{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P10082","secondaryAccessions":["Q5U5Q6","Q6FGH8"],"uniProtkbId":"PYY_HUMAN","entryAudit":{"firstPublicDate":"1989-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-01-11","entryVersion":210,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2587421"}],"value":"Peptide YY"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2587421"}],"value":"PYY"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9TR93"}],"value":"PYY-I"}},{"fullName":{"value":"Peptide tyrosine tyrosine"}}],"contains":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2587421"}],"value":"Peptide YY(3-36)"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9TR93"}],"value":"PYY-II"}}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"PYY"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P68005"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9EPS2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317848"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36525977"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7592910"}],"value":"Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R) (PubMed:1317848, PubMed:7592910, PubMed:36525977). Also binds NPY5R (By similarity). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:1317848, PubMed:7592910). Receptor activation by PYY also leads to an increase of intracellular Ca(2+) levels (PubMed:1317848, PubMed:36525977, PubMed:7592910). This gut peptide inhibits exocrine pancreatic secretion (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity)"}],"commentType":"FUNCTION","molecule":"Peptide YY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9EPS2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12167864"}],"value":"Is a NPY2R agonist involved in the down-regulation of appetite and food intake, probably acting on receptors located on proopiomelanocortin(POMC)-releasing and neuropeptide Y(NPY)-releasing neurons in the arcuate nucleus of hypothalamus (PubMed:12167864). In NPY-releasing neurons, NPY2R activation by PYY(3-36) leads to membrane hyperpolarization and reduced release of the orexigenic neuropeptide NPY (By similarity)"}],"commentType":"FUNCTION","molecule":"Peptide YY(3-36)"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P10082","intActId":"EBI-6655667"},"interactantTwo":{"uniProtKBAccession":"P25929","geneName":"NPY1R","intActId":"EBI-372227"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10082","intActId":"EBI-6655667"},"interactantTwo":{"uniProtKBAccession":"P49146","geneName":"NPY2R","intActId":"EBI-6655721"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Peptide YY","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3840109"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"Long"}],"isoformIds":["P10082-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"Short"}],"isoformIds":["P10082-2"],"sequenceIds":["VSP_005081"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21314817"}],"value":"The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the NPY family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/46182/PYY","ftp":false}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2587421"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3202875"}]},{"type":"Peptide","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Peptide YY","featureId":"PRO_0000025384"},{"type":"Peptide","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Peptide YY(3-36)","featureId":"PRO_0000025385"},{"type":"Propeptide","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","featureId":"PRO_0000025386"},{"type":"Region","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Cleavage; by FAP","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21314817"}]},{"type":"Modified residue","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P68005"}]},{"type":"Modified residue","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Tyrosine amide","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2587421"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3202875"}]},{"type":"Alternative sequence","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8318545"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_005081","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"in dbSNP:rs229969","featureCrossReferences":[{"database":"dbSNP","id":"rs229969"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2587421"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3202875"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8318545"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.2"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_047407","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"in dbSNP:rs1058046","featureCrossReferences":[{"database":"dbSNP","id":"rs1058046"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8318545"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_006382","alternativeSequence":{"originalSequence":"T","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"in dbSNP:rs465407","featureCrossReferences":[{"database":"dbSNP","id":"rs465407"}],"featureId":"VAR_047408","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Helix","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RT9"}]},{"type":"Helix","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RT9"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0027","category":"PTM","name":"Amidation"},{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0372","category":"Molecular function","name":"Hormone"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"8318545","citationType":"journal article","authors":["Kohri K.","Nata K.","Yonekura H.","Nagai A.","Konno K.","Okamoto H."],"citationCrossReferences":[{"database":"PubMed","id":"8318545"},{"database":"DOI","id":"10.1016/0167-4781(93)90136-2"}],"title":"Cloning and structural determination of human peptide YY cDNA and gene.","publicationDate":"1993","journal":"Biochim. Biophys. Acta","firstPage":"345","lastPage":"349","volume":"1173"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2)","VARIANTS GLY-37 AND ARG-72"],"referenceComments":[{"value":"Colon mucosa","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-FET7RA3R22LEO","citationType":"submission","authors":["Herzog H."],"title":"Genomic organisation and localisation of the gene for the human peptide YY.","publicationDate":"NOV-1993","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT GLY-37"]},{"referenceNumber":3,"citation":{"id":"CI-65UA89QGSSD50","citationType":"submission","authors":["Halleck A.","Ebert L.","Mkoundinya M.","Schick M.","Eisenstein S.","Neubert P.","Kstrang K.","Schatten R.","Shen B.","Henze S.","Mar W.","Korn B.","Zuo D.","Hu Y.","LaBaer J."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","VARIANTS GLY-37 AND ARG-72"]},{"referenceNumber":4,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.-K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)","VARIANTS GLY-37 AND ARG-72"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"3202875","citationType":"journal article","authors":["Tatemoto K.","Nakano I.","Makk G.","Angwin P.","Mann M.","Schilling J.","Go V.L.W."],"citationCrossReferences":[{"database":"PubMed","id":"3202875"},{"database":"DOI","id":"10.1016/s0006-291x(88)80308-5"}],"title":"Isolation and primary structure of human peptide YY.","publicationDate":"1988","journal":"Biochem. Biophys. Res. Commun.","firstPage":"713","lastPage":"717","volume":"157"},"referencePositions":["PROTEIN SEQUENCE OF 29-64","AMIDATION AT TYR-64","SYNTHESIS OF 29-64","VARIANT GLY-37"]},{"referenceNumber":7,"citation":{"id":"2587421","citationType":"journal article","authors":["Eberlein G.A.","Eysselein V.E.","Schaeffer M.","Layer P.","Grandt D.","Goebell H.","Niebel W.","Davis M.","Lee T.D.","Shively J.E.","Reeve J.R. Jr."],"citationCrossReferences":[{"database":"PubMed","id":"2587421"},{"database":"DOI","id":"10.1016/0196-9781(89)90116-2"}],"title":"A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36).","publicationDate":"1989","journal":"Peptides","firstPage":"797","lastPage":"803","volume":"10"},"referencePositions":["PROTEIN SEQUENCE OF 29-64","AMIDATION AT TYR-64","VARIANT GLY-37"]},{"referenceNumber":8,"citation":{"id":"3840109","citationType":"journal article","authors":["Adrian T.E.","Ferri G.L.","Bacarese-Hamilton A.J.","Fuessl H.S.","Polak J.M.","Bloom S.R."],"citationCrossReferences":[{"database":"PubMed","id":"3840109"},{"database":"DOI","id":"10.1016/0016-5085(85)90211-2"}],"title":"Human distribution and release of a putative new gut hormone, peptide YY.","publicationDate":"1985","journal":"Gastroenterology","firstPage":"1070","lastPage":"1077","volume":"89"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":9,"citation":{"id":"1317848","citationType":"journal article","authors":["Larhammar D.","Blomqvist A.G.","Yee F.","Jazin E.E.","Yoo H.","Wahlestedt C.R."],"citationCrossReferences":[{"database":"PubMed","id":"1317848"},{"database":"DOI","id":"10.1016/s0021-9258(19)49854-2"}],"title":"Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type.","publicationDate":"1992","journal":"J. Biol. Chem.","firstPage":"10935","lastPage":"10938","volume":"267"},"referencePositions":["FUNCTION"]},{"referenceNumber":10,"citation":{"id":"7592910","citationType":"journal article","authors":["Gerald C.","Walker M.W.","Vaysse P.J.-J.","He C.","Branchek T.A.","Weinshank R.L."],"citationCrossReferences":[{"database":"PubMed","id":"7592910"},{"database":"DOI","id":"10.1074/jbc.270.45.26758"}],"title":"Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.","publicationDate":"1995","journal":"J. Biol. Chem.","firstPage":"26758","lastPage":"26761","volume":"270"},"referencePositions":["FUNCTION"]},{"referenceNumber":11,"citation":{"id":"12167864","citationType":"journal article","authors":["Batterham R.L.","Cowley M.A.","Small C.J.","Herzog H.","Cohen M.A.","Dakin C.L.","Wren A.M.","Brynes A.E.","Low M.J.","Ghatei M.A.","Cone R.D.","Bloom S.R."],"citationCrossReferences":[{"database":"PubMed","id":"12167864"},{"database":"DOI","id":"10.1038/nature00887"}],"title":"Gut hormone PYY(3-36) physiologically inhibits food intake.","publicationDate":"2002","journal":"Nature","firstPage":"650","lastPage":"654","volume":"418"},"referencePositions":["FUNCTION (PEPTIDE YY(3-36))"]},{"referenceNumber":12,"citation":{"id":"21314817","citationType":"journal article","authors":["Keane F.M.","Nadvi N.A.","Yao T.W.","Gorrell M.D."],"citationCrossReferences":[{"database":"PubMed","id":"21314817"},{"database":"DOI","id":"10.1111/j.1742-4658.2011.08051.x"}],"title":"Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha.","publicationDate":"2011","journal":"FEBS J.","firstPage":"1316","lastPage":"1332","volume":"278"},"referencePositions":["CLEAVAGE BY FAP","CLEAVAGE SITE"]},{"referenceNumber":13,"citation":{"id":"16819834","citationType":"journal article","authors":["Nygaard R.","Nielbo S.","Schwartz T.W.","Poulsen F.M."],"citationCrossReferences":[{"database":"PubMed","id":"16819834"},{"database":"DOI","id":"10.1021/bi060359l"}],"title":"The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR.","publicationDate":"2006","journal":"Biochemistry","firstPage":"8350","lastPage":"8357","volume":"45"},"referencePositions":["STRUCTURE BY NMR OF 29-64"]},{"referenceNumber":14,"citation":{"id":"35180645","citationType":"journal article","authors":["Langley D.B.","Schofield P.","Jackson J.","Herzog H.","Christ D."],"citationCrossReferences":[{"database":"PubMed","id":"35180645"},{"database":"DOI","id":"10.1016/j.npep.2022.102231"}],"title":"Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY).","publicationDate":"2022","journal":"Neuropeptides","firstPage":"102231","lastPage":"102231","volume":"92"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 29-64"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RT9"}]},{"referenceNumber":15,"citation":{"id":"36525977","citationType":"journal article","authors":["Kang H.","Park C.","Choi Y.K.","Bae J.","Kwon S.","Kim J.","Choi C.","Seok C.","Im W.","Choi H.J."],"citationCrossReferences":[{"database":"PubMed","id":"36525977"},{"database":"DOI","id":"10.1016/j.str.2022.11.010"}],"title":"Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.","publicationDate":"2023","journal":"Structure","firstPage":"44","lastPage":"57.e6","volume":"31"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.95 ANGSTROMS) OF 31-64 IN COMPLEX WITH NPY2R AND GNAI1","FUNCTION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7YON"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D13897","properties":[{"key":"ProteinId","value":"BAA02997.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"D13897","properties":[{"key":"ProteinId","value":"BAA02998.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"D13899","properties":[{"key":"ProteinId","value":"BAA03000.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D13902","properties":[{"key":"ProteinId","value":"BAA03002.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L25648","properties":[{"key":"ProteinId","value":"AAA36433.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CR542129","properties":[{"key":"ProteinId","value":"CAG46926.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC007993","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC041057","properties":[{"key":"ProteinId","value":"AAH41057.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS32662.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P10082-1"},{"database":"CCDS","id":"CCDS92333.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P10082-2"},{"database":"PIR","id":"A31358","properties":[{"key":"EntryName","value":"A31358"}]},{"database":"PIR","id":"S33795","properties":[{"key":"EntryName","value":"S33795"}]},{"database":"PIR","id":"S34568","properties":[{"key":"EntryName","value":"S34568"}]},{"database":"PIR","id":"S34569","properties":[{"key":"EntryName","value":"S34569"}]},{"database":"RefSeq","id":"NP_001380957.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001394028.1"}],"isoformId":"P10082-1"},{"database":"RefSeq","id":"NP_001380958.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001394029.1"}],"isoformId":"P10082-2"},{"database":"RefSeq","id":"NP_004151.4","properties":[{"key":"NucleotideSequenceId","value":"NM_004160.6"}],"isoformId":"P10082-1"},{"database":"PDB","id":"2DEZ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=29-64"}]},{"database":"PDB","id":"2DF0","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=31-64"}]},{"database":"PDB","id":"2L60","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=32-64"}]},{"database":"PDB","id":"2NA5","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=31-64"}]},{"database":"PDB","id":"7RT9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"Y/Z=29-64"}]},{"database":"PDB","id":"7YON","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"L=31-64"}]},{"database":"PDBsum","id":"2DEZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2DF0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2L60","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2NA5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RT9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7YON","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33984","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"111670","properties":[{"key":"Interactions","value":"31"}]},{"database":"FunCoup","id":"P10082","properties":[{"key":"Number of interactors","value":"512"}]},{"database":"IntAct","id":"P10082","properties":[{"key":"Interactions","value":"9"}]},{"database":"MINT","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-PYY","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000353198","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PYY","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"317373516","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000353198","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52563","properties":[{"key":"Description","value":"-"}],"isoformId":"P10082-1"},{"database":"ProteomicsDB","id":"52564","properties":[{"key":"Description","value":"-"}],"isoformId":"P10082-2"},{"database":"ABCD","id":"P10082","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"Antibodypedia","id":"3390","properties":[{"key":"antibodies","value":"464 antibodies from 32 providers"}]},{"database":"DNASU","id":"5697","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000360085.6","properties":[{"key":"ProteinId","value":"ENSP00000353198.1"},{"key":"GeneId","value":"ENSG00000131096.12"}],"isoformId":"P10082-1"},{"database":"Ensembl","id":"ENST00000592796.2","properties":[{"key":"ProteinId","value":"ENSP00000467310.1"},{"key":"GeneId","value":"ENSG00000131096.12"}],"isoformId":"P10082-2"},{"database":"Ensembl","id":"ENST00000692052.1","properties":[{"key":"ProteinId","value":"ENSP00000509262.1"},{"key":"GeneId","value":"ENSG00000131096.12"}],"isoformId":"P10082-1"},{"database":"GeneID","id":"5697","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:5697","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000692052.1","properties":[{"key":"ProteinId","value":"ENSP00000509262.1"},{"key":"RefSeqNucleotideId","value":"NM_001394028.1"},{"key":"RefSeqProteinId","value":"NP_001380957.1"}]},{"database":"UCSC","id":"uc002ieq.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P10082-1"},{"database":"AGR","id":"HGNC:9748","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA34090","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5697","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5697","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PYY","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9748","properties":[{"key":"GeneName","value":"PYY"}]},{"database":"HPA","id":"ENSG00000131096","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (intestine)"}]},{"database":"MalaCards","id":"PYY","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"600781","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000131096","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000131096","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S267","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000160643","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_162379_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DSNRDQR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9852947at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P10082","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-375276","properties":[{"key":"PathwayName","value":"Peptide ligand-binding receptors"}]},{"database":"Reactome","id":"R-HSA-418594","properties":[{"key":"PathwayName","value":"G alpha (i) signalling events"}]},{"database":"SignaLink","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000131096","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"5697","properties":[{"key":"hits","value":"6 hits in 1140 CRISPR screens"}]},{"database":"ChiTaRS","id":"PYY","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P10082","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Peptide_YY","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"5697","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P10082","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P10082","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"P10082","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000131096","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of sigmoid colon and 92 other cell types or tissues"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"3840109"}]},{"database":"GO","id":"GO:0001664","properties":[{"key":"GoTerm","value":"F:G protein-coupled receptor binding"},{"key":"GoEvidenceType","value":"IPI:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"7592911"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"7493937"}]},{"database":"GO","id":"GO:0005179","properties":[{"key":"GoTerm","value":"F:hormone activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10698177"}]},{"database":"GO","id":"GO:0005184","properties":[{"key":"GoTerm","value":"F:neuropeptide hormone activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031841","properties":[{"key":"GoTerm","value":"F:neuropeptide Y receptor binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048018","properties":[{"key":"GoTerm","value":"F:receptor ligand activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7592910"}]},{"database":"GO","id":"GO:0007631","properties":[{"key":"GoTerm","value":"P:feeding behavior"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0060575","properties":[{"key":"GoTerm","value":"P:intestinal epithelial cell differentiation"},{"key":"GoEvidenceType","value":"TAS:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10488139"}]},{"database":"GO","id":"GO:1903999","properties":[{"key":"GoTerm","value":"P:negative regulation of eating behavior"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12167864"}]},{"database":"GO","id":"GO:0007218","properties":[{"key":"GoTerm","value":"P:neuropeptide signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd00126","properties":[{"key":"EntryName","value":"PAH"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.250.900","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001955","properties":[{"key":"EntryName","value":"Pancreatic_hormone-like"}]},{"database":"InterPro","id":"IPR020392","properties":[{"key":"EntryName","value":"Pancreatic_hormone-like_CS"}]},{"database":"PANTHER","id":"PTHR10533","properties":[{"key":"EntryName","value":"NEUROPEPTIDE Y/PANCREATIC HORMONE/PEPTIDE YY"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10533:SF14","properties":[{"key":"EntryName","value":"PEPTIDE YY-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00159","properties":[{"key":"EntryName","value":"Hormone_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00278","properties":[{"key":"EntryName","value":"PANCHORMONE"}]},{"database":"SMART","id":"SM00309","properties":[{"key":"EntryName","value":"PAH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00265","properties":[{"key":"EntryName","value":"PANCREATIC_HORMONE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50276","properties":[{"key":"EntryName","value":"PANCREATIC_HORMONE_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVFVRRPWPALTTVLLALLVCLGALVDAYPIKPEAPREDASPEELNRYYASLRHYLNLVTRQRYGKRDGPDTLLSKTFFPDGEDRPVRSRSEGPDLW","length":97,"molWeight":11145,"crc64":"C166B73412E356B1","md5":"A3250FA780B53CFE833A10C769A69244"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"PTM":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Peptide":2,"Propeptide":1,"Region":1,"Compositional bias":1,"Site":1,"Modified residue":2,"Alternative sequence":1,"Natural variant":3,"Helix":2},"uniParcId":"UPI000013CDD0"}}