{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P14373","secondaryAccessions":["A2BE15","Q5RJA8","Q5ST26","Q6LA73","Q6NXR9","Q9BZY6","Q9UJL3"],"uniProtkbId":"TRI27_HUMAN","entryAudit":{"firstPublicDate":"1990-01-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1990-01-01","entryVersion":253,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Zinc finger protein RFP"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22829933"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24144979"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26358190"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35670107"}],"value":"2.3.2.27"}]},"alternativeNames":[{"fullName":{"value":"RING finger protein 76"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1437549"}],"value":"Ret finger protein"}},{"fullName":{"value":"Tripartite motif-containing protein 27"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22128329"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:9975"}],"value":"TRIM27"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1437549"}],"value":"RFP"},{"value":"RNF76"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10976108"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12807881"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22128329"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22829933"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23452853"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24144979"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26358190"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29688809"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35670107"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36111389"}],"value":"E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:22829933, PubMed:24144979, PubMed:29688809, PubMed:36111389). Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. Forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-induced apoptosis (PubMed:24144979). In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation (PubMed:26358190, PubMed:29688809). Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome (PubMed:22829933). Alternatively, facilitates mitophagy via stabilization of active TBK1 (PubMed:36111389). Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 (PubMed:35670107). During starvation-induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy (PubMed:35670107)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29688809"}],"value":"(Microbial infection) Positively regulates hepatitis C virus replication by suppressing type I IFN response during infection"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22829933"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24144979"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26358190"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35670107"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22128329"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22829933"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26358190"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35670107"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10504338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10976108"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14530259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15837424"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17156811"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20864041"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22128329"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23452853"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26358190"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26365382"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36111389"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9570750"}],"value":"Homomultimerizes. Part of a complex consisting of TRIM27, USP7 and MAGEL2; directly interacts with USP7 (PubMed:26365382, PubMed:29688809). Interacts with PML, EIF3S6, EPC1, CHD4 and EID1. Interacts with MAGED4, MAGEF1 and MAGEL2. Interacts with PTPN11 (PubMed:26358190). Interacts with autophagy receptor p62/SQSTM1 (PubMed:36111389)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27698396"}],"value":"(Microbial infection) Interacts with M.tuberculosis PtpA, whick blocks TRIM27-promoted JNK/p38 MAPK pathway activation and cell apoptosis"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25320289"}],"value":"(Microbial infection) Interacts with herpes simplex virus protein ICP0"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q9NUQ8","geneName":"ABCF3","intActId":"EBI-717672"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q4G176","geneName":"ACSF3","intActId":"EBI-10714818"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q8WTP8","geneName":"AEN","intActId":"EBI-8637627"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q9Y4X0","geneName":"AMMECR1","intActId":"EBI-8583355"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q9Y2J4-4","geneName":"AMOTL2","intActId":"EBI-10187270"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q9BXS5","geneName":"AP1M1","intActId":"EBI-541426"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q9NR81","geneName":"ARHGEF3","intActId":"EBI-10312733"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q12774","geneName":"ARHGEF5","intActId":"EBI-602199"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q03989","geneName":"ARID5A","intActId":"EBI-948603"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q9H6L4","geneName":"ARMC7","intActId":"EBI-742909"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q7Z6K5","geneName":"ARPIN","intActId":"EBI-10258086"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q32MH5","geneName":"ATOSA","intActId":"EBI-2866142"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q7L5A3","geneName":"ATOSB","intActId":"EBI-745689"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q8N5M1","geneName":"ATPAF2","intActId":"EBI-1166928"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"A0A0S2Z4M1","geneName":"AXIN1","intActId":"EBI-16429430"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"O15169","geneName":"AXIN1","intActId":"EBI-710484"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q9NWV8","geneName":"BABAM1","intActId":"EBI-745725"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q99933","geneName":"BAG1","intActId":"EBI-1030678"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"O95817","geneName":"BAG3","intActId":"EBI-747185"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q9UL15","geneName":"BAG5","intActId":"EBI-356517"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"Q9BXY8","geneName":"BEX2","intActId":"EBI-745073"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"A8K571","geneName":"BMP7","intActId":"EBI-10174327"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14373","intActId":"EBI-719493"},"interactantTwo":{"uniProtKBAccession":"P18075","geneName":"BMP7","intActId":"EBI-1035195"},"numberOfExperiments":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