{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P15260","secondaryAccessions":["B4DFT7","E1P587","Q53Y96"],"uniProtkbId":"INGR1_HUMAN","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1990-04-01","entryVersion":248,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:5439"}],"value":"Interferon gamma receptor 1"},"shortNames":[{"value":"IFN-gamma receptor 1"},{"value":"IFN-gamma-R1"}]},"alternativeNames":[{"fullName":{"value":"CDw119"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7615558"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9367779"}],"value":"Interferon gamma receptor alpha-chain"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7615558"}],"value":"IFN-gamma-R-alpha"}]}],"cdAntigenNames":[{"value":"CD119"}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:5439"}],"value":"IFNGR1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P15261"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10986460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20015550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28883123"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2971451"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7615558"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7617032"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7673114"}],"value":"Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P15261"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7615558"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8156998"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9367779"}],"value":"Monomer (PubMed:9367779). Heterodimer with IFNGR2, to form the IFNG receptor complex (PubMed:7615558). Interacts with JAK1 (PubMed:7615558). Interacts (when phosphorylated) with STAT1 (PubMed:8156998). Interacts with SOCS1 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"Q13520","geneName":"AQP6","intActId":"EBI-13059134"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"Q9NPY3","geneName":"CD93","intActId":"EBI-1755002"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"P24071","geneName":"FCAR","intActId":"EBI-1036488"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"P01579","geneName":"IFNG","intActId":"EBI-1030767"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"O75019","geneName":"LILRA1","intActId":"EBI-21761495"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"Q8N423-1","geneName":"LILRB2","intActId":"EBI-64052402"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"Q8N423-2","geneName":"LILRB2","intActId":"EBI-21761536"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"Q9NZG7","geneName":"NINJ2","intActId":"EBI-10317425"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"Q96GQ5","geneName":"RUSF1","intActId":"EBI-8636004"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"Q08ET2","geneName":"SIGLEC14","intActId":"EBI-2214818"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"O15389","geneName":"SIGLEC5","intActId":"EBI-750381"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"Q92581-2","geneName":"SLC9A6","intActId":"EBI-17198620"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"P42224","geneName":"STAT1","intActId":"EBI-1057697"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"Q13586","geneName":"STIM1","intActId":"EBI-448878"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"Q9NV29","geneName":"TMEM100","intActId":"EBI-8644968"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15260","intActId":"EBI-1030755"},"interactantTwo":{"uniProtKBAccession":"Q96Q45-2","geneName":"TMEM237","intActId":"EBI-10982110"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10811850"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28883123"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P15260-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P15260-2"],"sequenceIds":["VSP_055589","VSP_055590","VSP_055591"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29343571"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7615558"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7673114"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8156998"}],"value":"Phosphorylated at Ser/Thr residues. Phosphorylation of Tyr-457 is required for IFNG receptor signal transduction (PubMed:8156998). Influenza virus infection leads to phosphorylation in a CSNK1A1-dependent manner (PubMed:29343571)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28883123"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29343571"}],"value":"Ubiquitinated after phosphorylation in a CSNK1A1-dependent manner, leading to the lysosome-dependent degradation (PubMed:29343571). Proteasomally degraded through 'Lys-48'-mediated ubiquitination (PubMed:28883123). Ubiquitination is necessary for efficient IFNGR1 signaling (PubMed:28883123)"}],"commentType":"PTM"},{"texts":[{"value":"A genetic variation in the IFNGR1 gene is associated with susceptibility to Helicobacter pylori infection [MIM:600263]"}],"commentType":"POLYMORPHISM"},{"commentType":"DISEASE","disease":{"diseaseId":"Immunodeficiency 27A","diseaseAccession":"DI-01964","acronym":"IMD27A","description":"A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas.","diseaseCrossReference":{"database":"MIM","id":"209950"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10811850"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11139207"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15589309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16195661"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16715106"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17514500"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20015550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20186794"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22708048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25592983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27868075"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28744922"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9389728"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Immunodeficiency 27B","diseaseAccession":"DI-04225","acronym":"IMD27B","description":"A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD27B commonly presents with recurrent, moderately severe infections with environmental mycobacteria or BCG. Salmonellosis is present in about 5% of patients.","diseaseCrossReference":{"database":"MIM","id":"615978"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10192386"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11335768"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the type II cytokine receptor family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"IFNGR1base","resourceUrl":"https://databases.lovd.nl/shared/genes/IFNGR1","ftp":false,"note":"IFNGR1 mutation db"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Interferon gamma receptor 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