{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DI83","uniProtkbId":"NARR_HUMAN","entryAudit":{"firstPublicDate":"2011-09-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-09-21","entryVersion":77,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Ras-related protein Rab-34, isoform NARR"}},"alternativeNames":[{"fullName":{"value":"Nine amino-acid residue-repeats"}}]},"genes":[{"geneName":{"value":"RAB34"},"synonyms":[{"value":"NARR"}]}],"comments":[{"texts":[{"value":"May interact with EIF5A and ERF1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Colocalizes with rDNA clusters"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}],"value":"Nucleus, nucleolus","id":"SL-0188"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"NARR"},"isoformIds":["P0DI83-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"1"},"isoformIds":["Q9BZG1-1"],"isoformSequenceStatus":"External"},{"name":{"value":"2"},"isoformIds":["Q9BZG1-2"],"isoformSequenceStatus":"External"},{"name":{"value":"4"},"isoformIds":["Q9BZG1-4"],"isoformSequenceStatus":"External"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}],"value":"Phosphorylated during M-phase"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Shares its exons with RAB34, but the first 5'-exon is longer, and the translation occurs 443 base pairs upstream from RAB34 initiator, in another frame. May be produced by an alternative promoter"}],"commentType":"CAUTION"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Ras-related protein Rab-34, isoform NARR","featureId":"PRO_0000412533"},{"type":"Repeat","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"6","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"7","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"8","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"9","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"10","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"11","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"12","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Repeat","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"13","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Region","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"13 x 9 AA approximate tandem-repeats of P-R-V-I-V-G-(S/T)-P-R"},{"type":"Region","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Modified residue","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Modified residue","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Modified residue","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Modified residue","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]},{"type":"Modified residue","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21586586"}]}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.-K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":3,"citation":{"id":"21586586","citationType":"journal article","authors":["Zougman A.","Mann M.","Wisniewski J.R."],"citationCrossReferences":[{"database":"PubMed","id":"21586586"},{"database":"DOI","id":"10.1093/nar/gkr273"}],"title":"Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene.","publicationDate":"2011","journal":"Nucleic Acids Res.","firstPage":"7103","lastPage":"7113","volume":"39"},"referencePositions":["PROTEIN SEQUENCE OF 2-26; 65-71; 74-109; 119-125; 128-145; 155-171 AND 186-193","CLEAVAGE OF INITIATOR METHIONINE","REPEATS","SUBCELLULAR LOCATION","INTERACTION WITH EIF5A AND ERF1","PHOSPHORYLATION AT SER-13; THR-69; SER-78; SER-87; SER-96 AND SER-123"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC010761","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CX872465","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001243210.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001256281.3"}],"isoformId":"P0DI83-1"},{"database":"AlphaFoldDB","id":"P0DI83","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"3188911","properties":[{"key":"Interactions","value":"7"}]},{"database":"IntAct","id":"P0DI83","properties":[{"key":"Interactions","value":"19"}]},{"database":"NDEx","id":"IQUERY-CP-RAB34","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"iPTMnet","id":"P0DI83","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P0DI83","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P0DI83","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"RAB34","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"347602360","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P0DI83","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P0DI83","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52535","properties":[{"key":"Description","value":"-"}],"isoformId":"P0DI83-1"},{"database":"Pumba","id":"P0DI83","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"14281","properties":[{"key":"antibodies","value":"122 antibodies from 27 providers"}]},{"database":"DNASU","id":"83871","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000636154.2","properties":[{"key":"ProteinId","value":"ENSP00000490450.1"},{"key":"GeneId","value":"ENSG00000109113.21"}]},{"database":"GeneID","id":"83871","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"HGNC:16519","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"83871","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"83871","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"RAB34","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:16519","properties":[{"key":"GeneName","value":"RAB34"}]},{"database":"HPA","id":"ENSG00000109113","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"RAB34","properties":[{"key":"Description","value":"-"}]},{"database":"OpenTargets","id":"ENSG00000109113","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000109113","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000159645","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"413584at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P0DI83","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P0DI83","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000109113","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"83871","properties":[{"key":"hits","value":"28 hits in 1157 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"RAB34","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"83871","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P0DI83","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"Bgee","id":"ENSG00000109113","properties":[{"key":"ExpressionPatterns","value":"Expressed in descending thoracic aorta and 176 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P0DI83","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"InterPro","id":"IPR059393","properties":[{"key":"EntryName","value":"DUF8349"}]},{"database":"Pfam","id":"PF27509","properties":[{"key":"EntryName","value":"DUF8349"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVGQPQPRDDVGSPRPRVIVGTIRPRVIVGTIRPRVIVGSARARPPPDGTPRPQLAAEESPRPRVIFGTPRARVILGSPRPRVIVSSPWPAVVVASPRPRTPVGSPWPRVVVGTPRPRVIVGSPRARVADADPASAPSQGALQGRRQDEHSGTRAEGSRPGGAAPVPEEGGRFARAQRLPPPRHLRLPGAPDRHRGQI","length":198,"molWeight":21118,"crc64":"E03CF9EB3272B766","md5":"642C91098849634AF6061CEA69E0857C"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"PTM":1,"CAUTION":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Repeat":13,"Region":3,"Compositional bias":3,"Modified residue":6},"uniParcId":"UPI00021D6339"}}