{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DI79","secondaryAccessions":["Q56XE6","Q8GXJ7","Q9XF11"],"uniProtkbId":"U496P_ARATH","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":62,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"UPF0496 protein At3g28300"}},"alternativeNames":[{"fullName":{"value":"Protein At14a"}}]},"genes":[{"orderedLocusNames":[{"value":"At3g28300"}],"orfNames":[{"value":"MZF16.9"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10196471"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10196471"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10196471"}],"value":"Widely expressed"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPF0496 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC42823.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"UPF0496 protein At3g28300","featureId":"PRO_0000419524"},{"type":"Transmembrane","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10196471","citationType":"journal article","authors":["Nagpal P.","Quatrano R.S."],"citationCrossReferences":[{"database":"PubMed","id":"10196471"},{"database":"DOI","id":"10.1016/s0378-1119(99)00068-2"}],"title":"Isolation and characterization of a cDNA clone from Arabidopsis thaliana with partial sequence similarity to integrins.","publicationDate":"1999","journal":"Gene","firstPage":"33","lastPage":"40","volume":"230"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TISSUE SPECIFICITY","SUBCELLULAR LOCATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"10907853","citationType":"journal article","authors":["Kaneko T.","Katoh T.","Sato S.","Nakamura Y.","Asamizu E.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"10907853"},{"database":"DOI","id":"10.1093/dnares/7.3.217"}],"title":"Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones.","publicationDate":"2000","journal":"DNA Res.","firstPage":"217","lastPage":"221","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"14593172","citationType":"journal article","authors":["Yamada K.","Lim J.","Dale J.M.","Chen H.","Shinn P.","Palm C.J.","Southwick A.M.","Wu H.C.","Kim C.J.","Nguyen M.","Pham P.K.","Cheuk R.F.","Karlin-Newmann G.","Liu S.X.","Lam B.","Sakano H.","Wu T.","Yu G.","Miranda M.","Quach H.L.","Tripp M.","Chang C.H.","Lee J.M.","Toriumi M.J.","Chan M.M.","Tang C.C.","Onodera C.S.","Deng J.M.","Akiyama K.","Ansari Y.","Arakawa T.","Banh J.","Banno F.","Bowser L.","Brooks S.Y.","Carninci P.","Chao Q.","Choy N.","Enju A.","Goldsmith A.D.","Gurjal M.","Hansen N.F.","Hayashizaki Y.","Johnson-Hopson C.","Hsuan V.W.","Iida K.","Karnes M.","Khan S.","Koesema E.","Ishida J.","Jiang P.X.","Jones T.","Kawai J.","Kamiya A.","Meyers C.","Nakajima M.","Narusaka M.","Seki M.","Sakurai T.","Satou M.","Tamse R.","Vaysberg M.","Wallender E.K.","Wong C.","Yamamura Y.","Yuan S.","Shinozaki K.","Davis R.W.","Theologis A.","Ecker J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14593172"},{"database":"DOI","id":"10.1126/science.1088305"}],"title":"Empirical analysis of transcriptional activity in the Arabidopsis genome.","publicationDate":"2003","journal":"Science","firstPage":"842","lastPage":"846","volume":"302"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"11910074","citationType":"journal article","authors":["Seki M.","Narusaka M.","Kamiya A.","Ishida J.","Satou M.","Sakurai T.","Nakajima M.","Enju A.","Akiyama K.","Oono Y.","Muramatsu M.","Hayashizaki Y.","Kawai J.","Carninci P.","Itoh M.","Ishii Y.","Arakawa T.","Shibata K.","Shinagawa A.","Shinozaki K."],"citationCrossReferences":[{"database":"PubMed","id":"11910074"},{"database":"DOI","id":"10.1126/science.1071006"}],"title":"Functional annotation of a full-length Arabidopsis cDNA collection.","publicationDate":"2002","journal":"Science","firstPage":"141","lastPage":"145","volume":"296"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-385"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"CI-B9D7AITG0S7MM","citationType":"submission","authors":["Totoki Y.","Seki M.","Ishida J.","Nakajima M.","Enju A.","Kamiya A.","Narusaka M.","Shin-i T.","Nakagawa M.","Sakamoto N.","Oishi K.","Kohara Y.","Kobayashi M.","Toyoda A.","Sakaki Y.","Sakurai T.","Iida K.","Akiyama K.","Satou M.","Toyoda T.","Konagaya A.","Carninci P.","Kawai J.","Hayashizaki Y.","Shinozaki K."],"title":"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.","publicationDate":"MAR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-385"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF126374","properties":[{"key":"ProteinId","value":"AAD26355.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AP002051","properties":[{"key":"ProteinId","value":"BAB02621.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002686","properties":[{"key":"ProteinId","value":"AEE77430.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408685","properties":[{"key":"ProteinId","value":"CAO7042701.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY057599","properties":[{"key":"ProteinId","value":"AAL14394.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK118201","properties":[{"key":"ProteinId","value":"BAC42823.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK221728","properties":[{"key":"ProteinId","value":"BAD93736.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_189470.1","properties":[{"key":"NucleotideSequenceId","value":"NM_113749.4"}]},{"database":"AlphaFoldDB","id":"P0DI79","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0DI79","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"7786","properties":[{"key":"Interactions","value":"2"}]},{"database":"FunCoup","id":"P0DI79","properties":[{"key":"Number of interactors","value":"1"}]},{"database":"STRING","id":"3702.P0DI79","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-P0DI79","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"822457","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT3G28290","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT3G28300","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT3G28300","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT3G28300","properties":[{"key":"GeneName","value":"AT14A"}]},{"database":"HOGENOM","id":"CLU_044778_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P0DI79","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P0DI79","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P0DI79","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"ExpressionAtlas","id":"P0DI79","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10196471"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"28887381"}]},{"database":"GO","id":"GO:0008305","properties":[{"key":"GoTerm","value":"C:integrin complex"},{"key":"GoEvidenceType","value":"ISS:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"10196471"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10196471"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22456678"}]},{"database":"GO","id":"GO:0098609","properties":[{"key":"GoTerm","value":"P:cell-cell adhesion"},{"key":"GoEvidenceType","value":"IMP:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22456678"}]},{"database":"GO","id":"GO:0008360","properties":[{"key":"GoTerm","value":"P:regulation of cell shape"},{"key":"GoEvidenceType","value":"IMP:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22456678"}]},{"database":"Gene3D","id":"1.20.1170.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007749","properties":[{"key":"EntryName","value":"DUF677"}]},{"database":"PANTHER","id":"PTHR31113:SF13","properties":[{"key":"EntryName","value":"(RAPE) HYPOTHETICAL PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31113","properties":[{"key":"EntryName","value":"UPF0496 PROTEIN 3-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05055","properties":[{"key":"EntryName","value":"DUF677"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVLSKENMLKYSAHLRAYNSACGDHPELKSFDSELQQKTSNLINSFTSDAKTGLVPLPQHAAYKEFTKHLAEVNQQVSDYIIGYGEVVWENSTLRSLVETYFESAKKTLDIAENVTEYVDEAKRGERYIVAAVAQFEKDKENDVGKKTKRYENTLRELKKFEAMGNPFDGDKFTTLFKLMHKEQESLLERVRETKEKLDEELKNIEMEISSRKKWSIISNVLFIGAFVAVAVGSMVLVCTGVGAGVGVAGLLSLPLIAIGWVGVHTILENKIQAREKQEEALKKAHRIANEMDKGMETDKVDMNSISGKVHALKSKITSMLNAVKDATEDGANEVDTKQVMETLTGDVVELTEDIKAVGDDVAKYSKMIEETSYHVLQKITGSGK","length":385,"molWeight":42955,"crc64":"3EA2EA4AE6ADD50C","md5":"476DB81DFC5B545DD1C68E97CFDFC85D"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Transmembrane":2,"Coiled coil":2},"uniParcId":"UPI00000A0F3E"}}