{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P11712","secondaryAccessions":["P11713","Q16756","Q16872","Q5VX92","Q6IRV8","Q8WW80"],"uniProtkbId":"CP2C9_HUMAN","entryAudit":{"firstPublicDate":"1989-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-30","entryVersion":252,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8809086"}],"value":"Cytochrome P450 2C9"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12865317"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21576599"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9435160"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9866708"}],"value":"1.14.14.1"}]},"alternativeNames":[{"fullName":{"value":"(R)-limonene 6-monooxygenase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11950794"}],"value":"1.14.14.53"}]},{"fullName":{"value":"(S)-limonene 6-monooxygenase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11950794"}],"value":"1.14.14.51"}]},{"fullName":{"value":"(S)-limonene 7-monooxygenase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11950794"}],"value":"1.14.14.52"}]},{"fullName":{"value":"CYPIIC9"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3079764"}],"value":"Cholesterol 25-hydroxylase"}},{"fullName":{"value":"Cytochrome P-450MP"}},{"fullName":{"value":"Cytochrome P450 MP-4"}},{"fullName":{"value":"Cytochrome P450 MP-8"}},{"fullName":{"value":"Cytochrome P450 PB-1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3079764"}],"value":"S-mephenytoin 4-hydroxylase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11950794"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2623"}],"value":"CYP2C9"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8215449"}],"value":"CYP2C10"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11950794"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12865317"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15766564"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19965576"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21576599"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25994031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7574697"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9435160"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9866708"}],"value":"A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599, PubMed:7574697, PubMed:9435160, PubMed:9866708). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599, PubMed:7574697, PubMed:9435160, PubMed:9866708). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:15766564, PubMed:19965576, PubMed:7574697, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9435160, PubMed:9866708). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + 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