{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P11922","secondaryAccessions":["Q66BU9"],"uniProtkbId":"INVA_YERPS","entryAudit":{"firstPublicDate":"1989-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-11-23","entryVersion":150,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Yersinia pseudotuberculosis serotype I (strain IP32953)","taxonId":273123,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Yersiniaceae","Yersinia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Invasin"}}},"genes":[{"orderedLocusNames":[{"value":"YPTB1668"}]}],"comments":[{"texts":[{"value":"Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cell surface","id":"SL-0310"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the intimin/invasin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"It is uncertain whether Met-1, Met-17 or Met-19 is the initiator"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAA27632.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAA27634.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAA27635.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":985,"modifier":"EXACT"}},"description":"Invasin","featureId":"PRO_0000211831"},{"type":"Topological domain","location":{"start":{"value":494,"modifier":"EXACT"},"end":{"value":985,"modifier":"EXACT"}},"description":"Extracellular"},{"type":"Domain","location":{"start":{"value":503,"modifier":"EXACT"},"end":{"value":594,"modifier":"EXACT"}},"description":"Big-1 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00445"}]},{"type":"Domain","location":{"start":{"value":601,"modifier":"EXACT"},"end":{"value":691,"modifier":"EXACT"}},"description":"Big-1 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00445"}]},{"type":"Region","location":{"start":{"value":494,"modifier":"EXACT"},"end":{"value":594,"modifier":"EXACT"}},"description":"D1"},{"type":"Region","location":{"start":{"value":595,"modifier":"EXACT"},"end":{"value":694,"modifier":"EXACT"}},"description":"D2"},{"type":"Region","location":{"start":{"value":695,"modifier":"EXACT"},"end":{"value":794,"modifier":"EXACT"}},"description":"D3"},{"type":"Region","location":{"start":{"value":795,"modifier":"EXACT"},"end":{"value":985,"modifier":"EXACT"}},"description":"Integrin-binding"},{"type":"Region","location":{"start":{"value":795,"modifier":"EXACT"},"end":{"value":886,"modifier":"EXACT"}},"description":"D4"},{"type":"Region","location":{"start":{"value":887,"modifier":"EXACT"},"end":{"value":985,"modifier":"EXACT"}},"description":"D5"},{"type":"Disulfide bond","location":{"start":{"value":906,"modifier":"EXACT"},"end":{"value":981,"modifier":"EXACT"}},"description":""},{"type":"Sequence conflict","location":{"start":{"value":767,"modifier":"EXACT"},"end":{"value":768,"modifier":"EXACT"}},"description":"in Ref. 1; AAA27633/AAA27632","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"TA","alternativeSequences":["SV"]}},{"type":"Sequence conflict","location":{"start":{"value":894,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"in Ref. 1; AAA27633/AAA27632","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":970,"modifier":"EXACT"},"end":{"value":971,"modifier":"EXACT"}},"description":"in Ref. 1; AAA27633/AAA27632","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"VQ","alternativeSequences":["QP"]}},{"type":"Sequence conflict","location":{"start":{"value":984,"modifier":"EXACT"},"end":{"value":984,"modifier":"EXACT"}},"description":"in Ref. 1; AAA27633/AAA27632","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Beta strand","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Turn","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Helix","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Helix","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Helix","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Helix","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Helix","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Helix","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1T"}]},{"type":"Beta strand","location":{"start":{"value":503,"modifier":"EXACT"},"end":{"value":510,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":512,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":521,"modifier":"EXACT"},"end":{"value":528,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":543,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":552,"modifier":"EXACT"},"end":{"value":556,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":561,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":581,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":584,"modifier":"EXACT"},"end":{"value":593,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Helix","location":{"start":{"value":599,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":603,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":619,"modifier":"EXACT"},"end":{"value":624,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":638,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":654,"modifier":"EXACT"},"end":{"value":663,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":668,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":679,"modifier":"EXACT"},"end":{"value":691,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Turn","location":{"start":{"value":698,"modifier":"EXACT"},"end":{"value":700,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":702,"modifier":"EXACT"},"end":{"value":706,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":708,"modifier":"EXACT"},"end":{"value":711,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":718,"modifier":"EXACT"},"end":{"value":723,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":737,"modifier":"EXACT"},"end":{"value":745,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Helix","location":{"start":{"value":750,"modifier":"EXACT"},"end":{"value":752,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":759,"modifier":"EXACT"},"end":{"value":764,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":769,"modifier":"EXACT"},"end":{"value":777,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Helix","location":{"start":{"value":783,"modifier":"EXACT"},"end":{"value":785,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":787,"modifier":"EXACT"},"end":{"value":792,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Helix","location":{"start":{"value":793,"modifier":"EXACT"},"end":{"value":795,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":797,"modifier":"EXACT"},"end":{"value":802,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":807,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":815,"modifier":"EXACT"},"end":{"value":818,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":822,"modifier":"EXACT"},"end":{"value":827,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Helix","location":{"start":{"value":831,"modifier":"EXACT"},"end":{"value":836,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":837,"modifier":"EXACT"},"end":{"value":843,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Turn","location":{"start":{"value":844,"modifier":"EXACT"},"end":{"value":846,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":847,"modifier":"EXACT"},"end":{"value":849,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":854,"modifier":"EXACT"},"end":{"value":857,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":865,"modifier":"EXACT"},"end":{"value":874,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":878,"modifier":"EXACT"},"end":{"value":883,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":887,"modifier":"EXACT"},"end":{"value":892,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Helix","location":{"start":{"value":899,"modifier":"EXACT"},"end":{"value":905,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":912,"modifier":"EXACT"},"end":{"value":914,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Helix","location":{"start":{"value":917,"modifier":"EXACT"},"end":{"value":920,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":926,"modifier":"EXACT"},"end":{"value":929,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Helix","location":{"start":{"value":931,"modifier":"EXACT"},"end":{"value":935,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Helix","location":{"start":{"value":938,"modifier":"EXACT"},"end":{"value":940,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":947,"modifier":"EXACT"},"end":{"value":957,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":959,"modifier":"EXACT"},"end":{"value":963,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Turn","location":{"start":{"value":964,"modifier":"EXACT"},"end":{"value":966,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]},{"type":"Beta strand","location":{"start":{"value":977,"modifier":"EXACT"},"end":{"value":984,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1CWV"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"3304658","citationType":"journal article","authors":["Isberg R.R.","Voorhis D.L.","Falkow S."],"citationCrossReferences":[{"database":"PubMed","id":"3304658"},{"database":"DOI","id":"10.1016/0092-8674(87)90335-7"}],"title":"Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells.","publicationDate":"1987","journal":"Cell","firstPage":"769","lastPage":"778","volume":"50"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15358858","citationType":"journal article","authors":["Chain P.S.G.","Carniel E.","Larimer F.W.","Lamerdin J.","Stoutland P.O.","Regala W.M.","Georgescu A.M.","Vergez L.M.","Land M.L.","Motin V.L.","Brubaker R.R.","Fowler J.","Hinnebusch J.","Marceau M.","Medigue C.","Simonet M.","Chenal-Francisque V.","Souza B.","Dacheux D.","Elliott J.M.","Derbise A.","Hauser L.J.","Garcia E."],"citationCrossReferences":[{"database":"PubMed","id":"15358858"},{"database":"DOI","id":"10.1073/pnas.0404012101"}],"title":"Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis.","publicationDate":"2004","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"13826","lastPage":"13831","volume":"101"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"IP32953","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"1693333","citationType":"journal article","authors":["Leong J.M.","Fournier R.S.","Isberg R.R."],"citationCrossReferences":[{"database":"PubMed","id":"1693333"},{"database":"DOI","id":"10.1002/j.1460-2075.1990.tb08326.x"}],"title":"Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein.","publicationDate":"1990","journal":"EMBO J.","firstPage":"1979","lastPage":"1989","volume":"9"},"referencePositions":["DOMAIN INTEGRIN-BINDING"]},{"referenceNumber":4,"citation":{"id":"10514372","citationType":"journal article","authors":["Hamburger Z.A.","Brown M.S.","Isberg R.R.","Bjorkman P.J."],"citationCrossReferences":[{"database":"PubMed","id":"10514372"},{"database":"DOI","id":"10.1126/science.286.5438.291"}],"title":"Crystal structure of invasin: a bacterial integrin-binding protein.","publicationDate":"1999","journal":"Science","firstPage":"291","lastPage":"295","volume":"286"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 494-985"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M17448","properties":[{"key":"ProteinId","value":"AAA27633.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M17448","properties":[{"key":"ProteinId","value":"AAA27632.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M17448","properties":[{"key":"ProteinId","value":"AAA27634.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M17448","properties":[{"key":"ProteinId","value":"AAA27635.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX936398","properties":[{"key":"ProteinId","value":"CAH20907.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A29646","properties":[{"key":"EntryName","value":"A29646"}]},{"database":"PDB","id":"1CWV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=494-985"}]},{"database":"PDB","id":"4E1T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.26 A"},{"key":"Chains","value":"A=146-390"}]},{"database":"PDBsum","id":"1CWV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4E1T","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P11922","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P11922","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB04272","properties":[{"key":"GenericName","value":"Citric acid"}]},{"database":"TCDB","id":"1.B.54.1.2","properties":[{"key":"FamilyName","value":"the intimin/invasin (int/inv) or autotransporter-3 (at-3) family"}]},{"database":"KEGG","id":"yps:YPTB1668","properties":[{"key":"Description","value":"-"}]},{"database":"EvolutionaryTrace","id":"P11922","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001011","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"2.60.40.10:FF:000182","properties":[{"key":"EntryName","value":"Gamma intimin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.160.160:FF:000001","properties":[{"key":"EntryName","value":"Intimin-like inverse autotransporter SinH"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1080","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"2.40.160.160","properties":[{"key":"EntryName","value":"Inverse autotransporter, beta-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.100.10","properties":[{"key":"EntryName","value":"Mannose-Binding Protein A, subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003344","properties":[{"key":"EntryName","value":"Big_1_dom"}]},{"database":"InterPro","id":"IPR016186","properties":[{"key":"EntryName","value":"C-type_lectin-like/link_sf"}]},{"database":"InterPro","id":"IPR016187","properties":[{"key":"EntryName","value":"CTDL_fold"}]},{"database":"InterPro","id":"IPR024519","properties":[{"key":"EntryName","value":"IAT_beta"}]},{"database":"InterPro","id":"IPR038177","properties":[{"key":"EntryName","value":"IAT_beta_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR063230","properties":[{"key":"EntryName","value":"Ig_Eae_1st"}]},{"database":"InterPro","id":"IPR051715","properties":[{"key":"EntryName","value":"Intimin-Invasin_domain"}]},{"database":"InterPro","id":"IPR003535","properties":[{"key":"EntryName","value":"Intimin/invasin_bac"}]},{"database":"InterPro","id":"IPR013117","properties":[{"key":"EntryName","value":"Intimin_C"}]},{"database":"InterPro","id":"IPR008964","properties":[{"key":"EntryName","value":"Invasin/intimin_cell_adhesion"}]},{"database":"InterPro","id":"IPR048658","properties":[{"key":"EntryName","value":"Invasin_D4"}]},{"database":"InterPro","id":"IPR015217","properties":[{"key":"EntryName","value":"Invasin_dom_3"}]},{"database":"PANTHER","id":"PTHR39576:SF2","properties":[{"key":"EntryName","value":"ATTACHING AND EFFACING PROTEIN HOMOLOG-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR39576","properties":[{"key":"EntryName","value":"ATTACHING AND EFFACING PROTEIN HOMOLOG-RELATED-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02369","properties":[{"key":"EntryName","value":"Big_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11924","properties":[{"key":"EntryName","value":"IAT_beta"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30549","properties":[{"key":"EntryName","value":"Ig_Eae_1st"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07979","properties":[{"key":"EntryName","value":"Intimin_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09134","properties":[{"key":"EntryName","value":"Invasin_D3"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF21764","properties":[{"key":"EntryName","value":"Invasin_D4"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01369","properties":[{"key":"EntryName","value":"INTIMIN"}]},{"database":"SMART","id":"SM00634","properties":[{"key":"EntryName","value":"BID_1"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF56436","properties":[{"key":"EntryName","value":"C-type lectin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49373","properties":[{"key":"EntryName","value":"Invasin/intimin cell-adhesion fragments"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS51127","properties":[{"key":"EntryName","value":"BIG1"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MVFQPISEFLLIRNAGMSMYFNKIISFNIISRIVICIFLICGMFMAGASEKYDANAPQQVQPYSVSSSAFENLHPNNEMESSINPFSASDTERNAAIIDRANKEQETEAVNKMISTGARLAASGRASDVAHSMVGDAVNQEIKQWLNRFGTAQVNLNFDKNFSLKESSLDWLAPWYDSASFLFFSQLGIRNKDSRNTLNLGVGIRTLENGWLYGLNTFYDNDLTGHNHRIGLGAEAWTDYLQLAANGYFRLNGWHSSRDFSDYKERPATGGDLRANAYLPALPQLGGKLMYEQYTGERVALFGKDNLQRNPYAVTAGINYTPVPLLTVGVDQRMGKSSKHETQWNLQMNYRLGESFQSQLSPSAVAGTRLLAESRYNLVDRNNNIVLEYQKQQVVKLTLSPATISGLPGQVYQVNAQVQGASAVREIVWSDAELIAAGGTLTPLSTTQFNLVLPPYKRTAQVSRVTDDLTANFYSLSALAVDHQGNRSNSFTLSVTVQQPQLTLTAAVIGDGAPANGKTAITVEFTVADFEGKPLAGQEVVITTNNGALPNKITEKTDANGVARIALTNTTDGVTVVTAEVEGQRQSVDTHFVKGTIAADKSTLAAVPTSIIADGLMASTITLELKDTYGDPQAGANVAFDTTLGNMGVITDHNDGTYSAPLTSTTLGVATVTVKVDGAAFSVPSVTVNFTADPIPDAGRSSFTVSTPDILADGTMSSTLSFVPVDKNGHFISGMQGLSFTQNGVPVSISPITEQPDSYTATVVGNTAGDVTITPQVDTLILSTLQKKISLFPVPTLTGILVNGQNFATDKGFPKTIFKNATFQLQMDNDVANNTQYEWSSSFTPNVSVNDQGQVTITYQTYSEVAVTAKSKKFPSYSVSYRFYPNRWIYDGGTSLVSSLEASRQCQGSDMSAVLESSRATNGTRAPDGTLWGEWGSLTAYSSDWQSGEYWVKKTSTDFETMNMDTGALVQGPAYLAFPLCALAI","length":985,"molWeight":106544,"crc64":"42007F9EEB984D50","md5":"B57F4152950D8A35DB2B8D8A0D0D93AC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1,"SEQUENCE CAUTION":3},"countByFeatureType":{"Chain":1,"Topological domain":1,"Domain":2,"Region":6,"Disulfide bond":1,"Sequence conflict":4,"Beta strand":52,"Turn":4,"Helix":15},"uniParcId":"UPI0000426ABE"}}