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Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed:19674967, PubMed:35932760). Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Required for skeletal homeostasis (PubMed:12538599). Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs (PubMed:12538599). Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion (By similarity). BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1 (PubMed:20637541)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1915066"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1954916"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20637541"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9048639"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9144344"}],"value":"Potent inhibitor of osteoclastic bone resorption"}],"commentType":"FUNCTION","molecule":"Osteostatin"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19674967"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35932760"}],"value":"Interacts with PTH1R (via N-terminal extracellular domain)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P12272","intActId":"EBI-2372758"},"interactantTwo":{"uniProtKBAccession":"Q03431","geneName":"PTH1R","intActId":"EBI-2860297"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3616618"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12852260"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12852260"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P12272-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P12272-2"],"sequenceIds":["VSP_004534"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P12272-3"],"sequenceIds":["VSP_004535"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"Additional isoforms seem to exist."}]}},{"texts":[{"value":"Ubiquitous. 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Wide variability in the number of digits affected occurs from person to person, even in the same family. Some individuals are moderately short of stature. 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