Tsai-Morris C.-H.","Sukhatme V.P."],"citationCrossReferences":[{"database":"PubMed","id":"2377485"},{"database":"DOI","id":"10.1093/nar/18.14.4283"}],"title":"cDNA sequence of the human cellular early growth response gene Egr-1.","publicationDate":"1990","journal":"Nucleic Acids Res.","firstPage":"4283","lastPage":"4283","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Foreskin","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"1569051","citationType":"journal article","authors":["Shimizu N.","Ohta M.","Fujiwara C.","Sagara J.","Mochizuki N.","Oda T.","Utiyama H."],"citationCrossReferences":[{"database":"PubMed","id":"1569051"},{"database":"DOI","id":"10.1093/oxfordjournals.jbchem.a123748"}],"title":"A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation.","publicationDate":"1992","journal":"J. Biochem.","firstPage":"272","lastPage":"277","volume":"111"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"2110381","citationType":"journal article","authors":["Wright J.J.","Gunter K.C.","Mitsuya H.","Irving S.G.","Kelly K.","Siebenlist U."],"citationCrossReferences":[{"database":"PubMed","id":"2110381"},{"database":"DOI","id":"10.1126/science.2110381"}],"title":"Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells.","publicationDate":"1990","journal":"Science","firstPage":"588","lastPage":"591","volume":"248"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"PNS","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"20121949","citationType":"journal article","authors":["Hu C.T.","Chang T.Y.","Cheng C.C.","Liu C.S.","Wu J.R.","Li M.C.","Wu W.S."],"citationCrossReferences":[{"database":"PubMed","id":"20121949"},{"database":"DOI","id":"10.1111/j.1742-4658.2009.07553.x"}],"title":"Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b.","publicationDate":"2010","journal":"FEBS J.","firstPage":"1202","lastPage":"1218","volume":"277"},"referencePositions":["INTERACTION WITH SNAI1 AND SP1","FUNCTION"]},{"referenceNumber":7,"citation":{"id":"20363028","citationType":"journal article","authors":["Cullen E.M.","Brazil J.C.","O'Connor C.M."],"citationCrossReferences":[{"database":"PubMed","id":"20363028"},{"database":"DOI","id":"10.1016/j.molimm.2010.03.003"}],"title":"Mature human neutrophils constitutively express the transcription factor EGR-1.","publicationDate":"2010","journal":"Mol. Immunol.","firstPage":"1701","lastPage":"1709","volume":"47"},"referencePositions":["SUBCELLULAR LOCATION","INDUCTION BY GROWTH FACTORS"]},{"referenceNumber":8,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-305","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"25258363","citationType":"journal article","authors":["Hashimoto H.","Olanrewaju Y.O.","Zheng Y.","Wilson G.G.","Zhang X.","Cheng X."],"citationCrossReferences":[{"database":"PubMed","id":"25258363"},{"database":"DOI","id":"10.1101/gad.250746.114"}],"title":"Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.","publicationDate":"2014","journal":"Genes Dev.","firstPage":"2304","lastPage":"2313","volume":"28"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS) OF 335-423 IN COMPLEX WITH ZINC AND TARGET DNA","FUNCTION","DOMAIN","SITES OF INTERACTION WITH DNA"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4R2D"}]},{"referenceNumber":10,"citation":{"id":"25999311","citationType":"journal article","authors":["Zandarashvili L.","White M.A.","Esadze A.","Iwahara J."],"citationCrossReferences":[{"database":"PubMed","id":"25999311"},{"database":"DOI","id":"10.1016/j.febslet.2015.05.022"}],"title":"Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1.","publicationDate":"2015","journal":"FEBS Lett.","firstPage":"1748","lastPage":"1753","volume":"589"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS) OF 335-423 IN COMPLEX WITH ZINC AND TARGET DNA","FUNCTION","DOMAIN","SITES OF INTERACTION WITH DNA"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4X9J"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X52541","properties":[{"key":"ProteinId","value":"CAA36777.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M62829","properties":[{"key":"ProteinId","value":"AAA35815.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M80583","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC073983","properties":[{"key":"ProteinId","value":"AAH73983.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS4206.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A41211","properties":[{"key":"EntryName","value":"A41211"}]},{"database":"RefSeq","id":"NP_001955.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001964.3"}]},{"database":"PDB","id":"4R2A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A=335-423"}]},{"database":"PDB","id":"4R2C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.89 A"},{"key":"Chains","value":"A=335-423"}]},{"database":"PDB","id":"4R2D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"A=335-423"}]},{"database":"PDB","id":"4X9J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.41 A"},{"key":"Chains","value":"A=335-423"}]},{"database":"PDB","id":"5N14","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=395-408"}]},{"database":"PDBsum","id":"4R2A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4R2C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4R2D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4X9J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5N14","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-65839","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"108278","properties":[{"key":"Interactions","value":"56"}]},{"database":"CORUM","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P18146","properties":[{"key":"Number of interactors","value":"4794"}]},{"database":"IntAct","id":"P18146","properties":[{"key":"Interactions","value":"30"}]},{"database":"MINT","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-EGR1","properties":[{"key":"Evidences","value":"26 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000239938","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3616355","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P18146","properties":[{"key":"glycosylation","value":"1 O-GlcNAc glycan (1 site)"}]},{"database":"GlyCosmos","id":"P18146","properties":[{"key":"glycosylation","value":"5 sites, 2 glycans"}]},{"database":"GlyGen","id":"P18146","properties":[{"key":"glycosylation","value":"12 sites, 2 O-linked glycans (12 sites)"}]},{"database":"iPTMnet","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"EGR1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"119242","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000239938","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"53552","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"14988","properties":[{"key":"antibodies","value":"560 antibodies from 44 providers"}]},{"database":"DNASU","id":"1958","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000239938.5","properties":[{"key":"ProteinId","value":"ENSP00000239938.4"},{"key":"GeneId","value":"ENSG00000120738.8"}]},{"database":"GeneID","id":"1958","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1958","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000239938.5","properties":[{"key":"ProteinId","value":"ENSP00000239938.4"},{"key":"RefSeqNucleotideId","value":"NM_001964.3"},{"key":"RefSeqProteinId","value":"NP_001955.1"}]},{"database":"AGR","id":"HGNC:3238","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA27673","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1958","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1958","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"EGR1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3238","properties":[{"key":"GeneName","value":"EGR1"}]},{"database":"HPA","id":"ENSG00000120738","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"EGR1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"128990","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000120738","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000120738","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1721","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000160184","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_043235_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NFQVPMI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10018191at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P18146","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-8943724","properties":[{"key":"PathwayName","value":"Regulation of PTEN gene transcription"}]},{"database":"Reactome","id":"R-HSA-9031628","properties":[{"key":"PathwayName","value":"NGF-stimulated transcription"}]},{"database":"Reactome","id":"R-HSA-909733","properties":[{"key":"PathwayName","value":"Interferon alpha/beta signaling"}]},{"database":"SignaLink","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000120738","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1958","properties":[{"key":"hits","value":"24 hits in 1177 CRISPR screens"}]},{"database":"ChiTaRS","id":"EGR1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P18146","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"EGR1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1958","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P18146","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P18146","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"P18146","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000120738","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of stomach and 210 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P18146","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19307576"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20363028"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20363028"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12560508"}]},{"database":"GO","id":"GO:0001228","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription activator activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19307576"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20018936"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12560508"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0010385","properties":[{"key":"GoTerm","value":"F:double-stranded methylated DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25258363"}]},{"database":"GO","id":"GO:0044729","properties":[{"key":"GoTerm","value":"F:hemi-methylated DNA-binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25258363"}]},{"database":"GO","id":"GO:0035035","properties":[{"key":"GoTerm","value":"F:histone acetyltransferase binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"20018936"}]},{"database":"GO","id":"GO:1990841","properties":[{"key":"GoTerm","value":"F:promoter-specific chromatin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20363028"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19307576"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20018936"}]},{"database":"GO","id":"GO:0000977","properties":[{"key":"GoTerm","value":"F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14979875"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1662794"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25258363"}]},{"database":"GO","id":"GO:1990837","properties":[{"key":"GoTerm","value":"F:sequence-specific double-stranded DNA binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28473536"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18718911"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25258363"}]},{"database":"GO","id":"GO:0071480","properties":[{"key":"GoTerm","value":"P:cellular response to gamma radiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071504","properties":[{"key":"GoTerm","value":"P:cellular response to heparin"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098759","properties":[{"key":"GoTerm","value":"P:cellular response to interleukin-8"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20363028"}]},{"database":"GO","id":"GO:0071506","properties":[{"key":"GoTerm","value":"P:cellular response to mycophenolic acid"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032922","properties":[{"key":"GoTerm","value":"P:circadian regulation of gene expression"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060086","properties":[{"key":"GoTerm","value":"P:circadian temperature homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0044849","properties":[{"key":"GoTerm","value":"P:estrous cycle"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0072110","properties":[{"key":"GoTerm","value":"P:glomerular mesangial cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070498","properties":[{"key":"GoTerm","value":"P:interleukin-1-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20018936"}]},{"database":"GO","id":"GO:0045475","properties":[{"key":"GoTerm","value":"P:locomotor rhythm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007616","properties":[{"key":"GoTerm","value":"P:long-term memory"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0090090","properties":[{"key":"GoTerm","value":"P:negative regulation of canonical Wnt signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032722","properties":[{"key":"GoTerm","value":"P:positive regulation of chemokine production"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12560508"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24244514"}]},{"database":"GO","id":"GO:0044029","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression via chromosomal CpG island demethylation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"31467272"}]},{"database":"GO","id":"GO:0072303","properties":[{"key":"GoTerm","value":"P:positive regulation of glomerular metanephric mesangial cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046886","properties":[{"key":"GoTerm","value":"P:positive regulation of hormone biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032731","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-1 beta production"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1902895","properties":[{"key":"GoTerm","value":"P:positive regulation of miRNA transcription"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19307576"}]},{"database":"GO","id":"GO:1901875","properties":[{"key":"GoTerm","value":"P:positive regulation of post-translational protein modification"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20018936"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26089202"}]},{"database":"GO","id":"GO:0043523","properties":[{"key":"GoTerm","value":"P:regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:2000182","properties":[{"key":"GoTerm","value":"P:regulation of progesterone biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033233","properties":[{"key":"GoTerm","value":"P:regulation of protein sumoylation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19057511"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0009749","properties":[{"key":"GoTerm","value":"P:response to glucose"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001666","properties":[{"key":"GoTerm","value":"P:response to hypoxia"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032868","properties":[{"key":"GoTerm","value":"P:response to insulin"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0002931","properties":[{"key":"GoTerm","value":"P:response to ischemia"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"FunFam","id":"3.30.160.60:FF:000769","properties":[{"key":"EntryName","value":"Early growth response 2b"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.60:FF:000324","properties":[{"key":"EntryName","value":"Early growth response protein 4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.60:FF:000419","properties":[{"key":"EntryName","value":"Early growth response protein 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR021839","properties":[{"key":"EntryName","value":"EGR1_C"}]},{"database":"InterPro","id":"IPR021849","properties":[{"key":"EntryName","value":"EGR_N"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"InterPro","id":"IPR013087","properties":[{"key":"EntryName","value":"Znf_C2H2_type"}]},{"database":"PANTHER","id":"PTHR24399:SF23","properties":[{"key":"EntryName","value":"C2H2-TYPE DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24399","properties":[{"key":"EntryName","value":"ZINC FINGER AND BTB DOMAIN-CONTAINING"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11914","properties":[{"key":"EntryName","value":"DUF3432"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11928","properties":[{"key":"EntryName","value":"DUF3446"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00096","properties":[{"key":"EntryName","value":"zf-C2H2"},{"key":"MatchStatus","value":"3"}]},{"database":"SMART","id":"SM00355","properties":[{"key":"EntryName","value":"ZnF_C2H2"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00028","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50157","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_2"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGSNSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAASSASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSSTYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPSSAVTNSFSASTGLSDMTATFSPRTIEIC","length":543,"molWeight":57507,"crc64":"768CE670D9743E4E","md5":"5355861F2C544A47F2B03AD931D066F9"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Zinc finger":3,"Region":5,"Compositional bias":5,"Site":9,"Cross-link":1,"Natural variant":4,"Beta strand":3,"Helix":4,"Turn":2},"uniParcId":"UPI00000008CD"}}