{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P15692","secondaryAccessions":["B5BU86","H0Y2S8","H0Y407","H0Y414","H0Y462","H0Y8N2","H3BLW7","O60720","O75875","Q074Z4","Q16889","Q5UB46","Q6P0P5","Q96KJ0","Q96L82","Q96NW5","Q9H1W8","Q9H1W9","Q9UH58","Q9UL23"],"uniProtkbId":"VEGFA_HUMAN","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2023-06-28","entryVersion":278,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Vascular endothelial growth factor A, long form"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11731620"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35455969"}],"value":"L-VEGF"}]},"alternativeNames":[{"fullName":{"value":"Vascular permeability factor"},"shortNames":[{"value":"VPF"}]}],"contains":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35455969"}],"value":"N-VEGF"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35455969"}],"value":"VEGFA"}}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"VEGFA"},"synonyms":[{"value":"VEGF"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q00731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35455969"}],"value":"Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity)"}],"commentType":"FUNCTION","molecule":"N-VEGF"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q00731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11427521"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16489009"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17446437"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25825981"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34530889"}],"value":"Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth (PubMed:34530889). Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437)"}],"commentType":"FUNCTION","molecule":"VEGFA"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15520188"}],"value":"Binds to the KDR receptor but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth"}],"commentType":"FUNCTION","molecule":"Isoform VEGF165B"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P16612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25825981"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26503042"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34530889"}],"value":"Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (PubMed:26503042). Interacts with isoform 2 of BSG (PubMed:25825981). Interacts with CD82; this interaction inhibits VEGFA-mediated signaling pathway (PubMed:34530889)"}],"commentType":"SUBUNIT","molecule":"VEGFA"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P15692","intActId":"EBI-1026643"},"interactantTwo":{"uniProtKBAccession":"P17948","geneName":"FLT1","intActId":"EBI-1026718"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692","intActId":"EBI-1026643"},"interactantTwo":{"uniProtKBAccession":"P35968","geneName":"KDR","intActId":"EBI-1005487"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692","intActId":"EBI-1026643"},"interactantTwo":{"uniProtKBAccession":"O14786","geneName":"NRP1","intActId":"EBI-1187100"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692","intActId":"EBI-1026643"},"interactantTwo":{"uniProtKBAccession":"P15692","geneName":"VEGFA","intActId":"EBI-1026643"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692-4","intActId":"EBI-1026691"},"interactantTwo":{"uniProtKBAccession":"P17948","geneName":"FLT1","intActId":"EBI-1026718"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692-4","intActId":"EBI-1026691"},"interactantTwo":{"uniProtKBAccession":"P35968","geneName":"KDR","intActId":"EBI-1005487"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692-4","intActId":"EBI-1026691"},"interactantTwo":{"uniProtKBAccession":"O14786","geneName":"NRP1","intActId":"EBI-1187100"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692-4","intActId":"EBI-1026691"},"interactantTwo":{"uniProtKBAccession":"O14786-2","geneName":"NRP1","intActId":"EBI-6285281"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692-4","intActId":"EBI-1026691"},"interactantTwo":{"uniProtKBAccession":"P15692-4","geneName":"VEGFA","intActId":"EBI-1026691"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692-12","intActId":"EBI-6622053"},"interactantTwo":{"uniProtKBAccession":"P08034","geneName":"GJB1","intActId":"EBI-17565645"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692-12","intActId":"EBI-6622053"},"interactantTwo":{"uniProtKBAccession":"P80188","geneName":"LCN2","intActId":"EBI-11911016"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692-12","intActId":"EBI-6622053"},"interactantTwo":{"uniProtKBAccession":"Q9NQQ7-3","geneName":"SLC35C2","intActId":"EBI-17295964"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15692-12","intActId":"EBI-6622053"},"interactantTwo":{"uniProtKBAccession":"Q96Q45-2","geneName":"TMEM237","intActId":"EBI-10982110"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"N-VEGF","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15896327"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35455969"}],"value":"Cytoplasmic in normoxic conditions and localizes to the nucleus under hypoxic conditions"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15896327"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15896327"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35455969"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"VEGFA","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11563986"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11731620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15896327"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform L-VEGF189","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11731620"}],"value":"Endoplasmic reticulum","id":"SL-0095"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11731620"}],"value":"Golgi apparatus","id":"SL-0132"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11563986"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform VEGF121","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15896327"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform VEGF165","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15896327"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform VEGF189","note":{"texts":[{"value":"Cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin"}]},"subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative promoter usage","Alternative splicing","Alternative initiation"],"isoforms":[{"name":{"value":"L-VEGF189"},"isoformIds":["P15692-13"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"VEGF206"},"isoformIds":["P15692-1"],"sequenceIds":["VSP_061891","VSP_061898"],"isoformSequenceStatus":"Described"},{"name":{"value":"VEGF189"},"isoformIds":["P15692-2"],"sequenceIds":["VSP_061891"],"isoformSequenceStatus":"Described"},{"name":{"value":"VEGF183"},"isoformIds":["P15692-3"],"sequenceIds":["VSP_061891","VSP_061897"],"isoformSequenceStatus":"Described"},{"name":{"value":"VEGF165"},"synonyms":[{"value":"VEGF"}],"isoformIds":["P15692-4"],"sequenceIds":["VSP_061891","VSP_061894"],"isoformSequenceStatus":"Described"},{"name":{"value":"VEGF148"},"isoformIds":["P15692-5"],"sequenceIds":["VSP_061891","VSP_061894","VSP_061901","VSP_061902"],"isoformSequenceStatus":"Described"},{"name":{"value":"VEGF145"},"isoformIds":["P15692-6"],"sequenceIds":["VSP_061891","VSP_061899","VSP_061900"],"isoformSequenceStatus":"Described"},{"name":{"value":"VEGF165B"},"isoformIds":["P15692-8"],"sequenceIds":["VSP_061891","VSP_061894","VSP_061903"],"isoformSequenceStatus":"Described"},{"name":{"value":"VEGF121"},"isoformIds":["P15692-9"],"sequenceIds":["VSP_061891","VSP_061895","VSP_061896"],"isoformSequenceStatus":"Described"},{"name":{"value":"VEGF111"},"isoformIds":["P15692-10"],"sequenceIds":["VSP_061891","VSP_061892","VSP_061893"],"isoformSequenceStatus":"Described"},{"name":{"value":"L-VEGF165"},"isoformIds":["P15692-11"],"sequenceIds":["VSP_061894"],"isoformSequenceStatus":"Described"},{"name":{"value":"L-VEGF121"},"isoformIds":["P15692-12"],"sequenceIds":["VSP_061895","VSP_061896"],"isoformSequenceStatus":"Described"},{"name":{"value":"L-VEGF206"},"isoformIds":["P15692-14"],"sequenceIds":["VSP_061898"],"isoformSequenceStatus":"Described"},{"name":{"value":"15"},"isoformIds":["P15692-15"],"sequenceIds":["VSP_061894","VSP_061903"],"isoformSequenceStatus":"Described"},{"name":{"value":"16"},"isoformIds":["P15692-16"],"sequenceIds":["VSP_061897"],"isoformSequenceStatus":"Described"},{"name":{"value":"17"},"isoformIds":["P15692-17"],"sequenceIds":["VSP_061894","VSP_061901","VSP_061902"],"isoformSequenceStatus":"Described"},{"name":{"value":"18"},"isoformIds":["P15692-18"],"sequenceIds":["VSP_061892","VSP_061893"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"A subset of isoforms are produced by use of an alternative upstream CUG codon, giving rise to long isoforms which have an N-terminal extension compared to the classical shorter AUG-initiated forms. These longer forms are post-translationally processed to produce an N-terminal N-VEGF chain and a C-terminal VEGFA chain."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22009797"}],"value":"Higher expression in pituitary tumors than the pituitary gland"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Widely expressed"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform VEGF189"},{"texts":[{"value":"Widely expressed"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform VEGF165"},{"texts":[{"value":"Widely expressed"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform VEGF121"},{"texts":[{"value":"Not widely expressed"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform VEGF206"},{"texts":[{"value":"Not widely expressed"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform VEGF145"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22009797"}],"value":"By hypoxia. Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoglycemia and oncogenic mutations"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11731620"}],"value":"Produced by use of an alternative upstream CUG codon and post-translationally processed into the N-terminal N-VEGF form and the C-terminal secreted VEGFA form"}],"commentType":"PTM","molecule":"Vascular endothelial growth factor A, long form"},{"commentType":"DISEASE","disease":{"diseaseId":"Microvascular complications of diabetes 1","diseaseAccession":"DI-02754","acronym":"MVCD1","description":"Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.","diseaseCrossReference":{"database":"MIM","id":"603933"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11978667"}]},"note":{"texts":[{"value":"Disease susceptibility is associated with variants affecting the gene represented in this entry"}]}},{"texts":[{"value":"Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon"}],"commentType":"MISCELLANEOUS","molecule":"Isoform L-VEGF189"},{"texts":[{"value":"Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon"}],"commentType":"MISCELLANEOUS","molecule":"Isoform L-VEGF165"},{"texts":[{"value":"Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon"}],"commentType":"MISCELLANEOUS","molecule":"Isoform L-VEGF121"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon"}],"commentType":"MISCELLANEOUS","molecule":"Isoform L-VEGF206"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Starts at an alternative upstream CUG codon"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 15"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Starts at an alternative upstream CUG codon"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 16"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Starts at an alternative upstream CUG codon"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 17"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Starts at an alternative upstream CUG codon"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 18"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the PDGF/VEGF growth factor family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAC63102.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAC63143.1","note":"Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor","ftp":false,"note":"VEGF entry"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"Vascular endothelial growth factor A, long form","featureId":"PRO_0000458064"},{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":null,"modifier":"UNKNOWN"}},"description":"N-VEGF","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11731620"}],"featureId":"PRO_0000458065"},{"type":"Chain","location":{"start":{"value":null,"modifier":"UNKNOWN"},"end":{"value":395,"modifier":"EXACT"}},"description":"VEGFA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11731620"}],"featureId":"PRO_0000458066"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Disulfide bond","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Interchain"},{"type":"Disulfide bond","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"Interchain"},{"type":"Disulfide bond","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":""},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in isoform VEGF206, isoform VEGF189, isoform VEGF183, isoform VEGF165, isoform VEGF148, isoform VEGF145, isoform VEGF165B, isoform VEGF121 and isoform VEGF111","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10464055"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12124351"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1791831"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2479986"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9054410"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9878851"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.12"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.16"}],"featureId":"VSP_061891","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"in isoform VEGF111 and isoform 18","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.16"}],"featureId":"VSP_061892","alternativeSequence":{"originalSequence":"PKKDRA","alternativeSequences":["CDKPRR"]}},{"type":"Alternative sequence","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"in isoform VEGF111 and isoform 18","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.16"}],"featureId":"VSP_061893","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"in isoform VEGF165, isoform VEGF148, isoform VEGF165B, isoform L-VEGF165, isoform 15 and isoform 17","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10464055"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12124351"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2479986"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9450968"}],"featureId":"VSP_061894","alternativeSequence":{"originalSequence":"KKSVRGKGKGQKRKRKKSRYKSWSV","alternativeSequences":["N"]}},{"type":"Alternative sequence","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"in isoform VEGF121 and isoform L-VEGF121","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.12"}],"featureId":"VSP_061895","alternativeSequence":{"originalSequence":"KSVRGK","alternativeSequences":["CDKPRR"]}},{"type":"Alternative sequence","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"in isoform VEGF121 and isoform L-VEGF121","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.12"}],"featureId":"VSP_061896","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"in isoform VEGF183 and isoform 16","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9878851"}],"featureId":"VSP_061897","alternativeSequence":{"originalSequence":"RYKSWSV","alternativeSequences":["R"]}},{"type":"Alternative sequence","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"in isoform VEGF206 and isoform L-VEGF206","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1791831"}],"featureId":"VSP_061898","alternativeSequence":{"originalSequence":"V","alternativeSequences":["VYVGARCCLMPWSLPGPH"]}},{"type":"Alternative sequence","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"in isoform VEGF145","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9054410"}],"featureId":"VSP_061899","alternativeSequence":{"originalSequence":"PCGPCS","alternativeSequences":["CDKPRR"]}},{"type":"Alternative sequence","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"in isoform VEGF145","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9054410"}],"featureId":"VSP_061900","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"in isoform VEGF148 and isoform 17","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10464055"}],"featureId":"VSP_061901","alternativeSequence":{"originalSequence":"A","alternativeSequences":["M"]}},{"type":"Alternative sequence","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"in isoform VEGF148 and isoform 17","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10464055"}],"featureId":"VSP_061902","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"in isoform VEGF165B and isoform 15","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12124351"}],"featureId":"VSP_061903","alternativeSequence":{"originalSequence":"CDKPRR","alternativeSequences":["SLTRKD"]}},{"type":"Sequence conflict","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"in Ref. 8; AAC63143","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"in Ref. 8; AAC63143","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Helix","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9JU1"}]},{"type":"Helix","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1MKK"}]},{"type":"Beta strand","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1MKK"}]},{"type":"Helix","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1MKK"}]},{"type":"Helix","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1MKK"}]},{"type":"Beta strand","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1MKK"}]},{"type":"Beta strand","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6D3O"}]},{"type":"Beta strand","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1MKK"}]},{"type":"Turn","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9JU1"}]},{"type":"Beta strand","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1MKK"}]},{"type":"Helix","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1VGH"}]},{"type":"Beta strand","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DEQ"}]},{"type":"Beta strand","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DEQ"}]},{"type":"Turn","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DEQ"}]},{"type":"Beta strand","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DEQ"}]},{"type":"Helix","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DEQ"}]},{"type":"Turn","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DEQ"}]},{"type":"Beta strand","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KMX"}]},{"type":"Turn","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DEQ"}]},{"type":"Beta strand","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KMX"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0024","category":"Coding sequence diversity","name":"Alternative initiation"},{"id":"KW-0877","category":"Coding sequence diversity","name":"Alternative promoter usage"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0037","category":"Biological process","name":"Angiogenesis"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"id":"KW-0358","category":"Molecular function","name":"Heparin-binding"},{"id":"KW-0497","category":"Molecular function","name":"Mitogen"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"}],"references":[{"referenceNumber":1,"citation":{"id":"2479986","citationType":"journal article","authors":["Leung D.W.","Cachianes G.","Kuang W.-J.","Goeddel D.V.","Ferrara N."],"citationCrossReferences":[{"database":"PubMed","id":"2479986"},{"database":"DOI","id":"10.1126/science.2479986"}],"title":"Vascular endothelial growth factor is a secreted angiogenic mitogen.","publicationDate":"1989","journal":"Science","firstPage":"1306","lastPage":"1309","volume":"246"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS VEGF189 AND VEGF165)"]},{"referenceNumber":2,"citation":{"id":"2479987","citationType":"journal article","authors":["Keck P.J.","Hauser S.D.","Krivi G.","Sanzo K.","Warren T.","Feder J.","Connolly D.T."],"citationCrossReferences":[{"database":"PubMed","id":"2479987"},{"database":"DOI","id":"10.1126/science.2479987"}],"title":"Vascular permeability factor, an endothelial cell mitogen related to PDGF.","publicationDate":"1989","journal":"Science","firstPage":"1309","lastPage":"1312","volume":"246"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF189)","PARTIAL PROTEIN SEQUENCE"]},{"referenceNumber":3,"citation":{"id":"1711045","citationType":"journal article","authors":["Tischer E.","Mitchell R.","Hartman T.","Silva M.","Gospodarowicz D.","Fiddes J.C.","Abraham J.A."],"citationCrossReferences":[{"database":"PubMed","id":"1711045"},{"database":"DOI","id":"10.1016/s0021-9258(18)99049-6"}],"title":"The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing.","publicationDate":"1991","journal":"J. Biol. Chem.","firstPage":"11947","lastPage":"11954","volume":"266"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM VEGF189)"]},{"referenceNumber":4,"citation":{"id":"1791831","citationType":"journal article","authors":["Houck K.A.","Ferrara N.","Winer J.","Cachianes G.","Li B.","Leung D.W."],"citationCrossReferences":[{"database":"PubMed","id":"1791831"},{"database":"DOI","id":"10.1210/mend-5-12-1806"}],"title":"The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA.","publicationDate":"1991","journal":"Mol. Endocrinol.","firstPage":"1806","lastPage":"1814","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM VEGF206)"]},{"referenceNumber":5,"citation":{"id":"1567395","citationType":"journal article","authors":["Weindel K.","Marme D.","Weich H.A."],"citationCrossReferences":[{"database":"PubMed","id":"1567395"},{"database":"DOI","id":"10.1016/s0006-291x(05)80313-4"}],"title":"AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor.","publicationDate":"1992","journal":"Biochem. Biophys. Res. Commun.","firstPage":"1167","lastPage":"1174","volume":"183"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF165)"]},{"referenceNumber":6,"citation":{"id":"9054410","citationType":"journal article","authors":["Poltorak Z.","Cohen T.","Sivan R.","Kandelis Y.","Spira G.","Vlodavsky I.","Keshet E.","Neufeld G."],"citationCrossReferences":[{"database":"PubMed","id":"9054410"},{"database":"DOI","id":"10.1074/jbc.272.11.7151"}],"title":"VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"7151","lastPage":"7158","volume":"272"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF145)"]},{"referenceNumber":7,"citation":{"id":"9878851","citationType":"journal article","authors":["Lei J.","Jiang A.","Pei D."],"citationCrossReferences":[{"database":"PubMed","id":"9878851"},{"database":"DOI","id":"10.1016/s0167-4781(98)00240-1"}],"title":"Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183.","publicationDate":"1998","journal":"Biochim. Biophys. Acta","firstPage":"400","lastPage":"406","volume":"1443"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF183)"],"referenceComments":[{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"9450968","citationType":"journal article","authors":["Claffey K.P.","Shih S.-C.","Mullen A.","Dziennis S.","Cusick J.L.","Abrams K.R.","Lee S.W.","Detmar M."],"citationCrossReferences":[{"database":"PubMed","id":"9450968"},{"database":"DOI","id":"10.1091/mbc.9.2.469"}],"title":"Identification of a human VPF/VEGF 3' untranslated region mediating hypoxia-induced mRNA stability.","publicationDate":"1998","journal":"Mol. Biol. Cell","firstPage":"469","lastPage":"481","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM L-VEGF165)"],"referenceComments":[{"value":"Mammary gland","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"10464055","citationType":"journal article","authors":["Whittle C.J.","Gillespie K.M.","Harrison R.","Mathieson P.W.","Harper S.J."],"citationCrossReferences":[{"database":"PubMed","id":"10464055"},{"database":"DOI","id":"10.1042/cs0970303"}],"title":"Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant.","publicationDate":"1999","journal":"Clin. Sci.","firstPage":"303","lastPage":"312","volume":"97"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF148)"],"referenceComments":[{"value":"Renal glomerulus","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"12124351","citationType":"journal article","authors":["Bates D.O.","Cui T.-G.","Doughty J.M.","Winkler M.","Sugiono M.","Shields J.D.","Peat D.","Gillatt D.","Harper S.J."],"citationCrossReferences":[{"database":"PubMed","id":"12124351"}],"title":"VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma.","publicationDate":"2002","journal":"Cancer Res.","firstPage":"4123","lastPage":"4131","volume":"62"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF165B)"],"referenceComments":[{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"CI-4GF5CQDOA55Q4","citationType":"submission","authors":["Murata H.","Fukushima J.","Hattori S.","Okuda K.","Yanagi H."],"title":"Human cDNA for the vascular endothelial growth factor isoform VEGF165.","publicationDate":"DEC-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF165)"],"referenceComments":[{"value":"Hemangioendothelioma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"CI-7DS8NM0956QO6","citationType":"submission","authors":["Sato J.D.","Whitney R.G."],"title":"Human cDNA for vascular endothelial growth factor isoform VEGF121.","publicationDate":"DEC-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF121)"]},{"referenceNumber":13,"citation":{"id":"CI-F07FU4HP6HCAK","citationType":"submission","authors":["Liu J.","Peng X.","Yuan J.","Qiang B."],"title":"Cloning of vascular endothelial growth factor (VEGF) cDNA.","publicationDate":"JUL-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF165)"]},{"referenceNumber":14,"citation":{"id":"CI-FIGMUQC61V52A","citationType":"submission","authors":["Shan Z.X.","Yu X.Y.","Lin Q.X.","Fu Y.H.","Zheng M.","Tan H.H.","Lin S.G."],"title":"Cloning and identification of vascular endothelial growth factor isoform VEGF165.","publicationDate":"FEB-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF165)"],"referenceComments":[{"value":"Heart","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"CI-C8P68G56KHOEI","citationType":"submission","authors":["Koul S.","Johnson T.","Meacham R.B.","Koul H.K."],"title":"Cloning and characterization of VEGF from LNCaP cells, a line of prostate cancer cells.","publicationDate":"SEP-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF165)"]},{"referenceNumber":16,"citation":{"id":"CI-2VSGF8C4P3FL9","citationType":"submission","authors":["Mineur P.J.","Colige A.C.","Lambert C.A."],"title":"VEGF111, a new VEGF-A variant lacking exons 5, 6 and 7.","publicationDate":"OCT-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF111)"]},{"referenceNumber":17,"citation":{"id":"19054851","citationType":"journal article","authors":["Goshima N.","Kawamura Y.","Fukumoto A.","Miura A.","Honma R.","Satoh R.","Wakamatsu A.","Yamamoto J.","Kimura K.","Nishikawa T.","Andoh T.","Iida Y.","Ishikawa K.","Ito E.","Kagawa N.","Kaminaga C.","Kanehori K.","Kawakami B.","Kenmochi K.","Kimura R.","Kobayashi M.","Kuroita T.","Kuwayama H.","Maruyama Y.","Matsuo K.","Minami K.","Mitsubori M.","Mori M.","Morishita R.","Murase A.","Nishikawa A.","Nishikawa S.","Okamoto T.","Sakagami N.","Sakamoto Y.","Sasaki Y.","Seki T.","Sono S.","Sugiyama A.","Sumiya T.","Takayama T.","Takayama Y.","Takeda H.","Togashi T.","Yahata K.","Yamada H.","Yanagisawa Y.","Endo Y.","Imamoto F.","Kisu Y.","Tanaka S.","Isogai T.","Imai J.","Watanabe S.","Nomura N."],"citationCrossReferences":[{"database":"PubMed","id":"19054851"},{"database":"DOI","id":"10.1038/nmeth.1273"}],"title":"Human protein factory for converting the transcriptome into an in vitro-expressed proteome.","publicationDate":"2008","journal":"Nat. Methods","firstPage":"1011","lastPage":"1017","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM VEGF165)"]},{"referenceNumber":18,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.R.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.S.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.E.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.N.D.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.F.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.J.C.T.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.M.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":19,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":20,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM L-VEGF121)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":21,"citation":{"id":"CI-6O51QLQIQDC3D","citationType":"submission","authoringGroup":["SeattleSNPs variation discovery resource"],"publicationDate":"OCT-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 203-395"]},{"referenceNumber":22,"citation":{"id":"7678805","citationType":"journal article","authors":["Fiebich B.L.","Jaeger B.","Schoellmann C.","Weindel K.","Wilting J.","Kochs G.","Marme D.","Hug H.","Weich H.A."],"citationCrossReferences":[{"database":"PubMed","id":"7678805"},{"database":"DOI","id":"10.1111/j.1432-1033.1993.tb19865.x"}],"title":"Synthesis and assembly of functionally active human vascular endothelial growth factor homodimers in insect cells.","publicationDate":"1993","journal":"Eur. J. Biochem.","firstPage":"19","lastPage":"26","volume":"211"},"referencePositions":["PROTEIN SEQUENCE OF 207-221"]},{"referenceNumber":23,"citation":{"id":"15340161","citationType":"journal article","authors":["Zhang Z.","Henzel W.J."],"citationCrossReferences":[{"database":"PubMed","id":"15340161"},{"database":"DOI","id":"10.1110/ps.04682504"}],"title":"Signal peptide prediction based on analysis of experimentally verified cleavage sites.","publicationDate":"2004","journal":"Protein Sci.","firstPage":"2819","lastPage":"2824","volume":"13"},"referencePositions":["PROTEIN SEQUENCE OF 207-221"]},{"referenceNumber":24,"citation":{"id":"2584205","citationType":"journal article","authors":["Connolly D.T.","Olander J.V.","Heuvelman D.","Nelson R.","Monsell R.","Siegel N.","Haymore B.L.","Leimgruber R.","Feder J."],"citationCrossReferences":[{"database":"PubMed","id":"2584205"},{"database":"DOI","id":"10.1016/s0021-9258(19)47212-8"}],"title":"Human vascular permeability factor. Isolation from U937 cells.","publicationDate":"1989","journal":"J. Biol. Chem.","firstPage":"20017","lastPage":"20024","volume":"264"},"referencePositions":["PRELIMINARY PROTEIN SEQUENCE OF 207-216; 223-230 AND 239-261"]},{"referenceNumber":25,"citation":{"id":"10067980","citationType":"journal article","authors":["Jingjing L.","Xue Y.","Agarwal N.","Roque R.S."],"citationCrossReferences":[{"database":"PubMed","id":"10067980"}],"title":"Human Muller cells express VEGF183, a novel spliced variant of vascular endothelial growth factor.","publicationDate":"1999","journal":"Invest. Ophthalmol. Vis. Sci.","firstPage":"752","lastPage":"759","volume":"40"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 294-372 (ISOFORM VEGF183)"],"referenceComments":[{"value":"Retina","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"11563986","citationType":"journal article","authors":["Tee M.K.","Jaffe R.B."],"citationCrossReferences":[{"database":"PubMed","id":"11563986"},{"database":"DOI","id":"10.1042/0264-6021:3590219"}],"title":"A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon.","publicationDate":"2001","journal":"Biochem. J.","firstPage":"219","lastPage":"226","volume":"359"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORMS L-VEGF121 AND L-VEGF165)","PROCESSING","SUBCELLULAR LOCATION"]},{"referenceNumber":27,"citation":{"id":"11427521","citationType":"journal article","authors":["Murphy J.F.","Fitzgerald D.J."],"citationCrossReferences":[{"database":"PubMed","id":"11427521"},{"database":"DOI","id":"10.1096/fj.00-0757fje"}],"title":"Vascular endothelial growth factor induces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor.","publicationDate":"2001","journal":"FASEB J.","firstPage":"1667","lastPage":"1669","volume":"15"},"referencePositions":["FUNCTION"]},{"referenceNumber":28,"citation":{"id":"11731620","citationType":"journal article","authors":["Huez I.","Bornes S.","Bresson D.","Creancier L.","Prats H."],"citationCrossReferences":[{"database":"PubMed","id":"11731620"},{"database":"DOI","id":"10.1210/mend.15.12.0738"}],"title":"New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation.","publicationDate":"2001","journal":"Mol. Endocrinol.","firstPage":"2197","lastPage":"2210","volume":"15"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM L-VEGF189)","PROCESSING","SUBCELLULAR LOCATION"]},{"referenceNumber":29,"citation":{"id":"11978667","citationType":"journal article","authors":["Awata T.","Inoue K.","Kurihara S.","Ohkubo T.","Watanabe M.","Inukai K.","Inoue I.","Katayama S."],"citationCrossReferences":[{"database":"PubMed","id":"11978667"},{"database":"DOI","id":"10.2337/diabetes.51.5.1635"}],"title":"A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes.","publicationDate":"2002","journal":"Diabetes","firstPage":"1635","lastPage":"1639","volume":"51"},"referencePositions":["INVOLVEMENT IN MVCD1"]},{"referenceNumber":30,"citation":{"id":"15520188","citationType":"journal article","authors":["Woolard J.","Wang W.-Y.","Bevan H.S.","Qiu Y.","Morbidelli L.","Pritchard-Jones R.O.","Cui T.-G.","Sugiono M.","Waine E.","Perrin R.","Foster R.","Digby-Bell J.","Shields J.D.","Whittles C.E.","Mushens R.E.","Gillatt D.A.","Ziche M.","Harper S.J.","Bates D.O."],"citationCrossReferences":[{"database":"PubMed","id":"15520188"},{"database":"DOI","id":"10.1158/0008-5472.can-04-0934"}],"title":"VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression.","publicationDate":"2004","journal":"Cancer Res.","firstPage":"7822","lastPage":"7835","volume":"64"},"referencePositions":["FUNCTION (ISOFORM VEGF165B)"]},{"referenceNumber":31,"citation":{"id":"14764596","citationType":"journal article","authors":["Bornes S.","Boulard M.","Hieblot C.","Zanibellato C.","Iacovoni J.S.","Prats H.","Touriol C."],"citationCrossReferences":[{"database":"PubMed","id":"14764596"},{"database":"DOI","id":"10.1074/jbc.m308410200"}],"title":"Control of the vascular endothelial growth factor internal ribosome entry site (IRES) activity and translation initiation by alternatively spliced coding sequences.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"18717","lastPage":"18726","volume":"279"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORMS L-VEGF121; L-VEGF165 AND L-VEGF189)"]},{"referenceNumber":32,"citation":{"id":"15896327","citationType":"journal article","authors":["Rosenbaum-Dekel Y.","Fuchs A.","Yakirevich E.","Azriel A.","Mazareb S.","Resnick M.B.","Levi B.Z."],"citationCrossReferences":[{"database":"PubMed","id":"15896327"},{"database":"DOI","id":"10.1016/j.bbrc.2005.04.123"}],"title":"Nuclear localization of long-VEGF is associated with hypoxia and tumor angiogenesis.","publicationDate":"2005","journal":"Biochem. Biophys. Res. Commun.","firstPage":"271","lastPage":"278","volume":"332"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORMS L-VEGF121 AND L-VEGF165)","PROCESSING","SUBCELLULAR LOCATION"]},{"referenceNumber":33,"citation":{"id":"16489009","citationType":"journal article","authors":["Dixelius J.","Olsson A.K.","Thulin A.","Lee C.","Johansson I.","Claesson-Welsh L."],"citationCrossReferences":[{"database":"PubMed","id":"16489009"},{"database":"DOI","id":"10.1158/0008-5472.can-05-2217"}],"title":"Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein.","publicationDate":"2006","journal":"Cancer Res.","firstPage":"2089","lastPage":"2097","volume":"66"},"referencePositions":["FUNCTION IN CELL MIGRATION"]},{"referenceNumber":34,"citation":{"id":"17446437","citationType":"journal article","authors":["Glorioso N.","Herrera V.L.","Bagamasbad P.","Filigheddu F.","Troffa C.","Argiolas G.","Bulla E.","Decano J.L.","Ruiz-Opazo N."],"citationCrossReferences":[{"database":"PubMed","id":"17446437"},{"database":"DOI","id":"10.1161/01.res.0000267716.96196.60"}],"title":"Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects.","publicationDate":"2007","journal":"Circ. Res.","firstPage":"1522","lastPage":"1529","volume":"100"},"referencePositions":["FUNCTION"]},{"referenceNumber":35,"citation":{"id":"22009797","citationType":"journal article","authors":["Shan B.","Gerez J.","Haedo M.","Fuertes M.","Theodoropoulou M.","Buchfelder M.","Losa M.","Stalla G.K.","Arzt E.","Renner U."],"citationCrossReferences":[{"database":"PubMed","id":"22009797"},{"database":"DOI","id":"10.1530/erc-11-0211"}],"title":"RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells.","publicationDate":"2012","journal":"Endocr. Relat. Cancer","firstPage":"13","lastPage":"27","volume":"19"},"referencePositions":["TISSUE SPECIFICITY","INDUCTION"]},{"referenceNumber":36,"citation":{"id":"26503042","citationType":"journal article","authors":["He W.","Bai G.","Zhou H.","Wei N.","White N.M.","Lauer J.","Liu H.","Shi Y.","Dumitru C.D.","Lettieri K.","Shubayev V.","Jordanova A.","Guergueltcheva V.","Griffin P.R.","Burgess R.W.","Pfaff S.L.","Yang X.L."],"citationCrossReferences":[{"database":"PubMed","id":"26503042"},{"database":"DOI","id":"10.1038/nature15510"}],"title":"CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.","publicationDate":"2015","journal":"Nature","firstPage":"710","lastPage":"714","volume":"526"},"referencePositions":["INTERACTION WITH NRP1"]},{"referenceNumber":37,"citation":{"id":"26789244","citationType":"journal article","authors":["He W.","Bai G.","Zhou H.","Wei N.","White N.M.","Lauer J.","Liu H.","Shi Y.","Dan Dumitru C.","Lettieri K.","Shubayev V.","Jordanova A.","Guergueltcheva V.","Griffin P.R.","Burgess R.W.","Pfaff S.L.","Yang X.L."],"citationCrossReferences":[{"database":"PubMed","id":"26789244"},{"database":"DOI","id":"10.1038/nature16499"}],"title":"Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.","publicationDate":"2016","journal":"Nature","firstPage":"402","lastPage":"402","volume":"532"},"referencePositions":["ERRATUM OF PUBMED:26503042"]},{"referenceNumber":38,"citation":{"id":"25825981","citationType":"journal article","authors":["Khayati F.","Perez-Cano L.","Maouche K.","Sadoux A.","Boutalbi Z.","Podgorniak M.P.","Maskos U.","Setterblad N.","Janin A.","Calvo F.","Lebbe C.","Menashi S.","Fernandez-Recio J.","Mourah S."],"citationCrossReferences":[{"database":"PubMed","id":"25825981"},{"database":"DOI","id":"10.18632/oncotarget.2870"}],"title":"EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF.","publicationDate":"2015","journal":"Oncotarget","firstPage":"9766","lastPage":"9780","volume":"6"},"referencePositions":["FUNCTION","INTERACTION WITH BSG"]},{"referenceNumber":39,"citation":{"id":"34530889","citationType":"journal article","authors":["Lee J.W.","Hur J.","Kwon Y.W.","Chae C.W.","Choi J.I.","Hwang I.","Yun J.Y.","Kang J.A.","Choi Y.E.","Kim Y.H.","Lee S.E.","Lee C.","Jo D.H.","Seok H.","Cho B.S.","Baek S.H.","Kim H.S."],"citationCrossReferences":[{"database":"PubMed","id":"34530889"},{"database":"DOI","id":"10.1186/s13045-021-01147-6"}],"title":"KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state.","publicationDate":"2021","journal":"J. Hematol. Oncol.","firstPage":"148","lastPage":"148","volume":"14"},"referencePositions":["FUNCTION","INTERACTION WITH CD82"]},{"referenceNumber":40,"citation":{"id":"35455969","citationType":"journal article","authors":["Katsman M.","Azriel A.","Horev G.","Reizel Y.","Levi B.Z."],"citationCrossReferences":[{"database":"PubMed","id":"35455969"},{"database":"DOI","id":"10.3390/cells11081289"}],"title":"N-VEGF, the Autoregulatory Arm of VEGF-A.","publicationDate":"2022","journal":"Cells","firstPage":"0","lastPage":"0","volume":"11"},"referencePositions":["FUNCTION (N-VEGF)","SUBCELLULAR LOCATION (N-VEGF)"]},{"referenceNumber":41,"citation":{"id":"9207067","citationType":"journal article","authors":["Muller Y.A.","Li B.","Christinger H.W.","Wells J.A.","Cunningham B.C.","de Vos A.M."],"citationCrossReferences":[{"database":"PubMed","id":"9207067"},{"database":"DOI","id":"10.1073/pnas.94.14.7192"}],"title":"Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.","publicationDate":"1997","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"7192","lastPage":"7197","volume":"94"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 214-315"]},{"referenceNumber":42,"citation":{"id":"9336848","citationType":"journal article","authors":["Fairbrother W.J.","Champe M.A.","Christinger H.W.","Keyt B.A.","Starovasnik M.A."],"citationCrossReferences":[{"database":"PubMed","id":"9336848"},{"database":"DOI","id":"10.1002/pro.5560061020"}],"title":"1H, 13C, and 15N backbone assignment and secondary structure of the receptor-binding domain of vascular endothelial growth factor.","publicationDate":"1997","journal":"Protein Sci.","firstPage":"2250","lastPage":"2260","volume":"6"},"referencePositions":["STRUCTURE BY NMR OF 214-315"]},{"referenceNumber":43,"citation":{"id":"9351807","citationType":"journal article","authors":["Muller Y.A.","Christinger H.W.","Keyt B.A.","de Vos A.M."],"citationCrossReferences":[{"database":"PubMed","id":"9351807"},{"database":"DOI","id":"10.1016/s0969-2126(97)00284-0"}],"title":"The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93-A resolution: multiple copy flexibility and receptor binding.","publicationDate":"1997","journal":"Structure","firstPage":"1325","lastPage":"1338","volume":"5"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) OF 214-315"]},{"referenceNumber":44,"citation":{"id":"9922142","citationType":"journal article","authors":["Wiesmann C.","Christinger H.W.","Cochran A.G.","Cunningham B.C.","Fairbrother W.J.","Keenan C.J.","Meng G.","de Vos A.M."],"citationCrossReferences":[{"database":"PubMed","id":"9922142"},{"database":"DOI","id":"10.1021/bi9819327"}],"title":"Crystal structure of the complex between VEGF and a receptor-blocking peptide.","publicationDate":"1998","journal":"Biochemistry","firstPage":"17765","lastPage":"17772","volume":"37"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 219-314"]},{"referenceNumber":45,"citation":{"id":"9634701","citationType":"journal article","authors":["Fairbrother W.J.","Champe M.A.","Christinger H.W.","Keyt B.A.","Starovasnik M.A."],"citationCrossReferences":[{"database":"PubMed","id":"9634701"},{"database":"DOI","id":"10.1016/s0969-2126(98)00065-3"}],"title":"Solution structure of the heparin-binding domain of vascular endothelial growth factor.","publicationDate":"1998","journal":"Structure","firstPage":"637","lastPage":"648","volume":"6"},"referencePositions":["STRUCTURE BY NMR OF 317-378"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M32977","properties":[{"key":"ProteinId","value":"AAA35789.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M27281","properties":[{"key":"ProteinId","value":"AAA36807.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M63978","properties":[{"key":"ProteinId","value":"AAA36804.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M63971","properties":[{"key":"ProteinId","value":"AAA36804.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M63972","properties":[{"key":"ProteinId","value":"AAA36804.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M63973","properties":[{"key":"ProteinId","value":"AAA36804.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M63974","properties":[{"key":"ProteinId","value":"AAA36804.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M63975","properties":[{"key":"ProteinId","value":"AAA36804.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M63976","properties":[{"key":"ProteinId","value":"AAA36804.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M63977","properties":[{"key":"ProteinId","value":"AAA36804.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"S85192","properties":[{"key":"ProteinId","value":"AAC63102.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AH006909","properties":[{"key":"ProteinId","value":"AAC63101.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X62568","properties":[{"key":"ProteinId","value":"CAA44447.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ010438","properties":[{"key":"ProteinId","value":"CAA09179.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF022375","properties":[{"key":"ProteinId","value":"AAC63143.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF091352","properties":[{"key":"ProteinId","value":"AAD55345.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF430806","properties":[{"key":"ProteinId","value":"AAL27435.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB021221","properties":[{"key":"ProteinId","value":"BAA78418.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF214570","properties":[{"key":"ProteinId","value":"AAF19659.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY047581","properties":[{"key":"ProteinId","value":"AAK95847.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF486837","properties":[{"key":"ProteinId","value":"AAM03108.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY766116","properties":[{"key":"ProteinId","value":"AAV34601.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ229900","properties":[{"key":"ProteinId","value":"ABB58912.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB451322","properties":[{"key":"ProteinId","value":"BAG70136.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB451451","properties":[{"key":"ProteinId","value":"BAG70265.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL136131","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471081","properties":[{"key":"ProteinId","value":"EAX04229.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC065522","properties":[{"key":"ProteinId","value":"AAH65522.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF437895","properties":[{"key":"ProteinId","value":"AAL27630.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF062645","properties":[{"key":"ProteinId","value":"AAC16730.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS34457.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-14"},{"database":"CCDS","id":"CCDS34458.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-11"},{"database":"CCDS","id":"CCDS47432.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-15"},{"database":"CCDS","id":"CCDS47433.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-16"},{"database":"CCDS","id":"CCDS47434.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-12"},{"database":"CCDS","id":"CCDS47435.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-17"},{"database":"CCDS","id":"CCDS4907.2","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-13"},{"database":"CCDS","id":"CCDS55007.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-18"},{"database":"CCDS","id":"CCDS55008.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-3"},{"database":"CCDS","id":"CCDS55009.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-2"},{"database":"CCDS","id":"CCDS55010.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-1"},{"database":"CCDS","id":"CCDS55011.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-5"},{"database":"CCDS","id":"CCDS55012.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-4"},{"database":"CCDS","id":"CCDS55013.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-8"},{"database":"CCDS","id":"CCDS55014.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-9"},{"database":"CCDS","id":"CCDS55015.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-10"},{"database":"PIR","id":"A41551","properties":[{"key":"EntryName","value":"A41551"}]},{"database":"RefSeq","id":"NP_001020537.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001025366.3"}],"isoformId":"P15692-14"},{"database":"RefSeq","id":"NP_001020538.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001025367.3"}],"isoformId":"P15692-16"},{"database":"RefSeq","id":"NP_001020539.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001025368.3"}],"isoformId":"P15692-11"},{"database":"RefSeq","id":"NP_001020540.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001025369.3"}],"isoformId":"P15692-17"},{"database":"RefSeq","id":"NP_001020541.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001025370.3"}],"isoformId":"P15692-12"},{"database":"RefSeq","id":"NP_001028928.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001033756.3"}],"isoformId":"P15692-15"},{"database":"RefSeq","id":"NP_001165093.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001171622.2"}],"isoformId":"P15692-18"},{"database":"RefSeq","id":"NP_001165094.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001171623.2"}],"isoformId":"P15692-1"},{"database":"RefSeq","id":"NP_001165095.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001171624.2"}],"isoformId":"P15692-2"},{"database":"RefSeq","id":"NP_001165096.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001171625.2"}],"isoformId":"P15692-3"},{"database":"RefSeq","id":"NP_001165097.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001171626.2"}],"isoformId":"P15692-4"},{"database":"RefSeq","id":"NP_001165098.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001171627.2"}],"isoformId":"P15692-5"},{"database":"RefSeq","id":"NP_001165099.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001171628.2"}],"isoformId":"P15692-9"},{"database":"RefSeq","id":"NP_001165100.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001171629.2"}],"isoformId":"P15692-8"},{"database":"RefSeq","id":"NP_001165101.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001171630.2"}],"isoformId":"P15692-10"},{"database":"RefSeq","id":"NP_001191313.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204384.2"}],"isoformId":"P15692-6"},{"database":"RefSeq","id":"NP_001191314.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204385.2"}]},{"database":"RefSeq","id":"NP_001273973.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001287044.2"}]},{"database":"RefSeq","id":"NP_001303939.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001317010.2"}]},{"database":"RefSeq","id":"NP_003367.4","properties":[{"key":"NucleotideSequenceId","value":"NM_003376.6"}],"isoformId":"P15692-13"},{"database":"PDB","id":"1BJ1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"V/W=214-315"}]},{"database":"PDB","id":"1CZ8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"V/W=220-313"}]},{"database":"PDB","id":"1FLT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"V/W=218-315"}]},{"database":"PDB","id":"1KAT","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"V/W=217-315"}]},{"database":"PDB","id":"1KMX","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=346-395"}]},{"database":"PDB","id":"1MJV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=220-314"}]},{"database":"PDB","id":"1MKG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D=220-314"}]},{"database":"PDB","id":"1MKK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.32 A"},{"key":"Chains","value":"A/B=220-314"}]},{"database":"PDB","id":"1QTY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"R/S/V/W=214-315"}]},{"database":"PDB","id":"1TZH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"V/W=214-315"}]},{"database":"PDB","id":"1TZI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"V=214-315"}]},{"database":"PDB","id":"1VGH","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=346-395"}]},{"database":"PDB","id":"1VPF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D=214-315"}]},{"database":"PDB","id":"1VPP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"V/W=214-315"}]},{"database":"PDB","id":"2FJG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"V/W=214-315"}]},{"database":"PDB","id":"2FJH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"V/W=214-315"}]},{"database":"PDB","id":"2QR0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"C/D/I/J/O/P/U/V=219-315"}]},{"database":"PDB","id":"2VGH","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=346-395"}]},{"database":"PDB","id":"2VPF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.93 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=214-315"}]},{"database":"PDB","id":"3BDY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"V=214-315"}]},{"database":"PDB","id":"3P9W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.41 A"},{"key":"Chains","value":"A/C/E/G=215-318"}]},{"database":"PDB","id":"3QTK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B/C/D/E/F=214-315"}]},{"database":"PDB","id":"3S1B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"V=218-313"}]},{"database":"PDB","id":"3S1K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"V/W=214-315"}]},{"database":"PDB","id":"3V2A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=207-320"}]},{"database":"PDB","id":"4DEQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"A/B=346-395"}]},{"database":"PDB","id":"4GLN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"E/F=214-315"}]},{"database":"PDB","id":"4GLS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"E/F=214-315"}]},{"database":"PDB","id":"4KZN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.71 A"},{"key":"Chains","value":"A=219-315"}]},{"database":"PDB","id":"4QAF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"C/D=214-315"}]},{"database":"PDB","id":"4WPB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.11 A"},{"key":"Chains","value":"A/B=214-315"}]},{"database":"PDB","id":"4ZFF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"C/D=217-315"}]},{"database":"PDB","id":"5DN2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"E/F/G=368-395"}]},{"database":"PDB","id":"5FV1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"V/W=207-316"}]},{"database":"PDB","id":"5FV2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.45 A"},{"key":"Chains","value":"V/W/X=207-316"}]},{"database":"PDB","id":"5HHC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=214-315"}]},{"database":"PDB","id":"5HHD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=214-315"}]},{"database":"PDB","id":"5O4E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"E/F=219-314"}]},{"database":"PDB","id":"5T89","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"V/W=207-321"}]},{"database":"PDB","id":"6BFT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"C/G=216-315"}]},{"database":"PDB","id":"6D3O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B=214-315"}]},{"database":"PDB","id":"6T9D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"CCC/DDD=207-321"}]},{"database":"PDB","id":"6V7K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B=214-315"}]},{"database":"PDB","id":"6Z13","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"V/W=219-313"}]},{"database":"PDB","id":"6Z3F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"V/W=219-313"}]},{"database":"PDB","id":"6ZBR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"V/W=219-313"}]},{"database":"PDB","id":"6ZCD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"V/W=219-313"}]},{"database":"PDB","id":"6ZFL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"V/W=219-313"}]},{"database":"PDB","id":"7KEZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.31 A"},{"key":"Chains","value":"V=207-316"}]},{"database":"PDB","id":"7KF0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.32 A"},{"key":"Chains","value":"C/V=207-316"}]},{"database":"PDB","id":"7KF1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"C/F/J/V=207-316"}]},{"database":"PDB","id":"7LL8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.31 A"},{"key":"Chains","value":"A/B=214-315"}]},{"database":"PDB","id":"7LL9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A/B/E/F=214-315"}]},{"database":"PDB","id":"8UWZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"E/F=207-321"}]},{"database":"PDB","id":"9JU1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A=214-315"}]},{"database":"PDB","id":"9KKU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.46 A"},{"key":"Chains","value":"A/B=214-315"}]},{"database":"PDBsum","id":"1BJ1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1CZ8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FLT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1KAT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1KMX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1MJV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1MKG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1MKK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1QTY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1TZH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1TZI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1VGH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1VPF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1VPP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2FJG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2FJH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2QR0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2VGH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2VPF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3BDY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3P9W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3QTK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3S1B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3S1K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3V2A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DEQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4GLN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4GLS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4KZN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4QAF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4WPB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4ZFF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5DN2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5FV1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5FV2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5HHC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5HHD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5O4E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5T89","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6BFT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6D3O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6T9D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V7K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Z13","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Z3F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ZBR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ZCD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ZFL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KEZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KF0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KF1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7LL8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7LL9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UWZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JU1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9KKU","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"113265","properties":[{"key":"Interactions","value":"68"}]},{"database":"ComplexPortal","id":"CPX-1977","properties":[{"key":"EntryName","value":"Vascular endothelial growth factor A complex"}]},{"database":"CORUM","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-5740N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P15692","properties":[{"key":"Number of interactors","value":"1102"}]},{"database":"IntAct","id":"P15692","properties":[{"key":"Interactions","value":"33"}]},{"database":"MINT","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-VEGFA","properties":[{"key":"Evidences","value":"72 NDEx IQuery Curated Pathways"}]},{"database":"BindingDB","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1783","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB05434","properties":[{"key":"GenericName","value":"ABT-510"}]},{"database":"DrugBank","id":"DB08885","properties":[{"key":"GenericName","value":"Aflibercept"}]},{"database":"DrugBank","id":"DB00112","properties":[{"key":"GenericName","value":"Bevacizumab"}]},{"database":"DrugBank","id":"DB06642","properties":[{"key":"GenericName","value":"Bevasiranib"}]},{"database":"DrugBank","id":"DB14864","properties":[{"key":"GenericName","value":"Brolucizumab"}]},{"database":"DrugBank","id":"DB01136","properties":[{"key":"GenericName","value":"Carvedilol"}]},{"database":"DrugBank","id":"DB09301","properties":[{"key":"GenericName","value":"Chondroitin sulfate"}]},{"database":"DrugBank","id":"DB06779","properties":[{"key":"GenericName","value":"Dalteparin"}]},{"database":"DrugBank","id":"DB05932","properties":[{"key":"GenericName","value":"Denibulin"}]},{"database":"DrugBank","id":"DB18010","properties":[{"key":"GenericName","value":"Emvododstat"}]},{"database":"DrugBank","id":"DB15303","properties":[{"key":"GenericName","value":"Faricimab"}]},{"database":"DrugBank","id":"DB10772","properties":[{"key":"GenericName","value":"Foreskin keratinocyte (neonatal)"}]},{"database":"DrugBank","id":"DB01120","properties":[{"key":"GenericName","value":"Gliclazide"}]},{"database":"DrugBank","id":"DB18931","properties":[{"key":"GenericName","value":"Ivonescimab"}]},{"database":"DrugBank","id":"DB01017","properties":[{"key":"GenericName","value":"Minocycline"}]},{"database":"DrugBank","id":"DB12818","properties":[{"key":"GenericName","value":"NM-3"}]},{"database":"DrugBank","id":"DB04895","properties":[{"key":"GenericName","value":"Pegaptanib"}]},{"database":"DrugBank","id":"DB03088","properties":[{"key":"GenericName","value":"Pidolic acid"}]},{"database":"DrugBank","id":"DB01270","properties":[{"key":"GenericName","value":"Ranibizumab"}]},{"database":"DrugBank","id":"DB14911","properties":[{"key":"GenericName","value":"Risuteganib"}]},{"database":"DrugBank","id":"DB05969","properties":[{"key":"GenericName","value":"SNS-032"}]},{"database":"DrugBank","id":"DB06461","properties":[{"key":"GenericName","value":"Squalamine"}]},{"database":"DrugBank","id":"DB05075","properties":[{"key":"GenericName","value":"TG-100801"}]},{"database":"DrugBank","id":"DB05294","properties":[{"key":"GenericName","value":"Vandetanib"}]},{"database":"DrugBank","id":"DB12317","properties":[{"key":"GenericName","value":"Vanucizumab"}]},{"database":"DrugBank","id":"DB05890","properties":[{"key":"GenericName","value":"Veglin"}]},{"database":"DrugCentral","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"MoonDB","id":"P15692","properties":[{"key":"Type","value":"Predicted"}]},{"database":"TCDB","id":"8.A.245.1.1","properties":[{"key":"FamilyName","value":"the vascular endothelial growth factor (vegf) family"}]},{"database":"GlyCosmos","id":"P15692","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GlyGen","id":"P15692","properties":[{"key":"glycosylation","value":"1 site, 1 N-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"VEGFA","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"17380528","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"34350","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"34645","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"34652","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"34682","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"35749","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"40743","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"53195","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-1"},{"database":"ProteomicsDB","id":"53196","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-10"},{"database":"ProteomicsDB","id":"53197","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-11"},{"database":"ProteomicsDB","id":"53198","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-12"},{"database":"ProteomicsDB","id":"53199","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-13"},{"database":"ProteomicsDB","id":"53200","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-14"},{"database":"ProteomicsDB","id":"53201","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-2"},{"database":"ProteomicsDB","id":"53202","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-3"},{"database":"ProteomicsDB","id":"53203","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-4"},{"database":"ProteomicsDB","id":"53204","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-5"},{"database":"ProteomicsDB","id":"53205","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-6"},{"database":"ProteomicsDB","id":"53206","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-8"},{"database":"ProteomicsDB","id":"53207","properties":[{"key":"Description","value":"-"}],"isoformId":"P15692-9"},{"database":"ABCD","id":"P15692","properties":[{"key":"antibodies","value":"52 sequenced antibodies"}]},{"database":"Antibodypedia","id":"3956","properties":[{"key":"antibodies","value":"2880 antibodies from 57 providers"}]},{"database":"CPTC","id":"P15692","properties":[{"key":"antibodies","value":"1 antibody"}]},{"database":"DNASU","id":"7422","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000324450.11","properties":[{"key":"ProteinId","value":"ENSP00000317598.7"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-18"},{"database":"Ensembl","id":"ENST00000372055.9","properties":[{"key":"ProteinId","value":"ENSP00000361125.5"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-14"},{"database":"Ensembl","id":"ENST00000372064.9","properties":[{"key":"ProteinId","value":"ENSP00000361134.5"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-12"},{"database":"Ensembl","id":"ENST00000372067.8","properties":[{"key":"ProteinId","value":"ENSP00000361137.4"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-11"},{"database":"Ensembl","id":"ENST00000372077.8","properties":[{"key":"ProteinId","value":"ENSP00000361148.4"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-9"},{"database":"Ensembl","id":"ENST00000413642.8","properties":[{"key":"ProteinId","value":"ENSP00000389864.4"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-16"},{"database":"Ensembl","id":"ENST00000417285.7","properties":[{"key":"ProteinId","value":"ENSP00000388663.3"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-17"},{"database":"Ensembl","id":"ENST00000457104.6","properties":[{"key":"ProteinId","value":"ENSP00000409911.2"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-10"},{"database":"Ensembl","id":"ENST00000482630.7","properties":[{"key":"ProteinId","value":"ENSP00000421561.2"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-15"},{"database":"Ensembl","id":"ENST00000518689.5","properties":[{"key":"ProteinId","value":"ENSP00000430829.1"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-3"},{"database":"Ensembl","id":"ENST00000518824.5","properties":[{"key":"ProteinId","value":"ENSP00000430002.1"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-8"},{"database":"Ensembl","id":"ENST00000520948.5","properties":[{"key":"ProteinId","value":"ENSP00000428321.1"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-2"},{"database":"Ensembl","id":"ENST00000523125.5","properties":[{"key":"ProteinId","value":"ENSP00000429008.1"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-5"},{"database":"Ensembl","id":"ENST00000523873.5","properties":[{"key":"ProteinId","value":"ENSP00000430479.1"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-1"},{"database":"Ensembl","id":"ENST00000523950.5","properties":[{"key":"ProteinId","value":"ENSP00000429643.1"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-4"},{"database":"Ensembl","id":"ENST00000672860.3","properties":[{"key":"ProteinId","value":"ENSP00000500082.3"},{"key":"GeneId","value":"ENSG00000112715.26"}],"isoformId":"P15692-13"},{"database":"GeneID","id":"7422","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:7422","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000672860.3","properties":[{"key":"ProteinId","value":"ENSP00000500082.3"},{"key":"RefSeqNucleotideId","value":"NM_003376.6"},{"key":"RefSeqProteinId","value":"NP_003367.4"}]},{"database":"UCSC","id":"uc003owd.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P15692-13"},{"database":"AGR","id":"HGNC:12680","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"7422","properties":[{"key":"Number of evidences","value":"15 evidence items across 9 molecular profiles"}]},{"database":"ClinPGx","id":"PA37302","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"7422","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"7422","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"VEGFA","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:12680","properties":[{"key":"GeneName","value":"VEGFA"}]},{"database":"HPA","id":"ENSG00000112715","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"VEGFA","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"192240","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"603933","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000112715","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000112715","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QVI8","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157284","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_042996_3_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HDLECEC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6370328at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P15692","properties":[{"key":"Number of GO annotations","value":"10 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-114608","properties":[{"key":"PathwayName","value":"Platelet degranulation"}]},{"database":"Reactome","id":"R-HSA-1234158","properties":[{"key":"PathwayName","value":"Regulation of gene expression by Hypoxia-inducible Factor"}]},{"database":"Reactome","id":"R-HSA-194138","properties":[{"key":"PathwayName","value":"Signaling by VEGF"}]},{"database":"Reactome","id":"R-HSA-194313","properties":[{"key":"PathwayName","value":"VEGF ligand-receptor interactions"}]},{"database":"Reactome","id":"R-HSA-195399","properties":[{"key":"PathwayName","value":"VEGF binds to VEGFR leading to receptor dimerization"}]},{"database":"Reactome","id":"R-HSA-4420097","properties":[{"key":"PathwayName","value":"VEGFA-VEGFR2 Pathway"}],"isoformId":"P15692-4"},{"database":"Reactome","id":"R-HSA-5218921","properties":[{"key":"PathwayName","value":"VEGFR2 mediated cell proliferation"}],"isoformId":"P15692-4"},{"database":"Reactome","id":"R-HSA-6785807","properties":[{"key":"PathwayName","value":"Interleukin-4 and Interleukin-13 signaling"}]},{"database":"Reactome","id":"R-HSA-8866910","properties":[{"key":"PathwayName","value":"TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"}]},{"database":"Reactome","id":"R-HSA-9679191","properties":[{"key":"PathwayName","value":"Potential therapeutics for SARS"}],"isoformId":"P15692-4"},{"database":"SignaLink","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000112715","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"7422","properties":[{"key":"hits","value":"14 hits in 1166 CRISPR screens"}]},{"database":"ChiTaRS","id":"VEGFA","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P15692","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Vascular_endothelial_growth_factor_A","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"7422","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P15692","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P15692","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"P15692","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000112715","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lobe of thyroid gland and 203 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P15692","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005912","properties":[{"key":"GoTerm","value":"C:adherens junction"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26598555"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17470632"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17082651"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11731620"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14570917"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16490744"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11731620"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15896327"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35455969"}]},{"database":"GO","id":"GO:0031093","properties":[{"key":"GoTerm","value":"C:platelet alpha granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030141","properties":[{"key":"GoTerm","value":"C:secretory granule"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17082651"}]},{"database":"GO","id":"GO:1990150","properties":[{"key":"GoTerm","value":"C:VEGF-A complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12207021"}]},{"database":"GO","id":"GO:0042056","properties":[{"key":"GoTerm","value":"F:chemoattractant activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17082651"}]},{"database":"GO","id":"GO:0005125","properties":[{"key":"GoTerm","value":"F:cytokine activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18440775"}]},{"database":"GO","id":"GO:0050840","properties":[{"key":"GoTerm","value":"F:extracellular matrix binding"},{"key":"GoEvidenceType","value":"IC:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"14570917"}]},{"database":"GO","id":"GO:0001968","properties":[{"key":"GoTerm","value":"F:fibronectin binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14570917"}]},{"database":"GO","id":"GO:0008083","properties":[{"key":"GoTerm","value":"F:growth factor activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20497126"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9202027"}]},{"database":"GO","id":"GO:0008201","properties":[{"key":"GoTerm","value":"F:heparin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15001987"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12207021"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25132001"}]},{"database":"GO","id":"GO:0038191","properties":[{"key":"GoTerm","value":"F:neuropilin binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}]},{"database":"GO","id":"GO:0005161","properties":[{"key":"GoTerm","value":"F:platelet-derived growth factor receptor binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"17470632"}]},{"database":"GO","id":"GO:0048018","properties":[{"key":"GoTerm","value":"F:receptor ligand activity"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23083510"}]},{"database":"GO","id":"GO:0030297","properties":[{"key":"GoTerm","value":"F:transmembrane receptor protein tyrosine kinase activator activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20497126"}]},{"database":"GO","id":"GO:0043183","properties":[{"key":"GoTerm","value":"F:vascular endothelial growth factor receptor 1 binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"1312256"}]},{"database":"GO","id":"GO:0043184","properties":[{"key":"GoTerm","value":"F:vascular endothelial growth factor receptor 2 binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25825981"}]},{"database":"GO","id":"GO:0005172","properties":[{"key":"GoTerm","value":"F:vascular endothelial growth factor receptor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10471394"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"11513746"}]},{"database":"GO","id":"GO:0001525","properties":[{"key":"GoTerm","value":"P:angiogenesis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11427521"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21771332"}]},{"database":"GO","id":"GO:0048844","properties":[{"key":"GoTerm","value":"P:artery morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0002575","properties":[{"key":"GoTerm","value":"P:basophil chemotaxis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0001569","properties":[{"key":"GoTerm","value":"P:branching involved in blood vessel morphogenesis"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23083510"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23688497"}]},{"database":"GO","id":"GO:0048593","properties":[{"key":"GoTerm","value":"P:camera-type eye morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0055013","properties":[{"key":"GoTerm","value":"P:cardiac muscle cell development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0060948","properties":[{"key":"GoTerm","value":"P:cardiac vascular smooth muscle cell development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0048469","properties":[{"key":"GoTerm","value":"P:cell maturation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0002042","properties":[{"key":"GoTerm","value":"P:cell migration involved in sprouting angiogenesis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20660291"}]},{"database":"GO","id":"GO:0071456","properties":[{"key":"GoTerm","value":"P:cellular response to hypoxia"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10575000"}]},{"database":"GO","id":"GO:0035924","properties":[{"key":"GoTerm","value":"P:cellular response to vascular endothelial growth factor stimulus"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18440775"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20497126"}]},{"database":"GO","id":"GO:0097533","properties":[{"key":"GoTerm","value":"P:cellular stress response to acid chemical"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26299712"}]},{"database":"GO","id":"GO:0071679","properties":[{"key":"GoTerm","value":"P:commissural neuron axon guidance"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0060982","properties":[{"key":"GoTerm","value":"P:coronary artery morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0003169","properties":[{"key":"GoTerm","value":"P:coronary vein morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0071542","properties":[{"key":"GoTerm","value":"P:dopaminergic neuron differentiation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0035767","properties":[{"key":"GoTerm","value":"P:endothelial cell chemotaxis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18440775"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21245381"}]},{"database":"GO","id":"GO:0030855","properties":[{"key":"GoTerm","value":"P:epithelial cell differentiation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0042462","properties":[{"key":"GoTerm","value":"P:eye photoreceptor cell development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0003007","properties":[{"key":"GoTerm","value":"P:heart morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0001701","properties":[{"key":"GoTerm","value":"P:in utero embryonic development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0050930","properties":[{"key":"GoTerm","value":"P:induction of positive chemotaxis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0001822","properties":[{"key":"GoTerm","value":"P:kidney development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0007595","properties":[{"key":"GoTerm","value":"P:lactation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0030324","properties":[{"key":"GoTerm","value":"P:lung development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0036303","properties":[{"key":"GoTerm","value":"P:lymph vessel morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0030225","properties":[{"key":"GoTerm","value":"P:macrophage differentiation"},{"key":"GoEvidenceType","value":"IDA:DFLAT"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21149635"}]},{"database":"GO","id":"GO:0060749","properties":[{"key":"GoTerm","value":"P:mammary gland alveolus development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0007498","properties":[{"key":"GoTerm","value":"P:mesoderm development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0030224","properties":[{"key":"GoTerm","value":"P:monocyte differentiation"},{"key":"GoEvidenceType","value":"IDA:DFLAT"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21149635"}]},{"database":"GO","id":"GO:0097475","properties":[{"key":"GoTerm","value":"P:motor neuron migration"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1903392","properties":[{"key":"GoTerm","value":"P:negative regulation of adherens junction organization"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26598555"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10066377"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11461089"}]},{"database":"GO","id":"GO:1905604","properties":[{"key":"GoTerm","value":"P:negative regulation of blood-brain barrier permeability"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19148554"}]},{"database":"GO","id":"GO:2000048","properties":[{"key":"GoTerm","value":"P:negative regulation of cell-cell adhesion mediated by cadherin"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26598555"}]},{"database":"GO","id":"GO:0010719","properties":[{"key":"GoTerm","value":"P:negative regulation of epithelial to mesenchymal transition"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1903141","properties":[{"key":"GoTerm","value":"P:negative regulation of establishment of endothelial barrier"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20048167"}]},{"database":"GO","id":"GO:0010629","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28977001"}]},{"database":"GO","id":"GO:1902894","properties":[{"key":"GoTerm","value":"P:negative regulation of miRNA transcription"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23878390"}]},{"database":"GO","id":"GO:0141151","properties":[{"key":"GoTerm","value":"P:negative regulation of nitric oxide-cGMP mediated signal transduction"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16150726"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18093989"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"15351965"}]},{"database":"GO","id":"GO:0003151","properties":[{"key":"GoTerm","value":"P:outflow tract morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0001541","properties":[{"key":"GoTerm","value":"P:ovarian follicle development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0007200","properties":[{"key":"GoTerm","value":"P:phospholipase C-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18059339"}]},{"database":"GO","id":"GO:0050918","properties":[{"key":"GoTerm","value":"P:positive chemotaxis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20497126"}]},{"database":"GO","id":"GO:0045766","properties":[{"key":"GoTerm","value":"P:positive regulation of angiogenesis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19033661"}]},{"database":"GO","id":"GO:0048842","properties":[{"key":"GoTerm","value":"P:positive regulation of axon extension involved in axon guidance"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:1905555","properties":[{"key":"GoTerm","value":"P:positive regulation of blood vessel branching"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20123964"}]},{"database":"GO","id":"GO:0043536","properties":[{"key":"GoTerm","value":"P:positive regulation of blood vessel endothelial cell migration"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18440775"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20497126"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9202027"}]},{"database":"GO","id":"GO:1903589","properties":[{"key":"GoTerm","value":"P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30106099"}]},{"database":"GO","id":"GO:0090190","properties":[{"key":"GoTerm","value":"P:positive regulation of branching involved in ureteric bud morphogenesis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0043123","properties":[{"key":"GoTerm","value":"P:positive regulation of canonical NF-kappaB signal transduction"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23878390"}]},{"database":"GO","id":"GO:0045785","properties":[{"key":"GoTerm","value":"P:positive regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19674970"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17470632"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7929439"}]},{"database":"GO","id":"GO:0090050","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration involved in sprouting angiogenesis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18059339"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20551324"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7929439"}]},{"database":"GO","id":"GO:0038091","properties":[{"key":"GoTerm","value":"P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17470632"}]},{"database":"GO","id":"GO:0120162","properties":[{"key":"GoTerm","value":"P:positive regulation of cold-induced thermogenesis"},{"key":"GoEvidenceType","value":"ISS:YuBioLab"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"26683794"}]},{"database":"GO","id":"GO:2000573","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA biosynthetic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:2001028","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelial cell chemotaxis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20497126"}]},{"database":"GO","id":"GO:0038033","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31915155"}]},{"database":"GO","id":"GO:0010595","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelial cell migration"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19033661"}]},{"database":"GO","id":"GO:0001938","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelial cell proliferation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16489009"}]},{"database":"GO","id":"GO:0050679","properties":[{"key":"GoTerm","value":"P:positive regulation of epithelial cell proliferation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:1905278","properties":[{"key":"GoTerm","value":"P:positive regulation of epithelial tube formation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0070374","properties":[{"key":"GoTerm","value":"P:positive regulation of ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0051894","properties":[{"key":"GoTerm","value":"P:positive regulation of focal adhesion assembly"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16489009"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0002687","properties":[{"key":"GoTerm","value":"P:positive regulation of leukocyte migration"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1312256"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18440775"}]},{"database":"GO","id":"GO:0060754","properties":[{"key":"GoTerm","value":"P:positive regulation of mast cell chemotaxis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0002052","properties":[{"key":"GoTerm","value":"P:positive regulation of neuroblast proliferation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0051897","properties":[{"key":"GoTerm","value":"P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0050927","properties":[{"key":"GoTerm","value":"P:positive regulation of positive chemotaxis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12744932"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7929439"}]},{"database":"GO","id":"GO:0031954","properties":[{"key":"GoTerm","value":"P:positive regulation of protein autophosphorylation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:1902966","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to early endosome"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0001934","properties":[{"key":"GoTerm","value":"P:positive regulation of protein phosphorylation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19033661"}]},{"database":"GO","id":"GO:0031334","properties":[{"key":"GoTerm","value":"P:positive regulation of protein-containing complex assembly"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19033661"}]},{"database":"GO","id":"GO:0002092","properties":[{"key":"GoTerm","value":"P:positive regulation of receptor internalization"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20660291"}]},{"database":"GO","id":"GO:1903672","properties":[{"key":"GoTerm","value":"P:positive regulation of sprouting angiogenesis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26299712"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18059339"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20497126"}]},{"database":"GO","id":"GO:1901165","properties":[{"key":"GoTerm","value":"P:positive regulation of trophoblast cell migration"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23083510"}]},{"database":"GO","id":"GO:1900748","properties":[{"key":"GoTerm","value":"P:positive regulation of vascular endothelial growth factor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23688497"}]},{"database":"GO","id":"GO:0043117","properties":[{"key":"GoTerm","value":"P:positive regulation of vascular permeability"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26598555"}]},{"database":"GO","id":"GO:0031077","properties":[{"key":"GoTerm","value":"P:post-embryonic camera-type eye development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0060319","properties":[{"key":"GoTerm","value":"P:primitive erythrocyte differentiation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0008360","properties":[{"key":"GoTerm","value":"P:regulation of cell shape"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10527820"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7929439"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}]},{"database":"GO","id":"GO:0001666","properties":[{"key":"GoTerm","value":"P:response to hypoxia"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16490744"}]},{"database":"GO","id":"GO:0031290","properties":[{"key":"GoTerm","value":"P:retinal ganglion cell axon guidance"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0002040","properties":[{"key":"GoTerm","value":"P:sprouting angiogenesis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0043129","properties":[{"key":"GoTerm","value":"P:surfactant homeostasis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0035148","properties":[{"key":"GoTerm","value":"P:tube formation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19033661"}]},{"database":"GO","id":"GO:0048010","properties":[{"key":"GoTerm","value":"P:vascular endothelial growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312256"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18059339"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18440775"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21245381"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7929439"}]},{"database":"GO","id":"GO:0036324","properties":[{"key":"GoTerm","value":"P:vascular endothelial growth factor receptor-2 signaling pathway"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23688497"}]},{"database":"GO","id":"GO:0038084","properties":[{"key":"GoTerm","value":"P:vascular endothelial growth factor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20660291"}]},{"database":"GO","id":"GO:0061042","properties":[{"key":"GoTerm","value":"P:vascular wound healing"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23688497"}]},{"database":"GO","id":"GO:0001570","properties":[{"key":"GoTerm","value":"P:vasculogenesis"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"15015550"}]},{"database":"GO","id":"GO:0038190","properties":[{"key":"GoTerm","value":"P:VEGF-activated neuropilin signaling pathway"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}]},{"database":"CDD","id":"cd00135","properties":[{"key":"EntryName","value":"PDGF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.160.10:FF:000001","properties":[{"key":"EntryName","value":"Vascular endothelial growth factor A"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.90.10:FF:000009","properties":[{"key":"EntryName","value":"Vascular endothelial growth factor A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.90.10","properties":[{"key":"EntryName","value":"Cystine-knot cytokines"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.160.10","properties":[{"key":"EntryName","value":"Vascular endothelial growth factor, heparin-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR029034","properties":[{"key":"EntryName","value":"Cystine-knot_cytokine"}]},{"database":"InterPro","id":"IPR023581","properties":[{"key":"EntryName","value":"PD_growth_factor_CS"}]},{"database":"InterPro","id":"IPR000072","properties":[{"key":"EntryName","value":"PDGF/VEGF_dom"}]},{"database":"InterPro","id":"IPR050507","properties":[{"key":"EntryName","value":"PDGF/VEGF_growth_factor"}]},{"database":"InterPro","id":"IPR027928","properties":[{"key":"EntryName","value":"VEGF_C"}]},{"database":"InterPro","id":"IPR036841","properties":[{"key":"EntryName","value":"VEGF_C_sf"}]},{"database":"PANTHER","id":"PTHR12025","properties":[{"key":"EntryName","value":"VASCULAR ENDOTHELIAL GROWTH FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12025:SF5","properties":[{"key":"EntryName","value":"VASCULAR ENDOTHELIAL GROWTH FACTOR A, LONG FORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00341","properties":[{"key":"EntryName","value":"PDGF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14554","properties":[{"key":"EntryName","value":"VEGF_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27240","properties":[{"key":"EntryName","value":"VEGFA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00141","properties":[{"key":"EntryName","value":"PDGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57501","properties":[{"key":"EntryName","value":"Cystine-knot cytokines"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57593","properties":[{"key":"EntryName","value":"Heparin-binding domain from vascular endothelial growth factor"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00249","properties":[{"key":"EntryName","value":"PDGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50278","properties":[{"key":"EntryName","value":"PDGF_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR","length":395,"molWeight":43597,"crc64":"8ADF6524B1835A2D","md5":"224DDFB196839CAD461DB564A9814C09"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"SUBUNIT":1,"INTERACTION":13,"SUBCELLULAR LOCATION":6,"ALTERNATIVE PRODUCTS":17,"TISSUE SPECIFICITY":6,"INDUCTION":1,"PTM":1,"DISEASE":1,"MISCELLANEOUS":8,"SIMILARITY":1,"SEQUENCE CAUTION":2,"WEB RESOURCE":1},"countByFeatureType":{"Chain":3,"Region":3,"Compositional bias":6,"Glycosylation":1,"Disulfide bond":5,"Alternative sequence":13,"Sequence conflict":2,"Helix":6,"Beta strand":10,"Turn":4},"uniParcId":"UPI00005C3040"}}