{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P10745","secondaryAccessions":["Q0QD34","Q5VSR0","Q8IXN0"],"uniProtkbId":"RET3_HUMAN","entryAudit":{"firstPublicDate":"1989-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1991-11-01","entryVersion":207,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Retinol-binding protein 3"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2792773"}],"value":"Interphotoreceptor retinoid-binding protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2792773"}],"value":"IRBP"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2542268"}],"value":"Interstitial retinol-binding protein"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:9921"}],"value":"RBP3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49194"}],"value":"Mediates the transport of 11-cis- and all-trans-retinoids between the retinal pigment epithelium (RPE) and photoreceptors, facilitating retinoid exchange required for the visual cycle"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"Q9UJX2","geneName":"CDC23","intActId":"EBI-396137"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"Q02930-3","geneName":"CREB5","intActId":"EBI-10192698"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"A8MQ03","geneName":"CYSRT1","intActId":"EBI-3867333"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"O95967","geneName":"EFEMP2","intActId":"EBI-743414"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"P49639","geneName":"HOXA1","intActId":"EBI-740785"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"O43593","geneName":"HR","intActId":"EBI-2880706"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"Q9H2F3","geneName":"HSD3B7","intActId":"EBI-3918847"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"Q5T749","geneName":"KPRP","intActId":"EBI-10981970"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"P60370","geneName":"KRTAP10-5","intActId":"EBI-10172150"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"Q8IV28","geneName":"NID2","intActId":"EBI-10261509"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"Q9NRQ2","geneName":"PLSCR4","intActId":"EBI-769257"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"Q12837","geneName":"POU4F2","intActId":"EBI-17236143"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10745","intActId":"EBI-12806054"},"interactantTwo":{"uniProtKBAccession":"Q99932-2","geneName":"SPAG8","intActId":"EBI-11959123"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells"}]},"subcellularLocations":[{"location":{"value":"Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix","id":"SL-0146"}}]},{"commentType":"DISEASE","disease":{"diseaseId":"Retinitis pigmentosa 66","diseaseAccession":"DI-03727","acronym":"RP66","description":"A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.","diseaseCrossReference":{"database":"MIM","id":"615233"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23486466"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the peptidase S41A family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"It is uncertain whether Met-1 or Met-2 is the initiator"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAC18875.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3827838"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":1247,"modifier":"EXACT"}},"description":"Retinol-binding protein 3","featureId":"PRO_0000021523"},{"type":"Repeat","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"1"},{"type":"Repeat","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":630,"modifier":"EXACT"}},"description":"2"},{"type":"Repeat","location":{"start":{"value":631,"modifier":"EXACT"},"end":{"value":931,"modifier":"EXACT"}},"description":"3"},{"type":"Repeat","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":1230,"modifier":"EXACT"}},"description":"4"},{"type":"Region","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":1230,"modifier":"EXACT"}},"description":"4 X approximate tandem repeats"},{"type":"Region","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":515,"modifier":"EXACT"},"end":{"value":515,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Natural variant","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"in dbSNP:rs864621997","featureCrossReferences":[{"database":"dbSNP","id":"rs864621997"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069669","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"in dbSNP:rs41302693","featureCrossReferences":[{"database":"dbSNP","id":"rs41302693"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069670","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"in dbSNP:rs782157576","featureCrossReferences":[{"database":"dbSNP","id":"rs782157576"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069671","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in dbSNP:rs35686775","featureCrossReferences":[{"database":"dbSNP","id":"rs35686775"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069672","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"in dbSNP:rs782398712","featureCrossReferences":[{"database":"dbSNP","id":"rs782398712"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069673","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"in dbSNP:rs200239015","featureCrossReferences":[{"database":"dbSNP","id":"rs200239015"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069674","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"in dbSNP:rs782095820","featureCrossReferences":[{"database":"dbSNP","id":"rs782095820"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069675","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"in dbSNP:rs376854254","featureCrossReferences":[{"database":"dbSNP","id":"rs376854254"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069676","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"in dbSNP:rs368898051","featureCrossReferences":[{"database":"dbSNP","id":"rs368898051"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069677","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"in dbSNP:rs111245635","featureCrossReferences":[{"database":"dbSNP","id":"rs111245635"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069678","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"in dbSNP:rs781840247","featureCrossReferences":[{"database":"dbSNP","id":"rs781840247"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069679","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"in dbSNP:rs375761633","featureCrossReferences":[{"database":"dbSNP","id":"rs375761633"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069680","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":443,"modifier":"EXACT"},"end":{"value":443,"modifier":"EXACT"}},"description":"in dbSNP:rs864621999","featureCrossReferences":[{"database":"dbSNP","id":"rs864621999"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069681","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":505,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"in dbSNP:rs201808774","featureCrossReferences":[{"database":"dbSNP","id":"rs201808774"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069682","alternativeSequence":{"originalSequence":"H","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":518,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"in dbSNP:rs563600593","featureCrossReferences":[{"database":"dbSNP","id":"rs563600593"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069683","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"in dbSNP:rs148093336","featureCrossReferences":[{"database":"dbSNP","id":"rs148093336"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069684","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"in a colorectal cancer sample; somatic mutation; dbSNP:rs1354470616","featureCrossReferences":[{"database":"dbSNP","id":"rs1354470616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_035929","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":535,"modifier":"EXACT"},"end":{"value":535,"modifier":"EXACT"}},"description":"in dbSNP:rs143632019","featureCrossReferences":[{"database":"dbSNP","id":"rs143632019"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069685","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":544,"modifier":"EXACT"},"end":{"value":544,"modifier":"EXACT"}},"description":"in dbSNP:rs41284962","featureCrossReferences":[{"database":"dbSNP","id":"rs41284962"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069686","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":593,"modifier":"EXACT"},"end":{"value":593,"modifier":"EXACT"}},"description":"in dbSNP:rs782233167","featureCrossReferences":[{"database":"dbSNP","id":"rs782233167"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069687","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":599,"modifier":"EXACT"},"end":{"value":599,"modifier":"EXACT"}},"description":"in dbSNP:rs144289912","featureCrossReferences":[{"database":"dbSNP","id":"rs144289912"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069688","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":614,"modifier":"EXACT"},"end":{"value":614,"modifier":"EXACT"}},"description":"in dbSNP:rs149642039","featureCrossReferences":[{"database":"dbSNP","id":"rs149642039"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069689","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":615,"modifier":"EXACT"},"end":{"value":615,"modifier":"EXACT"}},"description":"in dbSNP:rs368920246","featureCrossReferences":[{"database":"dbSNP","id":"rs368920246"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069690","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":675,"modifier":"EXACT"},"end":{"value":675,"modifier":"EXACT"}},"description":"in dbSNP:rs864622000","featureCrossReferences":[{"database":"dbSNP","id":"rs864622000"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069691","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":688,"modifier":"EXACT"},"end":{"value":688,"modifier":"EXACT"}},"description":"in dbSNP:rs200168559","featureCrossReferences":[{"database":"dbSNP","id":"rs200168559"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069692","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"in dbSNP:rs112888313","featureCrossReferences":[{"database":"dbSNP","id":"rs112888313"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069693","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":723,"modifier":"EXACT"},"end":{"value":723,"modifier":"EXACT"}},"description":"in dbSNP:rs148247227","featureCrossReferences":[{"database":"dbSNP","id":"rs148247227"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069694","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":741,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"in dbSNP:rs143110000","featureCrossReferences":[{"database":"dbSNP","id":"rs143110000"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069695","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":747,"modifier":"EXACT"},"end":{"value":747,"modifier":"EXACT"}},"description":"in dbSNP:rs782664364","featureCrossReferences":[{"database":"dbSNP","id":"rs782664364"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069696","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":785,"modifier":"EXACT"},"end":{"value":785,"modifier":"EXACT"}},"description":"in dbSNP:rs864622001","featureCrossReferences":[{"database":"dbSNP","id":"rs864622001"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069697","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":833,"modifier":"EXACT"},"end":{"value":833,"modifier":"EXACT"}},"description":"in dbSNP:rs142945423","featureCrossReferences":[{"database":"dbSNP","id":"rs142945423"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069698","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":835,"modifier":"EXACT"},"end":{"value":835,"modifier":"EXACT"}},"description":"in dbSNP:rs782480179","featureCrossReferences":[{"database":"dbSNP","id":"rs782480179"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069699","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":884,"modifier":"EXACT"},"end":{"value":884,"modifier":"EXACT"}},"description":"in dbSNP:rs11204213","featureCrossReferences":[{"database":"dbSNP","id":"rs11204213"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_051315","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":903,"modifier":"EXACT"},"end":{"value":903,"modifier":"EXACT"}},"description":"in dbSNP:rs373766942","featureCrossReferences":[{"database":"dbSNP","id":"rs373766942"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069700","alternativeSequence":{"originalSequence":"T","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":921,"modifier":"EXACT"},"end":{"value":921,"modifier":"EXACT"}},"description":"in dbSNP:rs548622709","featureCrossReferences":[{"database":"dbSNP","id":"rs548622709"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069701","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":956,"modifier":"EXACT"},"end":{"value":956,"modifier":"EXACT"}},"description":"in dbSNP:rs781847641","featureCrossReferences":[{"database":"dbSNP","id":"rs781847641"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069702","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":963,"modifier":"EXACT"},"end":{"value":963,"modifier":"EXACT"}},"description":"in dbSNP:rs200706310","featureCrossReferences":[{"database":"dbSNP","id":"rs200706310"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069703","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":1021,"modifier":"EXACT"},"end":{"value":1021,"modifier":"EXACT"}},"description":"in dbSNP:rs148591757","featureCrossReferences":[{"database":"dbSNP","id":"rs148591757"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069704","alternativeSequence":{"originalSequence":"S","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":1059,"modifier":"EXACT"},"end":{"value":1059,"modifier":"EXACT"}},"description":"in dbSNP:rs864622002","featureCrossReferences":[{"database":"dbSNP","id":"rs864622002"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069705","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":1080,"modifier":"EXACT"},"end":{"value":1080,"modifier":"EXACT"}},"description":"in RP66; abolishes secretion; results in mis-folded insoluble complexes degraded via the ER-associated protein catabolic process; dbSNP:rs146150511","featureCrossReferences":[{"database":"dbSNP","id":"rs146150511"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23486466"}],"featureId":"VAR_069706","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":1194,"modifier":"EXACT"},"end":{"value":1194,"modifier":"EXACT"}},"description":"in dbSNP:rs782099994","featureCrossReferences":[{"database":"dbSNP","id":"rs782099994"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19074801"}],"featureId":"VAR_069707","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Sequence conflict","location":{"start":{"value":757,"modifier":"EXACT"},"end":{"value":757,"modifier":"EXACT"}},"description":"in Ref. 5; BAJ84061 and 8; AAH39844","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0682","category":"Disease","name":"Retinitis pigmentosa"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0845","category":"Ligand","name":"Vitamin A"}],"references":[{"referenceNumber":1,"citation":{"id":"2542268","citationType":"journal article","authors":["Liou G.I.","Ma D.-P.","Yang Y.-W.","Geng L.","Zhu C.","Baehr W."],"citationCrossReferences":[{"database":"PubMed","id":"2542268"},{"database":"DOI","id":"10.1016/s0021-9258(18)83169-6"}],"title":"Human interstitial retinoid-binding protein. Gene structure and primary structure.","publicationDate":"1989","journal":"J. Biol. Chem.","firstPage":"8200","lastPage":"8206","volume":"264"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"2303470","citationType":"journal article","authors":["Fong S.-L.","Fong W.B.","Morris T.A.","Kedzie K.M.","Bridges C.D.B."],"citationCrossReferences":[{"database":"PubMed","id":"2303470"},{"database":"DOI","id":"10.1016/s0021-9258(19)39642-5"}],"title":"Characterization and comparative structural features of the gene for human interstitial retinol-binding protein.","publicationDate":"1990","journal":"J. Biol. Chem.","firstPage":"3648","lastPage":"3653","volume":"265"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]"]},{"referenceNumber":3,"citation":{"id":"2792773","citationType":"journal article","authors":["Si J.S.","Borst D.E.","Redmond T.M.","Nickerson J.M."],"citationCrossReferences":[{"database":"PubMed","id":"2792773"},{"database":"DOI","id":"10.1016/0378-1119(89)90254-0"}],"title":"Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences.","publicationDate":"1989","journal":"Gene","firstPage":"99","lastPage":"108","volume":"80"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":4,"citation":{"id":"3170584","citationType":"journal article","authors":["Fong S.-L.","Bridges C.D.B."],"citationCrossReferences":[{"database":"PubMed","id":"3170584"},{"database":"DOI","id":"10.1016/s0021-9258(19)37592-1"}],"title":"Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA.","publicationDate":"1988","journal":"J. Biol. Chem.","firstPage":"15330","lastPage":"15334","volume":"263"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]"]},{"referenceNumber":5,"citation":{"id":"21697133","citationType":"journal article","authors":["Oshikawa M.","Tsutsui C.","Ikegami T.","Fuchida Y.","Matsubara M.","Toyama S.","Usami R.","Ohtoko K.","Kato S."],"citationCrossReferences":[{"database":"PubMed","id":"21697133"},{"database":"DOI","id":"10.1167/iovs.11-7479"}],"title":"Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.","publicationDate":"2011","journal":"Invest. Ophthalmol. Vis. Sci.","firstPage":"6662","lastPage":"6670","volume":"52"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Retinoblastoma","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.R.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.S.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.M.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"3455009","citationType":"journal article","authors":["Liou G.I.","Fong S.-L.","Gosden J.","van Tuinen P.","Ledbetter D.H.","Christie S.","Rout D.","Bhattacharya S.","Cook R.G.","Li Y.","Wang C.","Bridges C.D.B."],"citationCrossReferences":[{"database":"PubMed","id":"3455009"},{"database":"DOI","id":"10.1007/bf01534925"}],"title":"Human interstitial retinol-binding protein (IRBP): cloning, partial sequence, and chromosomal localization.","publicationDate":"1987","journal":"Somat. Cell Mol. Genet.","firstPage":"315","lastPage":"323","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 2-1247"]},{"referenceNumber":10,"citation":{"id":"2402443","citationType":"journal article","authors":["Albini A.","Toffenetti J.","Zhen Z.","Chader G.J.","Noonan D.M."],"citationCrossReferences":[{"database":"PubMed","id":"2402443"},{"database":"DOI","id":"10.1093/nar/18.17.5181"}],"title":"Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promotor and first exon is linked to expression of the gene.","publicationDate":"1990","journal":"Nucleic Acids Res.","firstPage":"5181","lastPage":"5187","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-382"]},{"referenceNumber":11,"citation":{"id":"17286855","citationType":"journal article","authors":["Roni V.","Carpio R.","Wissinger B."],"citationCrossReferences":[{"database":"PubMed","id":"17286855"},{"database":"DOI","id":"10.1186/1471-2164-8-42"}],"title":"Mapping of transcription start sites of human retina expressed genes.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"42","lastPage":"42","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-10"],"referenceComments":[{"value":"Retina","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"3827838","citationType":"journal article","authors":["Redmond T.M.","Wiggert B.","Robey F.A.","Chader G.J."],"citationCrossReferences":[{"database":"PubMed","id":"3827838"},{"database":"DOI","id":"10.1042/bj2400019"}],"title":"Interspecies conservation of structure of interphotoreceptor retinoid-binding protein. Similarities and differences as adjudged by peptide mapping and N-terminal sequencing.","publicationDate":"1986","journal":"Biochem. J.","firstPage":"19","lastPage":"26","volume":"240"},"referencePositions":["PROTEIN SEQUENCE OF 18-42"]},{"referenceNumber":13,"citation":{"id":"3743780","citationType":"journal article","authors":["Fong S.-L.","Cook R.G.","Alvarez R.A.","Liou G.I.","Landers R.A.","Bridges C.D.B."],"citationCrossReferences":[{"database":"PubMed","id":"3743780"},{"database":"DOI","id":"10.1016/0014-5793(86)80918-8"}],"title":"N-terminal sequence homologies in interstitial retinol-binding proteins from 10 vertebrate species.","publicationDate":"1986","journal":"FEBS Lett.","firstPage":"309","lastPage":"312","volume":"205"},"referencePositions":["PROTEIN SEQUENCE OF 23-39"]},{"referenceNumber":14,"citation":{"id":"16959974","citationType":"journal article","authors":["Sjoeblom T.","Jones S.","Wood L.D.","Parsons D.W.","Lin J.","Barber T.D.","Mandelker D.","Leary R.J.","Ptak J.","Silliman N.","Szabo S.","Buckhaults P.","Farrell C.","Meeh P.","Markowitz S.D.","Willis J.","Dawson D.","Willson J.K.V.","Gazdar A.F.","Hartigan J.","Wu L.","Liu C.","Parmigiani G.","Park B.H.","Bachman K.E.","Papadopoulos N.","Vogelstein B.","Kinzler K.W.","Velculescu V.E."],"citationCrossReferences":[{"database":"PubMed","id":"16959974"},{"database":"DOI","id":"10.1126/science.1133427"}],"title":"The consensus coding sequences of human breast and colorectal cancers.","publicationDate":"2006","journal":"Science","firstPage":"268","lastPage":"274","volume":"314"},"referencePositions":["VARIANT [LARGE SCALE ANALYSIS] HIS-530"]},{"referenceNumber":15,"citation":{"id":"19074801","citationType":"journal article","authors":["den Hollander A.I.","McGee T.L.","Ziviello C.","Banfi S.","Dryja T.P.","Gonzalez-Fernandez F.","Ghosh D.","Berson E.L."],"citationCrossReferences":[{"database":"PubMed","id":"19074801"},{"database":"DOI","id":"10.1167/iovs.08-2497"}],"title":"A homozygous missense mutation in the IRBP gene (RBP3) associated with autosomal recessive retinitis pigmentosa.","publicationDate":"2009","journal":"Invest. Ophthalmol. Vis. Sci.","firstPage":"1864","lastPage":"1872","volume":"50"},"referencePositions":["VARIANT RP66 ASN-1080","VARIANTS VAL-18; HIS-122; MET-155; PRO-163; MET-196; GLN-267; MET-282; ILE-321; THR-325; HIS-346; THR-379; LEU-433; SER-443; LEU-505; ARG-518; GLN-523; CYS-535; HIS-544; ALA-593; VAL-599; ASN-614; VAL-615; ILE-675; VAL-688; MET-693; LEU-723; SER-741; CYS-747; LYS-785; CYS-833; SER-835; MET-884; ARG-903; ARG-921; LYS-956; ILE-963; TYR-1021; ILE-1059 AND MET-1194"]},{"referenceNumber":16,"citation":{"id":"23486466","citationType":"journal article","authors":["Li S.","Yang Z.","Hu J.","Gordon W.C.","Bazan N.G.","Haas A.L.","Bok D.","Jin M."],"citationCrossReferences":[{"database":"PubMed","id":"23486466"},{"database":"DOI","id":"10.1074/jbc.m112.418251"}],"title":"Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP).","publicationDate":"2013","journal":"J. Biol. Chem.","firstPage":"11395","lastPage":"11406","volume":"288"},"referencePositions":["CHARACTERIZATION OF VARIANT RP66 ASN-1080"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M33875","properties":[{"key":"ProteinId","value":"AAA59453.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M33864","properties":[{"key":"ProteinId","value":"AAA59453.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M33865","properties":[{"key":"ProteinId","value":"AAA59453.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M33866","properties":[{"key":"ProteinId","value":"AAA59453.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M22453","properties":[{"key":"ProteinId","value":"AAA36126.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"J05253","properties":[{"key":"ProteinId","value":"AAC18875.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB593121","properties":[{"key":"ProteinId","value":"BAJ84061.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL731561","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471251","properties":[{"key":"ProteinId","value":"EAW50659.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC039844","properties":[{"key":"ProteinId","value":"AAH39844.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"J03912","properties":[{"key":"ProteinId","value":"AAA59188.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X53044","properties":[{"key":"ProteinId","value":"CAA37213.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"DQ426897","properties":[{"key":"ProteinId","value":"ABD90548.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS73119.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A33812","properties":[{"key":"EntryName","value":"A33812"}]},{"database":"RefSeq","id":"NP_002891.1","properties":[{"key":"NucleotideSequenceId","value":"NM_002900.3"}]},{"database":"AlphaFoldDB","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"111883","properties":[{"key":"Interactions","value":"17"}]},{"database":"FunCoup","id":"P10745","properties":[{"key":"Number of interactors","value":"80"}]},{"database":"IntAct","id":"P10745","properties":[{"key":"Interactions","value":"16"}]},{"database":"STRING","id":"9606.ENSP00000463151","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB06755","properties":[{"key":"GenericName","value":"Beta carotene"}]},{"database":"DrugBank","id":"DB11948","properties":[{"key":"GenericName","value":"Lapachone"}]},{"database":"DrugBank","id":"DB00162","properties":[{"key":"GenericName","value":"Vitamin A"}]},{"database":"DrugCentral","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"S41.950","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"S41.951","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P10745","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"P10745","properties":[{"key":"glycosylation","value":"4 sites"}]},{"database":"iPTMnet","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"RBP3","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"124894","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000463151","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52643","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"72614","properties":[{"key":"antibodies","value":"236 antibodies from 27 providers"}]},{"database":"DNASU","id":"5949","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000584701.2","properties":[{"key":"ProteinId","value":"ENSP00000463151.1"},{"key":"GeneId","value":"ENSG00000265203.2"}]},{"database":"GeneID","id":"5949","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:5949","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000584701.2","properties":[{"key":"ProteinId","value":"ENSP00000463151.1"},{"key":"RefSeqNucleotideId","value":"NM_002900.3"},{"key":"RefSeqProteinId","value":"NP_002891.1"}]},{"database":"UCSC","id":"uc001jez.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:9921","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA34288","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5949","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5949","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"RBP3","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"RBP3","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9921","properties":[{"key":"GeneName","value":"RBP3"}]},{"database":"HPA","id":"ENSG00000265203","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (retina)"}]},{"database":"MalaCards","id":"RBP3","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"180290","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"615233","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000265203","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"791","properties":[{"key":"Disease","value":"Retinitis pigmentosa"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000265203","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QW81","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000014726","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_279077_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VHKVWEP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10268064at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P10745","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:ENSG00000107618-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-2187335","properties":[{"key":"PathwayName","value":"The retinoid cycle in cones (daylight vision)"}]},{"database":"Reactome","id":"R-HSA-2453902","properties":[{"key":"PathwayName","value":"The canonical retinoid cycle in rods (twilight vision)"}]},{"database":"SignaLink","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P10745","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000265203","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"5949","properties":[{"key":"hits","value":"25 hits in 1137 CRISPR screens"}]},{"database":"ChiTaRS","id":"RBP3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"RBP3","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"5949","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P10745","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P10745","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"RNAct","id":"P10745","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000265203","properties":[{"key":"ExpressionPatterns","value":"Expressed in male germ line stem cell (sensu Vertebrata) in testis and 28 other cell types or tissues"}]},{"database":"GO","id":"GO:0090658","properties":[{"key":"GoTerm","value":"C:cone matrix sheath"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23486466"}]},{"database":"GO","id":"GO:1903561","properties":[{"key":"GoTerm","value":"C:extracellular vesicle"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"24769233"}]},{"database":"GO","id":"GO:0005501","properties":[{"key":"GoTerm","value":"F:retinoid binding"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0019841","properties":[{"key":"GoTerm","value":"F:retinol binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008236","properties":[{"key":"GoTerm","value":"F:serine-type peptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006629","properties":[{"key":"GoTerm","value":"P:lipid metabolic process"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"2542268"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0001523","properties":[{"key":"GoTerm","value":"P:retinoid metabolic process"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0007601","properties":[{"key":"GoTerm","value":"P:visual perception"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"2542268"}]},{"database":"CDD","id":"cd07563","properties":[{"key":"EntryName","value":"Peptidase_S41_IRBP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"3.90.226.10:FF:000031","properties":[{"key":"EntryName","value":"Interphotoreceptor retinoid binding protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.750.44:FF:000009","properties":[{"key":"EntryName","value":"Retinol-binding protein 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.226.10:FF:000037","properties":[{"key":"EntryName","value":"Retinol-binding protein 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.226.10:FF:000038","properties":[{"key":"EntryName","value":"Retinol-binding protein 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.750.44","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"4"}]},{"database":"Gene3D","id":"3.90.226.10","properties":[{"key":"EntryName","value":"2-enoyl-CoA Hydratase, Chain A, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR029045","properties":[{"key":"EntryName","value":"ClpP/crotonase-like_dom_sf"}]},{"database":"InterPro","id":"IPR005151","properties":[{"key":"EntryName","value":"Tail-specific_protease"}]},{"database":"PANTHER","id":"PTHR11261","properties":[{"key":"EntryName","value":"INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11261:SF3","properties":[{"key":"EntryName","value":"RETINOL-BINDING PROTEIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03572","properties":[{"key":"EntryName","value":"Peptidase_S41"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF11918","properties":[{"key":"EntryName","value":"Peptidase_S41_N"},{"key":"MatchStatus","value":"4"}]},{"database":"SMART","id":"SM00245","properties":[{"key":"EntryName","value":"TSPc"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF52096","properties":[{"key":"EntryName","value":"ClpP/crotonase"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MMREWVLLMSVLLCGLAGPTHLFQPSLVLDMAKVLLDNYCFPENLLGMQEAIQQAIKSHEILSISDPQTLASVLTAGVQSSLNDPRLVISYEPSTPEPPPQVPALTSLSEEELLAWLQRGLRHEVLEGNVGYLRVDSVPGQEVLSMMGEFLVAHVWGNLMGTSALVLDLRHCTGGQVSGIPYIISYLHPGNTILHVDTIYNRPSNTTTEIWTLPQVLGERYGADKDVVVLTSSQTRGVAEDIAHILKQMRRAIVVGERTGGGALDLRKLRIGESDFFFTVPVSRSLGPLGGGSQTWEGSGVLPCVGTPAEQALEKALAILTLRSALPGVVHCLQEVLKDYYTLVDRVPTLLQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGPTETPSWPAPDAAAEDSPGVAPELPEDEAIRQALVDSVFQVSVLPGNVGYLRFDSFADASVLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVPLLLSYFQGPEAGPVHLFTTYDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVGEITAGNLLHTRTVPLLDTPEGSLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALDKAQEVLEFHQSLGALVEGTGHLLEAHYARPEVVGQTSALLRAKLAQGAYRTAVDLESLASQLTADLQEVSGDHRLLVFHSPGELVVEEAPPPPPAVPSPEELTYLIEALFKTEVLPGQLGYLRFDAMAELETVKAVGPQLVRLVWQQLVDTAALVIDLRYNPGSYSTAIPLLCSYFFEAEPRQHLYSVFDRATSKVTEVWTLPQVAGQRYGSHKDLYILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMAMSATTGKAWDLAGVEPDITVPMSEALSIAQDIVALRAKVPTVLQTAGKLVADNYASAELGAKMATKLSGLQSRYSRVTSEVALAEILGADLQMLSGDPHLKAAHIPENAKDRIPGIVPMQIPSPEVFEELIKFSFHTNVLEDNIGYLRFDMFGDGELLTQVSRLLVEHIWKKIMHTDAMIIDMRFNIGGPTSSIPILCSYFFDEGPPVLLDKIYSRPDDSVSELWTHAQVVGERYGSKKSMVILTSSVTAGTAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTNLYLTIPTARSVGASDGSSWEGVGVTPHVVVPAEEALARAKEMLQHNQLRVKRSPGLQDHL","length":1247,"molWeight":135363,"crc64":"6C1841411E012E0F","md5":"FC350027A00A9ABBA2CD8163F81561CC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":13,"SUBCELLULAR LOCATION":1,"DISEASE":1,"SIMILARITY":1,"CAUTION":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Repeat":4,"Region":2,"Glycosylation":2,"Natural variant":41,"Sequence conflict":1},"uniParcId":"UPI000012D87A"}}