{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P16284","secondaryAccessions":["A0A075B738","A8K3S7","D3DU31","Q6LDA9","Q8TBH1","Q96RF5","Q96RF6","Q9NP65","Q9NPB7","Q9NPG9","Q9NQS9","Q9NQT0","Q9NQT1","Q9NQT2"],"uniProtkbId":"PECA1_HUMAN","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-03-28","entryVersion":252,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Platelet endothelial cell adhesion molecule"},"shortNames":[{"value":"PECAM-1"}]},"alternativeNames":[{"fullName":{"value":"EndoCAM"}},{"fullName":{"value":"GPIIA'"}},{"fullName":{"value":"PECA1"}}],"cdAntigenNames":[{"value":"CD31"}],"flag":"Precursor"},"genes":[{"geneName":{"value":"PECAM1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q08481"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12110892"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17580308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18672896"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19342684"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27958302"}],"value":"Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18388311"}],"value":"Does not protect against apoptosis"}],"commentType":"FUNCTION","molecule":"Isoform Delta15"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P51866"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17580308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18388311"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18672896"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19342684"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702061"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27958302"}],"value":"Trans-homodimer (via Ig-like C2-type 1 and Ig-like C2-type 2 domains); trans-homodimerization is required for cell-cell interaction (PubMed:26702061, PubMed:27958302). Forms a complex with BDKRB2 and GNAQ (PubMed:18672896). Interacts with BDKRB2 and GNAQ (PubMed:18672896). Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment (PubMed:18388311, PubMed:19342684). Interacts with FER (By similarity). Interacts (via Ig-like C2-type domain 6) with CD177; the interaction is Ca(2+)-dependent; the interaction is direct (PubMed:17580308)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q6DHV7-2","geneName":"ADAL","intActId":"EBI-18899653"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q8N302-2","geneName":"AGGF1","intActId":"EBI-25838028"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P54819","geneName":"AK2","intActId":"EBI-1056291"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P61966-2","geneName":"AP1S1","intActId":"EBI-12067760"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q6XD76","geneName":"ASCL4","intActId":"EBI-10254793"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9UMX3","geneName":"BOK","intActId":"EBI-7105206"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q96G97-4","geneName":"BSCL2","intActId":"EBI-10178113"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q8TAB5","geneName":"C1orf216","intActId":"EBI-747505"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9UQM7","geneName":"CAMK2A","intActId":"EBI-1383687"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q96HB5","geneName":"CCDC120","intActId":"EBI-744556"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9Y3D0","geneName":"CIAO2B","intActId":"EBI-744045"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"O75175","geneName":"CNOT3","intActId":"EBI-743073"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9NX09","geneName":"DDIT4","intActId":"EBI-715104"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P49184","geneName":"DNASE1L1","intActId":"EBI-20894690"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"O77932","geneName":"DXO","intActId":"EBI-372173"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q99944","geneName":"EGFL8","intActId":"EBI-3924130"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q6NXG1","geneName":"ESRP1","intActId":"EBI-10213520"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q99504","geneName":"EYA3","intActId":"EBI-9089567"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q96GL9","geneName":"FAM163A","intActId":"EBI-11793142"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"O15287","geneName":"FANCG","intActId":"EBI-81610"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P14136","geneName":"GFAP","intActId":"EBI-744302"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q4G1C9-2","geneName":"GLIPR1L2","intActId":"EBI-20835942"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q96LI6","geneName":"HSFY2","intActId":"EBI-3957665"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"O75874","geneName":"IDH1","intActId":"EBI-715695"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q0VD86","geneName":"INCA1","intActId":"EBI-6509505"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P14923","geneName":"JUP","intActId":"EBI-702484"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q6ZU52","geneName":"KIAA0408","intActId":"EBI-739493"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q96E93","geneName":"KLRG1","intActId":"EBI-750770"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q6IAA8","geneName":"LAMTOR1","intActId":"EBI-715385"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q14847-2","geneName":"LASP1","intActId":"EBI-9088686"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P09382","geneName":"LGALS1","intActId":"EBI-1048875"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q6ZQX7-4","geneName":"LIAT1","intActId":"EBI-25830459"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9NS73-5","geneName":"MBIP","intActId":"EBI-10182361"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q14728","geneName":"MFSD10","intActId":"EBI-11337904"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q13405","geneName":"MRPL49","intActId":"EBI-5325200"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"I6L9F6","geneName":"NEFL","intActId":"EBI-10178578"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9GZQ6","geneName":"NPFFR1","intActId":"EBI-18212103"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9HB63","geneName":"NTN4","intActId":"EBI-743459"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9P286","geneName":"PAK5","intActId":"EBI-741896"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q16549","geneName":"PCSK7","intActId":"EBI-8059854"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q8TBJ4","geneName":"PLPPR1","intActId":"EBI-18063495"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q96PV4","geneName":"PNMA5","intActId":"EBI-10171633"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q8NBT0","geneName":"POC1A","intActId":"EBI-2557132"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q8WUY3","geneName":"PRUNE2","intActId":"EBI-743880"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q06124","geneName":"PTPN11","intActId":"EBI-297779"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P29350","geneName":"PTPN6","intActId":"EBI-78260"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q96I25","geneName":"RBM17","intActId":"EBI-740272"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9UJD0","geneName":"RIMS3","intActId":"EBI-3909436"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P61513","geneName":"RPL37A","intActId":"EBI-356793"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q8NC51","geneName":"SERBP1","intActId":"EBI-523558"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P12757","geneName":"SKIL","intActId":"EBI-2902468"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q8NCS7","geneName":"SLC44A5","intActId":"EBI-21504521"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q12824","geneName":"SMARCB1","intActId":"EBI-358419"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q7Z614-3","geneName":"SNX20","intActId":"EBI-12336127"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q8IUW3","geneName":"SPATA2L","intActId":"EBI-2510414"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q08AE8","geneName":"SPIRE1","intActId":"EBI-1055655"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q96BD6","geneName":"SPSB1","intActId":"EBI-2659201"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q99619","geneName":"SPSB2","intActId":"EBI-2323209"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P12931","geneName":"SRC","intActId":"EBI-621482"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P46977","geneName":"STT3A","intActId":"EBI-719212"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9H7C4","geneName":"SYNC","intActId":"EBI-11285923"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"O60506-4","geneName":"SYNCRIP","intActId":"EBI-11123832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"O15273","geneName":"TCAP","intActId":"EBI-954089"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P15923-3","geneName":"TCF3","intActId":"EBI-12000326"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q13428-5","geneName":"TCOF1","intActId":"EBI-25832010"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q5T1C6","geneName":"THEM4","intActId":"EBI-7684443"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q7Z403","geneName":"TMC6","intActId":"EBI-9088037"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q96JJ7-2","geneName":"TMX3","intActId":"EBI-25833898"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q12888","geneName":"TP53BP1","intActId":"EBI-396540"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q5VYS8-5","geneName":"TUT7","intActId":"EBI-9088812"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q08AM6","geneName":"VAC14","intActId":"EBI-2107455"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9H270","geneName":"VPS11","intActId":"EBI-373380"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q5JSH3","geneName":"WDR44","intActId":"EBI-3441235"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P19544-6","geneName":"WT1","intActId":"EBI-11745701"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q6ZSB9","geneName":"ZBTB49","intActId":"EBI-2859943"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P26651","geneName":"ZFP36","intActId":"EBI-374248"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"P17024","geneName":"ZNF20","intActId":"EBI-717634"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P16284","intActId":"EBI-716404"},"interactantTwo":{"uniProtKBAccession":"Q9BQ29","intActId":"EBI-22013570"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17580308"}],"value":"Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17580308"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform Long","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19342684"}],"value":"Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18388311"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19342684"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18388311"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17139370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22496122"}],"value":"Membrane raft","id":"SL-0370"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18388311"}],"value":"Cell junction","id":"SL-0038"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform Delta15","note":{"texts":[{"value":"Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18388311"}],"value":"Cell junction","id":"SL-0038"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"Long"},"isoformIds":["P16284-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"Delta12"},"isoformIds":["P16284-2"],"sequenceIds":["VSP_011806"],"isoformSequenceStatus":"Described"},{"name":{"value":"Delta13"},"isoformIds":["P16284-3"],"sequenceIds":["VSP_011807"],"isoformSequenceStatus":"Described"},{"name":{"value":"Delta14"},"isoformIds":["P16284-4"],"sequenceIds":["VSP_011809"],"isoformSequenceStatus":"Described"},{"name":{"value":"Delta14-15"},"isoformIds":["P16284-5"],"sequenceIds":["VSP_011808","VSP_011811"],"isoformSequenceStatus":"Described"},{"name":{"value":"Delta15"},"isoformIds":["P16284-6"],"sequenceIds":["VSP_011810","VSP_011811"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12433657"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17580308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18388311"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19342684"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21464369"}],"value":"Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:17580308, PubMed:19342684). Expressed on neutrophils (at protein level) (PubMed:17580308). Isoform Long predominates in all tissues examined (PubMed:12433657). Isoform Delta12 is detected only in trachea (PubMed:12433657). Isoform Delta14-15 is only detected in lung (PubMed:12433657). Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657). Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q08481"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18710921"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19342684"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21464369"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9298995"}],"value":"Phosphorylated on Ser and Tyr residues after cellular activation by src kinases (PubMed:18710921, PubMed:19342684, PubMed:21464369, PubMed:9298995). Upon activation, phosphorylated on Ser-729 which probably initiates the dissociation of the membrane-interaction segment (residues 709-729) from the cell membrane allowing the sequential phosphorylation of Tyr-713 and Tyr-690 (PubMed:21464369). Constitutively phosphorylated on Ser-734 in resting platelets (PubMed:21464369). Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation (PubMed:18710921)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17139370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22496122"}],"value":"Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts"}],"commentType":"PTM"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/CD31","ftp":false,"note":"CD31 entry"},{"commentType":"WEB RESOURCE","resourceName":"Functional Glycomics Gateway - Glycan Binding","resourceUrl":"http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_265","ftp":false,"note":"PECAM-1"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":738,"modifier":"EXACT"}},"description":"Platelet endothelial cell adhesion molecule","featureId":"PRO_0000014895"},{"type":"Topological domain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":620,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":621,"modifier":"EXACT"},"end":{"value":738,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Ig-like C2-type 1"},{"type":"Domain","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Ig-like C2-type 2"},{"type":"Domain","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Ig-like C2-type 3"},{"type":"Domain","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"Ig-like C2-type 4"},{"type":"Domain","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":493,"modifier":"EXACT"}},"description":"Ig-like C2-type 5"},{"type":"Domain","location":{"start":{"value":499,"modifier":"EXACT"},"end":{"value":591,"modifier":"EXACT"}},"description":"Ig-like C2-type 6"},{"type":"Region","location":{"start":{"value":658,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":709,"modifier":"EXACT"},"end":{"value":729,"modifier":"EXACT"}},"description":"Membrane-bound segment which detaches upon phosphorylation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21464369"}]},{"type":"Region","location":{"start":{"value":721,"modifier":"EXACT"},"end":{"value":738,"modifier":"EXACT"}},"description":"May play a role in cytoprotective signaling"},{"type":"Motif","location":{"start":{"value":688,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"ITIM motif 1","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27958302"}]},{"type":"Motif","location":{"start":{"value":711,"modifier":"EXACT"},"end":{"value":716,"modifier":"EXACT"}},"description":"ITIM motif 2","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27958302"}]},{"type":"Compositional bias","location":{"start":{"value":686,"modifier":"EXACT"},"end":{"value":698,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":699,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":690,"modifier":"EXACT"},"end":{"value":690,"modifier":"EXACT"}},"description":"Phosphotyrosine; by FER","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19342684"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21464369"}]},{"type":"Modified residue","location":{"start":{"value":713,"modifier":"EXACT"},"end":{"value":713,"modifier":"EXACT"}},"description":"Phosphotyrosine; by FER","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19342684"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21464369"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9298995"}]},{"type":"Modified residue","location":{"start":{"value":729,"modifier":"EXACT"},"end":{"value":729,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21464369"}]},{"type":"Modified residue","location":{"start":{"value":734,"modifier":"EXACT"},"end":{"value":734,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21464369"}]},{"type":"Lipidation","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17139370"}]},{"type":"Glycosylation","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702061"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5C14"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19349973"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702061"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5C14"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702061"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5C14"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19349973"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":551,"modifier":"EXACT"},"end":{"value":551,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19349973"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702061"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27958302"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5C14"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5GNI"}]},{"type":"Disulfide bond","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702061"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27958302"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5C14"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5GNI"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"}]},{"type":"Disulfide bond","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"}]},{"type":"Disulfide bond","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":476,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"}]},{"type":"Disulfide bond","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"}]},{"type":"Alternative sequence","location":{"start":{"value":664,"modifier":"EXACT"},"end":{"value":681,"modifier":"EXACT"}},"description":"in isoform Delta12","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_011806","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":682,"modifier":"EXACT"},"end":{"value":702,"modifier":"EXACT"}},"description":"in isoform Delta13","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_011807","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":703,"modifier":"EXACT"},"end":{"value":729,"modifier":"EXACT"}},"description":"in isoform Delta14-15","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_011808","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":703,"modifier":"EXACT"},"end":{"value":721,"modifier":"EXACT"}},"description":"in isoform Delta14","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_011809","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":722,"modifier":"EXACT"},"end":{"value":729,"modifier":"EXACT"}},"description":"in isoform Delta15","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_011810","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":730,"modifier":"EXACT"},"end":{"value":738,"modifier":"EXACT"}},"description":"in isoform Delta14-15 and isoform Delta15","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_011811","alternativeSequence":{"originalSequence":"RTEGSLDGT","alternativeSequences":["ENGRLP"]}},{"type":"Natural variant","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"in dbSNP:rs281865545","featureCrossReferences":[{"database":"dbSNP","id":"rs281865545"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11791967"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1690453"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17212705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8532023"}],"featureId":"VAR_013145","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"in dbSNP:rs7209607","featureCrossReferences":[{"database":"dbSNP","id":"rs7209607"}],"featureId":"VAR_059402","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":563,"modifier":"EXACT"}},"description":"in dbSNP:rs12953","featureCrossReferences":[{"database":"dbSNP","id":"rs12953"}],"featureId":"VAR_059403","alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":563,"modifier":"EXACT"}},"description":"in dbSNP:rs12953","featureCrossReferences":[{"database":"dbSNP","id":"rs12953"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1700999"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17212705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7994021"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.9"}],"featureId":"VAR_059404","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":670,"modifier":"EXACT"},"end":{"value":670,"modifier":"EXACT"}},"description":"in dbSNP:rs1131012","featureCrossReferences":[{"database":"dbSNP","id":"rs1131012"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1700999"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17212705"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.9"}],"featureId":"VAR_059405","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Probable loss of N-glycosylation. No effect on homophilic cell adhesion; when associated with Q-84 and Q-151.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27958302"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"Reduced homophilic cell adhesion; when associated with E-112; E-188 and E-190.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27958302"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Probable loss of N-glycosylation. No effect on homophilic cell adhesion; when associated with Q-52 and Q-151.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27958302"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Lacks homophilic binding ability and is distributed over the entire plasma membrane.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19342684"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Reduced homophilic cell adhesion; when associated with E-74; E-188 and E-190.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27958302"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"Probable loss of N-glycosylation. No effect on homophilic cell adhesion; when associated with Q-52 and Q-84.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27958302"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Reduced homophilic cell adhesion; when associated with E-74; E-112 and E-190.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27958302"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"Reduced homophilic cell adhesion; when associated with E-74; E-112 and E-188.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27958302"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"6-fold decrease in association with membrane microdomains.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17139370"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":690,"modifier":"EXACT"},"end":{"value":690,"modifier":"EXACT"}},"description":"No effect on Tyr-713 phosphorylation. Inhibits targeted recycling of PECAM1 from the lateral border recycling compartment (LBRC) around transmigrating monocytes. Decreases phosphorylation. No effect on interaction with PTPN11. Loss of phosphorylation and loss of binding to PTPN11; when associated with F-713.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18388311"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19342684"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21464369"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":713,"modifier":"EXACT"},"end":{"value":713,"modifier":"EXACT"}},"description":"Loss of Tyr-690 phosphorylation. Does not inhibit targeted recycling of PECAM1 from the lateral border recycling compartment (LBRC) around transmigrating monocytes. Decreases phosphorylation. Loss of interaction with PTPN11. Loss of phosphorylation and loss of binding to PTPN11; when associated with F-690.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18388311"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19342684"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21464369"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"in Ref. 7; BAF83381","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"in Ref. 1","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"GATMW","alternativeSequences":["ADV"]}},{"type":"Sequence conflict","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"in Ref. 11; AAK84009","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Sequence conflict","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"in Ref. 11; AAK84011","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"in Ref. 11; AAF91460","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":430,"modifier":"EXACT"}},"description":"in Ref. 11; AAF91451","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Beta strand","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Helix","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Helix","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Helix","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5GNI"}]},{"type":"Beta strand","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Helix","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5GNI"}]},{"type":"Beta strand","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Turn","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5GNI"}]},{"type":"Beta strand","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5C14"}]},{"type":"Beta strand","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5GNI"}]},{"type":"Helix","location":{"start":{"value":709,"modifier":"EXACT"},"end":{"value":728,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2KY5"}]},{"type":"Beta strand","location":{"start":{"value":731,"modifier":"EXACT"},"end":{"value":733,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2KY5"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"2351935","citationType":"journal article","authors":["Simmons D.L.","Walker C.","Power C.","Pigott R."],"citationCrossReferences":[{"database":"PubMed","id":"2351935"},{"database":"DOI","id":"10.1084/jem.171.6.2147"}],"title":"Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen.","publicationDate":"1990","journal":"J. Exp. Med.","firstPage":"2147","lastPage":"2152","volume":"171"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)"]},{"referenceNumber":2,"citation":{"id":"1700999","citationType":"journal article","authors":["Stockinger H.","Gadd S.J.","Eher R.","Majdic O.","Kasinrek W.","Schreiber W.","Strass B.","Schnabl E.","Knapp W."],"citationCrossReferences":[{"database":"PubMed","id":"1700999"},{"database":"DOI","id":"10.4049/jimmunol.145.11.3889"}],"title":"Molecular characterization and functional analysis of the leukocyte surface protein CD31.","publicationDate":"1990","journal":"J. Immunol.","firstPage":"3889","lastPage":"3897","volume":"145"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)","VARIANTS ASN-563 AND GLY-670"]},{"referenceNumber":3,"citation":{"id":"1690453","citationType":"journal article","authors":["Newman P.J.","Berndt M.C.","Gorski J.","White J.C. II","Lyman S.","Paddock C.","Muller W.A."],"citationCrossReferences":[{"database":"PubMed","id":"1690453"},{"database":"DOI","id":"10.1126/science.1690453"}],"title":"PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.","publicationDate":"1990","journal":"Science","firstPage":"1219","lastPage":"1222","volume":"247"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)","VARIANT LEU-125"]},{"referenceNumber":4,"citation":{"id":"1874786","citationType":"journal article","authors":["Albelda S.M.","Muller W.A.","Buck C.A.","Newman P.J."],"citationCrossReferences":[{"database":"PubMed","id":"1874786"},{"database":"DOI","id":"10.1083/jcb.114.5.1059"}],"title":"Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.","publicationDate":"1991","journal":"J. Cell Biol.","firstPage":"1059","lastPage":"1068","volume":"114"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)"]},{"referenceNumber":5,"citation":{"id":"7994021","citationType":"journal article","authors":["Kirschbaum N.E.","Gumina R.J.","Newman P.J."],"citationCrossReferences":[{"database":"PubMed","id":"7994021"},{"database":"DOI","id":"10.1182/blood.v84.12.4028.bloodjournal84124028"}],"title":"Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain.","publicationDate":"1994","journal":"Blood","firstPage":"4028","lastPage":"4037","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LONG)","VARIANT ASN-563"]},{"referenceNumber":6,"citation":{"id":"CI-89D9H15EA7740","citationType":"submission","authors":["Wang R.-Y.","Lun Y.-Z.","Jiang Z.-X.","Li X."],"title":"Gene cloning and sequence analysis of human nasopharyngeal carcinoma resistance cells CNE1/R platelet/endothelial cell adhesion molecule.","publicationDate":"DEC-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)","VARIANTS ASN-563 AND GLY-670"]},{"referenceNumber":7,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)","VARIANTS ASN-563 AND GLY-670"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.-K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]","VARIANTS ASN-563 AND GLY-670"]},{"referenceNumber":10,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)","VARIANTS ASN-563 AND GLY-670"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"17212705","citationType":"journal article","authors":["Robbins F.-M.","Hartzman R.J."],"citationCrossReferences":[{"database":"PubMed","id":"17212705"},{"database":"DOI","id":"10.1111/j.1399-0039.2006.00722.x"}],"title":"CD31/PECAM-1 genotyping and haplotype analyses show population diversity.","publicationDate":"2007","journal":"Tissue Antigens","firstPage":"28","lastPage":"37","volume":"69"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-734 (ISOFORM LONG)","VARIANTS LEU-125; ASN-563 AND GLY-670"]},{"referenceNumber":12,"citation":{"id":"8226797","citationType":"journal article","authors":["Tang D.G.","Chen Y.Q.","Newman P.J.","Shi L.","Gao X.","Diglio C.A.","Honn K.V."],"citationCrossReferences":[{"database":"PubMed","id":"8226797"},{"database":"DOI","id":"10.1016/s0021-9258(18)41609-2"}],"title":"Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium.","publicationDate":"1993","journal":"J. Biol. Chem.","firstPage":"22883","lastPage":"22894","volume":"268"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 507-584"]},{"referenceNumber":13,"citation":{"id":"9298995","citationType":"journal article","authors":["Famiglietti J.","Sun J.","DeLisser H.M.","Albelda S.M."],"citationCrossReferences":[{"database":"PubMed","id":"9298995"},{"database":"DOI","id":"10.1083/jcb.138.6.1425"}],"title":"Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificity.","publicationDate":"1997","journal":"J. Cell Biol.","firstPage":"1425","lastPage":"1435","volume":"138"},"referencePositions":["PHOSPHORYLATION AT TYR-713"]},{"referenceNumber":14,"citation":{"id":"12110892","citationType":"journal article","authors":["Brown S.","Heinisch I.","Ross E.","Shaw K.","Buckley C.D.","Savill J."],"citationCrossReferences":[{"database":"PubMed","id":"12110892"},{"database":"DOI","id":"10.1038/nature00811"}],"title":"Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment.","publicationDate":"2002","journal":"Nature","firstPage":"200","lastPage":"203","volume":"418"},"referencePositions":["FUNCTION"]},{"referenceNumber":15,"citation":{"id":"12433657","citationType":"journal article","authors":["Wang Y.","Su X.","Sorenson C.M.","Sheibani N."],"citationCrossReferences":[{"database":"PubMed","id":"12433657"},{"database":"DOI","id":"10.1152/ajpheart.00600.2002"}],"title":"Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms.","publicationDate":"2003","journal":"Am. J. Physiol.","firstPage":"H1008","lastPage":"H1017","volume":"284"},"referencePositions":["ALTERNATIVE SPLICING","TISSUE SPECIFICITY"]},{"referenceNumber":16,"citation":{"id":"17139370","citationType":"journal article","authors":["Sardjono C.T.","Harbour S.N.","Yip J.C.","Paddock C.","Tridandapani S.","Newman P.J.","Jackson D.E."],"citationCrossReferences":[{"database":"PubMed","id":"17139370"},{"database":"DOI","id":"10.1160/th06-08-0459"}],"title":"Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection.","publicationDate":"2006","journal":"Thromb. Haemost.","firstPage":"756","lastPage":"766","volume":"96"},"referencePositions":["PALMITOYLATION AT CYS-622","MUTAGENESIS OF CYS-622","SUBCELLULAR LOCATION"]},{"referenceNumber":17,"citation":{"id":"17580308","citationType":"journal article","authors":["Sachs U.J.","Andrei-Selmer C.L.","Maniar A.","Weiss T.","Paddock C.","Orlova V.V.","Choi E.Y.","Newman P.J.","Preissner K.T.","Chavakis T.","Santoso S."],"citationCrossReferences":[{"database":"PubMed","id":"17580308"},{"database":"DOI","id":"10.1074/jbc.m701120200"}],"title":"The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31).","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"23603","lastPage":"23612","volume":"282"},"referencePositions":["FUNCTION","INTERACTION WITH CD177","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":18,"citation":{"id":"18672896","citationType":"journal article","authors":["Yeh J.C.","Otte L.A.","Frangos J.A."],"citationCrossReferences":[{"database":"PubMed","id":"18672896"},{"database":"DOI","id":"10.1021/bi8003846"}],"title":"Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1.","publicationDate":"2008","journal":"Biochemistry","firstPage":"9029","lastPage":"9039","volume":"47"},"referencePositions":["FUNCTION","INTERACTION WITH BDKRB2 AND GNAQ"]},{"referenceNumber":19,"citation":{"id":"18710921","citationType":"journal article","authors":["Chiu Y.J.","McBeath E.","Fujiwara K."],"citationCrossReferences":[{"database":"PubMed","id":"18710921"},{"database":"DOI","id":"10.1083/jcb.200801062"}],"title":"Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation.","publicationDate":"2008","journal":"J. Cell Biol.","firstPage":"753","lastPage":"763","volume":"182"},"referencePositions":["PHOSPHORYLATION"]},{"referenceNumber":20,"citation":{"id":"18388311","citationType":"journal article","authors":["Bergom C.","Paddock C.","Gao C.","Holyst T.","Newman D.K.","Newman P.J."],"citationCrossReferences":[{"database":"PubMed","id":"18388311"},{"database":"DOI","id":"10.1242/jcs.025163"}],"title":"An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling.","publicationDate":"2008","journal":"J. Cell Sci.","firstPage":"1235","lastPage":"1242","volume":"121"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORMS DELTA14-15 AND DELTA15)","FUNCTION (ISOFORM DELTA15)","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","MUTAGENESIS OF TYR-690 AND TYR-713","INTERACTION WITH PTPN11"]},{"referenceNumber":21,"citation":{"id":"18088087","citationType":"journal article","authors":["Zahedi R.P.","Lewandrowski U.","Wiesner J.","Wortelkamp S.","Moebius J.","Schuetz C.","Walter U.","Gambaryan S.","Sickmann A."],"citationCrossReferences":[{"database":"PubMed","id":"18088087"},{"database":"DOI","id":"10.1021/pr0704130"}],"title":"Phosphoproteome of resting human platelets.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"526","lastPage":"534","volume":"7"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Platelet","type":"TISSUE"}]},{"referenceNumber":22,"citation":{"id":"19342684","citationType":"journal article","authors":["Dasgupta B.","Dufour E.","Mamdouh Z.","Muller W.A."],"citationCrossReferences":[{"database":"PubMed","id":"19342684"},{"database":"DOI","id":"10.4049/jimmunol.0803192"}],"title":"A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration.","publicationDate":"2009","journal":"J. Immunol.","firstPage":"5041","lastPage":"5051","volume":"182"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","PHOSPHORYLATION AT TYR-690 AND TYR-713","MUTAGENESIS OF LYS-89; TYR-690 AND TYR-713","INTERACTION WITH PTPN11"]},{"referenceNumber":23,"citation":{"id":"19159218","citationType":"journal article","authors":["Chen R.","Jiang X.","Sun D.","Han G.","Wang F.","Ye M.","Wang L.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"19159218"},{"database":"DOI","id":"10.1021/pr8008012"}],"title":"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.","publicationDate":"2009","journal":"J. Proteome Res.","firstPage":"651","lastPage":"661","volume":"8"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-151; ASN-320 AND ASN-453"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"19349973","citationType":"journal article","authors":["Wollscheid B.","Bausch-Fluck D.","Henderson C.","O'Brien R.","Bibel M.","Schiess R.","Aebersold R.","Watts J.D."],"citationCrossReferences":[{"database":"PubMed","id":"19349973"},{"database":"DOI","id":"10.1038/nbt.1532"}],"title":"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.","publicationDate":"2009","journal":"Nat. Biotechnol.","firstPage":"378","lastPage":"386","volume":"27"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-84; ASN-320 AND ASN-551"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":25,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"22496122","citationType":"journal article","authors":["Marin E.P.","Derakhshan B.","Lam T.T.","Davalos A.","Sessa W.C."],"citationCrossReferences":[{"database":"PubMed","id":"22496122"},{"database":"DOI","id":"10.1161/circresaha.112.269514"}],"title":"Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.","publicationDate":"2012","journal":"Circ. Res.","firstPage":"1336","lastPage":"1344","volume":"110"},"referencePositions":["PALMITOYLATION BY ZDHHC21","SUBCELLULAR LOCATION"]},{"referenceNumber":27,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":28,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":29,"citation":{"id":"21464369","citationType":"journal article","authors":["Paddock C.","Lytle B.L.","Peterson F.C.","Holyst T.","Newman P.J.","Volkman B.F.","Newman D.K."],"citationCrossReferences":[{"database":"PubMed","id":"21464369"},{"database":"DOI","id":"10.1182/blood-2010-11-317867"}],"title":"Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation.","publicationDate":"2011","journal":"Blood","firstPage":"6012","lastPage":"6023","volume":"117"},"referencePositions":["STRUCTURE BY NMR OF 686-738","TISSUE SPECIFICITY","MOTIF","PHOSPHORYLATION AT TYR-690; TYR-713; SER-729 AND SER-734","MUTAGENESIS OF TYR-690 AND TYR-713"]},{"referenceNumber":30,"citation":{"id":"26702061","citationType":"journal article","authors":["Paddock C.","Zhou D.","Lertkiatmongkol P.","Newman P.J.","Zhu J."],"citationCrossReferences":[{"database":"PubMed","id":"26702061"},{"database":"DOI","id":"10.1182/blood-2015-07-660092"}],"title":"Structural basis for PECAM-1 homophilic binding.","publicationDate":"2016","journal":"Blood","firstPage":"1052","lastPage":"1061","volume":"127"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 28-229","SUBUNIT","GLYCOSYLATION AT ASN-52; ASN-84 AND ASN-151","DISULFIDE BONDS"]},{"referenceNumber":31,"citation":{"id":"27958302","citationType":"journal article","authors":["Hu M.","Zhang H.","Liu Q.","Hao Q."],"citationCrossReferences":[{"database":"PubMed","id":"27958302"},{"database":"DOI","id":"10.1038/srep38655"}],"title":"Structural basis for human PECAM-1-mediated trans-homophilic cell adhesion.","publicationDate":"2016","journal":"Sci. Rep.","firstPage":"38655","lastPage":"38655","volume":"6"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.01 ANGSTROMS) OF 28-232","FUNCTION","SUBUNIT","DISULFIDE BONDS","MUTAGENESIS OF ASN-52; LEU-74; ASN-84; ILE-112; ASN-151; PHE-188 AND ILE-190"]},{"referenceNumber":32,"citation":{"id":"8532023","citationType":"journal article","authors":["Behar E.","Chao N.J.","Hiraki D.D.","Krishnaswamy S.","Brown B.W.","Zehnder J.L.","Grumet F.C."],"citationCrossReferences":[{"database":"PubMed","id":"8532023"},{"database":"DOI","id":"10.1056/nejm199602013340502"}],"title":"Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease.","publicationDate":"1996","journal":"N. Engl. J. Med.","firstPage":"286","lastPage":"291","volume":"334"},"referencePositions":["VARIANT LEU-125"]},{"referenceNumber":33,"citation":{"id":"11791967","citationType":"journal article","authors":["Casals-Pascual C.","Allen S.","Allen A.","Kai O.","Lowe B.","Pain A.","Roberts D.J."],"citationCrossReferences":[{"database":"PubMed","id":"11791967"},{"database":"DOI","id":"10.4269/ajtmh.2001.65.736"}],"title":"Codon 125 polymorphism of CD31 and susceptibility to malaria.","publicationDate":"2001","journal":"Am. J. Trop. Med. Hyg.","firstPage":"736","lastPage":"737","volume":"65"},"referencePositions":["VARIANT LEU-125"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M37780","properties":[{"key":"ProteinId","value":"AAA36186.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M28526","properties":[{"key":"ProteinId","value":"AAA36429.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L34657","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L34631","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L34637","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L34638","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L34639","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L34640","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L34641","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L34642","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L34644","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L34645","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L34649","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L34655","properties":[{"key":"ProteinId","value":"AAA60057.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"JQ287500","properties":[{"key":"ProteinId","value":"AFA36630.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK290692","properties":[{"key":"ProteinId","value":"BAF83381.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC016489","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC138744","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC234063","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471109","properties":[{"key":"ProteinId","value":"EAW94207.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471109","properties":[{"key":"ProteinId","value":"EAW94208.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC022512","properties":[{"key":"ProteinId","value":"AAH22512.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC051822","properties":[{"key":"ProteinId","value":"AAH51822.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281287","properties":[{"key":"ProteinId","value":"AAF91446.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281288","properties":[{"key":"ProteinId","value":"AAF91447.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281289","properties":[{"key":"ProteinId","value":"AAF91448.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281290","properties":[{"key":"ProteinId","value":"AAF91449.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281291","properties":[{"key":"ProteinId","value":"AAF91450.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281292","properties":[{"key":"ProteinId","value":"AAF91451.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281293","properties":[{"key":"ProteinId","value":"AAF91452.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281294","properties":[{"key":"ProteinId","value":"AAF91453.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281295","properties":[{"key":"ProteinId","value":"AAF91454.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281296","properties":[{"key":"ProteinId","value":"AAF91455.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281297","properties":[{"key":"ProteinId","value":"AAF91456.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281298","properties":[{"key":"ProteinId","value":"AAF91457.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281299","properties":[{"key":"ProteinId","value":"AAF91458.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281300","properties":[{"key":"ProteinId","value":"AAF91459.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF281301","properties":[{"key":"ProteinId","value":"AAF91460.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF393676","properties":[{"key":"ProteinId","value":"AAK84009.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF393677","properties":[{"key":"ProteinId","value":"AAK84010.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF393678","properties":[{"key":"ProteinId","value":"AAK84011.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"S66450","properties":[{"key":"ProteinId","value":"AAB28645.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS74132.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P16284-1"},{"database":"PIR","id":"A40096","properties":[{"key":"EntryName","value":"A40096"}]},{"database":"RefSeq","id":"NP_000433.4","properties":[{"key":"NucleotideSequenceId","value":"NM_000442.5"}],"isoformId":"P16284-1"},{"database":"RefSeq","id":"XP_005276937.1","properties":[{"key":"NucleotideSequenceId","value":"XM_005276880.2"}],"isoformId":"P16284-6"},{"database":"RefSeq","id":"XP_005276938.1","properties":[{"key":"NucleotideSequenceId","value":"XM_005276881.2"}],"isoformId":"P16284-4"},{"database":"RefSeq","id":"XP_005276939.1","properties":[{"key":"NucleotideSequenceId","value":"XM_005276882.2"}],"isoformId":"P16284-3"},{"database":"RefSeq","id":"XP_016880228.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017024739.2"}],"isoformId":"P16284-2"},{"database":"PDB","id":"2KY5","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=686-738"}]},{"database":"PDB","id":"5C14","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B=28-229"}]},{"database":"PDB","id":"5GNI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.01 A"},{"key":"Chains","value":"A/B=28-232"}]},{"database":"PDBsum","id":"2KY5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5C14","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5GNI","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"111201","properties":[{"key":"Interactions","value":"33"}]},{"database":"CORUM","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P16284","properties":[{"key":"Number of interactors","value":"368"}]},{"database":"IntAct","id":"P16284","properties":[{"key":"Interactions","value":"100"}]},{"database":"MINT","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-PECAM1","properties":[{"key":"Evidences","value":"5 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000457421","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P16284","properties":[{"key":"glycosylation","value":"12 N-Linked glycans (5 sites)"}]},{"database":"GlyCosmos","id":"P16284","properties":[{"key":"glycosylation","value":"10 sites, 14 glycans"}]},{"database":"GlyGen","id":"P16284","properties":[{"key":"glycosylation","value":"10 sites, 83 N-linked glycans (6 sites), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PECAM1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"129747","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-2602","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5858","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5949","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000457421","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"53335","properties":[{"key":"Description","value":"-"}],"isoformId":"P16284-1"},{"database":"ProteomicsDB","id":"53336","properties":[{"key":"Description","value":"-"}],"isoformId":"P16284-2"},{"database":"ProteomicsDB","id":"53337","properties":[{"key":"Description","value":"-"}],"isoformId":"P16284-3"},{"database":"ProteomicsDB","id":"53338","properties":[{"key":"Description","value":"-"}],"isoformId":"P16284-4"},{"database":"ProteomicsDB","id":"53339","properties":[{"key":"Description","value":"-"}],"isoformId":"P16284-5"},{"database":"ProteomicsDB","id":"53340","properties":[{"key":"Description","value":"-"}],"isoformId":"P16284-6"},{"database":"Pumba","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P16284-1","properties":[{"key":"Description","value":"-"}],"isoformId":"P16284-1"},{"database":"Antibodypedia","id":"58161","properties":[{"key":"antibodies","value":"4461 antibodies from 50 providers"}]},{"database":"DNASU","id":"5175","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000563924.6","properties":[{"key":"ProteinId","value":"ENSP00000457421.1"},{"key":"GeneId","value":"ENSG00000261371.7"}],"isoformId":"P16284-1"},{"database":"Ensembl","id":"ENST00000904873.1","properties":[{"key":"ProteinId","value":"ENSP00000574932.1"},{"key":"GeneId","value":"ENSG00000261371.7"}],"isoformId":"P16284-1"},{"database":"Ensembl","id":"ENST00000904874.1","properties":[{"key":"ProteinId","value":"ENSP00000574933.1"},{"key":"GeneId","value":"ENSG00000261371.7"}],"isoformId":"P16284-1"},{"database":"Ensembl","id":"ENST00000904875.1","properties":[{"key":"ProteinId","value":"ENSP00000574934.1"},{"key":"GeneId","value":"ENSG00000261371.7"}],"isoformId":"P16284-1"},{"database":"Ensembl","id":"ENST00000904876.1","properties":[{"key":"ProteinId","value":"ENSP00000574935.1"},{"key":"GeneId","value":"ENSG00000261371.7"}],"isoformId":"P16284-4"},{"database":"Ensembl","id":"ENST00000904878.1","properties":[{"key":"ProteinId","value":"ENSP00000574937.1"},{"key":"GeneId","value":"ENSG00000261371.7"}],"isoformId":"P16284-2"},{"database":"Ensembl","id":"ENST00000904879.1","properties":[{"key":"ProteinId","value":"ENSP00000574938.1"},{"key":"GeneId","value":"ENSG00000261371.7"}],"isoformId":"P16284-3"},{"database":"Ensembl","id":"ENST00000904884.1","properties":[{"key":"ProteinId","value":"ENSP00000574943.1"},{"key":"GeneId","value":"ENSG00000261371.7"}],"isoformId":"P16284-4"},{"database":"Ensembl","id":"ENST00000904889.1","properties":[{"key":"ProteinId","value":"ENSP00000574948.1"},{"key":"GeneId","value":"ENSG00000261371.7"}],"isoformId":"P16284-1"},{"database":"Ensembl","id":"ENST00000904890.1","properties":[{"key":"ProteinId","value":"ENSP00000574949.1"},{"key":"GeneId","value":"ENSG00000261371.7"}],"isoformId":"P16284-3"},{"database":"GeneID","id":"5175","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:5175","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000563924.6","properties":[{"key":"ProteinId","value":"ENSP00000457421.1"},{"key":"RefSeqNucleotideId","value":"NM_000442.5"},{"key":"RefSeqProteinId","value":"NP_000433.4"}]},{"database":"AGR","id":"HGNC:8823","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA33167","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5175","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5175","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PECAM1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:8823","properties":[{"key":"GeneName","value":"PECAM1"}]},{"database":"HPA","id":"ENSG00000261371","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (placenta)"}]},{"database":"MIM","id":"173445","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000261371","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000261371","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QW63","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01140000282577","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FLSCDYE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9950534at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P16284","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-114608","properties":[{"key":"PathwayName","value":"Platelet degranulation"}]},{"database":"Reactome","id":"R-HSA-202733","properties":[{"key":"PathwayName","value":"Cell surface interactions at the vascular wall"}]},{"database":"Reactome","id":"R-HSA-210990","properties":[{"key":"PathwayName","value":"PECAM1 interactions"}]},{"database":"Reactome","id":"R-HSA-216083","properties":[{"key":"PathwayName","value":"Integrin cell surface interactions"}]},{"database":"Reactome","id":"R-HSA-432142","properties":[{"key":"PathwayName","value":"Platelet sensitization by LDL"}]},{"database":"Reactome","id":"R-HSA-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"Reactome","id":"R-HSA-9856530","properties":[{"key":"PathwayName","value":"High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"}]},{"database":"SignaLink","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000261371","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"5175","properties":[{"key":"hits","value":"11 hits in 233 CRISPR screens"}]},{"database":"ChiTaRS","id":"PECAM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P16284","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CD31","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"5175","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P16284","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P16284","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"P16284","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000261371","properties":[{"key":"ExpressionPatterns","value":"Expressed in tendon of biceps brachii and 211 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P16284","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0070161","properties":[{"key":"GoTerm","value":"C:anchoring junction"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18388311"}]},{"database":"GO","id":"GO:0044291","properties":[{"key":"GoTerm","value":"C:cell-cell contact zone"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005911","properties":[{"key":"GoTerm","value":"C:cell-cell junction"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15572031"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9290466"}]},{"database":"GO","id":"GO:0045121","properties":[{"key":"GoTerm","value":"C:membrane raft"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17139370"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22496122"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17464107"}]},{"database":"GO","id":"GO:0031092","properties":[{"key":"GoTerm","value":"C:platelet alpha granule membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26607202"}]},{"database":"GO","id":"GO:0030667","properties":[{"key":"GoTerm","value":"C:secretory granule membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030485","properties":[{"key":"GoTerm","value":"C:smooth muscle contractile fiber"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26702061"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27958302"}]},{"database":"GO","id":"GO:0048018","properties":[{"key":"GoTerm","value":"F:receptor ligand activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9551996"}]},{"database":"GO","id":"GO:0004888","properties":[{"key":"GoTerm","value":"F:transmembrane signaling receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070830","properties":[{"key":"GoTerm","value":"P:bicellular tight junction assembly"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26607202"}]},{"database":"GO","id":"GO:0008037","properties":[{"key":"GoTerm","value":"P:cell recognition"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1690453"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15985432"}]},{"database":"GO","id":"GO:0098609","properties":[{"key":"GoTerm","value":"P:cell-cell adhesion"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15572031"}]},{"database":"GO","id":"GO:0071260","properties":[{"key":"GoTerm","value":"P:cellular response to mechanical stimulus"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15985432"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26706435"}]},{"database":"GO","id":"GO:0050982","properties":[{"key":"GoTerm","value":"P:detection of mechanical stimulus"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26706435"}]},{"database":"GO","id":"GO:0050904","properties":[{"key":"GoTerm","value":"P:diapedesis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19342684"}]},{"database":"GO","id":"GO:0061028","properties":[{"key":"GoTerm","value":"P:establishment of endothelial barrier"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7589563"}]},{"database":"GO","id":"GO:0072011","properties":[{"key":"GoTerm","value":"P:glomerular endothelium development"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"17464107"}]},{"database":"GO","id":"GO:0007156","properties":[{"key":"GoTerm","value":"P:homophilic cell-cell adhesion"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27958302"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007159","properties":[{"key":"GoTerm","value":"P:leukocyte cell-cell adhesion"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17580308"}]},{"database":"GO","id":"GO:0035633","properties":[{"key":"GoTerm","value":"P:maintenance of blood-brain barrier"},{"key":"GoEvidenceType","value":"NAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30280653"}]},{"database":"GO","id":"GO:0035696","properties":[{"key":"GoTerm","value":"P:monocyte extravasation"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11078691"}]},{"database":"GO","id":"GO:0072672","properties":[{"key":"GoTerm","value":"P:neutrophil extravasation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17580308"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22266279"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12110892"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15572031"}]},{"database":"GO","id":"GO:1902533","properties":[{"key":"GoTerm","value":"P:positive regulation of intracellular signal transduction"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26706435"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15985432"}]},{"database":"GO","id":"GO:0051897","properties":[{"key":"GoTerm","value":"P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26706435"}]},{"database":"GO","id":"GO:0150107","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to cell-cell junction"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26706435"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7994021"}]},{"database":"GO","id":"GO:0042110","properties":[{"key":"GoTerm","value":"P:T cell activation"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11259373"}]},{"database":"GO","id":"GO:0042311","properties":[{"key":"GoTerm","value":"P:vasodilation"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26706435"}]},{"database":"FunFam","id":"2.60.40.10:FF:001711","properties":[{"key":"EntryName","value":"Platelet and endothelial cell adhesion molecule 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001745","properties":[{"key":"EntryName","value":"Platelet and endothelial cell adhesion molecule 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001799","properties":[{"key":"EntryName","value":"Platelet and endothelial cell adhesion molecule 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001919","properties":[{"key":"EntryName","value":"Platelet endothelial cell adhesion molecule"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR050488","properties":[{"key":"EntryName","value":"Ig_Fc_receptor"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040878","properties":[{"key":"EntryName","value":"IL-40-like_Ig"}]},{"database":"PANTHER","id":"PTHR11481","properties":[{"key":"EntryName","value":"IMMUNOGLOBULIN FC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11481:SF5","properties":[{"key":"EntryName","value":"PLATELET ENDOTHELIAL CELL ADHESION MOLECULE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13895","properties":[{"key":"EntryName","value":"Ig_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17736","properties":[{"key":"EntryName","value":"Ig_C17orf99"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"5"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MQPRWAQGATMWLGVLLTLLLCSSLEGQENSFTINSVDMKSLPDWTVQNGKNLTLQCFADVSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYKCTVIVNNKEKTTAEYQVLVEGVPSPRVTLDKKEAIQGGIVRVNCSVPEEKAPIHFTIEKLELNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQTSESTKSELVTVTESFSTPKFHISPTGMIMEGAQLHIKCTIQVTHLAQEFPEIIIQKDKAIVAHNRHGNKAVYSVMAMVEHSGNYTCKVESSRISKVSSIVVNITELFSKPELESSFTHLDQGERLNLSCSIPGAPPANFTIQKEDTIVSQTQDFTKIASKSDSGTYICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDAQFEVIKGQTIEVRCESISGTLPISYQLLKTSKVLENSTKNSNDPAVFKDNPTEDVEYQCVADNCHSHAKMLSEVLRVKVIAPVDEVQISILSSKVVESGEDIVLQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQAFWTKQKASKEQEGEYYCTAFNRANHASSVPRSKILTVRVILAPWKKGLIAVVIIGVIIALLIIAAKCYFLRKAKAKQMPVEMSRPAVPLLNSNNEKMSDPNMEANSHYGHNDDVRNHAMKPINDNKEPLNSDVQYTEVQVSSAESHKDLGKKDTETVYSEVRKAVPDAVESRYSRTEGSLDGT","length":738,"molWeight":82522,"crc64":"9D531D2DDCCB7F92","md5":"33F2EDB9C7B3098E3CC72BEFC2F6C36D"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"INTERACTION":78,"SUBCELLULAR LOCATION":3,"ALTERNATIVE PRODUCTS":6,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":2,"WEB RESOURCE":2},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":6,"Region":3,"Motif":2,"Compositional bias":2,"Modified residue":4,"Lipidation":1,"Glycosylation":9,"Disulfide bond":6,"Alternative sequence":6,"Natural variant":5,"Mutagenesis":11,"Sequence conflict":6,"Beta strand":17,"Helix":5,"Turn":1},"uniParcId":"UPI0001EC962A"}}