{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DJY5","uniProtkbId":"U2_BPMU","entryAudit":{"firstPublicDate":"2014-05-14","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2014-05-14","entryVersion":33,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Escherichia phage Mu","commonName":"Bacteriophage Mu","taxonId":2681603,"lineage":["Viruses","Duplodnaviria","Heunggongvirae","Uroviricota","Caudoviricetes","Caudoviricetes incertae sedis","Muvirus","Muvirus mu"]},"organismHosts":[{"scientificName":"Enterobacteriaceae","taxonId":543}],"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Tail fiber assembly protein U'"}},"alternativeNames":[{"fullName":{"value":"Gene product U'"},"shortNames":[{"value":"gpU'"}]}]},"genes":[{"geneName":{"value":"U'"},"orderedLocusNames":[{"value":"Mup51"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Chaperone involved in tail fiber assembly. Remains associated to the tail fiber and participates in the host receptor binding. Binds to the primary receptor (Probable). Two alternate tail fiber assembly proteins U and U' are encoded extending the host range of the virus"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Tail fiber"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8599204"}],"value":"Virion","id":"SL-0274"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8599204"}],"value":"Host cytoplasm","id":"SL-0381"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8293968"}],"value":"Expressed in the late phase of the viral replicative cycle. Expression of late genes is activated by the viral late transcription activator C. Expressed alternatively with tail fiber assembly protein U. The switch from S-U to S'-U' is performed through inversion of a DNA segment called G by the phage invertase protein Gin"}],"commentType":"INDUCTION"},{"texts":[{"value":"The orientation of the G segment is defined as G+ and G-. G+ orientation provides S-U fibers whereas G- provides S'-U' fibers. S-U and S'-U' dont have the same host range (e.g. respectively E.coli and C.freundii)"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the tfa family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Tail fiber assembly protein U'","featureId":"PRO_0000429064"}],"keywords":[{"id":"KW-1035","category":"Cellular component","name":"Host cytoplasm"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0426","category":"Developmental stage","name":"Late protein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-1233","category":"Biological process","name":"Viral attachment to host adhesion receptor"},{"id":"KW-1161","category":"Biological process","name":"Viral attachment to host cell"},{"id":"KW-1264","category":"Biological process","name":"Viral receptor tropism switching"},{"id":"KW-1188","category":"Biological process","name":"Viral release from host cell"},{"id":"KW-1245","category":"Biological process","name":"Viral tail assembly"},{"id":"KW-1246","category":"Biological process","name":"Viral tail fiber assembly"},{"id":"KW-1230","category":"Cellular component","name":"Viral tail fiber protein"},{"id":"KW-1227","category":"Cellular component","name":"Viral tail protein"},{"id":"KW-0946","category":"Cellular component","name":"Virion"},{"id":"KW-1160","category":"Biological process","name":"Virus entry into host cell"}],"references":[{"referenceNumber":1,"citation":{"id":"11922669","citationType":"journal article","authors":["Morgan G.J.","Hatfull G.F.","Casjens S.","Hendrix R.W."],"citationCrossReferences":[{"database":"PubMed","id":"11922669"},{"database":"DOI","id":"10.1006/jmbi.2002.5437"}],"title":"Bacteriophage Mu genome sequence: analysis and comparison with Mu-like prophages in Haemophilus, Neisseria and Deinococcus.","publicationDate":"2002","journal":"J. Mol. Biol.","firstPage":"337","lastPage":"359","volume":"317"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"8293968","citationType":"journal article","authors":["Chiang L.W.","Howe M.M."],"citationCrossReferences":[{"database":"PubMed","id":"8293968"},{"database":"DOI","id":"10.1093/genetics/135.3.619"}],"title":"Mutational analysis of a C-dependent late promoter of bacteriophage Mu.","publicationDate":"1993","journal":"Genetics","firstPage":"619","lastPage":"629","volume":"135"},"referencePositions":["INDUCTION"]},{"referenceNumber":3,"citation":{"id":"8599204","citationType":"journal article","authors":["Grimaud R."],"citationCrossReferences":[{"database":"PubMed","id":"8599204"},{"database":"DOI","id":"10.1006/viro.1996.0107"}],"title":"Bacteriophage Mu head assembly.","publicationDate":"1996","journal":"Virology","firstPage":"200","lastPage":"210","volume":"217"},"referencePositions":["SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF083977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_602302.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000929.1"}]},{"database":"SMR","id":"P0DJY5","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"2636259","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002611","properties":[{"key":"Component","value":"Segment"}]},{"database":"GO","id":"GO:0030430","properties":[{"key":"GoTerm","value":"C:host cell cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0098024","properties":[{"key":"GoTerm","value":"C:virus tail, fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-KW"}]},{"database":"GO","id":"GO:0098671","properties":[{"key":"GoTerm","value":"P:adhesion receptor-mediated virion attachment to host cell"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-KW"}]},{"database":"GO","id":"GO:0046718","properties":[{"key":"GoTerm","value":"P:symbiont entry into host cell"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-KW"}]},{"database":"GO","id":"GO:0098678","properties":[{"key":"GoTerm","value":"P:viral tropism switching"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-KW"}]},{"database":"GO","id":"GO:0098004","properties":[{"key":"GoTerm","value":"P:virus tail fiber assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-KW"}]},{"database":"InterPro","id":"IPR003458","properties":[{"key":"EntryName","value":"Phage_T4_Gp38_tail_assem"}]},{"database":"Pfam","id":"PF02413","properties":[{"key":"EntryName","value":"Caudo_TAP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMHLKNITAGNPKTKEQYQLTKQFNIKWLYTEDGKNWYEEQKNFQPDTLKMVYDHNGVIICIEKDVSAINPEGANVVEVPDITANRRADISGKWMFKDGVVIKRTYTEEEQRQQAENEKQSLLQLVRDKTQLWDSQLRLGIISDENKQKLTEWMLYAQKVESTDTSSLPVTFPEQPE","length":177,"molWeight":20698,"crc64":"A7E29392E37B0137","md5":"EE00150AA6BF12EC3719329E153A52F5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"INDUCTION":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1},"uniParcId":"UPI0000163797"}}