{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0CG95","secondaryAccessions":["L0T7T3","Q6MX10","Q7ARR3","Q7D986"],"uniProtkbId":"Y814_MYCTU","entryAudit":{"firstPublicDate":"2010-08-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-08-10","entryVersion":74,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","taxonId":83332,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Mycobacteriales","Mycobacteriaceae","Mycobacterium","Mycobacterium tuberculosis complex"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein Rv0814c"}}},"genes":[{"geneName":{"value":"sseC2"},"orderedLocusNames":[{"value":"Rv0814c"}]}],"comments":[{"texts":[{"value":"Pupylation of this protein has been demonstrated, however it is unknown if it is the product of this gene, of the identical gene Rv3118 (AC P0CG96), or of both of them"}],"commentType":"MISCELLANEOUS"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Uncharacterized protein Rv0814c","featureId":"PRO_0000396092"},{"type":"Cross-link","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20066036"}]}],"keywords":[{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"9634230","citationType":"journal article","authors":["Cole S.T.","Brosch R.","Parkhill J.","Garnier T.","Churcher C.M.","Harris D.E.","Gordon S.V.","Eiglmeier K.","Gas S.","Barry C.E. III","Tekaia F.","Badcock K.","Basham D.","Brown D.","Chillingworth T.","Connor R.","Davies R.M.","Devlin K.","Feltwell T.","Gentles S.","Hamlin N.","Holroyd S.","Hornsby T.","Jagels K.","Krogh A.","McLean J.","Moule S.","Murphy L.D.","Oliver S.","Osborne J.","Quail M.A.","Rajandream M.A.","Rogers J.","Rutter S.","Seeger K.","Skelton S.","Squares S.","Squares R.","Sulston J.E.","Taylor K.","Whitehead S.","Barrell B.G."],"citationCrossReferences":[{"database":"PubMed","id":"9634230"},{"database":"DOI","id":"10.1038/31159"}],"title":"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.","publicationDate":"1998","journal":"Nature","firstPage":"537","lastPage":"544","volume":"393"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"20066036","citationType":"journal article","authors":["Festa R.A.","McAllister F.","Pearce M.J.","Mintseris J.","Burns K.E.","Gygi S.P.","Darwin K.H."],"citationCrossReferences":[{"database":"PubMed","id":"20066036"},{"database":"DOI","id":"10.1371/journal.pone.0008589"}],"title":"Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis.","publicationDate":"2010","journal":"PLoS ONE","firstPage":"E8589","lastPage":"E8589","volume":"5"},"referencePositions":["PUPYLATION AT LYS-98","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"21969609","citationType":"journal article","authors":["Kelkar D.S.","Kumar D.","Kumar P.","Balakrishnan L.","Muthusamy B.","Yadav A.K.","Shrivastava P.","Marimuthu A.","Anand S.","Sundaram H.","Kingsbury R.","Harsha H.C.","Nair B.","Prasad T.S.","Chauhan D.S.","Katoch K.","Katoch V.M.","Kumar P.","Chaerkady R.","Ramachandran S.","Dash D.","Pandey A."],"citationCrossReferences":[{"database":"PubMed","id":"21969609"},{"database":"DOI","id":"10.1074/mcp.m111.011445"}],"title":"Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.","publicationDate":"2011","journal":"Mol. Cell. Proteomics","firstPage":"M111.011627","lastPage":"M111.011627","volume":"10"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL123456","properties":[{"key":"ProteinId","value":"CCP43562.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"F70809","properties":[{"key":"EntryName","value":"F70809"}]},{"database":"RefSeq","id":"NP_215329.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"RefSeq","id":"WP_003404278.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"RefSeq","id":"YP_177930.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"AlphaFoldDB","id":"P0CG95","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0CG95","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"885435","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtu:Rv0814c","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtu:Rv3118","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtv:RVBD_0814c","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtv:RVBD_3118","properties":[{"key":"Description","value":"-"}]},{"database":"TubercuList","id":"Rv0814c","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P0CG95","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"3729294at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P0CG95","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001584","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P0CG95","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"HDA:MTBBASE"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"14532352"}]},{"database":"FunFam","id":"2.60.40.1120:FF:000013","properties":[{"key":"EntryName","value":"DUF1416 domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1120","properties":[{"key":"EntryName","value":"Carboxypeptidase-like, regulatory domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008969","properties":[{"key":"EntryName","value":"CarboxyPept-like_regulatory"}]},{"database":"InterPro","id":"IPR010814","properties":[{"key":"EntryName","value":"DUF1416"}]},{"database":"Pfam","id":"PF07210","properties":[{"key":"EntryName","value":"DUF1416"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49464","properties":[{"key":"EntryName","value":"Carboxypeptidase regulatory domain-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MCSGPKQGLTLPASVDLEKETVITGRVVDGDGQAVGGAFVRLLDSSDEFTAEVVASATGDFRFFAAPGSWTLRALSAAGNGDAVVQPSGAGIHEVDVKIT","length":100,"molWeight":10165,"crc64":"8CDBC094255BC876","md5":"E21467C8D237B49EF621971735CC97BF"},"extraAttributes":{"countByCommentType":{"MISCELLANEOUS":1},"countByFeatureType":{"Chain":1,"Cross-link":1},"uniParcId":"UPI00000D1246"}}