{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DN86","secondaryAccessions":["A1A5E0","B9ZVP5","P01233","Q13991","Q14000","Q3KPI3","Q3SY41","Q8WTT5","Q8WXL1","Q8WXL2","Q8WXL3","Q8WXL4"],"uniProtkbId":"CGB3_HUMAN","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2016-05-11","entryVersion":62,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Choriogonadotropin subunit beta 3"}},"alternativeNames":[{"fullName":{"value":"Choriogonadotropin subunit beta"},"shortNames":[{"value":"CG-beta"}]},{"fullName":{"value":"Chorionic gonadotropin chain beta"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"CGB3"},"synonyms":[{"value":"CGB"}]},{"geneName":{"value":"CGB5"}},{"geneName":{"value":"CGB8"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8202136"},{"evidenceCode":"ECO:0000305"}],"value":"Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P0DN86","intActId":"EBI-8626304"},"interactantTwo":{"uniProtKBAccession":"P01215","geneName":"CGA","intActId":"EBI-718913"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P0DN86","intActId":"EBI-8626304"},"interactantTwo":{"uniProtKBAccession":"P49901","geneName":"SMCP","intActId":"EBI-750494"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16123088"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P0DN86-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P0DN86-2"],"sequenceIds":["VSP_038396"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16123088"}],"value":"High expression in the placenta throughout pregnancy"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16123088"}],"value":"Expressed continuously during the whole pregnancy with a peak during the first trimester"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"value":"Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets"}],"commentType":"PHARMACEUTICAL"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861891"}],"value":"Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the glycoprotein hormones subunit beta family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAA25068.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAA25069.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Human_chorionic_gonadotropin","ftp":false,"note":"Chorionic gonadotropin entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1150658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6774259"}]},{"type":"Chain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Choriogonadotropin subunit beta 3","featureId":"PRO_0000011676"},{"type":"Region","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1HRP"}],"featureId":"CAR_000042"},{"type":"Glycosylation","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1HRP"}],"featureId":"CAR_000043"},{"type":"Glycosylation","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1150658"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1150658"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1150658"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1150658"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1688430"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8202136"}]},{"type":"Disulfide bond","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1688430"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8202136"}]},{"type":"Disulfide bond","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1688430"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8202136"}]},{"type":"Disulfide bond","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1688430"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8202136"}]},{"type":"Disulfide bond","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1688430"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8202136"}]},{"type":"Disulfide bond","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1688430"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8202136"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_038396","alternativeSequence":{"originalSequence":"MEMF","alternativeSequences":["MGRPGLGAAVSDPGEAVSLS"]}},{"type":"Natural variant","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"in dbSNP:rs767100833 and dbSNP:rs371475564","featureCrossReferences":[{"database":"dbSNP","id":"rs371475564"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_014585","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"in dbSNP:rs201240617","featureCrossReferences":[{"database":"dbSNP","id":"rs201240617"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861891"}],"featureId":"VAR_015231","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"in dbSNP:rs201575305 and dbSNP:rs199720009","featureCrossReferences":[{"database":"dbSNP","id":"rs199720009"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861891"}],"featureId":"VAR_014586","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"requires 2 nucleotide substitutions","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861891"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6194155"}],"featureId":"VAR_015232","alternativeSequence":{"originalSequence":"P","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"in dbSNP:rs1261895475","featureCrossReferences":[{"database":"dbSNP","id":"rs1261895475"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861891"}],"featureId":"VAR_015233","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"in dbSNP:rs201373221","featureCrossReferences":[{"database":"dbSNP","id":"rs201373221"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861891"}],"featureId":"VAR_015234","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"in dbSNP:rs201780746 and dbSNP:rs199824672","featureCrossReferences":[{"database":"dbSNP","id":"rs199824672"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861891"}],"featureId":"VAR_014587","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"in dbSNP:rs200199557 and dbSNP:rs199614255","featureCrossReferences":[{"database":"dbSNP","id":"rs199614255"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861891"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6194155"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6690982"}],"featureId":"VAR_003188","alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861891"}],"featureId":"VAR_015235","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Sequence conflict","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"in Ref. 11; AAL69709","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Beta strand","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1HCN"}]},{"type":"Beta strand","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1HCN"}]},{"type":"Beta strand","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7FIH"}]},{"type":"Helix","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7FIH"}]},{"type":"Beta strand","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1HCN"}]},{"type":"Beta strand","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1HCN"}]},{"type":"Turn","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1HCN"}]},{"type":"Beta strand","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1HCN"}]},{"type":"Sequence conflict","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"},"sequence":"P0DN86-2"},"description":"in Ref. 2; CAA25069","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"},"sequence":"P0DN86-2"},"description":"in Ref. 2; CAA25069","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"},"sequence":"P0DN86-2"},"description":"in Ref. 2; CAA25069","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0372","category":"Molecular function","name":"Hormone"},{"id":"KW-0582","category":"Technical term","name":"Pharmaceutical"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"6774259","citationType":"journal article","authors":["Fiddes J.C.","Goodman H.M."],"citationCrossReferences":[{"database":"PubMed","id":"6774259"},{"database":"DOI","id":"10.1038/286684a0"}],"title":"The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region.","publicationDate":"1980","journal":"Nature","firstPage":"684","lastPage":"687","volume":"286"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"6690982","citationType":"journal article","authors":["Talmadge K.","Vamvakopoulos N.C.","Fiddes J.C."],"citationCrossReferences":[{"database":"PubMed","id":"6690982"},{"database":"DOI","id":"10.1038/307037a0"}],"title":"Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone.","publicationDate":"1984","journal":"Nature","firstPage":"37","lastPage":"40","volume":"307"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT ALA-137"]},{"referenceNumber":3,"citation":{"id":"6194155","citationType":"journal article","authors":["Policastro P.","Ovitt C.E.","Hoshina M.","Fukuoka H.","Boothby M.R.","Boime I."],"citationCrossReferences":[{"database":"PubMed","id":"6194155"},{"database":"DOI","id":"10.1016/s0021-9258(17)44254-2"}],"title":"The beta subunit of human chorionic gonadotropin is encoded by multiple genes.","publicationDate":"1983","journal":"J. Biol. Chem.","firstPage":"11492","lastPage":"11499","volume":"258"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS MET-24 AND ALA-137"]},{"referenceNumber":4,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":5,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.S.","Terry A.","Schmutz J.","Lamerdin J.E.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.V.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.-H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.M.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)","VARIANTS LEU-4 AND ALA-137"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"7462224","citationType":"journal article","authors":["Birken S.","Fetherston J.","Canfield R.E.","Boime I."],"citationCrossReferences":[{"database":"PubMed","id":"7462224"},{"database":"DOI","id":"10.1016/s0021-9258(19)69881-9"}],"title":"The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin.","publicationDate":"1981","journal":"J. Biol. Chem.","firstPage":"1816","lastPage":"1823","volume":"256"},"referencePositions":["PROTEIN SEQUENCE OF 1-20 (PRECURSOR PROTEIN)"]},{"referenceNumber":10,"citation":{"id":"2422163","citationType":"journal article","authors":["Policastro P.F.","Daniels-Mcqueen S.","Carle G.","Boime I."],"citationCrossReferences":[{"database":"PubMed","id":"2422163"},{"database":"DOI","id":"10.1016/s0021-9258(17)38469-7"}],"title":"A map of the hCG beta-LH beta gene cluster.","publicationDate":"1986","journal":"J. Biol. Chem.","firstPage":"5907","lastPage":"5916","volume":"261"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5"]},{"referenceNumber":11,"citation":{"id":"11861891","citationType":"journal article","authors":["Maston G.A.","Ruvolo M."],"citationCrossReferences":[{"database":"PubMed","id":"11861891"},{"database":"DOI","id":"10.1093/oxfordjournals.molbev.a004085"}],"title":"Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection.","publicationDate":"2002","journal":"Mol. Biol. Evol.","firstPage":"320","lastPage":"335","volume":"19"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-164","VARIANTS ALA-18; ARG-22; MET-24; TRP-28; HIS-30; ILE-35; ALA-137 AND CYS-147","MISCELLANEOUS"]},{"referenceNumber":12,"citation":{"id":"1150658","citationType":"journal article","authors":["Morgan F.J.","Birken S.","Canfield R.E."],"citationCrossReferences":[{"database":"PubMed","id":"1150658"},{"database":"DOI","id":"10.1016/s0021-9258(19)41303-3"}],"title":"The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.","publicationDate":"1975","journal":"J. Biol. Chem.","firstPage":"5247","lastPage":"5258","volume":"250"},"referencePositions":["PROTEIN SEQUENCE OF 21-165"]},{"referenceNumber":13,"citation":{"id":"4795659","citationType":"journal article","authors":["Carlsen R.B.","Bahl O.P.","Swaminathan N."],"citationCrossReferences":[{"database":"PubMed","id":"4795659"},{"database":"DOI","id":"10.1016/s0021-9258(19)43425-x"}],"title":"Human chorionic gonadotropin. Linear amino acid sequence of the beta subunit.","publicationDate":"1973","journal":"J. Biol. Chem.","firstPage":"6810","lastPage":"6827","volume":"248"},"referencePositions":["PRELIMINARY PROTEIN SEQUENCE OF 21-165"]},{"referenceNumber":14,"citation":{"id":"7240231","citationType":"journal article","authors":["Mise T.","Bahl O.P."],"citationCrossReferences":[{"database":"PubMed","id":"7240231"},{"database":"DOI","id":"10.1016/s0021-9258(19)69030-7"}],"title":"Assignment of disulfide bonds in the beta subunit of human chorionic gonadotropin.","publicationDate":"1981","journal":"J. Biol. Chem.","firstPage":"6587","lastPage":"6592","volume":"256"},"referencePositions":["PRELIMINARY ASSIGNMENT OF DISULFIDE BONDS"]},{"referenceNumber":15,"citation":{"id":"1688430","citationType":"journal article","authors":["Saccuzo Beebe J.","Mountjoy K.","Krzesicki R.F.","Perini F.","Ruddon R.W."],"citationCrossReferences":[{"database":"PubMed","id":"1688430"},{"database":"DOI","id":"10.1016/s0021-9258(19)40231-7"}],"title":"Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form.","publicationDate":"1990","journal":"J. Biol. Chem.","firstPage":"312","lastPage":"317","volume":"265"},"referencePositions":["DISULFIDE BONDS"]},{"referenceNumber":16,"citation":{"id":"1820200","citationType":"journal article","authors":["Weisshaar G.","Hiyama J.","Renwick A.G.C."],"citationCrossReferences":[{"database":"PubMed","id":"1820200"},{"database":"DOI","id":"10.1093/glycob/1.4.393"}],"title":"Site-specific N-glycosylation of human chorionic gonadotrophin -- structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy.","publicationDate":"1991","journal":"Glycobiology","firstPage":"393","lastPage":"404","volume":"1"},"referencePositions":["STRUCTURE OF CARBOHYDRATES"]},{"referenceNumber":17,"citation":{"id":"8202136","citationType":"journal article","authors":["Lapthorn A.J.","Harris D.C.","Littlejohn A.","Lustbader J.W.","Canfield R.E.","Machin K.J.","Morgan F.J.","Isaacs N.W."],"citationCrossReferences":[{"database":"PubMed","id":"8202136"},{"database":"DOI","id":"10.1038/369455a0"}],"title":"Crystal structure of human chorionic gonadotropin.","publicationDate":"1994","journal":"Nature","firstPage":"455","lastPage":"461","volume":"369"},"referencePositions":["X-RAY CRYSTALLOGRAPHY","GLYCOSYLATION AT ASN-33 AND ASN-50","SUBUNIT"]},{"referenceNumber":18,"citation":{"id":"16123088","citationType":"journal article","authors":["Rull K.","Laan M."],"citationCrossReferences":[{"database":"PubMed","id":"16123088"},{"database":"DOI","id":"10.1093/humrep/dei261"}],"title":"Expression of beta-subunit of HCG genes during normal and failed pregnancy.","publicationDate":"2005","journal":"Hum. Reprod.","firstPage":"3360","lastPage":"3368","volume":"20"},"referencePositions":["TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"J00117","properties":[{"key":"ProteinId","value":"AAA96690.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X00265","properties":[{"key":"ProteinId","value":"CAA25068.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X00266","properties":[{"key":"ProteinId","value":"CAA25069.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"K03189","properties":[{"key":"ProteinId","value":"AAA53288.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"K03187","properties":[{"key":"ProteinId","value":"AAA53288.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"K03188","properties":[{"key":"ProteinId","value":"AAA53288.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"K03183","properties":[{"key":"ProteinId","value":"AAA53287.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"K00092","properties":[{"key":"ProteinId","value":"AAA53287.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"K03182","properties":[{"key":"ProteinId","value":"AAA53287.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT006890","properties":[{"key":"ProteinId","value":"AAP35536.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK291552","properties":[{"key":"ProteinId","value":"BAF84241.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC008687","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471177","properties":[{"key":"ProteinId","value":"EAW52434.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471177","properties":[{"key":"ProteinId","value":"EAW52437.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471177","properties":[{"key":"ProteinId","value":"EAW52438.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC006290","properties":[{"key":"ProteinId","value":"AAH06290.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC022796","properties":[{"key":"ProteinId","value":"AAH22796.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC030994","properties":[{"key":"ProteinId","value":"AAH30994.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC041054","properties":[{"key":"ProteinId","value":"AAH41054.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC051378","properties":[{"key":"ProteinId","value":"AAH51378.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC069526","properties":[{"key":"ProteinId","value":"AAH69526.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC103969","properties":[{"key":"ProteinId","value":"AAI03970.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC103970","properties":[{"key":"ProteinId","value":"AAI03971.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC103971","properties":[{"key":"ProteinId","value":"AAI03972.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC106059","properties":[{"key":"ProteinId","value":"AAI06060.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC106723","properties":[{"key":"ProteinId","value":"AAI06724.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC106724","properties":[{"key":"ProteinId","value":"AAI06725.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC128603","properties":[{"key":"ProteinId","value":"AAI28604.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M13503","properties":[{"key":"ProteinId","value":"AAA52009.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M13504","properties":[{"key":"ProteinId","value":"AAA52005.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M13505","properties":[{"key":"ProteinId","value":"AAA52008.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF397576","properties":[{"key":"ProteinId","value":"AAL69704.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF397577","properties":[{"key":"ProteinId","value":"AAL69705.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF397578","properties":[{"key":"ProteinId","value":"AAL69706.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF397579","properties":[{"key":"ProteinId","value":"AAL69707.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF397580","properties":[{"key":"ProteinId","value":"AAL69708.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF397581","properties":[{"key":"ProteinId","value":"AAL69709.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS12749.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P0DN86-1"},{"database":"PIR","id":"A93230","properties":[{"key":"EntryName","value":"KTHUB"}]},{"database":"PIR","id":"I37231","properties":[{"key":"EntryName","value":"I37231"}]},{"database":"RefSeq","id":"NP_000728.1","properties":[{"key":"NucleotideSequenceId","value":"NM_000737.5"}],"isoformId":"P0DN86-1"},{"database":"RefSeq","id":"NP_149032.1","properties":[{"key":"NucleotideSequenceId","value":"NM_033043.2"}],"isoformId":"P0DN86-1"},{"database":"RefSeq","id":"NP_149439.1","properties":[{"key":"NucleotideSequenceId","value":"NM_033183.3"}],"isoformId":"P0DN86-1"},{"database":"PDB","id":"1HCN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B=21-165"}]},{"database":"PDB","id":"1HRP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"B=21-165"}]},{"database":"PDB","id":"1QFW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"B=21-165"}]},{"database":"PDB","id":"7FIG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"Y=1-165"}]},{"database":"PDB","id":"7FIH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"Y=1-165"}]},{"database":"PDB","id":"7FII","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.30 A"},{"key":"Chains","value":"Y=1-165"}]},{"database":"PDB","id":"9RHU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"G2=21-93, G2=96-151"}]},{"database":"AlphaFoldDB","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31596","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31597","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31598","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"ComplexPortal","id":"CPX-748","properties":[{"key":"EntryName","value":"Chorionic gonadotropin hormone complex"}]},{"database":"FunCoup","id":"P0DN86","properties":[{"key":"Number of interactors","value":"49"}]},{"database":"IntAct","id":"P0DN86","properties":[{"key":"Interactions","value":"12"}]},{"database":"STRING","id":"9606.ENSP00000301408","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P0DN86","properties":[{"key":"glycosylation","value":"53 N-Linked glycans (2 sites), 6 O-Linked glycans"}]},{"database":"GlyCosmos","id":"P0DN86","properties":[{"key":"glycosylation","value":"8 sites, 43 glycans"}]},{"database":"GlyGen","id":"P0DN86","properties":[{"key":"glycosylation","value":"9 sites, 28 N-linked glycans (3 sites), 16 O-linked glycans (5 sites)"}]},{"database":"iPTMnet","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CGB5","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000301408","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P0DN86","properties":[{"key":"antibodies","value":"6 sequenced antibodies"}]},{"database":"Antibodypedia","id":"4392","properties":[{"key":"antibodies","value":"2239 antibodies from 40 providers"}]},{"database":"Antibodypedia","id":"74544","properties":[{"key":"antibodies","value":"114 antibodies from 12 providers"}]},{"database":"Antibodypedia","id":"76402","properties":[{"key":"antibodies","value":"30 antibodies from 4 providers"}]},{"database":"CPTC","id":"P0DN86","properties":[{"key":"antibodies","value":"10 antibodies"}]},{"database":"DNASU","id":"1082","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000301408.7","properties":[{"key":"ProteinId","value":"ENSP00000301408.5"},{"key":"GeneId","value":"ENSG00000189052.7"}],"isoformId":"P0DN86-1"},{"database":"Ensembl","id":"ENST00000357383.4","properties":[{"key":"ProteinId","value":"ENSP00000349954.2"},{"key":"GeneId","value":"ENSG00000104827.12"}],"isoformId":"P0DN86-1"},{"database":"Ensembl","id":"ENST00000448456.4","properties":[{"key":"ProteinId","value":"ENSP00000403649.2"},{"key":"GeneId","value":"ENSG00000213030.7"}],"isoformId":"P0DN86-1"},{"database":"GeneID","id":"1082","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"93659","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"94115","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1082","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:93659","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:94115","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000301408.7","properties":[{"key":"ProteinId","value":"ENSP00000301408.5"},{"key":"RefSeqNucleotideId","value":"NM_033043.2"},{"key":"RefSeqProteinId","value":"NP_149032.1"}]},{"database":"MANE-Select","id":"ENST00000357383.4","properties":[{"key":"ProteinId","value":"ENSP00000349954.2"},{"key":"RefSeqNucleotideId","value":"NM_000737.5"},{"key":"RefSeqProteinId","value":"NP_000728.1"}]},{"database":"MANE-Select","id":"ENST00000448456.4","properties":[{"key":"ProteinId","value":"ENSP00000403649.2"},{"key":"RefSeqNucleotideId","value":"NM_033183.3"},{"key":"RefSeqProteinId","value":"NP_149439.1"}]},{"database":"AGR","id":"HGNC:16452","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"HGNC:16453","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"HGNC:1886","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1082","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"93659","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"94115","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1082","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"93659","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"94115","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CGB3","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CGB5","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CGB8","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1886","properties":[{"key":"GeneName","value":"CGB3"}]},{"database":"HGNC","id":"HGNC:16452","properties":[{"key":"GeneName","value":"CGB5"}]},{"database":"HGNC","id":"HGNC:16453","properties":[{"key":"GeneName","value":"CGB8"}]},{"database":"HPA","id":"ENSG00000104827","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (pancreas, pituitary gland, placenta)"}]},{"database":"HPA","id":"ENSG00000189052","properties":[{"key":"ExpressionPatterns","value":"Group enriched (pituitary gland, placenta)"}]},{"database":"HPA","id":"ENSG00000213030","properties":[{"key":"ExpressionPatterns","value":"Group enriched (pituitary gland, placenta)"}]},{"database":"MIM","id":"118860","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"608825","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"608827","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000189052","properties":[{"key":"Description","value":"-"}]},{"database":"OpenTargets","id":"ENSG00000213030","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104827","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000189052","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000213030","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000163162","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ACAGFCQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9525526at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P0DN86","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-209822","properties":[{"key":"PathwayName","value":"Glycoprotein hormones"}]},{"database":"Reactome","id":"R-HSA-8866910","properties":[{"key":"PathwayName","value":"TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"}]},{"database":"SignaLink","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000104827","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"Agora","id":"ENSG00000189052","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1082","properties":[{"key":"hits","value":"25 hits in 222 CRISPR screens"}]},{"database":"BioGRID-ORCS","id":"93659","properties":[{"key":"hits","value":"29 hits in 598 CRISPR screens"}]},{"database":"BioGRID-ORCS","id":"94115","properties":[{"key":"hits","value":"21 hits in 244 CRISPR screens"}]},{"database":"ChiTaRS","id":"CGB8","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P0DN86","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P0DN86","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"P0DN86","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000104827","properties":[{"key":"ExpressionPatterns","value":"Expressed in placenta and 48 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P0DN86","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16123088"}]},{"database":"GO","id":"GO:0061696","properties":[{"key":"GoTerm","value":"C:pituitary gonadotropin complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"7922031"}]},{"database":"GO","id":"GO:0005179","properties":[{"key":"GoTerm","value":"F:hormone activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006915","properties":[{"key":"GoTerm","value":"P:apoptotic process"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7723844"}]},{"database":"GO","id":"GO:0007267","properties":[{"key":"GoTerm","value":"P:cell-cell signaling"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"6194155"}]},{"database":"GO","id":"GO:0007292","properties":[{"key":"GoTerm","value":"P:female gamete generation"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10468638"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0009755","properties":[{"key":"GoTerm","value":"P:hormone-mediated signaling pathway"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7922031"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10468638"}]},{"database":"CDD","id":"cd00069","properties":[{"key":"EntryName","value":"GHB_like"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP00013","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"2.10.90.10:FF:000007","properties":[{"key":"EntryName","value":"Luteinizing hormone beta subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.90.10","properties":[{"key":"EntryName","value":"Cystine-knot cytokines"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR029034","properties":[{"key":"EntryName","value":"Cystine-knot_cytokine"}]},{"database":"InterPro","id":"IPR006208","properties":[{"key":"EntryName","value":"Glyco_hormone_CN"}]},{"database":"InterPro","id":"IPR001545","properties":[{"key":"EntryName","value":"Gonadotropin_bsu"}]},{"database":"InterPro","id":"IPR018245","properties":[{"key":"EntryName","value":"Gonadotropin_bsu_CS"}]},{"database":"PANTHER","id":"PTHR11515:SF25","properties":[{"key":"EntryName","value":"CHORIOGONADOTROPIN SUBUNIT BETA 3-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11515","properties":[{"key":"EntryName","value":"GLYCOPROTEIN HORMONE BETA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00007","properties":[{"key":"EntryName","value":"Cys_knot"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00068","properties":[{"key":"EntryName","value":"GHB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57501","properties":[{"key":"EntryName","value":"Cystine-knot cytokines"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00261","properties":[{"key":"EntryName","value":"GLYCO_HORMONE_BETA_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00689","properties":[{"key":"EntryName","value":"GLYCO_HORMONE_BETA_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ","length":165,"molWeight":17739,"crc64":"5598FB9E51A05748","md5":"0E3F4B0524544731EB52C618B57E87B8"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"PHARMACEUTICAL":1,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":2,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Region":1,"Compositional bias":1,"Glycosylation":6,"Disulfide bond":6,"Alternative sequence":1,"Natural variant":9,"Sequence conflict":4,"Beta strand":6,"Helix":1,"Turn":1},"uniParcId":"UPI0000035497"}}