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In pancreatic beta cells, regulates insulin secretion through NMUR1 coupled to GNAI2 and GNAO1, resulting in reduced intracellular Ca2+ influx and cAMP levels (By similarity). Through NMUR1 in Th2-type T cells, enhances type 2 cytokine secretion and modulates inflammatory responses via activation of PLC-calcineurin-MEK and PI3K signaling pathways (By similarity)"}],"commentType":"FUNCTION","molecule":"Neuromedin-U-23"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28874765"}],"value":"Does not function as a ligand for either NMUR1 or NMUR2 (PubMed:28874765). Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36 (PubMed:28874765)"}],"commentType":"FUNCTION","molecule":"Neuromedin-U precursor-related peptide 33"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28874765"}],"value":"Does not function as a ligand for either NMUR1 or NMUR2 (PubMed:28874765). 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