{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P11926","secondaryAccessions":["Q53TU3","Q6LDS9"],"uniProtkbId":"DCOR_HUMAN","entryAudit":{"firstPublicDate":"1989-10-01","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"1990-04-01","entryVersion":241,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Ornithine decarboxylase"},"shortNames":[{"value":"ODC"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17407445"}],"value":"4.1.1.17"}]}},"genes":[{"geneName":{"value":"ODC1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17900240"}],"value":"Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-ornithine + H(+) = putrescine + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22964"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:46911"},{"database":"ChEBI","id":"CHEBI:326268"}],"ecNumber":"4.1.1.17","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17407445"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"pyridoxal 5'-phosphate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17407445"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26443277"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:597326"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10462479"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11461922"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17407445"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17900240"}],"value":"Inhibited by S-nitrosylation (PubMed:10462479, PubMed:11461922). Inhibited by antizymes (AZs) OAZ1, OAZ2 and OAZ3 in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers. Additionally, OAZ1 targets ODC monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240). Inhibited by 1-amino-oxy-3-aminopropane (APA, an isosteric analog of putrescine) (PubMed:17407445). Irreversibly inhibited by alpha-difluoromethylornithine (DFMO) (PubMed:17407445)"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":0.08,"unit":"mM","substrate":"L-ornithine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17407445"}]}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17407445"}],"value":"kcat is 3.3 sec(-1) with L-ornithine as substrate."}]}}},{"texts":[{"value":"Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00860"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"10623504"}],"value":"Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (Probable). Does not form a heterodimer with AZIN2 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P11926","intActId":"EBI-1044287"},"interactantTwo":{"uniProtKBAccession":"Q9H8Y8","geneName":"GORASP2","intActId":"EBI-739467"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P11926","intActId":"EBI-1044287"},"interactantTwo":{"uniProtKBAccession":"Q92993","geneName":"KAT5","intActId":"EBI-399080"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P11926","intActId":"EBI-1044287"},"interactantTwo":{"uniProtKBAccession":"Q9UMX2","geneName":"OAZ3","intActId":"EBI-10281601"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P11926","intActId":"EBI-1044287"},"interactantTwo":{"uniProtKBAccession":"Q9UMX2-2","geneName":"OAZ3","intActId":"EBI-12049527"},"numberOfExperiments":3,"organismDiffer":false}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16548883"}],"value":"Down-regulated in response to enterovirus 71 (EV71) infection (at protein level)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10462479"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11461922"}],"value":"S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Bachmann-Bupp syndrome","diseaseAccession":"DI-05945","acronym":"BABS","description":"An autosomal dominant disorder characterized by global developmental delay, alopecia, absolute or relative macrocephaly, and facial dysmorphism. Neuroimaging shows white matter abnormalities, prominent Virchow-Robin spaces, periventricular cysts, and abnormalities of the corpus callosum.","diseaseCrossReference":{"database":"MIM","id":"619075"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30239107"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30475435"}]},"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30475435"}],"value":"The disease is caused by variants affecting the gene represented in this entry. BABS is due to truncating variants that lead to a gain of function. This phenomenon apparently results from truncation proximal to or involving the C-terminal region of ODC1 protein, distal enough to allow escape from nonsense-mediated decay. A gain of function is corroborated by elevated plasma levels of N-acetylputrescine, with otherwise normal polyamine levels, in affected individuals"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Orn/Lys/Arg decarboxylase class-II family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Ornithine_decarboxylase","ftp":false,"note":"Ornithine decarboxylase entry"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"Ornithine decarboxylase","featureId":"PRO_0000149891"},{"type":"Active site","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Proton donor; shared with dimeric partner","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"10623504"}]},{"type":"Binding site","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17407445"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2OO0"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Binding site","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17407445"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2OO0"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Binding site","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17407445"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26305948"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26443277"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2OO0"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Binding site","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"in other chain","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:46911"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07805"}],"ligand":{"name":"L-ornithine","id":"ChEBI:CHEBI:46911","note":"ligand shared between dimeric partners"}},{"type":"Binding site","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:326268"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07805"}],"ligand":{"name":"putrescine","id":"ChEBI:CHEBI:326268"}},{"type":"Binding site","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"in other chain","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:46911"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07805"}],"ligand":{"name":"L-ornithine","id":"ChEBI:CHEBI:46911","note":"ligand shared between dimeric partners"}},{"type":"Binding site","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:326268"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07805"}],"ligand":{"name":"putrescine","id":"ChEBI:CHEBI:326268"}},{"type":"Binding site","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:46911"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07805"}],"ligand":{"name":"L-ornithine","id":"ChEBI:CHEBI:46911","note":"ligand shared between dimeric partners"}},{"type":"Binding site","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:326268"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07805"}],"ligand":{"name":"putrescine","id":"ChEBI:CHEBI:326268"}},{"type":"Binding site","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:46911"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07805"}],"ligand":{"name":"L-ornithine","id":"ChEBI:CHEBI:46911","note":"ligand shared between dimeric partners"}},{"type":"Binding site","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:326268"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07805"}],"ligand":{"name":"putrescine","id":"ChEBI:CHEBI:326268"}},{"type":"Binding site","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:46911"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07805"}],"ligand":{"name":"L-ornithine","id":"ChEBI:CHEBI:46911","note":"ligand shared between dimeric partners"}},{"type":"Binding site","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:326268"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07805"}],"ligand":{"name":"putrescine","id":"ChEBI:CHEBI:326268"}},{"type":"Binding site","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:597326"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17407445"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26305948"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26443277"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2OO0"}],"ligand":{"name":"pyridoxal 5'-phosphate","id":"ChEBI:CHEBI:597326"}},{"type":"Site","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediates","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00860"}]},{"type":"Modified residue","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26305948"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17407445"}]},{"type":"Modified residue","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Phosphoserine; by CK2","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00860"}]},{"type":"Modified residue","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"S-nitrosocysteine; in inhibited form","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11461922"}]},{"type":"Natural variant","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"in BABS","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30475435"}],"featureId":"VAR_085000","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"in BABS; gain-of-function variant resulting in increased putrescine biosynthesis as indicated by higher amount of putrescine in patient red blood cells compared to controls; increased ODC1 protein levels in patient red blood cells","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30239107"}],"featureId":"VAR_085001","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"25% decrease of in vitro nitrosylation level.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11461922"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OO0"}]},{"type":"Turn","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OO0"}]},{"type":"Beta strand","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Turn","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OO0"}]},{"type":"Beta strand","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U6U"}]},{"type":"Helix","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Turn","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BWA"}]},{"type":"Beta strand","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U6U"}]},{"type":"Helix","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U6U"}]},{"type":"Beta strand","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":380,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":397,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Beta strand","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]},{"type":"Helix","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S3G"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0210","category":"Molecular function","name":"Decarboxylase"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1063","category":"Disease","name":"Hypotrichosis"},{"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0620","category":"Biological process","name":"Polyamine biosynthesis"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0702","category":"PTM","name":"S-nitrosylation"}],"references":[{"referenceNumber":1,"citation":{"id":"3595418","citationType":"journal article","authors":["Hickok N.J.","Seppaenen P.J.","Gunsalus G.L.","Jaenne O.A."],"citationCrossReferences":[{"database":"PubMed","id":"3595418"},{"database":"DOI","id":"10.1089/dna.1987.6.179"}],"title":"Complete amino acid sequence of human ornithine decarboxylase deduced from complementary DNA.","publicationDate":"1987","journal":"DNA","firstPage":"179","lastPage":"187","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"CI-200QG3DHDIRSD","citationType":"submission","authors":["Jaenne O.A."],"publicationDate":"APR-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["SEQUENCE REVISION TO 415"]},{"referenceNumber":3,"citation":{"id":"2693021","citationType":"journal article","authors":["Fitzgerald M.C.","Flanagan M.A."],"citationCrossReferences":[{"database":"PubMed","id":"2693021"},{"database":"DOI","id":"10.1089/dna.1.1989.8.623"}],"title":"Characterization and sequence analysis of the human ornithine decarboxylase gene.","publicationDate":"1989","journal":"DNA","firstPage":"623","lastPage":"634","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"2587220","citationType":"journal article","authors":["van Steeg H.","van Oostrom C.T.M.","Martens J.W.M.","van Kreyl C.F.","Schepens J.","Wieringa B."],"citationCrossReferences":[{"database":"PubMed","id":"2587220"},{"database":"DOI","id":"10.1093/nar/17.21.8855"}],"title":"Nucleotide sequence of the human ornithine decarboxylase gene.","publicationDate":"1989","journal":"Nucleic Acids Res.","firstPage":"8855","lastPage":"8856","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"2227439","citationType":"journal article","authors":["Hickok N.J.","Wahlfors J.","Crozat A.","Halmekytoe M.","Alhonen L.","Jaenne J.","Jaenne O.A."],"citationCrossReferences":[{"database":"PubMed","id":"2227439"},{"database":"DOI","id":"10.1016/0378-1119(90)90233-h"}],"title":"Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene.","publicationDate":"1990","journal":"Gene","firstPage":"257","lastPage":"263","volume":"93"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"2318872","citationType":"journal article","authors":["Moshier J.A.","Gilbert J.D.","Skunca M.","Dosescu J.","Almodovar K.M.","Luk G.D."],"citationCrossReferences":[{"database":"PubMed","id":"2318872"},{"database":"DOI","id":"10.1016/s0021-9258(19)34057-8"}],"title":"Isolation and expression of a human ornithine decarboxylase gene.","publicationDate":"1990","journal":"J. Biol. Chem.","firstPage":"4884","lastPage":"4892","volume":"265"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"1598217","citationType":"journal article","authors":["Moshier J.A.","Osborne D.L.","Skunca M.","Dosescu J.","Gilbert J.D.","Fitzgerald M.C.","Polidori G.","Wagner R.L.","Friezner Degen S.J.","Luk G.D.","Flanagan M.A."],"citationCrossReferences":[{"database":"PubMed","id":"1598217"},{"database":"DOI","id":"10.1093/nar/20.10.2581"}],"title":"Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells.","publicationDate":"1992","journal":"Nucleic Acids Res.","firstPage":"2581","lastPage":"2590","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"8519686","citationType":"journal article","authors":["Wright P.S.","Cooper J.R.","Cross-Doersen D.E.","Miller J.A.","Chmielewski P.A.","Wagner R.L.","Streng K.A.","Flanagan M.A."],"citationCrossReferences":[{"database":"PubMed","id":"8519686"}],"title":"Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element.","publicationDate":"1995","journal":"Cell Growth Differ.","firstPage":"1097","lastPage":"1102","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":9,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Esophagus","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"CI-86ALM2TFFQ300","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"NOV-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":11,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":12,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":13,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Lymph","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"2317811","citationType":"journal article","authors":["Hsieh J.T.","Denning M.F.","Heidel S.M.","Verma A.K."],"citationCrossReferences":[{"database":"PubMed","id":"2317811"}],"title":"Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells.","publicationDate":"1990","journal":"Cancer Res.","firstPage":"2239","lastPage":"2244","volume":"50"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-22"]},{"referenceNumber":15,"citation":{"id":"3308908","citationType":"journal article","authors":["Kaczmarek L.","Calabretta B.","Ferrari S.","de Riel J.K."],"citationCrossReferences":[{"database":"PubMed","id":"3308908"},{"database":"DOI","id":"10.1002/jcp.1041320318"}],"title":"Cell-cycle-dependent expression of human ornithine decarboxylase.","publicationDate":"1987","journal":"J. Cell. Physiol.","firstPage":"545","lastPage":"551","volume":"132"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 112-461"]},{"referenceNumber":16,"citation":{"id":"10462479","citationType":"journal article","authors":["Bauer P.M.","Fukuto J.M.","Buga G.M.","Pegg A.E.","Ignarro L.J."],"citationCrossReferences":[{"database":"PubMed","id":"10462479"},{"database":"DOI","id":"10.1006/bbrc.1999.1210"}],"title":"Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation.","publicationDate":"1999","journal":"Biochem. Biophys. Res. Commun.","firstPage":"355","lastPage":"358","volume":"262"},"referencePositions":["S-NITROSYLATION"]},{"referenceNumber":17,"citation":{"id":"11461922","citationType":"journal article","authors":["Bauer P.M.","Buga G.M.","Fukuto J.M.","Pegg A.E.","Ignarro L.J."],"citationCrossReferences":[{"database":"PubMed","id":"11461922"},{"database":"DOI","id":"10.1074/jbc.m105219200"}],"title":"Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"34458","lastPage":"34464","volume":"276"},"referencePositions":["S-NITROSYLATION AT CYS-360","MUTAGENESIS OF CYS-360"]},{"referenceNumber":18,"citation":{"id":"16548883","citationType":"journal article","authors":["Leong W.F.","Chow V.T."],"citationCrossReferences":[{"database":"PubMed","id":"16548883"},{"database":"DOI","id":"10.1111/j.1462-5822.2005.00644.x"}],"title":"Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.","publicationDate":"2006","journal":"Cell. Microbiol.","firstPage":"565","lastPage":"580","volume":"8"},"referencePositions":["INDUCTION","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":19,"citation":{"id":"17900240","citationType":"journal article","authors":["Kanerva K.","Makitie L.T.","Pelander A.","Heiskala M.","Andersson L.C."],"citationCrossReferences":[{"database":"PubMed","id":"17900240"},{"database":"DOI","id":"10.1042/bj20071004"}],"title":"Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase.","publicationDate":"2008","journal":"Biochem. J.","firstPage":"187","lastPage":"192","volume":"409"},"referencePositions":["FUNCTION","ACTIVITY REGULATION"]},{"referenceNumber":20,"citation":{"id":"10623504","citationType":"journal article","authors":["Almrud J.J.","Oliveira M.A.","Kern A.D.","Grishin N.V.","Phillips M.A.","Hackert M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10623504"},{"database":"DOI","id":"10.1006/jmbi.1999.3331"}],"title":"Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding.","publicationDate":"2000","journal":"J. Mol. Biol.","firstPage":"7","lastPage":"16","volume":"295"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 7-427","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1D7K"}]},{"referenceNumber":21,"citation":{"id":"17407445","citationType":"journal article","authors":["Dufe V.T.","Ingner D.","Heby O.","Khomutov A.R.","Persson L.","Al-Karadaghi S."],"citationCrossReferences":[{"database":"PubMed","id":"17407445"},{"database":"DOI","id":"10.1042/bj20070188"}],"title":"A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.","publicationDate":"2007","journal":"Biochem. J.","firstPage":"261","lastPage":"268","volume":"405"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH COFACTOR AND SUBSTRATE ANALOGS","CATALYTIC ACTIVITY","BIOPHYSICOCHEMICAL PROPERTIES"]},{"referenceNumber":22,"citation":{"id":"26305948","citationType":"journal article","authors":["Wu H.Y.","Chen S.F.","Hsieh J.Y.","Chou F.","Wang Y.H.","Lin W.T.","Lee P.Y.","Yu Y.J.","Lin L.Y.","Lin T.S.","Lin C.L.","Liu G.Y.","Tzeng S.R.","Hung H.C.","Chan N.L."],"citationCrossReferences":[{"database":"PubMed","id":"26305948"},{"database":"DOI","id":"10.1073/pnas.1508187112"}],"title":"Structural basis of antizyme-mediated regulation of polyamine homeostasis.","publicationDate":"2015","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11229","lastPage":"11234","volume":"112"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) OF 2-421 IN COMPLEX WITH COFACTOR AND OAZ1"]},{"referenceNumber":23,"citation":{"id":"26443277","citationType":"journal article","authors":["Wu D.","Kaan H.Y.","Zheng X.","Tang X.","He Y.","Vanessa Tan Q.","Zhang N.","Song H."],"citationCrossReferences":[{"database":"PubMed","id":"26443277"},{"database":"DOI","id":"10.1038/srep14738"}],"title":"Structural basis of ornithine decarboxylase inactivation and accelerated degradation by polyamine sensor antizyme1.","publicationDate":"2015","journal":"Sci. Rep.","firstPage":"14738","lastPage":"14738","volume":"5"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) IN COMPLEX WITH COFACTOR; OAZ1 AND INHIBITOR"]},{"referenceNumber":24,"citation":{"id":"30239107","citationType":"journal article","authors":["Bupp C.P.","Schultz C.R.","Uhl K.L.","Rajasekaran S.","Bachmann A.S."],"citationCrossReferences":[{"database":"PubMed","id":"30239107"},{"database":"DOI","id":"10.1002/ajmg.a.40523"}],"title":"Novel de novo pathogenic variant in the ODC1 gene in a girl with developmental delay, alopecia, and dysmorphic features.","publicationDate":"2018","journal":"Am. J. Med. Genet. A","firstPage":"2548","lastPage":"2553","volume":"176"},"referencePositions":["VARIANT BABS 448-LYS--VAL-461 DEL","INVOLVEMENT IN BABS","CHARACTERIZATION OF VARIANT BABS 448-LYS--VAL-461 DEL"]},{"referenceNumber":25,"citation":{"id":"30475435","citationType":"journal article","authors":["Rodan L.H.","Anyane-Yeboa K.","Chong K.","Klein Wassink-Ruiter J.S.","Wilson A.","Smith L.","Kothare S.V.","Rajabi F.","Blaser S.","Ni M.","DeBerardinis R.J.","Poduri A.","Berry G.T."],"citationCrossReferences":[{"database":"PubMed","id":"30475435"},{"database":"DOI","id":"10.1002/ajmg.a.60677"}],"title":"Gain-of-function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities.","publicationDate":"2018","journal":"Am. J. Med. Genet. A","firstPage":"2554","lastPage":"2560","volume":"176"},"referencePositions":["VARIANT BABS 419-GLN--VAL-461 DEL","INVOLVEMENT IN BABS"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M16650","properties":[{"key":"ProteinId","value":"AAA59966.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M31061","properties":[{"key":"ProteinId","value":"AAA60563.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X16277","properties":[{"key":"ProteinId","value":"CAA34353.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M33764","properties":[{"key":"ProteinId","value":"AAA60564.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M34158","properties":[{"key":"ProteinId","value":"AAA59969.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M81740","properties":[{"key":"ProteinId","value":"AAA59967.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X55362","properties":[{"key":"ProteinId","value":"CAA39047.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK292352","properties":[{"key":"ProteinId","value":"BAF85041.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK312766","properties":[{"key":"ProteinId","value":"BAG35632.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY841870","properties":[{"key":"ProteinId","value":"AAV88093.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC007249","properties":[{"key":"ProteinId","value":"AAY15034.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471053","properties":[{"key":"ProteinId","value":"EAX00958.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471053","properties":[{"key":"ProteinId","value":"EAX00959.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC025296","properties":[{"key":"ProteinId","value":"AAH25296.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X53271","properties":[{"key":"ProteinId","value":"CAA37369.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M20372","properties":[{"key":"ProteinId","value":"AAA59968.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS1672.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S06900","properties":[{"key":"EntryName","value":"DCHUO"}]},{"database":"RefSeq","id":"NP_001274118.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001287189.2"}]},{"database":"RefSeq","id":"NP_001274119.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001287190.2"}]},{"database":"RefSeq","id":"NP_002530.1","properties":[{"key":"NucleotideSequenceId","value":"NM_002539.3"}]},{"database":"PDB","id":"1D7K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=7-427"}]},{"database":"PDB","id":"2ON3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B=1-461"}]},{"database":"PDB","id":"2OO0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=1-461"}]},{"database":"PDB","id":"4ZGY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.63 A"},{"key":"Chains","value":"A=2-421"}]},{"database":"PDB","id":"5BWA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1-461"}]},{"database":"PDB","id":"7S3F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.49 A"},{"key":"Chains","value":"A/B=1-424"}]},{"database":"PDB","id":"7S3G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A/B=1-424"}]},{"database":"PDB","id":"7U6P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A/B=1-424"}]},{"database":"PDB","id":"7U6U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B=1-424"}]},{"database":"PDB","id":"9B8M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A/B=1-422"}]},{"database":"PDB","id":"9B8N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=1-424"}]},{"database":"PDBsum","id":"1D7K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2ON3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2OO0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4ZGY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5BWA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7S3F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7S3G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7U6P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7U6U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9B8M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9B8N","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"111007","properties":[{"key":"Interactions","value":"23"}]},{"database":"CORUM","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P11926","properties":[{"key":"Number of interactors","value":"375"}]},{"database":"IntAct","id":"P11926","properties":[{"key":"Interactions","value":"17"}]},{"database":"MINT","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-ODC1","properties":[{"key":"Evidences","value":"5 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000234111","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1869","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB06243","properties":[{"key":"GenericName","value":"Eflornithine"}]},{"database":"DrugBank","id":"DB04263","properties":[{"key":"GenericName","value":"Geneticin"}]},{"database":"DrugBank","id":"DB03856","properties":[{"key":"GenericName","value":"L-Eflornithine"}]},{"database":"DrugBank","id":"DB04083","properties":[{"key":"GenericName","value":"N(6)-(pyridoxal phosphate)-L-lysine"}]},{"database":"DrugBank","id":"DB02824","properties":[{"key":"GenericName","value":"N-Pyridoxyl-Glycine-5-Monophosphate"}]},{"database":"DrugBank","id":"DB01917","properties":[{"key":"GenericName","value":"Putrescine"}]},{"database":"DrugBank","id":"DB00114","properties":[{"key":"GenericName","value":"Pyridoxal phosphate"}]},{"database":"DrugBank","id":"DB02209","properties":[{"key":"GenericName","value":"Pyridoxine phosphate"}]},{"database":"DrugBank","id":"DB00203","properties":[{"key":"GenericName","value":"Sildenafil"}]},{"database":"DrugBank","id":"DB00127","properties":[{"key":"GenericName","value":"Spermine"}]},{"database":"DrugBank","id":"DB00313","properties":[{"key":"GenericName","value":"Valproic acid"}]},{"database":"DrugCentral","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"1276","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ODC1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"118377","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000234111","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52813","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"781","properties":[{"key":"antibodies","value":"934 antibodies from 36 providers"}]},{"database":"CPTC","id":"P11926","properties":[{"key":"antibodies","value":"3 antibodies"}]},{"database":"DNASU","id":"4953","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000234111.9","properties":[{"key":"ProteinId","value":"ENSP00000234111.4"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000405333.5","properties":[{"key":"ProteinId","value":"ENSP00000385333.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000443218.2","properties":[{"key":"ProteinId","value":"ENSP00000390691.2"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000699835.1","properties":[{"key":"ProteinId","value":"ENSP00000514633.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000699836.1","properties":[{"key":"ProteinId","value":"ENSP00000514634.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000887501.1","properties":[{"key":"ProteinId","value":"ENSP00000557560.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000887502.1","properties":[{"key":"ProteinId","value":"ENSP00000557561.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000887503.1","properties":[{"key":"ProteinId","value":"ENSP00000557562.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000887504.1","properties":[{"key":"ProteinId","value":"ENSP00000557563.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000887505.1","properties":[{"key":"ProteinId","value":"ENSP00000557564.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000887506.1","properties":[{"key":"ProteinId","value":"ENSP00000557565.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000887507.1","properties":[{"key":"ProteinId","value":"ENSP00000557566.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000926727.1","properties":[{"key":"ProteinId","value":"ENSP00000596786.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000926729.1","properties":[{"key":"ProteinId","value":"ENSP00000596788.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000953421.1","properties":[{"key":"ProteinId","value":"ENSP00000623480.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000953422.1","properties":[{"key":"ProteinId","value":"ENSP00000623481.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000953423.1","properties":[{"key":"ProteinId","value":"ENSP00000623482.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"Ensembl","id":"ENST00000953424.1","properties":[{"key":"ProteinId","value":"ENSP00000623483.1"},{"key":"GeneId","value":"ENSG00000115758.15"}]},{"database":"GeneID","id":"4953","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:4953","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000234111.9","properties":[{"key":"ProteinId","value":"ENSP00000234111.4"},{"key":"RefSeqNucleotideId","value":"NM_002539.3"},{"key":"RefSeqProteinId","value":"NP_002530.1"}]},{"database":"UCSC","id":"uc002rao.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:8109","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA31897","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4953","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"4953","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ODC1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"ODC1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:8109","properties":[{"key":"GeneName","value":"ODC1"}]},{"database":"HPA","id":"ENSG00000115758","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"ODC1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"165640","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"619075","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000115758","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"544488","properties":[{"key":"Disease","value":"Global developmental delay-alopecia-macrocephaly-facial dysmorphism-structural brain anomalies syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000115758","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0622","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000182995","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_026444_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AYCRSMA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5034579at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P11926","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:HS03935-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"4.1.1.17","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-350562","properties":[{"key":"PathwayName","value":"Regulation of ornithine decarboxylase (ODC)"}]},{"database":"Reactome","id":"R-HSA-351202","properties":[{"key":"PathwayName","value":"Metabolism of polyamines"}]},{"database":"SABIO-RK","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00535","properties":[{"key":"RectionId","value":"UER00288"}]},{"database":"Agora","id":"ENSG00000115758","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"4953","properties":[{"key":"hits","value":"22 hits in 1174 CRISPR screens"}]},{"database":"ChiTaRS","id":"ODC1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P11926","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"ODC1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"4953","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P11926","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P11926","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"P11926","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000115758","properties":[{"key":"ExpressionPatterns","value":"Expressed in secondary oocyte and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P11926","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0042978","properties":[{"key":"GoTerm","value":"F:ornithine decarboxylase activator activity"},{"key":"GoEvidenceType","value":"EXP:Reactome"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10623504"}]},{"database":"GO","id":"GO:0004586","properties":[{"key":"GoTerm","value":"F:ornithine decarboxylase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17900240"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006595","properties":[{"key":"GoTerm","value":"P:polyamine metabolic process"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0033387","properties":[{"key":"GoTerm","value":"P:putrescine biosynthetic process from arginine, via ornithine"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042176","properties":[{"key":"GoTerm","value":"P:regulation of protein catabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0009615","properties":[{"key":"GoTerm","value":"P:response to virus"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"16548883"}]},{"database":"GO","id":"GO:0008295","properties":[{"key":"GoTerm","value":"P:spermidine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006597","properties":[{"key":"GoTerm","value":"P:spermine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd00622","properties":[{"key":"EntryName","value":"PLPDE_III_ODC"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP02673","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"2.40.37.10:FF:000005","properties":[{"key":"EntryName","value":"Ornithine decarboxylase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.20.20.10:FF:000006","properties":[{"key":"EntryName","value":"Ornithine decarboxylase 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.10","properties":[{"key":"EntryName","value":"Alanine racemase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.37.10","properties":[{"key":"EntryName","value":"Lyase, Ornithine Decarboxylase, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009006","properties":[{"key":"EntryName","value":"Ala_racemase/Decarboxylase_C"}]},{"database":"InterPro","id":"IPR022643","properties":[{"key":"EntryName","value":"De-COase2_C"}]},{"database":"InterPro","id":"IPR022657","properties":[{"key":"EntryName","value":"De-COase2_CS"}]},{"database":"InterPro","id":"IPR022644","properties":[{"key":"EntryName","value":"De-COase2_N"}]},{"database":"InterPro","id":"IPR022653","properties":[{"key":"EntryName","value":"De-COase2_pyr-phos_BS"}]},{"database":"InterPro","id":"IPR000183","properties":[{"key":"EntryName","value":"Orn/DAP/Arg_de-COase"}]},{"database":"InterPro","id":"IPR002433","properties":[{"key":"EntryName","value":"Orn_de-COase"}]},{"database":"InterPro","id":"IPR029066","properties":[{"key":"EntryName","value":"PLP-binding_barrel"}]},{"database":"PANTHER","id":"PTHR11482","properties":[{"key":"EntryName","value":"ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11482:SF42","properties":[{"key":"EntryName","value":"ORNITHINE DECARBOXYLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02784","properties":[{"key":"EntryName","value":"Orn_Arg_deC_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00278","properties":[{"key":"EntryName","value":"Orn_DAP_Arg_deC"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01179","properties":[{"key":"EntryName","value":"ODADCRBXLASE"}]},{"database":"PRINTS","id":"PR01182","properties":[{"key":"EntryName","value":"ORNDCRBXLASE"}]},{"database":"SUPFAM","id":"SSF50621","properties":[{"key":"EntryName","value":"Alanine racemase C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51419","properties":[{"key":"EntryName","value":"PLP-binding barrel"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00878","properties":[{"key":"EntryName","value":"ODR_DC_2_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00879","properties":[{"key":"EntryName","value":"ODR_DC_2_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV","length":461,"molWeight":51148,"crc64":"8CCB88CE80E823C5","md5":"F88E8C4D2A828BB0219633DDBBFA5543"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"ACTIVITY REGULATION":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"PATHWAY":1,"SUBUNIT":1,"INTERACTION":4,"INDUCTION":1,"PTM":1,"DISEASE":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Active site":1,"Binding site":14,"Site":1,"Modified residue":3,"Natural variant":2,"Mutagenesis":1,"Helix":23,"Turn":3,"Beta strand":22},"uniParcId":"UPI0000001283"}}