{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P13569","secondaryAccessions":["Q20BG8","Q20BH2","Q2I0A1","Q2I102"],"uniProtkbId":"CFTR_HUMAN","entryAudit":{"firstPublicDate":"1990-01-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-05-15","entryVersion":286,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cystic fibrosis transmembrane conductance regulator"},"shortNames":[{"value":"CFTR"}]},"alternativeNames":[{"fullName":{"value":"ATP-binding cassette sub-family C member 7"}},{"fullName":{"value":"Channel conductance-controlling ATPase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11524016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284228"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26627831"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8910473"}],"value":"5.6.1.6"}]},{"fullName":{"value":"cAMP-dependent chloride channel"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1884"}],"value":"CFTR"},"synonyms":[{"value":"ABCC7"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10792060"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11524016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11707463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12403779"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12519745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12529365"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12588899"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12727866"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14668433"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15010471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284228"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16645176"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17036051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1712898"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17182731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19019741"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19398555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19621064"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22178883"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25330774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26627831"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26823428"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26846474"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27714810"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27941075"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28087700"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29393851"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8910473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9804160"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19923167"}],"value":"Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.","ecNumber":"5.6.1.6","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11524016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284228"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26627831"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8910473"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"chloride(in) = chloride(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29823"},{"database":"ChEBI","id":"CHEBI:17996"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10792060"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11524016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11707463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12519745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12529365"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12588899"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12727866"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15010471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17036051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1712898"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17182731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19398555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19621064"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22178883"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25330774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26846474"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28087700"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8910473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9804160"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hydrogencarbonate(in) = hydrogencarbonate(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:28695"},{"database":"ChEBI","id":"CHEBI:17544"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15010471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19019741"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11524016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284228"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26627831"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8910473"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8910473"}]}]},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"maximumVelocities":[{"velocity":612.0,"unit":"pmol/h/ug","enzyme":"enzyme (in the presence of MgAMP-PNP)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12727866"}]}],"michaelisConstants":[{"constant":0.47,"unit":"mM","substrate":"glutathione (in the presence of MgAMP-PNP)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12727866"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26361"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P34158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11304524"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11524016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11707463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12403779"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15247260"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16331976"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17462998"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20933420"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21884936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22121115"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22178883"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23818989"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29393851"}],"value":"Monomer; does not require oligomerization for channel activity (PubMed:11524016). May form oligomers in the membrane (PubMed:11524016). Interacts with SLC26A3, SLC26A6 and SHANK2 (By similarity). Interacts with NHERF1 and MYO6 (PubMed:11304524, PubMed:12403779, PubMed:15247260). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity (PubMed:11707463, PubMed:16331976). Interacts with SLC4A7 through NHERF1 (PubMed:12403779). Found in a complex with MYO5B and RAB11A (PubMed:17462998). Interacts with ANO1 (PubMed:22178883). Interacts with SLC26A8 (PubMed:22121115). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (PubMed:20933420). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (PubMed:21884936). Interacts with MARCHF2; the interaction leads to CFTR ubiquitination and degradation (PubMed:23818989). Interacts with ADGRG2 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LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P34158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19398555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20008117"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21884936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22207244"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17462998"}],"value":"The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:17462998, PubMed:19398555, PubMed:20008117). In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia (PubMed:22207244). In Sertoli cells, a processed product is detected in the nucleus (By similarity). ER stress induces GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12519745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12529365"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1284548"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15247260"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15716351"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17462998"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19398555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19621064"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20008117"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22207244"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28130590"}],"value":"Apical cell membrane","id":"SL-0015"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.57"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19398555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20008117"}],"value":"Early endosome membrane","id":"SL-0093"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.57"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10792060"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11524016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11707463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12588899"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15010471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17036051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1712898"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17182731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19019741"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19398555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21884936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22178883"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25330774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26846474"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28001373"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28067262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28087700"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28130590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9804160"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8910473"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.57"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17462998"}],"value":"Recycling endosome membrane","id":"SL-0231"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.57"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11707463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25330774"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.57"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P34158"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P13569-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P13569-2"],"sequenceIds":["VSP_022123"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P13569-3"],"sequenceIds":["VSP_022124","VSP_022125"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1284548"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15716351"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19923167"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22207244"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28130590"}],"value":"Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level) (PubMed:15716351, PubMed:22207244). Detected in pancreatic intercalated ducts in the exocrine tissue, on epithelial cells in intralobular striated ducts in sublingual salivary glands, on apical membranes of crypt cells throughout the small and large intestine, and on the reabsorptive duct in eccrine sweat glands (PubMed:1284548, PubMed:28130590). Detected on the equatorial segment of the sperm head (at protein level) (PubMed:19923167). Detected in nasal and bronchial superficial epithelium (PubMed:15716351). Expressed by the central cells on the sebaceous glands, dermal adipocytes and, at lower levels, by epithelial cells (PubMed:28130590)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26361"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284228"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17036051"}],"value":"Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains (PubMed:15284228). The two ATP-binding domains interact with each other, forming a head-to-tail dimer (PubMed:17036051). Normal ATPase activity requires interaction between the two domains (PubMed:15284228). The first ABC transporter nucleotide-binding domain has no ATPase activity by itself (By similarity)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11304524"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11707463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16331976"}],"value":"The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, NHERF1/EBP50 complex"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10792060"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17660831"}],"value":"The R region is intrinsically disordered (PubMed:10792060, PubMed:17660831). It mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation (PubMed:10792060)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12529365"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1699669"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20008117"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21884936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28067262"}],"value":"N-glycosylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10792060"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12519745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12588899"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1377674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17036051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22119790"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25330774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8910473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9385646"}],"value":"Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel (PubMed:12588899, PubMed:17036051, PubMed:8910473). Dephosphorylation decreases the ATPase activity (in vitro) (PubMed:8910473). Phosphorylation at PKA sites activates the channel (PubMed:10792060, PubMed:12519745, PubMed:12588899, PubMed:25330774). Phosphorylation at PKC sites enhances the response to phosphorylation by PKA (PubMed:12588899). Phosphorylated by AMPK; this inhibits channel activity (PubMed:12519745)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19398555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22119790"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23818989"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24019521"}],"value":"Ubiquitinated, leading to its degradation in the lysosome (PubMed:19398555, PubMed:23818989). Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane (PubMed:19398555). Ubiquitinated by RNF185 during ER stress (PubMed:24019521). Ubiquitinated by MARCHF2 (PubMed:23818989)"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Cystic fibrosis","diseaseAccession":"DI-01466","acronym":"CF","description":"A common generalized disorder of the exocrine glands which impairs clearance of secretions in a variety of organs. It is characterized by the triad of chronic bronchopulmonary disease (with recurrent respiratory infections), pancreatic insufficiency (which leads to malabsorption and growth retardation) and elevated sweat electrolytes. It is the most common genetic disease in Caucasians, with a prevalence of about 1 in 2'000 live births. 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