{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P14866","secondaryAccessions":["A6ND69","A6NIT8","Q9H3P3"],"uniProtkbId":"HNRPL_HUMAN","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-11-25","entryVersion":245,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Heterogeneous nuclear ribonucleoprotein L"},"shortNames":[{"value":"hnRNP L"}]}},"genes":[{"geneName":{"value":"HNRNPL"},"synonyms":[{"value":"HNRPL"}],"orfNames":[{"value":"P/OKcl.14"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11809897"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22570490"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25623890"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26051023"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2687284"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33174841"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36537238"}],"value":"Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11809897"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18161049"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18669861"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19332550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33174841"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34333526"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36537238"}],"value":"Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with HNRNPLL (PubMed:18669861). Interacts with APEX1; the interaction is DNA-dependent (PubMed:11809897). Component of a complex with SETD2 (PubMed:19332550, PubMed:36537238). Interacts with ELAVL1 (PubMed:18161049). Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, ZNF827 and HNRNPK (PubMed:33174841). Interacts with CHD8 in an RNA-dependent manner. Interacts with FBXO16 (PubMed:34333526)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P14866","intActId":"EBI-719024"},"interactantTwo":{"uniProtKBAccession":"P22626","geneName":"HNRNPA2B1","intActId":"EBI-299649"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14866","intActId":"EBI-719024"},"interactantTwo":{"uniProtKBAccession":"P61978","geneName":"HNRNPK","intActId":"EBI-304185"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14866","intActId":"EBI-719024"},"interactantTwo":{"uniProtKBAccession":"Q8IUH3","geneName":"RBM45","intActId":"EBI-2512147"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14866","intActId":"EBI-719024"},"interactantTwo":{"uniProtKBAccession":"P40337","geneName":"VHL","intActId":"EBI-301246"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14866-1","intActId":"EBI-16071645"},"interactantTwo":{"uniProtKBAccession":"P22626","geneName":"HNRNPA2B1","intActId":"EBI-299649"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14866-1","intActId":"EBI-16071645"},"interactantTwo":{"uniProtKBAccession":"Q12906","geneName":"ILF3","intActId":"EBI-78756"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"}],"value":"Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2687284"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26051023"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"36537238"}],"value":"Nucleus, nucleoplasm","id":"SL-0190"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P14866-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P14866-2"],"sequenceIds":["VSP_044301"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23782695"}],"value":"RRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre-mRNA (PubMed:23782695)"}],"commentType":"DOMAIN"},{"texts":[{"value":"Several isoelectric forms of the L protein are probably the results of post-translational modifications"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22570490"}],"value":"Phosphorylation at Ser-544 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34333526"}],"value":"Ubiquitinated by the SCF-FBXO16 E3 ubiquitin ligase, leading to proteasomal degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19124611"}],"value":"Excess hnRNP L activates NMD of its own mRNA by promoting the inclusion of a 'poison exon' containing a premature stop codon and leading to nonsense-mediated decay. It also cross-regulates inclusion of an analogous 'poison exon' in the hnRNP L-like pre-mRNA (PubMed:19124611)"}],"commentType":"MISCELLANEOUS"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAA34261.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":589,"modifier":"EXACT"}},"description":"Heterogeneous nuclear ribonucleoprotein L","featureId":"PRO_0000081862"},{"type":"Domain","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"RRM 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00176"}]},{"type":"Domain","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"RRM 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00176"}]},{"type":"Domain","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"RRM 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00176"}]},{"type":"Domain","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"RRM 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00176"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8R081"}]},{"type":"Modified residue","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8R081"}]},{"type":"Modified residue","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8R081"}]},{"type":"Modified residue","location":{"start":{"value":544,"modifier":"EXACT"},"end":{"value":544,"modifier":"EXACT"}},"description":"Phosphoserine; by CaMK4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22570490"}]},{"type":"Cross-link","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":568,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_044301","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"6-fold decrease in RNA-binding affinity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23782695"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"4-fold increase in RNA-binding affinity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23782695"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"15-fold decrease in RNA-binding affinity; when associated with A-174.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23782695"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"1-fold increase in RNA-binding affinity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23782695"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"15-fold decrease in RNA-binding affinity; when associated with A-174.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23782695"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":504,"modifier":"EXACT"},"end":{"value":504,"modifier":"EXACT"}},"description":"Significant decrease in RNA-binding affinity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23782695"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":506,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"Significant decrease in RNA-binding affinity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23782695"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"in Ref. 1; BAB18649 and 5; CAA34261","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Helix","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3R27"}]},{"type":"Beta strand","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3R27"}]},{"type":"Helix","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3R27"}]},{"type":"Helix","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3R27"}]},{"type":"Beta strand","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3R27"}]},{"type":"Turn","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3R27"}]},{"type":"Beta strand","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3R27"}]},{"type":"Helix","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3R27"}]},{"type":"Beta strand","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3R27"}]},{"type":"Beta strand","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3R27"}]},{"type":"Beta strand","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EVR"}]},{"type":"Helix","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EVR"}]},{"type":"Turn","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EVR"}]},{"type":"Beta strand","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EVR"}]},{"type":"Beta strand","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EVR"}]},{"type":"Helix","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EVR"}]},{"type":"Beta strand","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EVR"}]},{"type":"Beta strand","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EVR"}]},{"type":"Beta strand","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7EVR"}]},{"type":"Beta strand","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Turn","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Helix","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Turn","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Beta strand","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Beta strand","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Helix","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Beta strand","location":{"start":{"value":442,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Beta strand","location":{"start":{"value":447,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Beta strand","location":{"start":{"value":472,"modifier":"EXACT"},"end":{"value":476,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Helix","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Beta strand","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Helix","location":{"start":{"value":514,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Helix","location":{"start":{"value":527,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Beta strand","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Beta strand","location":{"start":{"value":543,"modifier":"EXACT"},"end":{"value":548,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Helix","location":{"start":{"value":552,"modifier":"EXACT"},"end":{"value":562,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Beta strand","location":{"start":{"value":572,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]},{"type":"Beta strand","location":{"start":{"value":579,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TO8"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0687","category":"Molecular function","name":"Ribonucleoprotein"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"11280764","citationType":"journal article","authors":["Ito M.","Shichijo S.","Tsuda N.","Ochi M.","Harashima N.","Saito N.","Itoh K."],"citationCrossReferences":[{"database":"PubMed","id":"11280764"}],"title":"Molecular basis of T cell-mediated recognition of pancreatic cancer cells.","publicationDate":"2001","journal":"Cancer Res.","firstPage":"2038","lastPage":"2046","volume":"61"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Pancreatic cancer","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Synovium","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.S.","Terry A.","Schmutz J.","Lamerdin J.E.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.V.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.-H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.M.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"2687284","citationType":"journal article","authors":["Pinol-Roma S.","Swanson M.S.","Gall J.G.","Dreyfuss G."],"citationCrossReferences":[{"database":"PubMed","id":"2687284"},{"database":"DOI","id":"10.1083/jcb.109.6.2575"}],"title":"A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts.","publicationDate":"1989","journal":"J. Cell Biol.","firstPage":"2575","lastPage":"2587","volume":"109"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 23-589 (ISOFORM 1)","FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":6,"citation":{"id":"CI-5JLPE8IQ42OFK","citationType":"submission","authors":["Lubec G.","Vishwanath V.","Chen W.-Q.","Sun Y."],"publicationDate":"DEC-2008","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 67-76; 199-215; 218-233; 386-403; 425-448 AND 549-558","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Cajal-Retzius cell","type":"TISSUE"},{"value":"Fetal brain cortex","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"1286667","citationType":"journal article","authors":["Rasmussen H.H.","van Damme J.","Puype M.","Gesser B.","Celis J.E.","Vandekerckhove J."],"citationCrossReferences":[{"database":"PubMed","id":"1286667"},{"database":"DOI","id":"10.1002/elps.11501301199"}],"title":"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.","publicationDate":"1992","journal":"Electrophoresis","firstPage":"960","lastPage":"969","volume":"13"},"referencePositions":["PARTIAL PROTEIN SEQUENCE"],"referenceComments":[{"value":"Keratinocyte","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"11809897","citationType":"journal article","authors":["Kuninger D.T.","Izumi T.","Papaconstantinou J.","Mitra S."],"citationCrossReferences":[{"database":"PubMed","id":"11809897"},{"database":"DOI","id":"10.1093/nar/30.3.823"}],"title":"Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.","publicationDate":"2002","journal":"Nucleic Acids Res.","firstPage":"823","lastPage":"829","volume":"30"},"referencePositions":["FUNCTION","INTERACTION WITH APEX1"]},{"referenceNumber":9,"citation":{"id":"17289661","citationType":"journal article","authors":["Joeson L.","Vikesaa J.","Krogh A.","Nielsen L.K.","Hansen T.","Borup R.","Johnsen A.H.","Christiansen J.","Nielsen F.C."],"citationCrossReferences":[{"database":"PubMed","id":"17289661"},{"database":"DOI","id":"10.1074/mcp.m600346-mcp200"}],"title":"Molecular composition of IMP1 ribonucleoprotein granules.","publicationDate":"2007","journal":"Mol. Cell. Proteomics","firstPage":"798","lastPage":"811","volume":"6"},"referencePositions":["IDENTIFICATION IN A MRNP GRANULE COMPLEX","IDENTIFICATION BY MASS SPECTROMETRY","SUBCELLULAR LOCATION"]},{"referenceNumber":10,"citation":{"id":"18161049","citationType":"journal article","authors":["Matsui K.","Nishizawa M.","Ozaki T.","Kimura T.","Hashimoto I.","Yamada M.","Kaibori M.","Kamiyama Y.","Ito S.","Okumura T."],"citationCrossReferences":[{"database":"PubMed","id":"18161049"},{"database":"DOI","id":"10.1002/hep.22036"}],"title":"Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes.","publicationDate":"2008","journal":"Hepatology","firstPage":"686","lastPage":"697","volume":"47"},"referencePositions":["INTERACTION WITH ELAVL1"]},{"referenceNumber":11,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52 AND SER-298","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"18669861","citationType":"journal article","authors":["Oberdoerffer S.","Moita L.F.","Neems D.","Freitas R.P.","Hacohen N.","Rao A."],"citationCrossReferences":[{"database":"PubMed","id":"18669861"},{"database":"DOI","id":"10.1126/science.1157610"}],"title":"Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL.","publicationDate":"2008","journal":"Science","firstPage":"686","lastPage":"691","volume":"321"},"referencePositions":["INTERACTION WITH HNRNPLL"]},{"referenceNumber":13,"citation":{"id":"19332550","citationType":"journal article","authors":["Yuan W.","Xie J.","Long C.","Erdjument-Bromage H.","Ding X.","Zheng Y.","Tempst P.","Chen S.","Zhu B.","Reinberg D."],"citationCrossReferences":[{"database":"PubMed","id":"19332550"},{"database":"DOI","id":"10.1074/jbc.m808431200"}],"title":"Heterogeneous nuclear ribonucleoprotein L is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"15701","lastPage":"15707","volume":"284"},"referencePositions":["INTERACTION WITH SETD2"]},{"referenceNumber":14,"citation":{"id":"19124611","citationType":"journal article","authors":["Rossbach O.","Hung L.H.","Schreiner S.","Grishina I.","Heiner M.","Hui J.","Bindereif A."],"citationCrossReferences":[{"database":"PubMed","id":"19124611"},{"database":"DOI","id":"10.1128/mcb.01689-08"}],"title":"Auto- and cross-regulation of the hnRNP L proteins by alternative splicing.","publicationDate":"2009","journal":"Mol. Cell. Biol.","firstPage":"1442","lastPage":"1451","volume":"29"},"referencePositions":["ALTERNATIVE SPLICING","MISCELLANEOUS"]},{"referenceNumber":15,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-269","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":16,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52; SER-185 AND SER-298","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52; SER-101; SER-185; SER-291 AND SER-298","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"22570490","citationType":"journal article","authors":["Liu G.","Razanau A.","Hai Y.","Yu J.","Sohail M.","Lobo V.G.","Chu J.","Kung S.K.","Xie J."],"citationCrossReferences":[{"database":"PubMed","id":"22570490"},{"database":"DOI","id":"10.1074/jbc.m112.357343"}],"title":"A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels.","publicationDate":"2012","journal":"J. Biol. Chem.","firstPage":"22709","lastPage":"22716","volume":"287"},"referencePositions":["PHOSPHORYLATION AT SER-544","FUNCTION"]},{"referenceNumber":20,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":21,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52; SER-101; SER-185 AND SER-298","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":22,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"24164894","citationType":"journal article","authors":["Shankarling G.","Cole B.S.","Mallory M.J.","Lynch K.W."],"citationCrossReferences":[{"database":"PubMed","id":"24164894"},{"database":"DOI","id":"10.1128/mcb.00740-13"}],"title":"Transcriptome-wide RNA interaction profiling reveals physical and functional targets of hnRNP L in human T cells.","publicationDate":"2014","journal":"Mol. Cell. Biol.","firstPage":"71","lastPage":"83","volume":"34"},"referencePositions":["FUNCTION"]},{"referenceNumber":24,"citation":{"id":"25218447","citationType":"journal article","authors":["Hendriks I.A.","D'Souza R.C.","Yang B.","Verlaan-de Vries M.","Mann M.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25218447"},{"database":"DOI","id":"10.1038/nsmb.2890"}],"title":"Uncovering global SUMOylation signaling networks in a site-specific manner.","publicationDate":"2014","journal":"Nat. Struct. Mol. Biol.","firstPage":"927","lastPage":"936","volume":"21"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-62","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":25,"citation":{"id":"25623890","citationType":"journal article","authors":["Loh T.J.","Cho S.","Moon H.","Jang H.N.","Williams D.R.","Jung D.W.","Kim I.C.","Ghigna C.","Biamonti G.","Zheng X.","Shen H."],"citationCrossReferences":[{"database":"PubMed","id":"25623890"},{"database":"DOI","id":"10.1016/j.bbagrm.2015.01.004"}],"title":"hnRNP L inhibits CD44 V10 exon splicing through interacting with its upstream intron.","publicationDate":"2015","journal":"Biochim. Biophys. Acta","firstPage":"743","lastPage":"750","volume":"1849"},"referencePositions":["FUNCTION"]},{"referenceNumber":26,"citation":{"id":"25772364","citationType":"journal article","authors":["Hendriks I.A.","Treffers L.W.","Verlaan-de Vries M.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25772364"},{"database":"DOI","id":"10.1016/j.celrep.2015.02.033"}],"title":"SUMO-2 orchestrates chromatin modifiers in response to DNA damage.","publicationDate":"2015","journal":"Cell Rep.","firstPage":"1778","lastPage":"1791","volume":"10"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-136","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":27,"citation":{"id":"26051023","citationType":"journal article","authors":["Blatter M.","Dunin-Horkawicz S.","Grishina I.","Maris C.","Thore S.","Maier T.","Bindereif A.","Bujnicki J.M.","Allain F.H."],"citationCrossReferences":[{"database":"PubMed","id":"26051023"},{"database":"DOI","id":"10.1016/j.jmb.2015.05.020"}],"title":"The signature of the five-stranded vRRM fold defined by functional, structural and computational analysis of the hnRNP L protein.","publicationDate":"2015","journal":"J. Mol. Biol.","firstPage":"3001","lastPage":"3022","volume":"427"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":28,"citation":{"id":"25755297","citationType":"journal article","authors":["Xiao Z.","Chang J.G.","Hendriks I.A.","Sigurdsson J.O.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25755297"},{"database":"DOI","id":"10.1074/mcp.o114.044792"}],"title":"System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.","publicationDate":"2015","journal":"Mol. Cell. Proteomics","firstPage":"1419","lastPage":"1434","volume":"14"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-62","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":29,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":30,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-59; LYS-62; LYS-136; LYS-302 AND LYS-568","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":31,"citation":{"id":"33174841","citationType":"journal article","authors":["Hollensen A.K.","Thomsen H.S.","Lloret-Llinares M.","Kamstrup A.B.","Jensen J.M.","Luckmann M.","Birkmose N.","Palmfeldt J.","Jensen T.H.","Hansen T.B.","Damgaard C.K."],"citationCrossReferences":[{"database":"PubMed","id":"33174841"},{"database":"DOI","id":"10.7554/elife.58478"}],"title":"circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation.","publicationDate":"2020","journal":"Elife","firstPage":"0","lastPage":"0","volume":"9"},"referencePositions":["FUNCTION","SUBUNIT"]},{"referenceNumber":32,"citation":{"id":"34333526","citationType":"journal article","authors":["Ji M.","Zhao Z.","Li Y.","Xu P.","Shi J.","Li Z.","Wang K.","Huang X.","Ji J.","Liu W.","Liu B."],"citationCrossReferences":[{"database":"PubMed","id":"34333526"},{"database":"DOI","id":"10.1038/s41419-021-04040-9"}],"title":"FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer.","publicationDate":"2021","journal":"Cell Death Dis.","firstPage":"758","lastPage":"758","volume":"12"},"referencePositions":["INTERACTION WITH FBXO16","UBIQUITINATION"]},{"referenceNumber":33,"citation":{"id":"36537238","citationType":"journal article","authors":["Kerschbamer E.","Arnoldi M.","Tripathi T.","Pellegrini M.","Maturi S.","Erdin S.","Salviato E.","Di Leva F.","Sebestyen E.","Dassi E.","Zarantonello G.","Benelli M.","Campos E.","Basson M.A.","Gusella J.F.","Gustincich S.","Piazza S.","Demichelis F.","Talkowski M.E.","Ferrari F.","Biagioli M."],"citationCrossReferences":[{"database":"PubMed","id":"36537238"},{"database":"DOI","id":"10.1093/nar/gkac1134"}],"title":"CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing.","publicationDate":"2022","journal":"Nucleic Acids Res.","firstPage":"12809","lastPage":"12828","volume":"50"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH CHD8 AND SETD2"]},{"referenceNumber":34,"citation":{"id":"23782695","citationType":"journal article","authors":["Zhang W.","Zeng F.","Liu Y.","Zhao Y.","Lv H.","Niu L.","Teng M.","Li X."],"citationCrossReferences":[{"database":"PubMed","id":"23782695"},{"database":"DOI","id":"10.1074/jbc.m113.463901"}],"title":"Crystal structures and RNA-binding properties of the RNA recognition motifs of heterogeneous nuclear ribonucleoprotein L: insights into its roles in alternative splicing regulation.","publicationDate":"2013","journal":"J. Biol. Chem.","firstPage":"22636","lastPage":"22649","volume":"288"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS) OF 90-180","X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 380-589","RNA-BINDING","RRM DOMAINS","MUTAGENESIS OF HIS-105; VAL-132; LEU-141; ASN-172; SER-174; HIS-504 AND PHE-506"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB044547","properties":[{"key":"ProteinId","value":"BAB18649.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK292115","properties":[{"key":"ProteinId","value":"BAF84804.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC008982","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471126","properties":[{"key":"ProteinId","value":"EAW56828.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X16135","properties":[{"key":"ProteinId","value":"CAA34261.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS33015.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P14866-1"},{"database":"CCDS","id":"CCDS33016.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P14866-2"},{"database":"PIR","id":"A33616","properties":[{"key":"EntryName","value":"A33616"}]},{"database":"RefSeq","id":"NP_001005335.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001005335.2"}],"isoformId":"P14866-2"},{"database":"RefSeq","id":"NP_001524.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001533.3"}],"isoformId":"P14866-1"},{"database":"PDB","id":"3R27","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.04 A"},{"key":"Chains","value":"A/B=90-180"}]},{"database":"PDB","id":"3TO8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"A=380-589"}]},{"database":"PDB","id":"7EVR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/C=186-289"}]},{"database":"PDBsum","id":"3R27","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3TO8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EVR","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109432","properties":[{"key":"Interactions","value":"2024"}]},{"database":"CORUM","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-36355N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P14866","properties":[{"key":"Number of interactors","value":"3850"}]},{"database":"IntAct","id":"P14866","properties":[{"key":"Interactions","value":"200"}]},{"database":"MINT","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-HNRNPL","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000221419","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5724651","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB09130","properties":[{"key":"GenericName","value":"Copper"}]},{"database":"GlyGen","id":"P14866","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HNRNPL","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"215274006","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"IPI00027834","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000221419","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"1284","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"53090","properties":[{"key":"Description","value":"-"}],"isoformId":"P14866-1"},{"database":"Pumba","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4276","properties":[{"key":"antibodies","value":"463 antibodies from 39 providers"}]},{"database":"DNASU","id":"3191","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000221419.10","properties":[{"key":"ProteinId","value":"ENSP00000221419.4"},{"key":"GeneId","value":"ENSG00000104824.19"}],"isoformId":"P14866-1"},{"database":"Ensembl","id":"ENST00000600873.5","properties":[{"key":"ProteinId","value":"ENSP00000470231.1"},{"key":"GeneId","value":"ENSG00000104824.19"}],"isoformId":"P14866-2"},{"database":"Ensembl","id":"ENST00000634237.1","properties":[{"key":"ProteinId","value":"ENSP00000489244.1"},{"key":"GeneId","value":"ENSG00000282947.2"}],"isoformId":"P14866-2"},{"database":"Ensembl","id":"ENST00000634753.1","properties":[{"key":"ProteinId","value":"ENSP00000489021.1"},{"key":"GeneId","value":"ENSG00000282947.2"}],"isoformId":"P14866-1"},{"database":"GeneID","id":"3191","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3191","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000221419.10","properties":[{"key":"ProteinId","value":"ENSP00000221419.4"},{"key":"RefSeqNucleotideId","value":"NM_001533.3"},{"key":"RefSeqProteinId","value":"NP_001524.2"}]},{"database":"UCSC","id":"uc060yfy.1","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P14866-1"},{"database":"AGR","id":"HGNC:5045","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162391389","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3191","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3191","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HNRNPL","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5045","properties":[{"key":"GeneName","value":"HNRNPL"}]},{"database":"HPA","id":"ENSG00000104824","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"HNRNPL","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"603083","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000104824","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104824","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1456","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01030000234642","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_015171_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VYNAQYP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"302770at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P14866","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-72163","properties":[{"key":"PathwayName","value":"mRNA Splicing - Major Pathway"}]},{"database":"Reactome","id":"R-HSA-72203","properties":[{"key":"PathwayName","value":"Processing of Capped Intron-Containing Pre-mRNA"}]},{"database":"Reactome","id":"R-HSA-9770562","properties":[{"key":"PathwayName","value":"mRNA Polyadenylation"}]},{"database":"Reactome","id":"R-HSA-9918481","properties":[{"key":"PathwayName","value":"Dengue Virus-Host Interactions"}]},{"database":"SignaLink","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000104824","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3191","properties":[{"key":"hits","value":"763 hits in 1158 CRISPR screens"}]},{"database":"CD-CODE","id":"232F8A39","properties":[{"key":"EntryName","value":"P-body"}]},{"database":"CD-CODE","id":"62EA6512","properties":[{"key":"EntryName","value":"Sam68 nuclear body"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"CD-CODE","id":"F85A2E29","properties":[{"key":"EntryName","value":"IMP1 RNP granule"}]},{"database":"ChiTaRS","id":"HNRNPL","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P14866","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"HNRNPL","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3191","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P14866","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P14866","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"P14866","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000104824","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P14866","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33174841"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33174841"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2687284"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33174841"}]},{"database":"GO","id":"GO:0045120","properties":[{"key":"GoTerm","value":"C:pronucleus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1990904","properties":[{"key":"GoTerm","value":"C:ribonucleoprotein complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17289661"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2687284"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33174841"}]},{"database":"GO","id":"GO:0035770","properties":[{"key":"GoTerm","value":"C:ribonucleoprotein granule"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17289661"}]},{"database":"GO","id":"GO:0045202","properties":[{"key":"GoTerm","value":"C:synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097157","properties":[{"key":"GoTerm","value":"F:pre-mRNA intronic binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25623890"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22681889"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11809897"}]},{"database":"GO","id":"GO:0006397","properties":[{"key":"GoTerm","value":"P:mRNA processing"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"33174841"}]},{"database":"GO","id":"GO:0000381","properties":[{"key":"GoTerm","value":"P:regulation of alternative mRNA splicing, via spliceosome"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25623890"}]},{"database":"GO","id":"GO:0006396","properties":[{"key":"GoTerm","value":"P:RNA processing"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"2687284"}]},{"database":"CDD","id":"cd12780","properties":[{"key":"EntryName","value":"RRM1_hnRNPL"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd12785","properties":[{"key":"EntryName","value":"RRM2_hnRNPL"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd12699","properties":[{"key":"EntryName","value":"RRM3_hnRNPL"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd12704","properties":[{"key":"EntryName","value":"RRM4_hnRNPL"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.330:FF:000072","properties":[{"key":"EntryName","value":"heterogeneous nuclear ribonucleoprotein L isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.330:FF:000052","properties":[{"key":"EntryName","value":"Heterogeneous nuclear ribonucleoprotein L like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.330:FF:000073","properties":[{"key":"EntryName","value":"Heterogeneous nuclear ribonucleoprotein L like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.330:FF:000104","properties":[{"key":"EntryName","value":"Heterogeneous nuclear ribonucleoprotein L like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.330","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR006536","properties":[{"key":"EntryName","value":"HnRNP-L/PTB"}]},{"database":"InterPro","id":"IPR034816","properties":[{"key":"EntryName","value":"hnRNP-L_RRM3"}]},{"database":"InterPro","id":"IPR055204","properties":[{"key":"EntryName","value":"HNRNPL_RRM"}]},{"database":"InterPro","id":"IPR035005","properties":[{"key":"EntryName","value":"hnRNPL_RRM1"}]},{"database":"InterPro","id":"IPR035008","properties":[{"key":"EntryName","value":"hnRNPL_RRM2"}]},{"database":"InterPro","id":"IPR034817","properties":[{"key":"EntryName","value":"hnRNPL_RRM4"}]},{"database":"InterPro","id":"IPR012677","properties":[{"key":"EntryName","value":"Nucleotide-bd_a/b_plait_sf"}]},{"database":"InterPro","id":"IPR021790","properties":[{"key":"EntryName","value":"PTBP1-like_RRM2"}]},{"database":"InterPro","id":"IPR035979","properties":[{"key":"EntryName","value":"RBD_domain_sf"}]},{"database":"InterPro","id":"IPR000504","properties":[{"key":"EntryName","value":"RRM_dom"}]},{"database":"NCBIfam","id":"TIGR01649","properties":[{"key":"EntryName","value":"hnRNP-L_PTB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15592","properties":[{"key":"EntryName","value":"MATRIN 3/NUCLEAR PROTEIN 220-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00076","properties":[{"key":"EntryName","value":"RRM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22976","properties":[{"key":"EntryName","value":"RRM_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13893","properties":[{"key":"EntryName","value":"RRM_5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11835","properties":[{"key":"EntryName","value":"RRM_8"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00360","properties":[{"key":"EntryName","value":"RRM"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF54928","properties":[{"key":"EntryName","value":"RNA-binding domain, RBD"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50102","properties":[{"key":"EntryName","value":"RRM"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS","length":589,"molWeight":64133,"crc64":"31EEB51AF1C65F83","md5":"0AB10B8D979682865F1B2A09CC27145B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":6,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"DOMAIN":1,"PTM":3,"MISCELLANEOUS":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":4,"Region":2,"Compositional bias":6,"Modified residue":10,"Cross-link":5,"Alternative sequence":1,"Mutagenesis":7,"Sequence conflict":1,"Helix":12,"Beta strand":22,"Turn":4},"uniParcId":"UPI00004432FA"}}