{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DXO8","uniProtkbId":"SF33K_ADEB3","entryAudit":{"firstPublicDate":"2026-01-28","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-01-28","entryVersion":3,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Bovine adenovirus B serotype 3","commonName":"BAdV-3","synonyms":["Mastadenovirus bos3"],"taxonId":10510,"lineage":["Viruses","Varidnaviria","Bamfordvirae","Preplasmiviricota","Polisuviricotina","Pharingeaviricetes","Rowavirales","Adenoviridae","Mastadenovirus","Mastadenovirus bostertium","Bovine mastadenovirus B"]},"organismHosts":[{"scientificName":"Bos taurus","commonName":"Bovine","taxonId":9913}],"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein 33K"},"shortNames":[{"value":"L4-33K"}]},"alternativeNames":[{"fullName":{"value":"33 kDa protein"}},{"fullName":{"value":"Splicing factor 33K"}},{"fullName":{"value":"Terminase, small subunit"}}]},"genes":[{"geneName":{"value":"L4"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15165819"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25974868"}],"value":"Binds and stimulates the transcription from the major late promoter (MLP) by binding to the downstream sequence elements (PubMed:25974868). Probably required in the assembly of progeny virions since the deletion of the region containing 33 kDa and 22 kDa proteins leads to a severe defect in the production of progeny virus (PubMed:15165819)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P24940"}],"value":"Probably functions as the small terminase that is part of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. This motor is located at a unique vertex and comprises at least the IVa2 ATPase, the small terminase 33K and probably a portal. Forms a ring-like structure of about 17 nm in which genomic DNA is translocated into the capsid. Stimulates IVa2 ATPase activity in the presence of the viral genome. Once the DNA is packaged, the terminase detaches: the 33K protein is present in the empty particles, but not in the mature virions. 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