{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P15927","secondaryAccessions":["Q52II0","Q5TEI9","Q5TEJ5"],"uniProtkbId":"RFA2_HUMAN","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1990-04-01","entryVersion":244,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Replication protein A 32 kDa subunit"},"shortNames":[{"value":"RP-A p32"}]},"alternativeNames":[{"fullName":{"value":"Replication factor A protein 2"},"shortNames":[{"value":"RF-A protein 2"}]},{"fullName":{"value":"Replication protein A 34 kDa subunit"},"shortNames":[{"value":"RP-A p34"}]}]},"genes":[{"geneName":{"value":"RPA2"},"synonyms":[{"value":"REPA2"},{"value":"RPA32"},{"value":"RPA34"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15205463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17596542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17765923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17959650"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19116208"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20154705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21504906"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2406247"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24332808"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7697716"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7700386"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8702565"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9430682"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9765279"}],"value":"As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10449415"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10982866"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11081631"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17141802"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17296725"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17596542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17765923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19793861"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19793862"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19793863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20154705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21504906"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21558276"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22521144"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22684010"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23319600"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2406247"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24332808"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24910198"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26474068"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27601467"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27723717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27723720"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28575657"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29290612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7700386"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8702565"}],"value":"Component of the replication protein A complex (RPA/RP-A), a heterotrimeric complex composed of RPA1, RPA2 and RPA3 (PubMed:10449415, PubMed:19116208, PubMed:2406247). Interacts with PRPF19; the PRP19-CDC5L complex is recruited to the sites of DNA repair where it ubiquitinates the replication protein A complex (RPA) (PubMed:24332808). Interacts with SERTAD3 (PubMed:10982866). Interacts with TIPIN (PubMed:17141802, PubMed:17296725). Interacts with TIMELESS (PubMed:17141802). Interacts with PPP4R2; the interaction is direct, DNA damage-dependent and mediates the recruitment of the PP4 catalytic subunit PPP4C (PubMed:20154705). Interacts (hyperphosphorylated) with RAD51 (PubMed:20154705). Interacts with SMARCAL1; the interaction is direct and mediates the recruitment to the RPA complex of SMARCAL1 (PubMed:19793861, PubMed:19793862, PubMed:19793863, PubMed:24910198). Interacts with RAD52 and XPA; those interactions are direct and associate RAD52 and XPA to the RPA complex (PubMed:11081631, PubMed:17765923, PubMed:7700386, PubMed:8702565). Interacts with FBH1 (PubMed:23319600). Interacts with ETAA1; the interaction is direct and promotes ETAA1 recruitment at stalled replication forks (PubMed:27601467, PubMed:27723717, PubMed:27723720). Interacts with RFWD3 (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657). Interacts with DDI2 (PubMed:29290612). Interacts (in unphosphorylated form via N-terminus) with EIF4EBP3; the interaction enhances EIF4EBP3-mediated inhibition of EIF4E-mediated mRNA nuclear export (PubMed:22684010). Interacts with BRIP1/FANCJ via the RPA1 subunit; following DNA damage they colocalize in foci in the nucleus (PubMed:17596542). Interacts with nuclear UNG (isoform 2); this interaction mediates UNG recruitment to RPA-coated single-stranded DNA at stalled replication forks"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"P24863","geneName":"CCNC","intActId":"EBI-395261"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"O75419","geneName":"CDC45","intActId":"EBI-374969"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"O60516","geneName":"EIF4EBP3","intActId":"EBI-746950"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"P04406","geneName":"GAPDH","intActId":"EBI-354056"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"P49643-1","geneName":"PRIM2","intActId":"EBI-15866483"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"Q6PCD5","geneName":"RFWD3","intActId":"EBI-2129159"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"P27694","geneName":"RPA1","intActId":"EBI-621389"},"numberOfExperiments":20,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"P35244","geneName":"RPA3","intActId":"EBI-621428"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"Q9UJW9","geneName":"SERTAD3","intActId":"EBI-748621"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"Q9NZC9","geneName":"SMARCAL1","intActId":"EBI-5457961"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"P40763","geneName":"STAT3","intActId":"EBI-518675"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"Q9BVW5","geneName":"TIPIN","intActId":"EBI-2515360"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"P13051","geneName":"UNG","intActId":"EBI-1025947"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15927","intActId":"EBI-621404"},"interactantTwo":{"uniProtKBAccession":"P23025","geneName":"XPA","intActId":"EBI-295222"},"numberOfExperiments":10,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12814551"}],"value":"Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10982866"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12814551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17596542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20154705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21504906"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12814551"}],"value":"Nucleus, PML body","id":"SL-0465"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P15927-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P15927-2"],"sequenceIds":["VSP_017201"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P15927-3"],"sequenceIds":["VSP_017202"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23393223"}],"value":"Translationally up-regulated in response to DNA damage (at protein level)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12814551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1318195"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20154705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21558276"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21731742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26474068"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8246944"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9139719"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295339"}],"value":"Differentially phosphorylated throughout the cell cycle, becoming phosphorylated at the G1-S transition and dephosphorylated in late mitosis. Mainly phosphorylated at Ser-23 and Ser-29, by cyclin A-CDK2 and cyclin B-CDK1, respectively during DNA replication and mitosis. Dephosphorylation may require the serine/threonine-protein phosphatase 4. Phosphorylation at Ser-23 and Ser-29 is a prerequisite for further phosphorylation. Becomes hyperphosphorylated on additional residues including Ser-4, Ser-8, Thr-21 and Ser-33 in response to DNA damage. Hyperphosphorylation is mediated by ATM, ATR and PRKDC. Primarily recruited to DNA repair nuclear foci as a hypophosphorylated form it undergoes subsequent hyperphosphorylation, catalyzed by ATR. Hyperphosphorylation is required for RAD51 recruitment to chromatin and efficient DNA repair. Phosphorylation at Thr-21 depends upon RFWD3 presence"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24332808"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26474068"}],"value":"DNA damage-induced 'Lys-63'-linked polyubiquitination by PRPF19 mediates ATRIP recruitment to the RPA complex at sites of DNA damage and activation of ATR (PubMed:24332808). Ubiquitinated by RFWD3 at stalled replication forks in response to DNA damage: ubiquitination by RFWD3 does not lead to degradation by the proteasome and promotes removal of the RPA complex from stalled replication forks, promoting homologous recombination (PubMed:26474068)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the replication factor A protein 2 family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/42146/RPA2","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Replication protein A 32 kDa subunit","featureId":"PRO_0000097270"},{"type":"DNA binding","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"OB"},{"type":"Region","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Interaction with RAD52, TIPIN, UNG and XPA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11081631"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9139719"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"Phosphoserine; by PRKDC","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21731742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26474068"}]},{"type":"Modified residue","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"Phosphoserine; by PRKDC","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21731742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26474068"}]},{"type":"Modified residue","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Phosphothreonine; by PRKDC","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21558276"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26474068"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9139719"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295339"}]},{"type":"Modified residue","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Phosphoserine; by CDK2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1318195"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8246944"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295339"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Phosphoserine; by CDK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1318195"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8246944"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9139719"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295339"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Phosphoserine; by PRKDC","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26474068"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9139719"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295339"}]},{"type":"Cross-link","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26474068"}]},{"type":"Cross-link","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26474068"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_017201","alternativeSequence":{"originalSequence":"MWNS","alternativeSequences":["MGRGDRNKRSIR"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_017202","alternativeSequence":{"originalSequence":"MWNS","alternativeSequences":["MWNSNDGGAGWRRKRIAGGFSKRASLGSERRVVAGEEGRERSWGVWGSPAGRRRGRLGRLGQCLKGRSLREPAGFSEAWDVAQALILLFKTG"]}},{"type":"Natural variant","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"in dbSNP:rs28988896","featureCrossReferences":[{"database":"dbSNP","id":"rs28988896"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_023300","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"in dbSNP:rs28988897","featureCrossReferences":[{"database":"dbSNP","id":"rs28988897"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_023301","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"in dbSNP:rs28904899","featureCrossReferences":[{"database":"dbSNP","id":"rs28904899"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_023302","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"Increased RAD51 foci formation and homologous recombination efficiency at DNA double-strand breaks; when associated with A-8.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21731742"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"Increased RAD51 foci formation and homologous recombination efficiency at DNA double-strand breaks; when associated with A-4.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20154705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21731742"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"Lower homologous recombination efficiency following DNA double strand break. Impaired DNA synthesis following DNA damage; when associated with D-33. No effect on cell-cycle progression, nor DNA synthesis in undamaged cells; when associated with D-23; D-29 and D-33. Impaired DNA double strand breaks repair; when associated with D-23; D-29 and D-33. Extended DNA damage-induced G2-M checkpoint; when associated with D-23; D-29 and D-33. Preferentially interacts with RAD51; when associated with D-23; D-29 and D-33.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20154705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21731742"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"No effect on DNA synthesis following DNA damage; when associated with D-29. No effect on cell-cycle progression, nor DNA synthesis in undamaged cells; when associated with D-8; D-29 and D-33. Impaired DNA double strand breaks repair; when associated with D-8; D-29 and D-33. Extended DNA damage-induced G2-M checkpoint; when associated with D-8; D-29 and D-33. Preferentially interacts with RAD51; when associated with D-8; D-29 and D-33.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20154705"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Reduces phosphorylation by CDK1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20154705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9139719"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"No effect on DNA synthesis following DNA damage; when associated with D-23. No effect on cell-cycle progression, nor DNA synthesis in undamaged cells; when associated with D-8; D-23 and D-33. Impaired DNA double strand breaks repair; when associated with D-8; D-23 and D-33. Extended DNA damage-induced G2-M checkpoint; when associated with D-8; D-23 and D-33. Preferentially interacts with RAD51; when associated with D-8; D-23 and D-33.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20154705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9139719"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Lower homologous recombination efficiency following DNA double strand break. Impaired DNA synthesis following DNA damage; when associated with D-8. No effect on cell-cycle progression, nor DNA synthesis in undamaged cells; when associated with D-8; D-23 and D-29. Impaired DNA double strand breaks repair; when associated with D-8; D-23 and D-29. Extended DNA damage-induced G2-M checkpoint; when associated with D-8; D-23 and D-29. Preferentially interacts with RAD51; when associated with D-8; D-23 and D-29.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20154705"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Impaired ubiquitination without affecting homologous recombination.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26474068"}],"alternativeSequence":{"originalSequence":"KK","alternativeSequences":["RR"]}},{"type":"Mutagenesis","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Abolishes interaction with RFWD3, leading to impair DNA interstrand cross-links (ICL) 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