{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P15292","secondaryAccessions":["Q02VE4"],"uniProtkbId":"P3P_LACLS","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-09","entryVersion":155,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Lactococcus lactis subsp. cremoris (strain SK11)","taxonId":272622,"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Lactobacillales","Streptococcaceae","Lactococcus","Lactococcus cremoris subsp. cremoris"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"PIII-type proteinase"},"ecNumbers":[{"value":"3.4.21.96"}]},"alternativeNames":[{"fullName":{"value":"Cell wall-associated serine proteinase"}},{"fullName":{"value":"Lactocepin"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"prtP"},"orderedLocusNames":[{"value":"LACR_C42"}]}],"comments":[{"texts":[{"value":"Protease which breaks down milk proteins during the growth of the bacteria on milk"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Endopeptidase activity with very broad specificity, although some subsite preference have been noted, e.g. large hydrophobic residues in the P1 and P4 positions, and Pro in the P2 position. Best known for its action on caseins, although it has been shown to hydrolyze hemoglobin and oxidized insulin B-chain.","ecNumber":"3.4.21.96"}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00477"}],"value":"Secreted, cell wall","id":"SL-0041"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00477"}],"value":"Peptidoglycan-anchor","id":"SL-9900"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the peptidase S8 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":""},{"type":"Propeptide","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2760036"}],"featureId":"PRO_0000027095"},{"type":"Chain","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":1930,"modifier":"EXACT"}},"description":"PIII-type proteinase","featureId":"PRO_0000027096"},{"type":"Propeptide","location":{"start":{"value":1931,"modifier":"EXACT"},"end":{"value":1962,"modifier":"EXACT"}},"description":"Removed by sortase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00477"}],"featureId":"PRO_0000027097"},{"type":"Domain","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":697,"modifier":"EXACT"}},"description":"Peptidase S8","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01240"}]},{"type":"Region","location":{"start":{"value":1796,"modifier":"EXACT"},"end":{"value":1938,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":1927,"modifier":"EXACT"},"end":{"value":1931,"modifier":"EXACT"}},"description":"LPXTG sorting signal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00477"}]},{"type":"Compositional bias","location":{"start":{"value":1797,"modifier":"EXACT"},"end":{"value":1812,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1856,"modifier":"EXACT"},"end":{"value":1865,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1890,"modifier":"EXACT"},"end":{"value":1903,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01240"}]},{"type":"Active site","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01240"}]},{"type":"Active site","location":{"start":{"value":620,"modifier":"EXACT"},"end":{"value":620,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01240"}]},{"type":"Modified residue","location":{"start":{"value":1930,"modifier":"EXACT"},"end":{"value":1930,"modifier":"EXACT"}},"description":"Pentaglycyl murein peptidoglycan amidated threonine","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00477"}]},{"type":"Sequence conflict","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":899,"modifier":"EXACT"},"end":{"value":899,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":1213,"modifier":"EXACT"},"end":{"value":1213,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Sequence conflict","location":{"start":{"value":1251,"modifier":"EXACT"},"end":{"value":1251,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":1282,"modifier":"EXACT"},"end":{"value":1282,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":1304,"modifier":"EXACT"},"end":{"value":1304,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":1313,"modifier":"EXACT"},"end":{"value":1313,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":1316,"modifier":"EXACT"},"end":{"value":1318,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"ANE","alternativeSequences":["TNK"]}},{"type":"Sequence conflict","location":{"start":{"value":1394,"modifier":"EXACT"},"end":{"value":1394,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":1448,"modifier":"EXACT"},"end":{"value":1448,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":1515,"modifier":"EXACT"},"end":{"value":1515,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":1523,"modifier":"EXACT"},"end":{"value":1523,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":1550,"modifier":"EXACT"},"end":{"value":1550,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":1673,"modifier":"EXACT"},"end":{"value":1673,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":1685,"modifier":"EXACT"},"end":{"value":1685,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":1719,"modifier":"EXACT"},"end":{"value":1719,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":1722,"modifier":"EXACT"},"end":{"value":1722,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":1859,"modifier":"EXACT"},"end":{"value":1918,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03533","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{}}],"geneLocations":[{"value":"pSK111","geneEncodingType":"Plasmid"},{"value":"pLACR3","geneEncodingType":"Plasmid"}],"keywords":[{"id":"KW-0134","category":"Cellular component","name":"Cell wall"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0572","category":"PTM","name":"Peptidoglycan-anchor"},{"id":"KW-0614","category":"Technical term","name":"Plasmid"},{"id":"KW-0645","category":"Molecular function","name":"Protease"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0720","category":"Molecular function","name":"Serine protease"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0865","category":"PTM","name":"Zymogen"}],"references":[{"referenceNumber":1,"citation":{"id":"2760036","citationType":"journal article","authors":["Vos P.","Simons G.","Siezen R.J.","de Vos W.M."],"citationCrossReferences":[{"database":"PubMed","id":"2760036"},{"database":"DOI","id":"10.1016/s0021-9258(18)80036-9"}],"title":"Primary structure and organization of the gene for a procaryotic, cell envelope-located serine proteinase.","publicationDate":"1989","journal":"J. Biol. Chem.","firstPage":"13579","lastPage":"13585","volume":"264"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","PROTEIN SEQUENCE OF 188-197"],"referenceComments":[{"value":"pSK111","type":"PLASMID"}]},{"referenceNumber":2,"citation":{"id":"17030793","citationType":"journal article","authors":["Makarova K.S.","Slesarev A.","Wolf Y.I.","Sorokin A.","Mirkin B.","Koonin E.V.","Pavlov A.","Pavlova N.","Karamychev V.","Polouchine N.","Shakhova V.","Grigoriev I.","Lou Y.","Rohksar D.","Lucas S.","Huang K.","Goodstein D.M.","Hawkins T.","Plengvidhya V.","Welker D.","Hughes J.","Goh Y.","Benson A.","Baldwin K.","Lee J.-H.","Diaz-Muniz I.","Dosti B.","Smeianov V.","Wechter W.","Barabote R.","Lorca G.","Altermann E.","Barrangou R.","Ganesan B.","Xie Y.","Rawsthorne H.","Tamir D.","Parker C.","Breidt F.","Broadbent J.R.","Hutkins R.","O'Sullivan D.","Steele J.","Unlu G.","Saier M.H. Jr.","Klaenhammer T.","Richardson P.","Kozyavkin S.","Weimer B.C.","Mills D.A."],"citationCrossReferences":[{"database":"PubMed","id":"17030793"},{"database":"DOI","id":"10.1073/pnas.0607117103"}],"title":"Comparative genomics of the lactic acid bacteria.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"15611","lastPage":"15616","volume":"103"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"SK11","type":"STRAIN"},{"value":"pLACR3","type":"PLASMID"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"J04962","properties":[{"key":"ProteinId","value":"AAA03533.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Unassigned_DNA"}]},{"database":"EMBL","id":"CP000428","properties":[{"key":"ProteinId","value":"ABJ74078.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_011669079.1","properties":[{"key":"NucleotideSequenceId","value":"NC_008505.1"}]},{"database":"AlphaFoldDB","id":"P15292","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P15292","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"S08.019","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"S08.116","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"llc:LACR_C42","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_001299_0_0_9","properties":[{"key":"Description","value":"-"}]},{"database":"SABIO-RK","id":"P15292","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd07475","properties":[{"key":"EntryName","value":"Peptidases_S8_C5a_Peptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.4070","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.50.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.50.200","properties":[{"key":"EntryName","value":"Peptidase S8/S53 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1710","properties":[{"key":"EntryName","value":"Subtilisin-like superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010435","properties":[{"key":"EntryName","value":"C5a/SBT2-like_Fn3"}]},{"database":"InterPro","id":"IPR034216","properties":[{"key":"EntryName","value":"C5a_Peptidase"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR019931","properties":[{"key":"EntryName","value":"LPXTG_anchor"}]},{"database":"InterPro","id":"IPR046450","properties":[{"key":"EntryName","value":"PA_dom_sf"}]},{"database":"InterPro","id":"IPR003137","properties":[{"key":"EntryName","value":"PA_domain"}]},{"database":"InterPro","id":"IPR000209","properties":[{"key":"EntryName","value":"Peptidase_S8/S53_dom"}]},{"database":"InterPro","id":"IPR036852","properties":[{"key":"EntryName","value":"Peptidase_S8/S53_dom_sf"}]},{"database":"InterPro","id":"IPR023827","properties":[{"key":"EntryName","value":"Peptidase_S8_Asp-AS"}]},{"database":"InterPro","id":"IPR022398","properties":[{"key":"EntryName","value":"Peptidase_S8_His-AS"}]},{"database":"InterPro","id":"IPR023828","properties":[{"key":"EntryName","value":"Peptidase_S8_Ser-AS"}]},{"database":"InterPro","id":"IPR050131","properties":[{"key":"EntryName","value":"Peptidase_S8_subtilisin-like"}]},{"database":"InterPro","id":"IPR015500","properties":[{"key":"EntryName","value":"Peptidase_S8_subtilisin-rel"}]},{"database":"NCBIfam","id":"TIGR01167","properties":[{"key":"EntryName","value":"LPXTG_anchor"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43806:SF11","properties":[{"key":"EntryName","value":"CEREVISIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43806","properties":[{"key":"EntryName","value":"PEPTIDASE S8"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06280","properties":[{"key":"EntryName","value":"fn3_5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09136","properties":[{"key":"EntryName","value":"Glucodextran_B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00746","properties":[{"key":"EntryName","value":"Gram_pos_anchor"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02225","properties":[{"key":"EntryName","value":"PA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00082","properties":[{"key":"EntryName","value":"Peptidase_S8"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00723","properties":[{"key":"EntryName","value":"SUBTILISIN"}]},{"database":"SUPFAM","id":"SSF52025","properties":[{"key":"EntryName","value":"PA domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52743","properties":[{"key":"EntryName","value":"Subtilisin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50847","properties":[{"key":"EntryName","value":"GRAM_POS_ANCHORING"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51892","properties":[{"key":"EntryName","value":"SUBTILASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00136","properties":[{"key":"EntryName","value":"SUBTILASE_ASP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00137","properties":[{"key":"EntryName","value":"SUBTILASE_HIS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00138","properties":[{"key":"EntryName","value":"SUBTILASE_SER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQRKKKGLSILLAGTVALGALAVLPVGEIQAKAAISQQTKGSSLANTVTAATAKQAATDTTAATTNQAIATQLAAKGIDYNKLNKVQQQDIYVDVIVQMSAAPASENGTLRTDYSSTAEIQQETNKVIAAQASVKAAVEQVTQQTAGESYGYVVNGFSTKVRVVDIPKLKQIAGVKTVTLAKVYYPTDAKANSMANVQAVWSNYKYKGEGTVVSVIDSGIDPTHKDMRLSDDKDVKLTKSDVEKFTDTAKHGRYFNSKVPYGFNYADNNDTITDDTVDEQHGMHVAGIIGANGTGDDPAKSVVGVAPEAQLLAMKVFTNSDTSATTGSATLVSAIEDSAKIGADVLNMSLGSDSGNQTLEDPELAAVQNANESGTAAVISAGNSGTSGSATEGVNKDYYGLQDNEMVGSPGTSRGATTVASAENTDVITQAVTITDGTGLQLGPETIQLSSHDFTGSFDQKKFYIVKDASGNLSKGALADYTADAKGKIAIVKRGEFSFDDKQKYAQAAGAAGLIIVNTDGTATPMTSIALTTTFPTFGLSSVTGQKLVDWVTAHPDDSLGVKITLAMLPNQKYTEDKMSDFTSYGPVSNLSFKPDITAPGGNIWSTQNNNGYTNMSGTSMASPFIAGSQALLKQALNNKNNPFYAYYKQLKGTALTDFLKTVEMNTAQPINDINYNNVIVSPRRQGAGLVDVKAAIDALEKNPSTVVAENGYPAVELKDFTSTDKTFKLTFTNRTTHELTYQMDSNTDTNAVYTSATDPNSGVLYDKKIDGAAIKAGSNITVPAGKTAQIEFTLSLPKSFDQQQFVEGFLNFKGSDGSRLNLPYMGFFGDWNDGKIVDSLNGITYSPAGGNFGTVPLLKNKNTGTQYYGGMVTDADGNKTVDDQAIAFSSDKNALYNEISMKYYLLRNISNVQVDILDGQGNKVTTLSSSTNRKKTYYNAHSQQYIYYNAPAWDGTYYDQRDGNIKTADDGSYTYRISGVPEGGDKRQVFDVPFKLDSKAPTVRHVALSAKTENGKTQYYLTAEAKDDLSGLDATKSVKTEINEVTNLDATFTDAGTTADGYTKIETPLSDEQAQALGNGDNSAELYLTDNASNATDQDASVQKPGSTSFDLIVNGGGIPDKISSTTTGYEANTQGGGTYTFSGTYPAAVDGTYTDAQGKKHDLNTTYDAATNSFTASMPVTNADYAAQVDLYADKAHTQLLKHFDTKVRLTAPTFTDLKFNNGSDQTSEATIKVTGTVSADTKTVNVGDTVAALDAQHHFSVDVPVNYGDNTIKVTATDEDGNTTTEQKTITSSYDPDMLKNSVTFDQGVTFGANEFNATSAKFYDPKTGIATITGKVKHPTTTLQVDGKQIPIKDDLTFSFTLDLGTLGQKPFGVVVGDTTQNKTFQEALTFILDAVAPTLSLDSSTDAPVYTNDPNFQITGTATDNAQYLSLSINGSSVASQYVDININSGKPGHMAIDQPVKLLEGKNVLTVAVTDSEDNTTTKNITVYYEPKKTLAAPTVTPSTTEPAKTVTLTANSAATGETVQYSADGGKTYQDVPAAGVTVTANGTFKFKSTDLYGNESPAVDYVVTNIKADDPAQLQAAKQELTNLIASAKTLSASGKYDDATTTALAAATQKAQTALDQTNASVDSLTGANRDLQTAINQLAAKLPADKKTSLLNQLQSVKAALGTDLGNQTDSSTGKTFTAALDDLVAQAQAGTQTDDQLQATLAKVLDAVLAKLAEGIKAATPAEVGNAKDAATGKTWYADIADTLTSGQASADASDKLAHLQALQSLKTKVAAAVEAAKTVGKGDGTTGTSDKGGGQGTPAPAPGDTGKDKGDEGSQPSSGGNIPTKPATTTSTTTDDTTDRNGQLTSGTSDKGGGQGTPAPAPGDIGKDKGDEGSQPSSGGNIPTNPATTTSTTTDDTTDRNGQLTSGKGALPKTGETTERPAFGFLGVIVVSLMGVLGLKRKQREE","length":1962,"molWeight":205996,"crc64":"39B5FD18598DC5CC","md5":"97FBCD0B9B7577C2FE3FD9E4CA6D5DC8"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Propeptide":2,"Chain":1,"Domain":1,"Region":1,"Motif":1,"Compositional bias":3,"Active site":3,"Modified residue":1,"Sequence conflict":24},"uniParcId":"UPI0000574843"}}