{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0CZ18","secondaryAccessions":["P23701"],"uniProtkbId":"OMCB_CHLPS","entryAudit":{"firstPublicDate":"2011-06-28","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-06-28","entryVersion":36,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia psittaci","commonName":"Chlamydophila psittaci","taxonId":83554,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Large cysteine-rich periplasmic protein omcB"},"shortNames":[{"value":"Large-CRP"}]},"alternativeNames":[{"fullName":{"value":"60 kDa cysteine-rich OMP"}},{"fullName":{"value":"60 kDa outer membrane protein"}},{"fullName":{"value":"Cysteine-rich outer membrane protein"}}],"contains":[{"recommendedName":{"fullName":{"value":"Large cysteine-rich periplasmic protein omcB-alpha"}}},{"recommendedName":{"fullName":{"value":"Large cysteine-rich periplasmic protein omcB-beta"}}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"omcB"},"synonyms":[{"value":"envB"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (omcA) and the large cysteine-rich periplasmic protein (omcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Periplasm","id":"SL-0200"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7582008"}],"value":"It is present but the disulfide bonds are reduced in the intracellular reticulate bodies (RBs)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Was thought to be an outer membrane protein as it is part of a disulfide cross-linked complex that is insoluble in the detergent Sarkosyl. In PubMed:7532170 it was shown to likely be periplasmic"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Propeptide","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}],"featureId":"PRO_0000020166"},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"Large cysteine-rich periplasmic protein omcB-alpha","featureId":"PRO_0000020167"},{"type":"Chain","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"Large cysteine-rich periplasmic protein omcB-beta","featureId":"PRO_0000248870"}],"keywords":[{"id":"KW-0133","category":"Biological process","name":"Cell 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